O conhecimento constitui bem jurídico, passível de tutela tanto sob a ótica da criação - por meio dos direitos de propriedade intelectual - quanto sob a ótica da sua utilidade econômica - juntamente com os demais elementos intangíveis do estabelecimento empresarial. Questão amplamente debatida e objeto de controvérsia é a destinação desses bens intangíveis por ocasião do afastamento de um sócio da sociedade empresária. Discute-se se esses bens devem integrar a base de cálculo dos haveres do sócio afastado. Neste trabalho, pretende-se oferecer resposta a essa indagação. Para tanto, analisaremos de que maneira são formadas as dimensões patrimoniais da sociedade - capital social, patrimônio líquido e estabelecimento -, as diversas hipóteses de extinção parcial do vínculo societário, o conteúdo econômico dos elementos intangíveis integrantes do estabelecimento e a natureza jurídica do eventual pagamento por esses bens ao sócio que se desliga da sociedade. / Knowledge is legally protected both as a creation - by means of intellectual property rights - and as na economic asset - jointly with the other intangible components of the goodwill. A highly controversial topic concerning this issue is the treatment given to these intangible assets when a shareholder or partner decides to withdraw from the company. Should such intangible assets be included in the appraisal rights of the withdrawing party? This study aims at attempting to answer this question by analyzing the development of the equity dimensions of a company; the different reasons for a partner and/or shareholder to withdraw; the economic features of intangible assets; and the legal nature of a possible payment made to the withdrawing partner and/or shareholder in consideration of said intangible assets.

Research shows that children with language impairment (LI) often have deficits in social communication. The purpose of this study was to examine the effectiveness of a social communication intervention targeting emotion understanding on teacher perceptions of withdrawal in six elementary-aged boys with LI. The intervention incorporated four elements into treatment sessions: a) Story sharing of children's literature that was rich in emotional content and prosocial behaviors; b) Story enactment of the same children's literature; c) identification and discussion of pictures of facial expressions; and d) journaling to help internalize and reflect on emotions and social behaviors targeted. Two withdrawal subscales of the Teacher Behavior Rating Scale (TBRS), reticence and solitary-passive behavior, were used as variables with which to measure teacher perception. Pre and postintervention measures of teacher ratings were taken and compared for each participant. Results indicated that four of the six participants improved in ratings of withdrawn behaviors following treatment. Two of the boys improved 2 SD for ratings of reticence. Two additional participants did not show improvement, but remained stable in their pre and posttreatment scores for both reticence and solitary-passive withdrawal. These results indicate a generally favorable outcome of the social communication intervention with regard to social withdrawal in children with LI.

Personality researchers have described dispositional traits to typically show stability over the life course and yet one such trait, shyness, has rarely been examined in later life. Shyness as a global trait has been linked negatively to multiple psychological indices of childhood well-being, including loneliness. Despite the fact that older adults may be already at risk for experiencing heightened loneliness, regret, or decreased fulfillment, research has not assessed these experiences in relation to personality in later life. In recent years, withdrawal research has begun to move past shyness as a global trait to examine the motivations behind socially withdrawn behavior. The current study used regression analyses to examine ways that three facets of withdrawal (shyness, avoidance, and unsociability) may relate to loneliness, regret, and fulfillment in later life. Data from 309 older participants of the Huntsman Senior Games were used to explore associations. Results indicated that shyness, avoidance, and unsociability significantly predicted increased loneliness and regret, and decreased fulfillment to some extent. Further, marital status (married, divorced, widowed) moderated links between withdrawal and psychological indices of later life well-being.

Recent studies and literature regarding children with language impairment (LI) indicate that these children have difficulty with social communication skills. This study assessed the effect of a social communication intervention on teacher perceptions of withdrawal in six elementary school age participants with LI. The social communication intervention included story sharing, identifying pictures of facial expressions, and journaling to target emotion understanding. The Teacher Behavior Rating Scale (TBRS) was utilized to measure teacher perception of withdrawal. The TBRS examined three subscales of social withdrawal: solitary-active withdrawal, solitary-passive withdrawal, and reticence. Following treatment, teacher ratings of withdrawn behavior decreased for all six participants on some of the subscales. Solitary-active behavior decreased for four of the six participants, solitary-passive behavior decreased for five participants, and reticent behavior decreased for three participants. Teacher ratings of withdrawal for two participants increased on a single subscale, however. These changes suggest positive post-treatment outcomes with regard to withdrawn behavior in children with LI.

This longitudinal study examined the relationship between husband and wife shame and husband and wife sexual satisfaction one year later with husband and wife relational aggression as mediating variables. The sample included 353 heterosexual married couples who participated in the Flourishing Families Research Project, a longitudinal study of daily family life. Results showed that husband and wife shame was negatively related with husband and wife sexual satisfaction, respectively. Husband love withdrawal was negatively related with both husband and wife sexual satisfaction, while wife love withdrawal was negatively related with only husband sexual satisfaction. Each partner's use of social sabotage was negatively related with their partner's sexual satisfaction. Research and clinical implications were discussed.

The current literature lacks empirically-supported preventative approaches for kindergarten students who are socially withdrawn and behind in the development of social skills. Furthermore, parents are underutilized in interventions during this critical period of social development. In response to this need, a classroom-based intervention consisting of (a) social skills training, (b) self-evaluation and reinforcement, (c) home notes and parent involvement, and (d) adult mediation was implemented to increase the positive social engagement of three kindergarten students. The effects of this intervention were evaluated on the playground during recess using partial interval recording of target students’ positive or negative engagement with at least one peer. Improvements of social interactions on the playground were demonstrated by each target student during the implementation of the intervention, but only one student maintained these improvements in the follow-up phase. Future studies should investigate whether addressing the limitations of this study would yield stronger results with this under-identified population of students.

Fatal and non-fatal opioid overdoses resulting from opioid induced respiratory depression are a significant problem throughout the world. Whilst the opioid receptor antagonist, naloxone hydrochloride, can effectively reverse opioid overdoses, its use is limited because of the adverse effects it produces. These include severe withdrawal and the reversal of analgesia produced by opioid receptor agonists. In this project, the peripherally acting opioid receptor antagonist, naloxone methiodide, was investigated for its potential to reverse opioid induced respiratory depression without altering centrally mediated effects, such as withdrawal. In the publications presented in this thesis, naloxone hydrochloride and naloxone methiodide were shown to effectively reverse the decreases in respiratory rate produced by the administration of morphine, methadone and heroin in mice. Naloxone hydrochloride and naloxone methiodide also reversed the analgesia produced by these opioid receptor agonist treatments, but only naloxone hydrochloride induced significant withdrawal. The doses of naloxone methiodide required to produce the effects described above were higher than the naloxone hydrochloride doses required. Radioligand binding techniques indicated that this was due to a difference in the affinity of naloxone hydrochloride and naloxone methiodide for µ, δ and κ opioid receptor binding sites. Radioligand binding techniques were also used to confirm that naloxone methiodide, or its metabolites, could not readily cross the blood brain barrier. Therefore, the effects of naloxone methiodide appear to be mediated outside the central nervous system. The final publication aimed to extend our knowledge of opioid induced respiratory depression by utilising new radiotelemetry technology to test the efficacy of naloxone methiodide in rats subjected to a chronic opioid administration regime. This experiment showed that circadian rhythm plays a role in the development of tolerance to the cardiorespiratory effects of continuous and chronic methadone administration, and that naloxone hydrochloride and naloxone methiodide treatment can increase respiratory rate and heart rate after this methadone administration. Therefore, naloxone methiodide can effectively antagonise the peripheral effects produced by opioid receptor agonists. Peripherally acting opioid receptor antagonists should be developed in the future to prevent or treat the adverse effects of opioid receptor agonists. / Thesis (Ph.D.)--Department of Clinical and Experimental Pharmacology, 2004.

Increased demands on amphetamine dependence treatment services point to a need for effective pharmacotherapies for withdrawal symptom suppression. However, empirical data on which to base effective treatments are scarce. To address the need for an evidence base, four studies were conducted in two countries - Australia and Thailand. Firstly, the time course and severity of amphetamine withdrawal symptoms were characterised in two inpatient samples of amphetamine users. Results identified the first week of abstinence as an acute withdrawal phase characterised by increased sleeping, eating and a cluster of mood and anxiety - related symptoms. Following the acute phase, most withdrawal symptoms remained stable and at low levels for the remaining two weeks of abstinence ( the sub - acute phase ). Data from these two studies formed the basis for a new instrument, the Amphetamine Cessation Symptom Assessment scale ( ACSA ). On psychometric testing, the ACSA showed satisfactory reliability and a clear psychometric structure, delineating symptom clusters and their correlates with a three factor solution providing the best fit to the data. Using the ACSA to measure outcome, the safety and efficacy of the serotonin and noradrenaline reuptake inhibitor antidepressant mirtazapine ( 15 - 60 mg per day, n = 13 ), and the wake-promoting drug, modafinil ( 400mg per day, n = 14 ) were assessed in successive, open - label, inpatient pilot trials. Study medication was administered for up to ten days. An historical comparison group ( n = 22 ) who received treatment as usual consisting of pericyazine 2.5 - 10mg per day for control of agitation served as a comparison. Results showed that modafinil and mirtazapine were well tolerated, producing minimal positive subjective effects. There were significant group differences in withdrawal severity ( F = 18.6, df 2,219 p < 0.001 ). Post - hoc analysis showed that modafinil was more effective than mirtazapine ( p = 0.041 ), and both were more effective than treatment as usual ( both p < 0.001 ) in ameliorating withdrawal severity. Overall, these studies identified a peak in withdrawal severity during the first week of abstinence ; demonstrated the reliability and validity of the ACSA and identified modafinil as a safe and potentially effective pharmacotherapy for the treatment of amphetamine withdrawal symptoms. / Thesis (Ph.D.)--Medical School, 2005.

Thesis (Ph.D.)--University of Toledo, 2007. / "In partial fulfillment of the requirements for the degree of Doctor of Philosophy in Biomedical Sciences." Major advisor: Elizabeth Tietz. Includes abstract. Title from title page of PDF document. Bibliography: pages 88-94, 130-136, 178-189, 218-266.

SAMMANFATTNING Syftet med föreliggande studie var att undersöka dialyssjuksköterskors upplevelse i mötet med en patient som vill avsluta, eller som inte är kapabel att uttrycka sig kring, sin livsuppehållande dialysbehandling. En deskriptiv intervjustudie med kvalitativ ansats utfördes på två dialysmottagningar i Mellansverige. Innehållsanalys av intervjuerna genomfördes vilket gav fem huvudkategorier; sjuksköterskors upplevelse av bristfällig kommunikation och samarbete med läkare, sjuksköterskors upplevelse av läkares svårigheter att diskutera avslutande av dialysbehandling, sjuksköterskors upplevelse av att vårda patienter som inte är kapabla att uttrycka sig kring sin dialysbehandling, sjuksköterskors upplevelse av att vårda patienter som säger, eller på något annat sätt uttrycker, att de vill avsluta sin dialysbehandling och sjuksköterskors upplevelse av stöd och samtal i vården kring patienter som vill avsluta sin dialysbehandling. Huvudresultatet visar att dialyssjuksköterskor upplever många etiska dilemman i mötet med denna patientgrupp. Mötet med en patient som säger, eller på något annat sätt uttrycker att de vill avsluta behandlingen upplevdes positivt, dock upplevdes innebörden av uttrycken ibland vara svåra att tolka. Sjuksköterskorna upplevde det många gånger frustrerande att vårda en patient som inte är kapabel att uttrycka sin vilja om fortsatt eller avslutande dialysbehandling. Slutsatsen var att ytterligare forskning inom detta område är nödvändig för att rutiner och riktlinjer skall kunna utformas. / ABSTRACT The aim of the study was to investigate the dialysis nurses' experience of meeting with a patient who wants to end, or a patient who is not able to express itself about, its life-sustaining dialysis treatment. A descriptive interview study with qualitative approach was used on two dialysis centers in central Sweden. Content analysis of the interviews were conducted which resulted in five main categories: nurses' experience of poor communication and cooperation with physicians, nurses' experience of physician's difficulty to discuss the closure of the dialysis treatment, nurses' experience of caring for patients who are unable to express themselves about their dialysis treatment, nurses' experience of caring for patients saying, or otherwise expressing, that they want to end their dialysis treatment and nurses' experience of support and conversations in health care, around patients who want to end their dialysis treatment. The main result shows that dialysis nurses experience many ethical dilemmas facing these patients. The meeting with a patient saying, or otherwise expressing, that they want to end their dialysis treatment was perceived positively, however, could the meaning of the expression sometimes be difficult to interpret. The nurses, often times, felt frustrating to care for a patient who is unable to express themselves about their dialysis treatment. The conclusion was that further research in this area is necessary so that procedures and guidelines can be designed.