Aim The aim for this present study was to investigate the acute metabolic response from intermittent resistance exercise during hypoxia, with the following research questions: (1) Are blood levels of lactate and glucose different between hypoxia and normoxia? (2) Does hypoxia induce higher lactate accumulation and pH reduction in the human skeletal muscle? (3) Is there a relationship between plasma-, blood- and muscle lactate? Method Eight healthy males (30 ± 2 years) performed 6 sets of unilateral leg extension on each leg (75% of 1RM) with randomized normoxic (20,9% inspired đ2) and normobaric hypoxic (12% inspired đ2) conditions. A total of 5 muscle biopsies was extracted from m. Vastus Lateralis (pre-, post exercise, 90-, 180min and 24h post exercise) during both normoxia and hypoxia trials, separated by one week for all participants. Blood samples were repeatedly taken with 20 min intervals. Heart Rate (HR) and saturation (đđđ2) were measured by a pulsoximeter during resistance exercise. Results No significant main effect was observed for blood lactate and glucose levels as well as the muscle lactate accumulation and pH between normoxia and hypoxia. However, pH in muscle showed a trend between the conditions post exercise where hypoxia reached lower levels in total (P=0.08). Significant correlations were observed for blood- and plasma lactate, where hypoxia showed a stronger relationship than normoxia (r=0.98 compared to r=0.87). Equal findings for the correlation of muscle- and plasma lactate showed an even greater coefficient value for hypoxia compared to normoxia (r=0.860 compared to r=0.59). Conclusion Summarized data indicated that no significant difference between hypoxia and normoxia was evident. Nonetheless, tendencies illustrate that hypoxia may alter the metabolic response slightly. However, further research is needed to draw a conclusion between the conditions. / Syftet med denna studie Ă€r att undersöka kroppens akuta metabola svar frĂ„n intermittent styrketrĂ€ning under hypoxi, med följande frĂ„gestĂ€llningar: (1) Skiljer sig nivĂ„erna av laktat och glukos i blodet mellan hypoxi och normoxi? (2) Skapar hypoxi större laktatansamling och pH reduktion i mĂ€nniskoskelettmuskeln? (3) Finns det en relation mellan plasma-, blod- och muskellaktat? Metod Ă tta friska mĂ€n (30 ± 2 Ă„r) deltog dĂ€r deltagarna utförde 6 set unilateral benextension för varje ben (75% 1RM). Intermittent styrketrĂ€ning randomiserades med hypoxi som utfördes med 12% syrgas och normoxi som bibehöll normal syrgasnivĂ„ (20,9% syrgas). Under tvĂ„ testdagar togs 5 muskelbiopsier frĂ„n m. Vastus Lateralis (före-, efter trĂ€ning, 90-, 180min och 24h efter trĂ€ning) pĂ„ vartannat ben per testdag. HjĂ€rtfrekvensen och đđđ2 mĂ€ttes via pulsoximeter under trĂ€ningen. Resultat Ingen signifikant huvudeffekt pĂ„visades mellan hypoxi och normoxi för blodlaktat samt glukos, sĂ„vĂ€l som laktatackumulationen och pH vĂ€rdet i muskeln. Muskel pH visade en trend dĂ€r hypoxi efter styrketrĂ€ning nĂ„dde lĂ€gre totalnivĂ„ Ă€n normoxi (P=0,08). Vidare observerades hypoxi att ha starka relationer mellan blod- och plasmalaktat jĂ€mfört med normoxi (r=0,98 vs. r=0,87). Större skillnad framgick för korrelationen mellan muskel- och plasmalaktat dĂ€r hypoxi-försöket utgav starkare koefficient jĂ€mfört med normoxi (r=0,86 vs. r=0,59). Konklusion Sammanfattad data visar att hypoxi inte skapar större metabolisk respons vid intermittent styrketrĂ€ning. Trots detta framkom tendenser som illustrerar att hypoxi kan pĂ„verka den metabola stressen under styrketrĂ€ning. DĂ€remot krĂ€vs vidare forskning för att kunna sĂ€kerstĂ€lla effekten av hypoxi pĂ„ kroppens metabola svar. / IngĂ„r i Marcus Mobergs projekt: âResistance exercise under hypoxia and the acute molecular effects in human skeletal muscle
| Identifer | oai:union.ndltd.org:UPSALLA1/oai:DiVA.org:gih-5791 |
| Date | January 2019 |
| Creators | Falgin Hultgren, Jonas |
| Publisher | Gymnastik- och idrottshögskolan, GIH, Institutionen för idrotts- och hÀlsovetenskap |
| Source Sets | DiVA Archive at Upsalla University |
| Language | English |
| Detected Language | English |
| Type | Student thesis, info:eu-repo/semantics/bachelorThesis, text |
| Format | application/pdf |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | Examensarbete ; 2019:30 |
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