Wilson's disease (WD), bepatolenticular degeneration, is an autosomal recessive disorder caused by mutations in the ATP7B gene, and is characterised by abnormal metabolism and deposition of copper in the liver, brain and other organs. The main aim of this thesis was to investigate the occurrence of psychopathology, as well as personality traits and neuropsychological function in Swedish patients with treated WD. The research subjects were 29 patients with confirmed WD, investigated at the Department of Internal Medicine at Uppsala University Hospital between 1996 and 2000. The treated WD patients showed prominent psychopathology as determined by the Comprehensive Psychopathological Rating Scale. The spectrum of psychopathological symptoms is not typical of classic psychiatric syndromes, and includes symptoms from Anxiety, Depression and Obsessive-Compulsive disorders as well as Negative Symptoms. In self-assessment, the WD patients tended to underestimate the presence of psychopathological symptoms. The treated WD patients differed in their sleep pattern from the control group, as measured with the Uppsala Sleep Inventory. The spectrum of self-reported symptoms suggests an altered REM sleep function. The treated WD patients had significant deviations in personality traits, especially in aggressivity-hostility related scales and Psychic anxiety, compared to healthy controls, as measured with the Karolinska Scales of Personality. The deviations were not related to age, age at onset or duration of WD. The treated WD patients displayed a specific profile of moderate neuropsychological impairment, as determined by the Automated Psychological Test battery. Finally, an attempt was made to search for, possible genotype-phenotype relationships in some ATP7B mutations.

Le laboratoire Woyzeck propose une approche de l'oeuvre de Büchner en trois temps, ordonnée autour de la métaphore anatomique. L'écriture de Woyzeck prend la forme d'une autopsie, indissociable des travaux scientifiques de Büchner réalisés à la même période. Le premier chapitre évoque ce geste d'écriture incisif et sa réception. Un état des recherches permet de considérer les analyses philologiques et herméneutiques de l'oeuvre qui font aujourd'hui autorité. Sont ici rappelés les lieux communs de la critique et les interprétations marquantes de la pièce. Si leur validité est ensuite interrogée, leur valeur symptomatique est aussi prise en compte sur un autre plan. Le deuxième chapitre prend la forme d'un essai portant sur les personnages et les corps, objets de l'autopsie. Il explore autrement des hypothèses formulées dans le premier chapitre autour du langage et du fragment. Le lieu de cette autopsie, la scène, est abordé dans le troisième chapitre à travers les mises à l'épreuve scéniques. Les trois spectacles choisis adoptent des partis pris dramaturgiques distincts. Celui de Thomas Ostermeier se présente comme un atelier social; « le cirque des travailleurs » d'Àrpàd Schilling est une machine à jouer qui semble relever le pari du théâtre de la cruauté artaudien; Robert Wilson travaille de pair avec Tom Waits pour créer un spectacle musical qui fait figure de conte populaire universel et autoréférentiel. Parmi les enjeux de ces mises à l'épreuve figurent notamment le rapport au réel et au présent, ainsi que le regard porté sur les corps que le texte de Georg Büchner invite à questionner. Dans un esprit d'ouverture et de confluence, en adéquation avec les travaux de Büchner, cette réflexion puise autant dans des notions d'analyse théâtrale que dans l'esthétique et l'histoire de la médecine. ______________________________________________________________________________ MOTS-CLÉS DE L’AUTEUR : Woyzeck, Regard, Fragment, Mise en scène.

Syftet med denna C-uppsats är (1) att finna en teoretisk modell kring begreppet sekt och (2) att utifrån denna modell undersöka vilka sektliknande drag Amish uppvisar i ett avgränsat material.

Thesis (M. Phil.)--University of Queensland, 2002. / Includes bibliographical references.

Not available / text

The topic of this thesis is the Domestic Architecture of the Natal Architect, William Street-Wilson (1856-1928) and spans the period from 1889 to 1913. It is based on the original drawing collection which can be found in the Barrie Bierman Architectural Library, University of Natal. Street-Wilson carried out his architectural training in England, and the study sets out to identify the stylistic changes which took place within the Arts and Crafts Movement in England, to establish any English precedent in Street-Wilson domestic architecture in Natal. In order to contexturalise Street-Wilson's domestic architecture in Natal, an overview of the political, social, economic and architectural background is given prior to, and during the year of Street-Wilson's arrival in 1887. The drawing collection is set chronologically during the period of 1889-1913, against the political, social and economic background, in order to study the effect of such influences on the Street-Wilson's houses. The study defines and identifies the different components which compose the plan and then carries out an analysis of the plan, form and style of the different categories of house types, namely the typical single storey, villa/double storey and semi-detached house, to highlight the evolution of the house type from the late nineteenth century to the early twentieth century. Since the verandah is the common thread throughout the drawing collection, a special study explores its possible origin and application in a colonial context. Examples of detail drawings have been extracted from the drawing collection to illustrate construction techniques and typical detailing employed by Street-Wilson and his partners, accompanied by a brief history of building materials to contexturalise materials within the studied period. The evolution of services, pertaining to comfort and sanitation, have been examined and applied to the houses designed by Street-Wilson. / Thesis (M.Arch.)-University of Natal, Durban, 1996.

Mémoire numérisé par la Division de la gestion de documents et des archives de l'Université de Montréal

Mémoire numérisé par la Division de la gestion de documents et des archives de l'Université de Montréal

The purpose of this biographical study was to determine what influence Vice President Thomas R. Marshall (1854-1925) had on the events and personalities of the Wilson era. An only child and the son of a country doctor, Marshall distinguished himself early as an exceptional student and country lawyer. His political heritage was that of the Democratic party, strong in his northeastern Indiana county but weak in the larger Congressional district. An early defeat for public office (1880) convinced Marshall that he could do more for the party as a worker on the local, district, and state levels with his oratory and his legal acumen. Despite his lack of ambition to hold public office, Marshall in 1908 found himself his party's compromise candidate for governor of Indiana. Elected essentially on a platform that supported local option at the expense of prohibition, the upstate Hoosier lawyer became the head of his state for a four-year term (1909-1913), expanding the progressive or melioristic programs of his Republican predecessors.Midway through his incumbency Thomas Marshall had achieved national reputation as one of the most popular and successful Democratic governors, and supporters began to advance his cause as a Presidential nominee at the 1912 Baltimore Convention. The more active campaigning of the Woodrow Wilson forces achieved the nomination of their candidate, and the political machinations of Indiana's Thomas Taggart succeeded in placing Marshall as a running-mate with Wilson on the Democratic ticket, eventually achieving his election as Vice President.With the frugality of a Scotsman Marshall and his wife, Lois, entered smoothly into Washington society, occasionally entertaining but more often being invited as guests to state functions and private parties. As Vice President (1913-1921) Marshall proved to be an utterly loyal supporter of the Democratic administration and a capable and well-liked presiding officer of the Senate.Correspondence between Wilson and Marshall reveals the President's use as well as his appreciation of the Vice President. More often than not Marshall was a solid party asset on the campaign trail, journeying throughout the country every two years on behalf of the Democratic Congressional candidates. During the war years he was one of the active speakers at Liberty Loan drives, stimulating a patriotic and pecuniary response from the people. He provided distinctive introductory remarks for the allied war missions when they visited the United States Senate, and on occasion represented Wilson as his official emissary before foreign diplomats and monarchs.The last two dozen months in office were the most disappointing to him and the most challenging to his reputation. He was tempted by certain men to usurp the Presidency during Wilson's incapacitating illness and by others to manipulate the Senate debating procedure during discussion of the League of Nations Covenant. He refused to be a party to the former, and though a believer in the Covenant he was powerless to prevent its defeat by the Republican majority whose rights on the Senate floor he steadfastly protected.Noteworthy about Marshall were his unpretentiousness, his natural gift of humor, his exceptional speaking ability, and his occasional self-derogation. His reputation has been overshadowed by the President's personality and by other prominent persons and events of the time. Some written criticisms by administration officials, preserved and transmitted by historians, have obscured his role and personality. Thomas R. Marshall unquestionably had superior talents and did in fact use them in meaningful but unostentatious ways as President of the Senate and as servant of the President and of his country.

The Pentagon career of Charles E. Wilson, President Dwight D. Eisenhower's Secretary of Defense from 1953-1957, is a neglected, yet important, field of study for studentsof the Eisenhower Presidency. Therefore, a study of Wilson's controversial tenure as Secretary of Defense is necessary for at least three reasons. First, Wilson served as Secretary of Defense for four and a half years, more than twice as long as any of his predecessors. Only Robert McNamara, who administered the Defense Department from 1961-1967, served longer than Wilson as the chief Pentagon official. Furthermore, Wilson became the Defense Department's civilian leader at a time when the agency was in its infancy.. His longevity as Secretary of Defense enabled him to make a significant impact upon the government's largest operation.Second, Wilson left a considerable store of personal papers, which are conveniently arranged at Anderson College in Anderson, Indiana. A serious examination of those materials gives one an additional measure of insight into the workings and concern of the Eisenhower Administration.Third, Wilson deserves study because he was a major figure in an important Administration. He has, however, been overlooked by virtually every chronicler of the Eisenhower Presidency. The prevailing view of Wilson maintains that he was an able administrator in the automobile industry, but woefully miscast as a political figure. That interpretation may not be totally wrong, but it is incomplete.More significantly, a study of Wilson enables the historian to challenge two views of the orthodox interpretation of the Eisenhower years. The first view maintains that the figures in the Eisenhower Cabinet were dull, unimaginative representatives of the business community. Indeed, one writer characterized the President and his advisers as "the bland leading the bland." That statement is misleading, at least in reference to Wilson.Charles E. Wilson was a wealthy industrialist, but he was hardly bland. He was many things; robust, blunt, energetic, sometimes simplistic, sometimes politically unskillful, but never bland. Furthermore, he possessed a down-to-earth intelligence which enabled him to direct the government's largest agency for almost a half-decade.A second view of the orthodox interpretation contends that the Eisenhower years were largely devoid of partisanship and a sense of political purpose. That, too, is misleading, especially regarding the issue of national defense. An examination of the debates over defense policy during those years reveals a high degree of partisanship with Wilson Persistently defending the Administration programs while the political opposition consistently sought to alter them. Furthermore, Wilson and his Democratic critics in the Senate were hardy rivals, with influential Democrats calling for Wilson's resignation at regular intervals. Wilson's encounters with Richard Russell, Lyndon B. Johnson, Stuart Symington and others may have lacked the drama of Harry Truman's lambasting of the "do-nothing, good-for-nothing" 80th congress during the 1948 presidential campaign. Yet the encounter between Wilson and his Senate critics were genuinely partisan and both Administration and Congress fought tooth-and-nail for political victory.I should like to state the purpose of this study. It is not an attempt at a biography of Wilson or even a summary of his career at the Pentagon. Instead, I have tried to examine the theme of conflict between Wilson and his Senate critics. The emphasis, and hopefully not the bias, is on Wilson's role as the Secretary of Defense in advocating his policies before skeptical groups of Senators. Hopefully, the study will succeed in a larger objective of shedding additional light on the inner workings of the Eisenhower Administration.