The problem of this study was to measure the effectiveness of a public school Montessori program. The purpose of this study was to measure and compare student academic achievement and self-concept, attendance and promotion rates, and level of parental involvement in the schools of students enrolled in public school Montessori and traditional programs. The 95 subjects in this study were third-grade subjects selected from the student populations in Montessori and traditional school sites. The Iowa Test of Basic Skills (ITBS) was used as the pre-test scores, and the Norm-referenced Assessment Program for Texas (NAPT) was used as the post-test scores to compare academic achievement in reading and mathematics. Multiple regression was used to compare the levels of academic achievement and self-concept. Multiple regression was also used to test for possible relationship between the Montessori and traditional programs and gender and ethnicity.

The purposes of this study were to identify public school districts that currently offer, or are planning to offer, transitional first-grade programs, to describe existing transitional programs, to describe the genesis of transitional first-grade classes in the North Texas area, and to assist in the establishment of a networking system for schools in the North Central Texas area that currently have, or are planning to have, transitional first-grade classes. The 158 school districts in Regions 10 and 11 were surveyed. The findings of the study indicate that about one-third of the districts offered transitional first-grade programs during the 1988-89 school year, and two-thirds of the districts saw a need for transitional first-grade classes. These transitional programs were implemented to meet the needs of children who had completed kindergarten but were not ready for regular first grade. Transitional first-grade programs focus primarily on language arts and math skills for kindergarten and early first grade. While curriculum materials vary from district to district, language arts is likely to be based on a whole-language approach, and math is likely to focus on manipulatives.. Kindergarten teacher observation is used in the screening procedures in the majority of the districts. A number of instruments are used in the transitional screening process. The Gesell School Readiness Inventory, used in 24% of the districts, is most popular. About one-half of the districts use an informal method of evaluating the transitional program. A pretest-posttest method is used in 32% of the districts, and a longitudinal student tracking method is used in 20% of the districts. Of the 158 districts surveyed, 122, or 77%, of the districts are interested in being included in a networking system to exchange information about transitional first-grade programs.

The purpose of this study was to determine the effectiveness of a transitional first grade program on the attitude and readiness scores of a group of regular first grade students who qualified for the transitional program but attended regular first grade (control group) and a group of transitional first grade students (experimental group). The study utilized a pretest/posttest design. The regular first grade students received formal instruction in all academic areas. The experimental group received no formal instruction.

The purpose of this study was to determine the effectiveness of a transitional first grade program. A comparison of reading and math achievement and school attitude was the focus of the study. The study utilized a pretest/posttest design. The group of regular first grade students who qualified for the transitional program but attended regular first grade was the control group. The group of transitional first grade students was the experimental group. The regular first grade students received formal instruction in all academic areas. The experimental group received no formal instruction. All students were pretested and posttested using the Iowa Test of Basic Skills and the Minnesota School Attitude Survey. Testing was administered to small groups of five or less by the researcher. Scoring was done also by the researcher. An analysis of covariance was used to determine if a significant difference existed between the groups. The analysis of covariance did not produce a significant F at the .05 level when applied to the Iowa Test of Basic Skills except for reading for boys in both groups. The numbers in each cell were low and no further comparisons were made. Due to a testing date that was approved late in the year, the Minnesota School Attitude Survey was determined to be invalid. Scores are reported for the reader's perusal only.

Les gliomes de bas-grade représentent la tumeur cérébrale la plus fréquente chez l’enfant. Elles sont caractérisées par un large spectre de sous-types tumoraux, très hétérogènes. Leur définition actuelle est principalement basée sur des critères histologiques ce qui représente une limite importante car ces classifications souffrent d’un manque de précision. Les progrès récents de la génomique nous permettent d’approfondir considérablement les connaissances sur la biologie de ces tumeurs afin d’enrichir leur classification actuelle. Ce travail présente une analyse approfondie des altérations génomiques de l’ADN et l’ARN des gliomes de bas-grade pédiatriques. Le premier niveau d’analyse se base sur l’analyse du séquençage à haut débit de 169 gliomes de bas-grade de l’enfant. Bien que les mutations des gènes BRAF et FGFR1 sont les plus fréquemment décrites dans ces tumeurs, nous avons identifié pour la première fois le réarrangement chromosomique MYB-QKI majoritairement associé aux gliomes angiocentriques. Dans un deuxième temps ce travail décrit l’analyse du transcriptome de 151 gliomes de bas grade extraits à partir de tissu conservé en paraffine. Nous avons observé des différences moléculaires en fonction de leur sous-type histologique, de la localisation tumorale et de leur statut BRAF. Dans le dernier volet de ce travail, nous avons testé la faisabilité d’isoler par cytométrie en flux une cellule unique en les distinguant selon un marqueur de différenciation glial (A2B5+ et A2B5-) et d’effectuer une analyse transcriptomique à haut-débit en séquençant l’ARN à l’échelle d’une cellule unique. Cette technique nous a permis de décrire des différences moléculaires intéressantes entre des cellules A2B5+ et A2B5-. Ces résultats soulignent l’intérêt d’exploiter des nouvelles technologies de pointe pour servir de base à l’étude des caractéristiques biologiques des cellules tumorales. / Low-grade gliomas represent the most frequent brain tumor arising during childhood. They are characterized by a broad spectrum of tumor types.The definition of low-grade gliomas has been mainly based on morphology. This histological classification of pediatric low-grade gliomas (PLGG), suffers from the lack of reproducibility. The recent progress in molecular biology and genetics has brought new insights in the biology of those tumors and allows better understanding of their biology. This work provides a comprehensive analysis of two different genetic approaches in PLGGs. The first part is based on the description of somatic genetic alterations of the DNA. Using a large PLGG cohort, we have dissect the genome of those tumors and draw the landscape of their genetic alteration. Although BRAF and FGFR1 alterations are predominantly altered, we have discovered a new translocation, MYB-QKI, that is almost exclusively present in a specific histological subgroup; angiocentric gliomasThe second part of the thesis describes transcriptomic analysis of bulk PLGGs. This work describes molecular differences between PLGGs from distinct histologies and arising from different locations in the brain as well as different BRAF mutation status.We were also able to test single-cell expression analyses in three pilocytic astrocytomas (PAs) using RNA-sequencing. In this experimental work we have successfully tested the hypothesis that we can isolate single-cells from fresh PLGG tumors in order to analyze the trasncriptome at a large scale. We observed that single-cells expressing A2B5, a glial progenitor marker, isolated in pediatric PAs are characterized as a distinct biological population. These results underline the importance to improve the precision of the transcriptomic studies to capture the molecular signal of tumor cells and further understand the different pattern between normal cells and tumor cells.

Les gliomes diffus de bas grade sont des tumeurs cérébrales des jeunes adultes. Dans cette thèse, nous nous intéressons à la segmentation et à la modélisation de ces tumeurs. Dans la première partie du manuscrit, nous étudions la segmentation des gliomes diffus de bas grade à base de différentes méthodes manuelles et semi-automatiques. La délimitation de ces tumeurs peut être problématique en raison de leur caractère très infiltrant et inhomogène. En pratique clinique, le suivi des gliomes diffus de bas grade repose sur l'estimation du volume tumoral, soit par une segmentation suivie d'une reconstruction logicielle, soit par la méthode des trois diamètres. Pour la segmentation, elle est manuelle et est exécutée par des praticiens sur des IRM en pondération FLAIR ou T2. La méthode des trois diamètres est rapide mais s'avère difficile à implémenter dans le cas de gliomes diffus de bas grade très infiltrants ou en post-traitement. La solution par segmentation manuelle et reconstruction logicielle du volume est chronophage mais demeure plus précise en comparaison de la méthode des trois diamètres. Nous étudions ici la reproductibilité de la segmentation manuelle avec le logiciel OsiriX en réalisant un test subjectif dans le Living Lab PROMETEE de TELECOM Nancy. Les résultats de cette étude montrent que ni la spécialité du praticien ni le nombre d’années d’expérience ne semblent impacter significativement la qualité de la segmentation. Nous comparons par ailleurs les résultats obtenus à ceux d'un deuxième test où nous appliquons la méthode des trois diamètres. Enfin, nous explorons deux algorithmes de segmentation semi-automatique basés, respectivement, sur les contours actifs et sur la méthode des level set. Même si la segmentation automatique semble être une voie prometteuse, nous recommandons aujourd’hui l’utilisation de la segmentation manuelle du fait notamment du caractère diffus des gliomes de bas grade qui rend le contour complexe à délimiter. La seconde partie du manuscrit est consacrée à la modélisation des gliomes diffus de bas grade eux-mêmes ou, plus exactement, à la modélisation de l'évolution du diamètre tumoral en phase de chimiothérapie. La prise en charge thérapeutique des patients atteints de ces tumeurs inclut en effet souvent une chimiothérapie. Pour ce travail, nous nous intéressons à la chimiothérapie par Témozolomide en première ligne de traitement. Une fois le traitement entamé, les praticiens aimeraient déterminer l'instant optimal d'arrêt de traitement. Nous proposons une modélisation statistique du diamètre tumoral sous chimiothérapie. Cette modélisation s'appuie sur des modèles de régression linéaire et exponentielle. Elle permet de prédire le diamètre tumoral à partir d'un jeu de données d'apprentissage et d'alerter le clinicien sur l'état d'évolution du diamètre sous traitement. Nous espérons que ces modèles pourront un jour être utilisés comme un outil dans la planification de la chimiothérapie en milieu clinique. / Diffuse low-grade gliomas are brain tumors of young adults. In this thesis, we focus on the segmentation and on the modeling of these tumors. In the first part of the manuscript, we study the segmentation of diffuse low-grade gliomas based on different manual and semi-automatic methods. The delineation of these tumors can be problematic because of their very infiltrating and inhomogeneous nature. In clinical practice, the monitoring of diffuse low-grade gliomas is based on the estimation of tumor volume, obtained either through a segmentation followed by a software reconstruction or through the three diameters method. As for the segmentation, it is manual and it is performed by practitioners on FLAIR-weighted or T2-weighted MRI.The three diameters approach is fast but it is difficult to implement in the case of highly infiltrating diffuse low grade gliomas or after a treatment. The manual segmentation and software-based volume reconstruction solution is time-consuming but it remains more accurate in comparison with the three diameters method. We investigate in this work the reproducibility of the manual segmentation with the OsiriX software by performing a subjective test in the Living Lab PROMETEE in TELECOM Nancy. The results of this study show that neither the practitioners' specialty nor their number of years of experience seem to have a significant impact on the quality of the segmentation. We also compare the results to those of a second test where we apply the three diameters method. Finally, we explore two semi-automatic segmentation algorithms which are, respectively, based on active contours and on the level set method. Even if automatic segmentation seems to be a promising avenue, we recommend for now the use of manual segmentation because of the diffuse nature of low-grade gliomas, which makes the tumor's contours complex to delineate. The second part of the manuscript is dedicated to the modeling of diffuse low-grade gliomas themselves or, to be more precise, to the modeling of the evolution of the tumor's diameter during chemotherapy. The therapeutic management of patients with these tumors often includes indeed chemotherapy. For this work, we focus on Temozolomide chemotherapy in first-line treatment. After the beginning of the treatment, the practitioners would like to determine the optimum time of discontinuation. We propose a statistical modeling of tumor diameter under chemotherapy. This modeling is based on linear and exponential regression models. It can predict the tumor diameter from a set of training dataset and can alert the clinician on the state of change in diameter under treatment. We hope that these models will, eventually, be used as a tool in the planning of chemotherapy in a clinical environment.

I riksdagsvalet 2006 fick Sverige en ny regering med borgerligt styre. Förslag som utlovades i valrörelsen, särskilt från folkpartiet, som rör grundskolans senare år var bland annat att man vill införa betyg tidigare, använda sig av ett ordningsomdöme och att den ogiltiga frånvaron ska synas i betyget. Syftet med denna uppsats är att undersöka vad lärare och elever tycker om dessa förslag. Metoden som jag använt mig av har varit en enkätundersökning som genomförts i tre sjätteklasser och tre sjundeklasser samt att intervjua fyra lärare som tjänstgjort olika länge på grundskolans senare år. Resultatet visar att antalet elever är jämnt fördelade om de vill ha betyg tidigare eller inte medan två av tre elever vill att ett ordningsomdöme ska införas och att skolk ska synas i betyget. Någon större skillnad mellan årskurserna och mellan pojkar och flickor kunde ej uppmätas. Resultatet hos lärarna är att de flesta är positiva till att ha betyg tidigare än i årskurs åtta, tycker att förslaget med ett ordningsomdöme är en bra idé medan de är tveksamma till att frånvaro ska stå med i betyget oavsett om den är giltig eller inte. / In the referendum of parliament 2006 Sweden got a new government when the alliance with moderaterna, folkpartiet, kristdemokraterna and centerpartiet won. Suggestions that was promised in the election campaign, especially from folkpartiet, that concerns the elementary school later years, was among others to give grades earlier, make use of a grade in order and that invalid absence shall be noticed in the grades. The purpose with this paper is to examine what teachers and pupils thinks of these suggestions. The method I have used is an opinion poll that’s been carried through in three classes of the sixth degree and three classes of the seventh degree. I also interviewed four teachers who been working varying times in the elementary schools later year. The result shows that the number of pupils are equal divided among them who wants grades earlier or those who don’t. Two of three pupils wants to have a grade in order and the invalid absence shall be noticed in the grade. Any kind of difference between the grades and between boys and girls couldn’t be measured. The result among the teachers shows that most of them are positive to earlier grades compared to today. The most of them think also that the suggestion to have grades in order is a good idea but they are uncertain if absence shall be noted in the grades no matter how it is invalid or not.

Purification of metallurgical grade silicon (MG- Si) by a combination of solvent refining and physical separation has been studied. MG-Si was alloyed with iron and solidified under different cooling rates to grow pure Si dendrites from the alloy. The Si dendrites and FeSi2 that were formed after solidification were then separated by a gravity-based method. The separation method relies on significantly different densities of Si and FeSi2, and uses a heavy liquid with specific gravity between the two phases to float the former on the surface of a heavy liquid, while the latter sinks to the bottom. The effect of particle size and cooling rate on the Si yield and separation efficiency of the Si phase was investigated. The floated Si particles were further purified by removing the physically adherent Fe-Si phase, using an acid leaching method. Analysis of the produced silicon indicates that several impurity elements including P and B can be efficiently removed using this simple and low-cost technique.

Purification of metallurgical grade silicon (MG- Si) by a combination of solvent refining and physical separation has been studied. MG-Si was alloyed with iron and solidified under different cooling rates to grow pure Si dendrites from the alloy. The Si dendrites and FeSi2 that were formed after solidification were then separated by a gravity-based method. The separation method relies on significantly different densities of Si and FeSi2, and uses a heavy liquid with specific gravity between the two phases to float the former on the surface of a heavy liquid, while the latter sinks to the bottom. The effect of particle size and cooling rate on the Si yield and separation efficiency of the Si phase was investigated. The floated Si particles were further purified by removing the physically adherent Fe-Si phase, using an acid leaching method. Analysis of the produced silicon indicates that several impurity elements including P and B can be efficiently removed using this simple and low-cost technique.

Pre-collegiate teachers in Saskatchewan recognize the value of integrating archaeological content into natural and social science curricula. However, there is currently a lack of curriculum-relevant resources available to teachers who are interested in teaching with archaeology. In addition to meeting Saskatchewan Core Curriculum standards and objectives, the holistic, multi-disciplinary, activities-based approach inherent in archaeology education provides students with opportunities to inquire, investigate, connect, cooperate and collaborate as they develop higher-level understanding and cognition independently and as members of a community of learners (Short and Burke 1991). Thus, the integration of archaeology into existing curricula complements contemporary cognitive development and social constructivist theories of knowledge of scholars Jean Piaget and Lev Vygotsky. Furthermore, learning through archaeology increases students awareness and appreciation of other cultures, and promotes understanding of the need to protect and conserve cultural resources. <p>There were two aims in the research: 1) To answer the question: What do teachers require to integrate archaeology concepts, themes and activities into Grade 6 Science and Grade 9 Social Studies curricula; and, 2) To assess the validity of the two assumptions that were taken after the review of the literature: i) If successful archaeology education programs in North America employed the use of hands-on, active learning, then the inclusion of hands-on, active learning in the archaeology education resources developed for the research will also prove effective ; and ii) If successful archaeology education programs in North America incorporated constructivist theories of learning, including the cognitive development theory of Jean Piaget and the sociocultural theory of Lev Vygotsky in their designs, then reference to constructivist theories of learning, including Piagets cognitive development theory and Vygotskys sociocultural theory, will result in the development of appropriate archaeology education materials.<p>The research occurred between January 2003 and June 2005, and involved the collaboration of nine teachers, a First Nations Elder, 689 Grade 6 and Grade 9 students, and 13 archaeologists. The research design followed a qualitative, action research approach, with the collection of data occurring through semi-structured interviews using McCrackens (1988) long interview method, as well as questionnaires, a survey, and participant observation. An open-coding approach was used to code data collected during the research.<p>In addition to providing answers to the research question and assessments of the validity of the two assumptions taken in the research, the results indicate that the benefits of integrating archaeological content into pre-collegiate curricula transcend professional jurisdictions. Outcomes include the development of Grade 6 Science and Grade 9 Social Studies archaeology units that can serve as templates and resources for teachers, curriculum developers, and archaeologists. Also, participants learned about: Saskatchewans human and environmental histories; how archaeology can be used to reveal these histories; and why it is necessary to protect and conserve cultural resourcesall goals of avocational and professional archaeological associations across North America.