Made available in DSpace on 2016-04-28T14:58:37Z (GMT). No. of bitstreams: 1 2006-Mauricio Kadooka Shimizu.pdf: 1137662 bytes, checksum: 12facf4ab3f2c1cdb83680e9f5bcf89c (MD5) Previous issue date: 2006-02-21 / The present study was released at the UFRRJ, having the objectives to analyze the age influence on the dwarf-green coconut s constituent in fruits originated from inflorescences emitted at the winter time, in the Baixada de Sepetiba area, and to determine the ideal harvest point for the liquid albumen consumption of in natura fruits. Initially, the inflorescences were marked, and experimental samples were taken from the 4th month until the 12th month after the inflorescence emission. After that, fruits in the CEASA-RJ had been acquired, proceeding from different producing regions (Linhares/ES, Rio Bananal/ES, Itagua?/RJ and Santa Cruz/RJ) and compared with fruits harvested in the 6th and 7th months in the previous experiment. The external measures (Length, Width and Length/Width Relation) and interns ones (Length and Width of the internal socket; and Length/Width Relation of the internal socket) had been analyzed too, observing the liquid albumen volume and income performance, the solid albumen thickness, Total Soluble Solids (TSS), Titulable Total Acidity (TTA), the TSS/TTA relation and pH. According to the data gotten in the present work, the harvest of fruits from inflorescences emitted during the winter time, in the Baixada de Sepetiba area (Rio de Janeiro), must be carried through the period between the 6th and 7th months of development. The fruits reach its maximum size between the 7th and 8th months, the fruits have a round shape between the 5th and 7th months, with bigger weight between the 7th and 9th months, greater volume of liquid albumen between the 6th and 7th months and greater income of liquid albumen (%) between the 5th and 6th months. When compared with fruits proceeding from the local market, the fruits with 6 and 7 months old had gotten compatible arithmetic mean, with characteristics as recommended in the technician regulation of coconut water identity and quality settings (Normative Instruction n?39/2002 M.A.P.A.). / O presente trabalho foi realizado no Laborat?rio de P?s-Colheita do Departamento de Fitotecnia Instituto de Agronomia da UFRRJ, com objetivo de avaliar a influ?ncia da idade sobre os constituintes de frutos de coqueiro an?o-verde em infloresc?ncias emitidas no per?odo do inverno, na regi?o da Baixada de Sepetiba, e determinar o ponto de colheita ideal para consumo do alb?men l?quido dos frutos in natura. Inicialmente, foram marcadas as infloresc?ncias e tomadas amostras do 4? m?s at? o 12? m?s ap?s a emiss?o da infloresc?ncia. Em seguida, foram adquiridos frutos na CEASA-RIO, provenientes de diferentes regi?es produtoras (Linhares/ES, Rio Bananal/ES, Itagua?/RJ e Santa Cruz/RJ) e comparadas com frutos colhidos no 6? e 7? meses no experimento anterior. Foram realizadas avalia??es quanto ?s medidas externas (Comprimento, Largura e Rela??o Comprimento/Largura) e internas (Comprimento e Largura da cavidade interna; e Rela??o Comprimento/Largura da cavidade interna), foram avaliados o volume do alb?men l?quido, rendimento do alb?men l?quido, espessura do alb?men s?lido, S?lidos Sol?veis Totais (SST), Acidez Total Titul?vel (ATT), rela??o SST/ATT e pH. Pelos dados obtidos no presente trabalho, a colheita de frutos a partir de infloresc?ncias emitidas no per?odo de inverno, na regi?o da Baixada de Sepetiba (RJ), devem ser realizada no per?odo do 6o at? o 7o m?s de desenvolvimento. Os frutos atingem tamanho m?ximo entre o 7? e 8? meses, s?o frutos mais arredondados entre o 5? e 7? meses, com maior peso entre o 7? e 9? meses, maior volume do alb?men l?quido entre 6? e 7? meses e maior rendimento do alb?men l?quido (%) entre o 5? e 6? meses. Quando comparados com frutos provenientes do mercado, os frutos com 6 e 7 meses obtiveram m?dias compat?veis e com caracter?sticas preconizadas no regulamento t?cnico para fixa??o de identidade e qualidade da ?gua-de-coco (Instru??o Normativa n?39/2002 M.A.P.A.).

Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2017-06-13T19:59:23Z No. of bitstreams: 1 HenriqueJorgeMaiaCosta_TESE.pdf: 2983042 bytes, checksum: e69d54482caf7ae9786e28e71023539e (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2017-06-19T12:14:15Z (GMT) No. of bitstreams: 1 HenriqueJorgeMaiaCosta_TESE.pdf: 2983042 bytes, checksum: e69d54482caf7ae9786e28e71023539e (MD5) / Made available in DSpace on 2017-06-19T12:14:15Z (GMT). No. of bitstreams: 1 HenriqueJorgeMaiaCosta_TESE.pdf: 2983042 bytes, checksum: e69d54482caf7ae9786e28e71023539e (MD5) Previous issue date: 2016-08-29 / O jejum pr?-operat?rio foi institu?do h? muitos anos, no in?cio das pr?ticas anest?sicas, para garantir o esvaziamento do conte?do g?strico, evitar bronco-aspira??o, v?mitos, regurgita??o, administra??o de v?rias drogas para reduzir a acidez g?strica e volume. Protocolos de jejum pr?-operat?rio sugerem per?odos menores de jejum, principalmente para l?quidos, permitindo mais conforto aos pacientes, e menor risco de hipoglicemia e desidrata??o, sem aumentar a incid?ncia de aspira??o pulmonar perioperat?ria. O objetivo do estudo foi avaliar se o bioproduto ? base de ?gua de coco e maltodextrina (ACP Surgery) supria as necessidades dos protocolos cl?nicos de jejum pr?-operat?rio de curta dura??o do projeto ACERTO (Acelera??o da Recupera??o Total P?s-operat?ria) com boa toler?ncia e aceita??o. Foi realizado um estudo prospectivo, aleat?rio, controlado e duplo cego em seres humanos, em um grupo de 49 pacientes na Santa Casa de Miseric?rdia de Fortaleza, para comprovar a efici?ncia e efic?cia do ACP Surgery para atingir as metas e efeitos planejados nos protocolos de jejum pr?-operat?rio de curta dura??o. Os grupos experimentais foram: G1 [grupo controle; Nutri Dextrin (Nutrimed, Fortaleza, Cear?); n = 20) e G2 [interven??o; ACP Surgery (ACP Biotecnologia, Fortaleza, Cear?; n = 29]. No intervalo entre 10 e 20 horas da realiza??o da cirurgia, amostra de sangue era colhida de cada paciente e encaminhada para o Laborat?rio de An?lises Cl?nicas do hospital para mensura??o dos n?veis s?ricos de leuc?citos totais, glicose, s?dio, pot?ssio e cloro. Os dados foram submetidos ao teste t (? = 95%, p > 0,05 e ?rea de rejei??o t > 1,96) e expressos em m?dia e desvio padr?o. Os grupos G1 (Nutri Dextrin) e G2 (ACP Surgery) apresentaram os seguintes resultados quanto ?s an?lises sangu?neas: leuc?citos totais G1 = 11.322,64 + 5.033,94, e G2 = 11.074,14 + 4.480,35; s?dio G1 = 140,8 + 4,14 mEq/l, e G2 = 139,3 + 4,38 mEq/l; pot?ssio G1 = 4,16 + 0,65 mEq/l, e G2 = 4,18 + 0,47 mEq/l; cloro G1 = 107,4 + 4,69 mEq/l, e G2 = 107,1 + 6,88 mEq/l; e glicose G1 =130,3 + 39,96 mg/dl, e G2 = 123,9 + 36,47 mg/dl. Em todas as vari?veis estudadas o p > 0,05, portanto, pode-se considerar que os produtos Nutri Dextrin e ACP Surgery s?o equivalentes. A aceita??o do ACP Surgery foi de 97%, sem relatos de pigarro ou n?useas (toler?ncia de 100%), sem perda de palatabilidade. Conclui-se que o bioproduto produzido supriu as necessidades e especifica??es dos protocolos de jejum pr?-operat?rio de curta dura??o apresentando aceita??o e toler?ncia compat?vel com o produto comercial ao mesmo tempo em que reduziu os custos e facilitou a execu??o do protocolo. / The preoperative fasting was instituted many years ago, at the beginning of the anesthetic practice, to ensure the emptying of the stomach contents, avoid bronchial aspiration, vomiting, regurgitation, administration of various drugs to reduce gastric acidity and volume. Preoperative fasting protocols suggest shorter fasting periods especially for liquids, providing more comfort to the patient, and less risk of hypoglycemia and dehydration, without increasing the incidence of perioperative pulmonary aspiration. The aim of the study was to assess whether the bioproduct based on coconut water and maltodextrin (ACP Surgery) supplied the needs of clinical trials of ERAS project (Enhanced Recovery After Surgery) with good tolerance and acceptance. It was conducted a prospective, randomized, controlled, double-blind study in humans with a group of 49 patients at the Santa Casa de Misericordia de Fortaleza, to prove the efficiency and effectiveness of ACP Surgery to achieve the goals and planned effects on ERAS project. The experimental groups were: G1 [control group; Nutri Dextrin (Nutrimed, Fortaleza, Cear?); n = 20) and G2 [intervention; ACP Surgery (ACP Biotecnologia, Fortaleza, Cear?;. N = 29]. In the interval between 10 and 20 hours prior to the surgery, blood sample was taken from each patient and sent to the Hospital's Laboratory of Clinics Analysis for measurement of serum levels of total leukocytes, glucose, sodium, potassium and chlorine. The data were submitted to t test (? = 95%, p> 0.05 and t rejection area > 1.96) and expressed as mean and standard deviation. The G1 (Nutri Dextrin) and G2 (ACP Surgery) showed the following results regarding blood tests: total leukocyte G1 = 11,322.64 + 5,033.94, and G2 = 11,074.14 + 4,480.35; sodium G1 = 140.8 + 4.14 mEq/L, and G2 = 139.3 + 4.38 mEq/L; potassium G1 = 4.16 + 0.65 mEq/L, and G2 = 4.18 + 0.47 mEq/L; chloro G1 = 107.4 + 4.69 mEq/L, and G2 = 107.1 + 6.88 mEq/L; and glucose G1 = 130.3 + 39.96 mg/dL, and G2 = 123.9 + 36.47 mg/dL. In all variables p> 0.05, so it can be considered that Nutri Dextrin and ACP Surgery products are equivalent. The acceptance of the ACP Surgery was 97%, with no reports of cough or nausea (100% tolerance), without loss of palatability. It follows that the produced bioproduct met the needs and specifications of preoperative fasting protocols of short duration, showing acceptance and tolerance compatible with the commercial product at the same time reducing costs and facilitating protocol implement.

Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2017-10-18T19:26:57Z No. of bitstreams: 1 VanessaDeFatimaLimaDePaivaMedeiros_TESE.pdf: 805024 bytes, checksum: efb811147a84e64fde7c523a46b27c9c (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2017-10-18T22:44:14Z (GMT) No. of bitstreams: 1 VanessaDeFatimaLimaDePaivaMedeiros_TESE.pdf: 805024 bytes, checksum: efb811147a84e64fde7c523a46b27c9c (MD5) / Made available in DSpace on 2017-10-18T22:44:14Z (GMT). No. of bitstreams: 1 VanessaDeFatimaLimaDePaivaMedeiros_TESE.pdf: 805024 bytes, checksum: efb811147a84e64fde7c523a46b27c9c (MD5) Previous issue date: 2017-07-28 / Reanima??o e tratamento de choque e sepse s?o controversos e desafiadores. O objetivo deste estudo foi examinar os efeitos da ?gua de coco + NaCl 3% + sinvastatina na reanima??o em modelo murino de sepse abdominal e choque hemorr?gico. Ratos Wistar machos adultos foram submetidos a sepse por ligadura e pun??o do ceco e choque hemorr?gico, e divididos em quatro grupos de reposi??o hidroeletrol?tica. 1. solu??o salina 0,9%; 2. ?gua de coco + NaCl 3%; 3. ?gua de coco + NaCl 3% + sinvastatina (microemuls?o) 10 mg / Kg i.v; 4. ?gua de coco n?o modificada. Escore cl?nico, histologia e fluoresc?ncia do pulm?o foram avaliados neste estudo. Dosagem s?rica das citocinas TNF-?, IL-1? e contagem de leuc?citos foram determinados. O tratamento com ?gua de coco + NaCl 3% + sinvastatina resultou em resultados significativamente melhores de sobreviv?ncia, an?lises bioqu?micas e histopatologia quando comparando com os animais submetidos aos tratamentos ?gua de coco + NaCl 3% e ?gua de coco n?o modificada. Em conclus?o, a ressuscita??o com ?gua de coco com Nacl 3% + sinvastatina teve efeito ben?fico significativo sobre a redu??o dos n?veis de citocinas e na atenua??o de les?es pulmonares em modelo de sepse abdominal e choque hemorr?gico. Tamb?m foi demonstrado que o tratamento com ?gua de coco com Nacl 3% + simvastatina atuou positivamente na fun??o do f?gado e dos rins, e no escore cl?nico. / Resuscitation and treatment of shock and sepsis are controversial and challenging. The aim of this study was to examine the effects of coconut water + Nacl 3%+ simvastatin in resuscitation in a murine model of sepsis and hemorrhagic shock. In methods, adult male Wistar rats were subjected to sepsis by cecal ligation and puncture and hemorrhagic shock assigned to four fluid replenishment groups. Animals received 1. saline 0,9%; 2. coconut water (CW) + NaCl 3%; 3. coconut water + NaCl 3% + simvastatin (microemulsion)10 mg/Kg i.v; 4. Coconut water. Clinical score was determined and lung tissue was assessed for inflammation. Serum cytokines TNF-?, IL-1 ? and leucocytes were measured. The results of this study indicated that coconut water+NaCl 3%+ simvastatin decreased significantly serum cytokines, survival, biochemical analysis and lung histopathological testing when compared to saline, water+NaCl 3% and coconut water. In conclusion, resuscitation with coconut water with Nacl 3%+simvastatin had a significant beneficial effect on downregulating cytokines and decreasing lung injury in a rat model of abdominal sepsis and hemorrhagic shock. We also demonstrated that coconut water with Nacl 3%+simvastatin administration clearly made liver and kidney function better and improved clinical score.