Most of us try to do performance in pure style (mime, drama, clownerie, slap stick, physical theatre, opera, musical, ballet). I am interested in mixing of these styles. Robert Wilson works this way. For him movement is one of the basic means of communication. He works ? as mime theatre does ? with images (pictures). He works with hyperbole and big stylization, that is close to mime theatre. This thesis is interested in mime theatre or theatre of movement and its relation to other elements of theatre. The thesis also deals with the work of Robert Wilson and tries to show the interaction of the elements he uses for the stage image. A how he touches the audience with his work.

abstract: ABSTRACT Understanding complex and adaptive socio-ecological systems (SES) to deal with our most challenging and overlapping problems such as global climate change, biodiversity loss, and rising consumption rates requires sustainability theory that is commensurate with these problems’ size and complexity. The received United Nations-based sustainability framework aims to achieve a balance among three pillars—economics, environment, and social equity—for today and for future generations. Yet, despite applying this sustainability framework for over a quarter of a century, the Earth is less sustainable, not more. Theoretical trade-offs between environmental conservation and economic growth have often reinforced business-as-usual practices and educational paradigms, and emphasized economic values over ecological limits. How can the principles of foundational naturalists help clarify, enhance, and advance sustainability discourse? I propose that the principles of Henry David Thoreau (1817-1862), Aldo Leopold (1887-1948), Rachel Carson (1907-1964), and Edward O. Wilson (1927-), express a worldview that captures and integrates a range and depth of historical, normative, economic, ecological, scientific, and social values for a viable and applicable discourse of sustainability. This analytical study relies on (i.) textual analysis and interpretation of four key naturalists and humanists, (ii.) analysis of secondary sources that illuminate their proto- ecological and sustainability principles, and (iii.) interviews with leading sustainability scholars. Because these thinkers integrate science and ethics, natural history and philosophy, ecology and society, and environmental and economic problems within a holistic worldview, I call them systems naturalists. Their transdisciplinary worldview of one holistic system, with economics subordinated to environmental limits, links important values from the natural sciences and the humanities. The writings and examples of systems naturalists provide more robust historical sustainability principles that can help solve our most challenging SES problems by synthesizing a broad range of knowledge in the sciences, social sciences, and the humanities to inform sustainability paradigm, practices, and pedagogy. / Dissertation/Thesis / Doctoral Dissertation Sustainability 2015

INTRODUÇÃO: A doença de Wilson é um distúrbio autossômico recessivo, decorrente de mutações no gene ATP7B, resultando em acúmulo tóxico de cobre no organismo. Devido a sua raridade, séries com grande casuística e longo seguimento são escassas na literatura. Nesse estudo relatamos a experiência do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HC-FMUSP) com os pacientes diagnosticados com doença de Wilson entre o período de 1946 a 2010. MÉTODOS: Realizamos análise retrospectiva de 262 casos, descrevendo as formas de apresentação clínica, os achados dos exames diagnósticos, os padrões de resposta terapêutica e a evolução clínica da doença. RESULTADOS: A idade média do início dos sintomas foi 17,4 anos (7-49 anos). Os pacientes foram acompanhados em média 9,6 anos (0-45 anos). As apresentações clínicas mais frequentes foram hepática (36,3%), neurológica (34,7%), assintomática (16,8%), neuro-psiquiátrica (8,3%) e hematológica (1,9%). Outras formas menos comuns foram renal, neuro-hepática, e osteoarticular. Disartria e manifestações clínicas de cirrose hepática descompensada foram as principais características neurológicas e hepáticas, respectivamente. Os parâmetros diagnósticos observados foram anéis de Kayser-Fleisher 78,3%, reduzidos níveis séricos de ceruloplasmina 98,3%, níveis elevados de cuprúria basal de 24 horas 73,0%, teste da D-penicilamina positivo em 54,0% e comprometimento nos dois alelos do gene ATP7B 84,4%. O exame de ressonância magnética encefálica mostrou alterações nos núcleos da base em 77,7% dos examinados. D-penicilamina foi prescrita inicialmente em 93,6% dos 245 casos tratados, e 53% relataram efeitos adversos. Houve necessidade de substituição em 50 indivíduos. Outras medicações utilizadas foram os sais de zinco e trientina. Não evidenciamos diferença significativa entre os resultados terapêuticos dessas três drogas (p=0,2). Os casos de má aderência à terapia evoluiram com pior desfecho quando comparados aos usuários regulares (p <0,0001). Nove pacientes realizaram transplante hepático. Durante o seguimento 82 casos faleceram. As principais causas dos óbitos foram descompensação hepática 41,5% (hemorragia digestiva, peritonite bacteriana espontânea, encefalopatia) e pneumonia 20,7%. Três pacientes cometeram suicídio. CONCLUSÕES: Não existe um exame padrão ouro ou achado patognomônico da doença. Todo paciente jovem com manifestações hepáticas, neurológicas, neuropsiquiátricas, hematológicas, renais ou osteoarticulares de causa indefinida deverá ser investigado para doença de Wilson. Além da farmacoterapia específica é necessária a avaliação psiquiátrica para detectar precocemente sintomas depressivos. / INTRODUCTION: Wilson\'s disease is an autosomal recessive disorder, caused by mutations in the gene ATP7B, leading to toxic copper accumulation in the body. Because it is a rare disease, large series with long-term follow-up are limited in literature. We reported the experience of Hospital das Clínicas of Sao Paulo University School of Medicine (HC-FMUSP) with Wilson\'s disease patients diagnosed between 1946 and 2010. METHODS: A retrospective analysis of 262 cases was performed describing the clinical presentation, the results of diagnostic tests, the patterns of treatment response and outcome. RESULTS: The mean age at the onset of symptoms was 17.4 years (7- 49 years). Patients were followed for a mean of 9.6 years (0-45 years). The most frequent clinical presentations were hepatic (36.3%), neurological (34.7%), asymptomatic (16.8%), neuro-psychiatric (8.3%) and hematologic (1.9%). Other less common forms were renal, neurological-hepatic, and musculoskeletal. Dysarthria and clinical manifestations of decompensated liver cirrhosis were the main neurological and liver features, respectively. The diagnostic parameters observed in this cohort of patients were Kayser-Fleischer rings in 78.3%, low serum ceruloplasmin in 98.3%, high 24-h urinary excretion of copper in 73.0%, positive challenge test with d-pencillamine in 54.0% and detection of two mutations of ATP7B gene in 84.4%. The magnetic resonance of brain showed abnormalities in the basal ganglia in 77.7% of those examined. D-penicillamine was prescribed in 93.6% of 245 cases as the first drug, and 53% reported adverse effects. It was need to replace it in 50 individuals. Other drugs used were salts of zinc and trientine. There was no significant difference between the therapeutic results of these three drugs (p = 0.2). The cases with poor adherence to therapy evolved with a worse outcome when compared to regular users (p <0.0001). Nine patients underwent liver transplantation. During the follow-up 82 patients died. The main causes of death were hepatic decompensation 41.5% (variceal hemorrhage, spontaneous bacterial peritonitis, encephalopathy) and pneumonia 20.7%. Three patients committed suicide. CONCLUSIONS: There is no gold standard or pathognomonic test for diagnosing this disease. Any young patient with hepatic, neurological, neuropsychiatric, hematologic, renal, or osteoarticular manifestations of unknown cause should be investigated for Wilson\'s disease. In addition to the classical pharmacotherapy, specific psychiatric evaluation is necessary to detect early symptoms of depression.

Submitted by Rosa Assis (rosa_assis@yahoo.com.br) on 2017-03-21T18:54:51Z No. of bitstreams: 2 LUCAS LEOCÁDIO DAS NEVES.pdf: 9169463 bytes, checksum: 1d244ed938380c2c5aadc7abf9a4dee1 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) / Approved for entry into archive by Paola Damato (repositorio@mackenzie.br) on 2017-03-22T15:35:26Z (GMT) No. of bitstreams: 2 LUCAS LEOCÁDIO DAS NEVES.pdf: 9169463 bytes, checksum: 1d244ed938380c2c5aadc7abf9a4dee1 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) / Made available in DSpace on 2017-03-22T15:35:26Z (GMT). No. of bitstreams: 2 LUCAS LEOCÁDIO DAS NEVES.pdf: 9169463 bytes, checksum: 1d244ed938380c2c5aadc7abf9a4dee1 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Previous issue date: 2016-08-17 / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / The Wilson-Cowan model describes the interaction between an excitatory neuronal population connected to an inhibitory neuronal population. In this work, the dynamics of this network is analytically studied by using a linear approximarion. It is shown that the activity of these neuronal populations can be stationary or periodic, depending on the parameter values. Then, two Wilson-Cowan networks are coupled and the activity of this new system is investigated, also by using a linear approximation. It is numerically shown that coupled networks can exhibit stationary, periodic, or chaotic behavior. The motivation for this work comes from studies on the codes employed by the nervous system to transmit information. / O modelo de Wilson-Cowan descreve a interacão entre uma populacão neuronal excitatória conectada a uma populacão neuronal inibitória. Neste trabalho, estuda-se analiticamente a dinâmica dessa rede usando uma aproximacão linear. Mostra-se que a atividade desses populacões neuronais pode ser estacionária ou periódica, dependendo dos valores dos parâmetros. Então, acoplam-se duas redes de Wilson-Cowan e investigase a atividade desse novo sistema, também usando uma aproximacão linear. Mostra-se, numericamente, que redes acopladas podem exibir comportamento estacionário, periódico ou caótico. A motivacão para este trabalho vem dos estudos sobre os códigos usados pelo sistema nervoso para transmitir informacão.

Made available in DSpace on 2014-06-12T18:06:54Z (GMT). No. of bitstreams: 3 arquivo7763_1.pdf: 6132198 bytes, checksum: 9583aed73df9b715c6ac388fd2960d11 (MD5) arquivo7763_2.pdf: 8554510 bytes, checksum: 5c593d6759a4c5587c110585188fab4d (MD5) license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5) Previous issue date: 2006 / Conselho Nacional de Desenvolvimento Científico e Tecnológico / A atividade de um conjunto de neurônios interligados é um problema de atual interesse que pode ser abordado com uma descrição detalhada dos neurônios da população ou, estudando a dinâmica da resposta dessas populações sim descrever em detalhe o comportamento individual dos neurônios. O modelo de Wilson-Cowan consiste em equações para as taxas de disparo de subpopulações localizadas de neurônios excitatórios e inibitórios. A principal suposição para chegar nas equações está baseada no alto grau de redundância local (ou seja, a suposição de que neurônios vizinhos respondem da mesma forma a estímulos similares) e a aleatoriedade das conexões locais. A vantagem destas equações consiste em reduzir a atividade de um número grande de neurônios a uma descrição de duas variáveis, com o que se consegue simpli ficar consideravelmente o problema. Particularmente, elas prevêem a existência de atividade de ciclo-limite em resposta a um estímulo constante usando uma auto-interação mais forte na subpopulação excitatória que na inibitória. Nós analisamos se uma rede aleatória de neurô- nios de FitzHugh-Nagumo que tenta reproduzir a hipótese de Wilson-Cowan tem de fato esse comportamento dinâmico de baixa dimensionalidade. Os neurônios são conectados com sinapses químicas excitatórias e inibitórias que se descrevem usando modelos de Markov de dois estados. As sinapses são distribuídas aleatoriamente, gerando assim quatro grafos dirigidos de Erdos-Rényi: cada um dos NE(NI) neurônios excitatórios (inibitórios), recebe, em média, KEE(KEI) sinapses excitatórias da subpopulação excitatória, e KIE(KII) sinapses inibitórias da subpopulação inibitória. Os resultados mostram a existência de ciclos-limite e pontos fixos quando projetamos nosso sistema no plano de fase de Wilson-Cowan. Particularmente, o comportamento bidimensional de ciclo-limite é mais claro quando pelo menos uma das subpopulações (geralmente a popula ção excitatória) está aproximadamente sincronizada (sincronização perfeita não é observada devido à desordem própria da conectividade sináptica). Entretanto, quando as conectividades médias são pequenas, os neurônios se comportam de maneira diferente e a projeção no plano de Wilson-Cowan sugere uma descrição num espaço de fase com dimensão mais alta. Para quanti ficar essa alta dimensionalidade, calculamos a dimensão de imersão (embedding) necessária para desdobrar o atrator que descreve o sistema

Wilson disease (WD) is an autosomal recessive disorder characterized by deposition of copper in the body, mainly in the liver and brain. WD patients present with hepatic, neurological, and psychiatric problems. The diagnosis of WD is very challenging, and is performed by taking into account both clinical and biochemical parameters. The treatment of WD exists, which aims at initial chelation therapy followed by maintenance therapy. WD is caused by mutations in the ATP7B gene. Till date, more than 600 mutations in ATP7B have already been described from many countries, including India. However, there are a very few large cohort studies which are reported from Indian population. In this study, we have attempted to perform mutation analysis of ATP7B in a large cohort of WD families from Bangalore, south India, and further look into the molecular consequences of the novel mutations identified in the present study.

No description available.

The gauge/string duality, a.k.a. the holographic principle is a profound assertion that emerged from string theory. It relates strongly-coupled gauge theories to weakly coupled string theories living in a higher-dimensional curved geometry. Nevertheless, it is a conjecture, and only a few instances of its more concrete form, the AdS/CFT correspondence, are well-understood. The most well-studied example is the duality between N=4 SYM, which is a CFT, and type IIB string theory in AdS5xS5 background. Generalization to less symmetric cases is a must, and the next logical step is to add a mass scale to N=4 SYM, therefore breaking its conformal symmetry and leading to N=2* SYM, the theory we study in this thesis. It is supersymmetric enough to employ the powerful localization method that reduces its partition function to a matrix model. We will see that the mass scale causes non-trivial phase structures in its vacuum configuration, visible in the holographic regime. We will probe them using Wilson loops in different representations of the gauge group. On the other hand, the dual supergravity background was derived by Pilch-Warner, making N=2* theory an explicitly testable non-conformal holographic case, which is a rare example. We will prove that the duality works for the dual observables (string action, D-branes) we managed to compute, even at a quantum-level.

Magister Artium - MA / The rich corpus of postcolonial scholarly engagement on indigenous intermediaries, interpreters, clerks and assistants has a made a strong argument for the active participation of African agents in social scientific knowledge production on Africa. This literature has highlighted the complex and negotiated nature of fieldwork in African anthropology. While this literature has begun to deepen our understanding of the knowledge work of anthropologists and their research assistants, it has not adequately explored the relationship between anthropologists and informants in what one scholar has recently called ‘a triangulation of relationships’ between the anthropologist, the assistant and the informant. This research project proposes to explore these relationships in a detailed case study: that of the British anthropologist Godfrey Wilson (1908–1944), his interpreter Zachariah Mawere, and three primary informants, during three years of pioneering research into the effects of migrant labour at Broken Hill, Northern Rhodesia (Zambia) between 1938 and 1941. Using a close textual reading and detailed analysis of Wilsons Bemba and English fieldnotes held in the Godfrey and Monica Wilson collection at the University of Cape Town’s African Studies Library, the study will apply a micro-historical and biographical approach. It will seek to reconstruct the biographies and anthropological contributions of one interpreter and three central Bemba informants in order to explore the micro-politics of knowledge production in African anthropology.

No description available.