Syftet med den här studien var att ur ett lärarperspektiv synliggöra problematiken med att få till stånd ett gemensamt synsätt vad gäller barns utveckling, kunskap och lärande mellan lärare i förskoleklassen och grunskolans år ett. Frågeställningen var: Vilka faktorer anser lärare främjar respektive hindrar utvecklingen av ett gemensamt synsätt? Studien var kvaltitativ och genomfördes med hjälp av inspelade intervjuer av sex lärare varav tre är verksamma i förskoleklass och de andra tre i årskurs ett. I studiens resultat framkom en mängd faktorer som anses utgöra hinder och/eller möjligheter för att främja en gemensam syn. Det mest primära var att lärarna i arbetslaget för en dialog om verksamheten. Andra viktiga faktorer var till exempel arbetslagets sammansättning, samt att tid avsätts för att kunna föra diskussioner kring barnen, deras kunskap och utveckling. Det visade sig också att det inte räcker med att en faktor uppfylls- om exempelvis tid finns men viljan till smatal inte finns nås inget resultat i sig. Det visade sig att den ena faktorn inte utesluter den andra, samt att de faktorer som ses som hinder även kan framsrå som möjligheter. / The purpose of this study is to present the complexity of creating a shared platform around the work among teachers in pre-school and the first year of school concerning promoting the children´s development, knowledge and learning. The subject for our study is: What "tool" contribute or hinder the process of creating a shared plarform around the work accordning to teachers? This qualitative study is based on taped interviews with pre-school teachers and three teachers in firts year of compulsory school. The result of the study revaels a number of tools either contributing or hindering reaching a shared plarform around the work. The single most imprtant tool in implementing the curriculum is the joint reflection but also tools like the make-up of the work team and the setting aside of time for planning and reflection are of great importance. The result also shows that different approaches and various working experience among the members of the work team create different interpretations which might either contribute or hinder the development towards a shared platform.

Decoding the genomes from organisms that encompass all taxonomies provides the foundation for extensive, large scale studies of biological molecules such as RNA, protein and carbohydrates. The high-throughput studies facilitated by the existence of these genome sequences necessitate the development of new analytic methods for the interpretation of large sets of results. The work herein focuses on the development of a novel clustering method for the analysis of protein array results and examines its utilization in the analysis of integrated interaction data sets. Sets of proteins that interact with a molecule of interest were clustered according to their functional similarity. The simUI distance metric in the statistical analysis package BioConductor was applied to measure the similarity of two proteins utilizing the assembly of their Gene Ontology annotation. Clusters were identified by partitioning around medoids and interpreted using the summary label provided by the Gene Ontology annotation of the medoid. The utility of the method was tested on two published yeast protein array data sets and shown to allow interpretation of the data to yield novel biological hypotheses. We performed a protein array screen using the E3 ubiquitin ligase and PDZ domain-containing protein LNX1. We combined these results with other published LNX1 interactors to produce a set of 220 proteins that was clustered according to Gene Ontology annotation. From the clustering results, 14 proteins were selected for subsequent examination by co-immunoprecipitation, of which 8 proteins were confirmed as LNX1 interactors. Recognition of 6 proteins by specific LNX1 PDZ domains was confirmed by fusion protein pull-downs. This work supports the role of LNX1 as a signalling scaffold. The interpretation of protein array results using our novel clustering method facilitated the identification of candidate molecules for subsequent experimental analysis. Thus our analytical method facilitates identification of biologically relevant molecules within a large data set, making this method an essential component of complex, high-throughput experimentation.

Decoding the genomes from organisms that encompass all taxonomies provides the foundation for extensive, large scale studies of biological molecules such as RNA, protein and carbohydrates. The high-throughput studies facilitated by the existence of these genome sequences necessitate the development of new analytic methods for the interpretation of large sets of results. The work herein focuses on the development of a novel clustering method for the analysis of protein array results and examines its utilization in the analysis of integrated interaction data sets. Sets of proteins that interact with a molecule of interest were clustered according to their functional similarity. The simUI distance metric in the statistical analysis package BioConductor was applied to measure the similarity of two proteins utilizing the assembly of their Gene Ontology annotation. Clusters were identified by partitioning around medoids and interpreted using the summary label provided by the Gene Ontology annotation of the medoid. The utility of the method was tested on two published yeast protein array data sets and shown to allow interpretation of the data to yield novel biological hypotheses. We performed a protein array screen using the E3 ubiquitin ligase and PDZ domain-containing protein LNX1. We combined these results with other published LNX1 interactors to produce a set of 220 proteins that was clustered according to Gene Ontology annotation. From the clustering results, 14 proteins were selected for subsequent examination by co-immunoprecipitation, of which 8 proteins were confirmed as LNX1 interactors. Recognition of 6 proteins by specific LNX1 PDZ domains was confirmed by fusion protein pull-downs. This work supports the role of LNX1 as a signalling scaffold. The interpretation of protein array results using our novel clustering method facilitated the identification of candidate molecules for subsequent experimental analysis. Thus our analytical method facilitates identification of biologically relevant molecules within a large data set, making this method an essential component of complex, high-throughput experimentation.

<p>Syftet med den här studien var att ur ett lärarperspektiv synliggöra problematiken med att få till stånd ett gemensamt synsätt vad gäller barns utveckling, kunskap och lärande mellan lärare i förskoleklassen och grunskolans år ett. Frågeställningen var: Vilka faktorer anser lärare främjar respektive hindrar utvecklingen av ett gemensamt synsätt?</p><p>Studien var kvaltitativ och genomfördes med hjälp av inspelade intervjuer av sex lärare varav tre är verksamma i förskoleklass och de andra tre i årskurs ett.</p><p>I studiens resultat framkom en mängd faktorer som anses utgöra hinder och/eller möjligheter för att främja en gemensam syn. Det mest primära var att lärarna i arbetslaget för en dialog om verksamheten. Andra viktiga faktorer var till exempel arbetslagets sammansättning, samt att tid avsätts för att kunna föra diskussioner kring barnen, deras kunskap och utveckling. Det visade sig också att det inte räcker med att en faktor uppfylls- om exempelvis tid finns men viljan till smatal inte finns nås inget resultat i sig. Det visade sig att den ena faktorn inte utesluter den andra, samt att de faktorer som ses som hinder även kan framsrå som möjligheter.</p> / <p>The purpose of this study is to present the complexity of creating a shared platform around the work among teachers in pre-school and the first year of school concerning promoting the children´s development, knowledge and learning. The subject for our study is: What "tool" contribute or hinder the process of creating a shared plarform around the work accordning to teachers?</p><p>This qualitative study is based on taped interviews with pre-school teachers and three teachers in firts year of compulsory school.</p><p>The result of the study revaels a number of tools either contributing or hindering reaching a shared plarform around the work. The single most imprtant tool in implementing the curriculum is the joint reflection but also tools like the make-up of the work team and the setting aside of time for planning and reflection are of great importance.</p><p>The result also shows that different approaches and various working experience among the members of the work team create different interpretations which might either contribute or hinder the development towards a shared platform.</p>

This work deals with the analysis of selected works by the famous Austrian writer Arthur Schnitzler. For the purpose of zeitgeist illustration the dramas Anatole and Reigen were used. The analysis of the works is preceded by theoretical section with a closer description of the socio-historical situation in Vienna at the turn of the 19th and 20 century. A part of the main section is a short treatise on the importance of one-act plays cycle in the development of the author´s works, dramas analysis and characterization of the characters, on the basis of which the conclusions are drawn about the image of Victorian society, which the author deals with in his works . The last part concludes the analysis and provides an outline description of the image and the zeitgeist as it can be deduced on the basis of both Schnitzler´s dramas compared to socio-historical knowledge of that time.

Depuis plus d'un demi-siècle, le monde de la microélectronique est rythmé par une course à la miniaturisation de son élément central, le transistor MOS, dans le but d'améliorer la densité d'intégration, les performances et le coût des circuits électroniques intégrés. Depuis plusieurs générations technologiques maintenant, la simple réduction des dimensions du transistor n'est plus suffisante et de nouveaux modules technologiques (utilisation de la contrainte, empilement de grille high-k/métal…) ont du être mis en place. Cependant, le transistor MOS conventionnel, même optimisé, ne suffira bientôt plus à répondre aux attentes toujours plus élevées des nouvelles technologies. De nouvelles architectures doivent alors être envisagées pour épauler puis, à terme, remplacer la technologie BULK. Dans ce contexte, cette thèse porte sur l'étude, la fabrication et la caractérisation électrique des architectures à film mince que sont le SOI localisé (ou LSOI) et le double grille planaire à grille enrobante (ou GAA). Les résultats obtenus mettent ainsi en évidence l'intérêt de ces dispositifs qui permettent une réduction du courant de fuite (et donc de la consommation), un excellent contrôle des effets électrostatiques et fonctionnent sans dopage canal (faible variabilité) tout en proposant de très bonnes performances statiques. L'impact d'une orientation de substrat (110) sur les propriétés de transport dans les transistors LSOI est également étudié. Ce travail de thèse garde comme ligne de mire la réalisation d'une plateforme basse consommation complète, impliquant une éventuelle intégration hybride avec des dispositifs BULK et la possibilité d'offrir plusieurs niveaux de tension de seuil, le tout sur une même puce. / For more than 50 years, microelectronic industry is driven by a race to the miniaturisation of its central element, the MOS transistor, to improve the integration density, the performances and the cost of the electronic integrated circuits. Since the adoption of 100nm node, the only reduction of the dimensions of the transistor is no more sufficient and new technological modules (use of strain, high-k/metal gatestack…) have been introduced. However, conventional MOSFET, even opimized, will soon be unable to reach the specifications, always higher, of new technologies. Then, new structures should be considered to help and, finally, to replace the BULK technology. In this context, the work concerns the study, the fabrication and the electrical characterization of the thin film devices : Localized-SOI (LSOI) and planar gate-all-around (GAA). The obtained resultats point out the interest of such devices which allow the reduction of the leakage current (and thus the consumption), an excellent control of electrostatics and are able to work with an undoped channel while offering very good static performances. Impact of (110) substrates on transport properties in LSOI transistors is also studied. This work focuses on the integration of a full low-power platform, what induces the possibility of an hybrid integration with BULK devices and to offer several threshold voltages, everything on the same chip.

Nesta dissertação, estuda-se a transição de esteira no escoamento ao redor de um aerofólio NACA 0012 com ângulos de ataque de zero dez e vinte graus. Dois casos são considerados: fólio isolado e fólio alinhado com um cilindro. Nas duas configurações, analisa-se a estabilidade linear em relação a perturbações tridimensionais. Tais perturbações foram estudadas usando a teoria de Floquet para um conjunto de números de Reynolds e ângulos de ataques. O escoamento base é calculado usando o método de elementos finitos espectrais para a discretização espacial. Dos resultados de estabilidade no caso do aerofólio isolado, pode-se observar dois picos de instabilidade com diferentes comprimentos de onda na envergadura. A simetria dos modos instáveis é também apresentada. Um dos modos instáveis presente na esteira do aerofólio isolado foi também observado no caso do cilindro alinhado com o fólio, enquanto o outro modo foi suprimido em tal geometria / Study of hydrodynamic stability of the flow around a cylinder aligned with on airfoil

This thesis is focused on the construction of traffic communications and their influence over the surroundings. The introduction of the work shows reasons leading to the increase of an importance of the road transportation and it appreciates a transport policy and an urban planning. Further work describes transport from the view of public finance and there are mentioned specialities of appraisals of transport projects. Main theme of this thesis deals with construction of peripheral by-pass road around Prague. It concerns on the north-west part of the by-pass road because there are two possibilities of the route location, the south version is supported for a long time, the north version was suggested as an alternative route few years ago because of its better impacts to surrounding environment.

Master thesis concerns of the architecture of Jan Blažej Santini- Aichel from the point of view of cultural tourism in the Czech Republic.First part is concentrated on definition cultural tourism and its components. Second part clarifies the importance and position of Santini`s architecture in art history. Third part takes note of attendance and present touristic offer of sights whose common denominator is architect Santini, and also is attentive to activities of citizen`s association Travel around Santini. The conclusion endeavours to define the position of Santini`s sights in the cultural tourism in the Czech Republic and also tries to point out assets and negatives of activities of citizen`s association Travel around Santini, and outlines potential direction of activities of the citizen`s association in the future.

京都大学 / 0048 / 新制・課程博士 / 博士(理学) / 甲第21444号 / 理博第4437号 / 新制||理||1638(附属図書館) / 京都大学大学院理学研究科数学・数理解析専攻 / (主査)准教授 前川 泰則, 教授 上 正明, 教授 堤 誉志雄 / 学位規則第4条第1項該当 / Doctor of Science / Kyoto University / DFAM