Cette thèse vise à développer un capteur d’ions cuivre dans des échantillons humains tels que le plasma ou les urines où l’accumulation des ions induit la maladie de Wilson. Le manque d’outil de diagnostic efficace et non invasif rend cette maladie traitable, potentiellement fatale. Notre capteur, basé sur la technologie des transistors à effet de champ de type metal-oxide-semiconducteur, a l’originalité d’utiliser une monocouche de lipide de type DC8,9PC de 2.4 nm d’épaisseur comme diélectrique de grille. Nous démontrons dans cette thèse que ces lipides peuvent être chimiquement modifiés en de monocouches, à stabilité mécanique et électrique élevée, transformées en sondes spécifiques par greffage sur le groupement de tête des lipides d’une fonction chélatante spécifique aux ions cuivre. La monocouche lipidique est formée à la surface du canal semiconducteur du transistor par fusion vésiculaire et est stabilisée par réticulation des lipides suivant un protocole que nous avons développé. Dans une première partie, nous décrivons la fabrication du transistor ainsi que l’ingénierie chimique des lipides avec le chélateur. Des mesures, en solutions aqueuses contenant des ions cuivre et d’autres ions potentiellement compétiteurs, ont validé la sensibilité et la spécificité du capteur. La deuxième partie est dédiée à l’optimisation des monocouches en tant qu’isolants électriques stables. Nous introduisons dans cette thèse la notion de double polymérisation des lipides dans la monocouche avec réticulation des chaînes aliphatiques et des groupements de tête. Nous démontrons que celle-ci conduit à l’amélioration drastique des propriétés mécaniques et électriques des monocouches. / This thesis aims at developing a sensor for the detection of Cu2+ in human samples such as urine. Copper is an ion of pathological interest in the body and its accumulation in tissues is responsible for the Wilson disease. While the disease can be effectively treated, the lack of efficient and non-invasive diagnosis techniques makes it potentially deadly. Our project aims for developing an efficient, sensitive, specific, and low cost sensor device based on metal-oxide-semiconductor field effect transistor technology and has the originality of using a 2.4 nm thick monolayer of DC8,9PC lipids as gate dielectric. We demonstrate that such lipids can be chemically engineered to allow the fabrication of monolayers with high mechanical and electrical stability and to confer them specific probe function. Specificity of the sensor is given by the grafting of a copper specific chelator to the lipids head-groups. The lipid monolayer is formed on the transistor semiconducting channel by the vesicle fusion. In the first part of the thesis, we describe the fabrication of the transistor including the chemical engineering of the lipids with the chelator. Sensitivity and specificity measurements were realized in aqueous solutions containing copper ions and potentially competitive ions. The second part is dedicated to improving the performances of the lipid monolayer as a stable insulator. We introduce in this thesis the concept of double polymerization of the lipids in the monolayer with a reticulation at both the levels of their aliphatic chains and their head-groups. We demonstrate that that leads to drastic improvements of both the mechanical and electrical properties of the monolayer.

[pt] Em uma perspectiva interdisciplinar entre os estudos de literatura e os estudos teatrais, esta dissertação propõe um olhar atento sobre a linguagem e a sonoridade no trabalho do diretor teatral norte-americano Robert Wilson nas três décadas que separam duas de suas realizações cênicas: Deafman Glance (1970), peça marcada pela ausência de palavras e sons, e Monsters of Grace II (2013), sua primeira obra radiofônica. A partir de pressupostos teóricos do teatro pósdramático e do teatro performativo, investigam-se o processo de aproximação de Wilson à linguagem oral, bem como novas abordagens do uso da voz no teatro. Objeto central da pesquisa, a peça Monsters of Grace II ganha uma análise detalhada, seja no contexto de produções na intersecção entre teatro e rádio, seja como dispositivo para investigar as possibilidades materiais e corporais da experiência radiofônica. / [en] From an interdisciplinary angle that takes in both literature and theater studies, this thesis turns its gaze on both language and sound in the oeuvre of American theater director Robert Wilson in the three decades that separate two of his works: Deafman Glance (1970), a play characterized by the absence of words and sound, and Monsters of Grace II (2013), his first work for radio. Wielding theoretical propositions from postdramatic and performative theater, this analysis investigates the process by which Wilson came to reconcile himself with oral language, as well as exploring new approaches to the use of voice in theater. The central object of this study, Monsters of Grace II is examined in greater detail, be it in the context of productions at the crossroads between theater and radio or as a framework by which to investigate the material and corporeal possibilities of experimentation in radio.

Les cellules de la crête neurale se caractérisent par leur capacité de migration dansl’embryon et la variété des types cellulaires qu’elles sont capables de générer (mélanocytes,système nerveux entérique (SNE) et périphérique). Chez l’homme, plusieurs maladiescongénitales affectant des organes et tissus divers, ont pour origine une anomalie demigration, prolifération, survie ou différenciation de ces cellules. Au laboratoire, nousétudions deux d’entre elles, le syndrome de Waardenburg-Hirschsprung (WS4- anomalie depigmentation, surdité et maladie de Hirschsprung (HSCR : anomalie entérique)) et lesyndrome de Mowat et Wilson (MWS – retard mental sévère, dysmorphie faciale avec ousans HSCR). A l’heure actuelle, quatre gènes ont été impliqués : l’endothéline 3 (EDN3) etson récepteur à sept domaines transmembranaires EDNRB et les deux facteurs de transcriptionZEB2 et SOX10. Au cours de ma thèse, nous avons montré que des délétions de SOX10 sontégalement responsables de 15% des cas de WS2 (défauts de pigmentation et surdité sansHSCR), élargissant le spectre des phénotypes liés à une mutation au sein de ce gène(Bondurand, Dastot-Le Moal, Stanchina et al. Am. J Hum. Genet, 2007).Parallèlement à ces études génétiques, nous avons souhaité mieux définir la fonction et lesinteractions entre les différents gènes impliqués dans le WS4 (SOX10, EDN3 et EDNRB).Pour cela, nous avons croisé les modèles murins invalidés pour ces gènes, et comparé lephénotype des simples et doubles mutants. A travers cette analyse phénotypique, nous avonsdémontré qu’une interaction entre ces molécules est nécessaire au développement normal duSNE et des mélanocytes dérivés de la crête neurale. En effet, par rapport aux simples mutants,les doubles mutants Sox10;Edn3 et Sox10;Ednrb présentent une augmentation de ladépigmentation, et une forte aggravation du phénotype entérique. Le suivi du devenir descellules formant le SNE au cours du développement nous a permis de montrer quel’aggravation du phénotype entérique est due à une diminution du pool de cellulesprogénitrices par apoptose (Stanchina et al. 2006).Dans la continuité des travaux déjà réalisés, nous avons voulu améliorer notrecompréhension du rôle joué par le gène du MWS : ZEB2, et étudier ses interactions avec lesgènes du WS4. Dans un premier temps, nous avons analysé l’effet de l’expression constitutiveou l’inhibition de ce facteur sur la survie, prolifération et différenciation des cellulesprogénitrices du SNE à l’aide d’un système de culture de progéniteurs entériques disponibleau laboratoire. Nos résultats suggèrent un effet répresseur de ZEB2 sur la différenciationneuronale. Ce facteur pourrait donc être nécessaire au maintien du pool de cellulesprogénitrices dans un état indifférencié. Nous avons ensuite étudié les interactions entre ZEB2et les gènes du WS4. Nous avons croisé les souris portant une invalidation du gène ZEB2 avecles souris invalidées pour SOX10 ou portant une mutation de EDN3 ou EDNRB, et démontréqu’une interaction entre ZEB2 et SOX10 est nécessaire au développement normal du SNE. Eneffet, par rapport aux simples mutants, les doubles mutants présentent une forte aggravationdu phénotype entérique, due à une diminution de la prolifération des cellules progénitrices et àune augmentation de la différenciation neuronale. L’analyse phénotype des mutantsZeb2;Edn3 et Zeb2;Ednrb suggère également l’existence d’une interaction entre ces troismolécules, mais l’origine du défaut entérique reste inexplorée.Ces études nous ont permis de mieux appréhender les réseaux moléculaires mis en place aucours du développement du SNE, de comprendre l’origine des anomalies entériques observéeschez les patients, améliorant leur prise en charge. / To understand in more details the molecular and cellular bases of hereditary diseases resulting from defects of neural crest (NC) development, we study several neurocristopathies, in particular Waardenburg syndrome (WS – pigmentary abnormalities and hearing loss), and Mowat-Wilson syndrome (MWS, severe mental retardation, facial dysmorphy, with or without HSCR (congenital megacolon)). To date, about ten causative genes have been identified, among which are the seven transmembrane domain receptor EDNRB and its ligand endothelin 3 (EDN3), the two transcription factors SOX10 and ZEB2.We contributed to the research efforts engaged to unravel these disorders. In particular, we identified the first mutations of SOX10 in patients presenting with WS4 (association of WS with HSCR disease) and WS2 (Bondurand, Dastot-Le Moal, Stanchina et al. Am. J Hum. Genet, 2007), and participated to functional studies describing its role during enteric nervous system (ENS) development. More recently, we identified the gene ZEB2 as responsible for MWS. The goal of my thesis was to understand the function of these genes and their interaction during the development of NC and ENS in particular. For this purpose, we combined an in vitro approach (isolation of ENS progenitors) to in vivo experiments (phenotype analysis of simple and double mutant mice). We demonstrated that an interaction between SOX10, EDN3 and EDNRB is necessary for the normal development of the ENS and melanocytes (Stanchina et al. 2006), and then focused our efforts in understanding the function of ZEB2 during the development of the ENS as well as its interactions with WS4 genes. Preliminary results suggest that ZEB2 inhibition accelerates neuronal differentiation in vitro. In the same time, generation of Zeb2;Sox10, Zeb2;Edn3 and Zeb2;Ednrb have been realized. Through phenotype analysis of Sox10;Zeb2 double mutants, we showed that a coordinated and balanced interaction between these two genes is required for normal ENS development. Indeed, double mutants present with more severe ENS defects due to decreased proliferation of enteric progenitors and increased neuronal differentiation from E11.5 onwards. These data revealed that crosstalks between these two transcription factors are crucial for proper ENS development. Analysis of Zeb2;Edn3 and Zeb2;Ednrb double mutant suggest also an interaction between these genes. Future experiments will help us to confirm these results and to determine the cellular and molecular origin of these interactions. These studies will enable us to better apprehend the molecular bases of these diseases, and to understand the origin of the enteric anomalies observed in patients. This knowledge may also help to develop new therapeutic strategies

[ES] La enfermedad de Wilson (EW) es un trastorno hereditario del metabolismo del cobre causado por mutaciones en ATP7B, que codifica una proteína transportadora de cobre en el hígado. Su mal funcionamiento provoca un fallo en la excreción biliar de cobre y una acumulación progresiva de este metal en el organismo, especialmente en hígado y cerebro. En este trabajo, se explora la posible utilidad de miRNAs circulantes en plasma para identificar biomarcadores que sirvan para controlar la progresión de la enfermedad en pacientes con EW bajo tratamiento. Los modelos desarrollados para cada miRNA mostraron un buen rendimiento al clasificar a los pacientes con factores de evolución desfavorable, por lo que estos tres miRNAs se proponen como candidatos para mejorar el seguimiento clínico o para respaldar la eficacia de nuevas terapias en la EW. / [CA] La malaltia de Wilson és un trastorn hereditari del metabolisme del coure causat per mutacions en ATP7B, que codifica per a una proteïna transportadora del coure al fetge. El seu mal funcionament produeix alteracions en l'excreció biliar i l'acumulació progressiva de coure, especialment en fetge i cervell. Es va explorar la possible utilitat del perfil de miRNAs circulants com biomarcadors de progressió de la patologia hepàtica. L'avaluació dels models obtinguts per a cadascun dels tres miRNAs va mostrar un bon rendiment per a classificar al grup de pacients amb factors d’evolució desfavorable, en conseqüència, es proposen com a candidats per tal de millorar el seguiment clínic o comprovar l’efectivitat de noves teràpies en la malaltia de Wilson. / [EN] Wilson disease (WD) is an inherited disorder of copper metabolism caused by mutations in ATP7B, which encodes for a liver copper-transporting protein. Its dysfunction causes a deficit in biliary copper excretion and a progressive accumulation of this metal in the organism, mainly in liver and brain. In this work, circulating miRNAs profiling in plasma has been accomplished to identify biomarkers that could serve to monitor disease progression in WD patients under chelation therapy. Developed models for each miRNA exhibited good performance classifying patients with poor outcome factors, consequently, these three miRNAs are proposed as candidates to improve clinical follow-up or to support efficacy of novel therapies in WD. / Esta Tesis Doctoral ha sido financiada por los siguientes proyectos de investigación: “Avanzar en el diagnóstico y la prognosis de la enfermedad de Wilson” Duración: 2016-2019, Fundació Per Amor a l’Art (FPAA) IP: C. Espinós; “Bases genéticas y biomarcadores pronóstico de la enfermedad de Wilson y Wilson-like” 2020-2022, Fundació Per Amor a l’Art (FPAA) IP: C. Espinós; “Estudios clínicos, bases genéticas y biomarcadores pronóstico en enfermedades raras neurodegenerativas” 2019-2021, Instituto de Salud Carlos III (Expediente: PI18/00147) IP: C. Espinós; “De genes a terapia en enfermedades neurodegenerativas y neuromusculares” 2018-2021, Generalitat Valenciana, Programa Prometeo para grupos de investigación de excelencia (Expediente: PROMETEO/2018/135) Consorcio de investigadores formado por F. V. Pallardó (coordinador), J.M. Millán, I. Galindo, P. Sanz, T. Sevilla y C. Espinós. / Sánchez Monteagudo, A. (2021). Genética molecular y biomarcadores de la enfermedad de Wilson [Tesis doctoral]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/171454

[pt] Durante o começo da pandemia de Covid-19, em 2020, enquanto as autoridades estaduais do Rio de Janeiro se apressavam na compra de equipamentos e na construção de hospitais de campanha, surgiu uma intensa cobertura jornalística sobre o gasto de recursos públicos. Dezenas de reportagens de diferentes veículos de comunicação denunciaram que havia indícios de superfaturamento em compras, inconsistências em contratos e mesmo fraude em contratações. Após as reportagens, foram instauradas investigações criminais sobre a corrupção no governo Wilson Witzel e também foi aberto um processo inédito de impeachment na Assembleia Legislativa, que terminou com a cassação do governador. Para realização desse estudo, foram analisadas as primeiras reportagens desta cobertura jornalística de quatro veículos – Blog do Berta, Folha de São Paulo, RJ2 (TV Globo) e O Globo – e conduzidas entrevistas com repórteres envolvidos na cobertura, a fim de identificar as fontes de informação utilizadas e discutir práticas, rotinas produtivas e seu resultado final no processo de construção das reportagens investigativas. A metodologia utilizada privilegiou a análise de conteúdo e a técnica da entrevista em profundidade. A pesquisa concluiu que as ferramentas de transparência e acesso às informações de órgãos públicos desempenharam um papel fundamental no incremento à credibilidade das reportagens, representando 46% das fontes de informação identificadas nas matérias analisadas, resultado que foi corroborado pela percepção dos jornalistas entrevistados. / [en] In the beginning of the Covid-19 pandemic in 2020, while state authorities in Rio de Janeiro rushed to purchase equipment and build field hospitals, there was also intense journalistic coverage on the expenditure of public resources. Dozens of reports from different media outlets exposed indications of overpricing in purchases, inconsistencies in contracts, and even fraud in hiring processes. Following these reports, criminal investigations were initiated into corruption in the government of Wilson Witzel during the pandemic, and an unprecedented impeachment process was launched in the Legislative Assembly, which ended with the governor s removal from office. For the purpose of this study, the initial reports of this journalistic coverage from four sources - Blog do Berta, Folha de São Paulo, RJ2 (TV Globo) and O Globo - were analyzed, and interviews were conducted with reporters involved in the coverage in order to identify the sources of information used and discuss practices, productive routines and the final outcome in the process of constructing investigative reports. Content analysis and in-depth interviews were employed as the research methods. The findings reveal that transparency tools and access to information from public agencies played a crucial role in enhancing the credibility of the news reports, accounting for 46 per cent of the identified sources of information in the analyzed articles, a result which was corroborated by the perception of the interviewed journalists

Konforme Feldtheorien (CFT) spielen eine Schlüsselrolle in der modernen theoretischen Physik. Mit CFT beschreibt man reale physikalische Systeme bei Kritikalität. Dank der AdS/CFT-Korrespondenz spielt sie auch bei der Untersuchung der Quantengravitation eine zentrale Rolle. Auf der Seite der CFT steht die N=4 supersymmetrische Yang-Mills (SYM) Theorie. Diese Arbeit dreht sich hauptsächlich um die supersymmetrische Wilson-Linie und ihre Interpretation als konformer Defekt in N=4 SYM. Insbesondere konzentrieren wir uns auf Anregungen, die auf dem Defekt lokalisiert sind, sogenannte Einfügungen, deren Korrelatoren durch eine eindimensionale CFT beschrieben werden. Das erste Hauptergebnis dieser Arbeit ist ein effizienter Algorithmus zur Berechnung von Mehrpunkt Korrelationsfunktionen von Skalareinfügungen auf der Wilson-Linie bis zur nächsten Ordnung bei schwacher Kopplung kodieren. Es werden verschiedene Berechnungen solcher Vier-, Fünf- und Sechspunkt-Korrelatoren gezeigt und ihre Eigenschaften diskutiert. Darüber hinaus wird am Beispiel der Vierpunkt-Funktion die Leistungsfähigkeit der Ward-Identitäten veranschaulicht, die für die Ableitung eines Ergebnisses nächster, vorletzter und führender Ordnung entscheidend sind. Dank dieser perturbativen Ergebnisse vermuten wir eine Mehrpunkt-Erweiterung der Ward-Identitäten, die von den Vier-Punkt-Funktionen erfüllt werden. Diese nichtperturbativen Beschränkungen erweisen sich als fundamentale Bestandteile des Bootstraps einer Fünfpunkt-Funktion bei starker Kopplung. Zum Abschluss dieser Arbeit definieren wir eine inhärent eindimensionale Mellin-Amplitude auf der nichtperturbativen Ebene mit geeigneten Subtraktionen und analytischen Fortsetzungen. Die Effizienz des 1d-Mellin-Formalismus zeigt sich auf der perturbativen Ebene. Man findet einen Ausdruck in geschlossener Form für die Mellin-Transformation von Kontaktwechselwirkungen führender Ordnung, den man verwendet, um CFT-Daten zu extrahieren. / Conformal field theory (CFT) plays a key role in modern theoretical physics. Through CFT we describe real physical systems at criticality and fixed points of the renormalization group flow. It is also central in the study of quantum gravity, thanks to the AdS/CFT correspondence. This thesis originates in the context of the N=4 supersymmetric Yang-Mills (SYM) theory, which represents the CFT side of this correspondence. This work mainly revolves around the supersymmetric Wilson line and its interpretation as a conformal defect in N=4 SYM. Particularly, we focus on excitations localized on the defect called insertions, whose correlators are described by a one-dimensional CFT. The first main result of this work is an efficient algorithm for computing multipoint correlation functions of scalar insertions on the Wilson line, consisting of recursion relations encoding the possible interactions up to next-to-leading order at weak coupling. We show various computations of such four-, five- and six-point correlators, and discuss their properties. Moreover, we use the four-point function case to illustrate the power of the Ward identities, which are crucial in deriving a next-to-next-to-leading order result. Thanks to these perturbative results, we find a family of differential operators annihilating our correlation functions, which we conjecture to be a multipoint extension of the Ward identities satisfied by the four-point functions. These non-perturbative constraints are shown to be fundamental ingredients in the bootstrap of a five-point function at strong coupling. To conclude this thesis, we define an inherently one-dimensional Mellin amplitude at the non-perturbative level with appropriate subtractions and analytical continuations. The efficiency of the 1d Mellin formalism is manifest at the perturbative level. We find a closed-form expression for the Mellin transform of leading order contact interactions and use it to extract CFT data.

Sedan början av 1990-talet har det i Sverige utvecklats flera bostadsområden där många leverunder ekonomiskt pressade förhållanden. Genom åren har kriminaliteten i sådana områdenökat, vilket har påverkat de boende genom att skapa en känsla av otrygghet och en rad hinderför dem att leva normala liv. En viktig samhällsgrupp att ta hänsyn till och hjälpa i sådanaområden är ungdomarna. Ungdomar påverkas av sin omgivning och därför är det av storbetydelse att ge dem de rätta förutsättningarna och möjligheterna att forma sin framtid genomatt arbeta för förbättringen av de utsatta områdena. I den här studien har riskområdenaEneborg, Högaborg och Wilson Park i Helsingborg studerats utifrån ett ungdomsperspektiv.Syftet är att undersöka hur ungdomarna upplever sina områden, och vad som kan göras för attskapa rätt förutsättningar för dem att forma sina liv på ett positivt sätt. Metoden har baseratspå en kvalitativ ansats där sex ungdomar har intervjuats som är bosatta eller är aktiva istudiens fokusområden. Som komplement till intervjustudien har det även genomförts enlitteraturstudie och observationer. De teorier som tillämpats är fenomenologi ochplatsidentitet, de har använts för att fokusera på individuella upplevelser av plats och rum.Genom att tillämpa dessa teorier har en djup förståelse för ungdomarnas personligaupplevelser och känslor kunnat uppnås. Resultatet visade att ungdomarna generellt sett tyckteatt området känns tråkigt och stilla. De var positiva gentemot ett parkområde, men negativatill nästan resten av området. I intervjuerna diskuterades frågor som rör olika ämnen, så somaktiviteter, trygghet, den fysiska omgivningen och social tillhörighet. Med hjälp av derasåsikter och erfarenheter kunde sedan strategier identifierats, både aktiviteter och metoder föratt på ett socialt sätt närma sig och hjälpa ungdomarna i området. / Since the early 1990s, several housing areas have developed in Sweden where many peoplelive under financially pressured conditions. Over the years, crime in such areas has increased,affecting residents by creating a sense of insecurity and a range of obstacles for them to livenormal lives. One important societal group to consider and help in such areas is adolescents.Adolescents are influenced by their environment, and therefore it is crucial to provide themwith the right conditions and opportunities to shape their future by working towardsimproving vulnerable areas. In this study, the risk areas of Eneborg, Högaborg and WilsonPark in Helsingborg have been studied from a youth perspective. The aim was to investigatehow adolescents experience their areas and what can be done to create the right conditions forthem to shape their lives positively. The method has been based on a qualitative approach,where six adolescents living or active in the study’s focus areas have been interviewed. Inaddition to the interview study, a literature review and observations have also beenconducted. The theories applied are phenomenology and place identity, which have been usedto focus on individual experiences of place and space. By applying these theories, a deepunderstanding of adolescents' personal experiences and feelings has been achieved. Theresults showed that the adolescents generally felt that the area is dull and quiet. They werepositive towards a park area but negative towards almost the rest of the area. The interviewsdiscussed issues related to various subjects, such as activities, safety, the physicalenvironment and social belonging. With the help of their opinions and experiences, strategieswere discovered, including activities and methods for socially approaching and helpingadolescents in the area.

Master of Arts / Department of English / Dean G. Hall / Salman Rushdie's 1999 novel The Ground Beneath Her Feet is ostensibly a rock 'n' roll novel, largely set in the 1960s, that traces the commercial rise of Indian rock star protagonists Vina Apsara and Ormus Cama. As their fame and wealth rise to global status and their stage show comes to entail a logistical complexity of military proportions, it becomes increasingly difficult to discern the couple's earlier countercultural ideals within their new established culture status. I argue that despite the change from countercultural to establishment-based values in the novel's protagonists, Rushdie does make a case in The Ground Beneath Her Feet for the possibility of countercultural efficacy against the commodifying culture of global capitalism (which I refer to as the "Frame"). His recipe for combating the exclusive hierarchies produced by the Frame is a combination of the non-totalizing politics of postmodernism and the subversive potential of uncommodified rock music. I pay close attention to establishing the historical templates--John Lennon of the Beatles and Brian Wilson of the Beach Boys--of the novel's protagonists in an effort to understand the sort of countercultural alternative Rushdie is proposing. I likewise focus on the novel's depiction of the Beach Boys' Smile album, which as a still commercially unreleased record, reinforces Rushdie's imperative in The Ground Beneath Her Feet for an uncommodifying counterculture and works in tandem with his portrayals of the artistic plights of several minor characters in the novel as well.

Existing studies of this topic have not made enough use of the British archives. Nor have they analysed the American domestic response to UDI in sufficient depth. The policies of successive American administrations as regards the Rhodesian problem can only be fully understood as part of Washington’s attitude to Britain, to Africa in general, and to southern Africa in particular. And, because the issue of white minority rule in Africa raised powerful emotions both in the African American community and among white opponents of civil rights, the Rhodesian crisis became a part of the politics of racial equality within the USA, playing a key role in the developing ideologies of these two communities. This thesis is based on research in both American and British archives and aims to show that the prevailing interpretation, especially of the policies of the Johnson Administration once Rhodesia had made its illegal declaration of independence in November 1965, is mistaken. Scholars have tended to take at face value the oft-repeated claim of US policy-makers that Rhodesia was a British problem, that they wished to be no more than helpful bystanders, supporting British efforts to see the downfall of the illegal regime and the creation of a government based on majority rule, and that when they did intervene, it was merely to urge the British to be firmer in their resolve to end the rebellion. The central contention of this thesis is that the officials shaping African policy in the Johnson Administration were intimately involved in the management of the crisis and that, far from resisting a solution that legitimised the white minority regime, they actively encouraged the British to settle with the illegal government.

Mémoire numérisé par la Division de la gestion de documents et des archives de l'Université de Montréal.