[pt] A dissertação busca compreender como sujeitos (auto)denominados ex- viciados criam inteligibilidade sobre eles próprios e o mundo ao relatarem suas histórias de vida (re)significando experiências passadas, (re)desenhando o presente e o futuro e abandonando, fabricando e reivindicando identidades e pertencimento a grupos sociais. Com o propósito de atingir estes objetivos, lanço mão da Análise de Narrativa enquanto ferramenta teórico-metodológica de estudo, visto que o interesse da pesquisa é focado na compreensão do que fazemos ao narrar, ou seja, o caráter performativo da linguagem. Os dados selecionados para análise são narrativas testemunhais vinculadas a um programa televisionado da Igreja Universal do Reino de Deus chamado Vício Tem Cura, que apresenta sujeitos que atingiram a cura para o vício através da fé, por intermédio das igrejas iurdianas. Frente a esse recorte, são observados os alinhamentos discursivos que entram em jogo ao longo das interações, pautando consensos que se atrelam às substâncias e ao seu consumo, que difundem normas e desvios ao passo que promovem cisões identitárias em e entre sujeitos e grupos sociais. Além disso, o trabalho visa verificar se há algum padrão estrutural nas narrativas analisadas, uma vez que não são prototípicas. Por fim, conclui-se que o discurso que permeia as igrejas iurdianas gera narrativas de superação do uso de substâncias que limitam a compreensão do uso de substâncias a uma mesma história, o que cria uma identidade homogênea e marginalizada — como se fosse possível, nos tempos atuais, performarmos todos um mesmo self —, ratificando e propagando preconceitos e estereótipos. / [en] This dissertation pursues the understanding of how self-appointed former addicts create intelligibility about themselves and the world by telling their life stories (re)signifying past experiences, (re)designing present and future and abandoning, manufacturing and claiming identities and belonging to social groups. Seeking to reach these objectives, the chosen theoretical-methodological tool is Narrative Analysis, since this research s interest is focused on the comprehension of what we do as we narrate, that is, the performative character of language. The selected data to be analyzed are testimonial narratives articulated to a television program from Igreja Universal do Reino de Deus (Universal Church of the Kingdom of God), called Vício Tem Cura (There s a cure for addiction, in a free translation). This program portrays people who have reached a recovery from addiction through faith, by the mediation of UCKG churches. Based in this sample, I observe the discursive alignments that come into play throughout the interactions, underscoring the consensus linked to substances and their consumption, that disseminates their norms and deviations while promoting split identities in and among subjects and social groups. Furthermore, this investigation aims to verify whether there are any structural patterns in the analyzed narratives, since they are not prototypical. Finally, I conclude that the discourse which permeates UCKG churches promotes narratives of overcoming substances use that limits the understanding of substances consumption to the same story, which creates a homogeneous and marginalized identity — as if it were possible, in current times, for us all to perform the same self — ratifying and propagating prejudices and stereotypes.

Portfolio diversification has been a subject frequently addressed since the publications of Markowitz in 1952 and 1959. However, the Modern Portfolio Theory and its mean variance framework have been criticized. The critiques refer to the assumptions that return distributions are normally distributed and the symmetric definition of risk. This paper elaborates on these short comings and applies a heuristic downside risk approach to avoid the pitfalls inherent in the mean variance framework. The result of the downside risk approach is compared and contrasted with the result of the mean variance framework. The return data refers to the real estate sector in Sweden and diversification is reached through property type and geographical location. The result reveals that diversification is reached differently between the two approaches. The downside risk measure applied here frequently diversifies successfully with use of fewer proxies. The efficient portfolios derived also reveals that the downside risk approach would have contributed to a historically higher average total return. This paper outlines a framework for portfolio diversification, the result is empirical and further research is needed in order to grasp the potential of the downside risk measures.

Enligt SOFS 2011: 9 ska kommuner ha ett kvalitetsledningssystem, detta ska generera kunskap och utveckling inom organisationen och respektive förvaltning. En del av denna utveckling, och således kvalitetssäkringen, är arbetet med avvikelsehantering inom de verksamheterna som bedrivs, både inom kommunen och i de av kommunen upphandlade verksamheter. Om arbetet med avvikelser inte återspeglas i organisationens samtliga nivåer kan brister inte åtgärdas långsiktigt och organisationen och verksamheternas utvecklingspotential uppmärksammas inte. Att låta medarbetare få återkoppling och bekräftelse samt att skapa förutsättning för kunskapsutveckling i verksamheter är nödvändigt för att hela organisationen ska kunna utvecklas. För att detta ska kunna realiseras måste kvalitetsperspektivet löpa som en röd tråd genom förvaltningar, ledarskapet, de digitala systemen och styrdokument måste sammanfogas till en helhet. Det krävs en sammanhållen bild av vad organisationen och förvaltningen står för och vad som är det primära målet. En bild, inte löst liggande pusselbitar utan eget syfte. Denna studie påvisar ett behov av att sammanfoga dessa pusselbitar till en bild som alla kan se tolka och vara med att lägga. / According to SOFS 2011: 9, municipalities must have a quality management system, this should generate knowledge and development within the organization and the respective administration. Part of this development and thus quality assurance is the work with deviation control within the different care facilities both run by municipality but also care facilities procured by the municipality. If the work with deviations is not reflected in all levels of the organization, deficiencies cannot be remedied in the long term, and the organization and the development potential of the businesses are not noticed. To allow employees to receive feedback and confirmation and to create the prerequisite for knowledge development in operations is necessary for the entire organization to develop. For this to be realized, the quality perspective must be the main thread through administrations, leadership, digital systems and governance documents must be joined together as a whole. A clear picture of what the organization and management stand for and what is the primary goal. A cohensive image, not single pieces of a jigsaw puzzle, pieces without their own purpose. This study demonstrates a need to join these jigsaw puzzle pieces into an image that everyone can see, interpret and contribute to. / <p>2020-06-26</p>

Depuis plus d’un siècle, l’œil est décrit comme un site immuno-privilégié : les réponses immunitaires sont fortement contrôlées localement et un mécanisme de déviation immunitaire peut être induit en périphérie après injection d’antigènes en chambre antérieure (ACAID, Anterior Chamber-Associated Immune Deviation). Mieux caractériser le statut immunitaire de l’œil, et en particulier de la rétine, est devenu un enjeu majeur à l’heure actuel au vu des nombreuses approches thérapeutiques innovantes pour le traitement de pathologies rétiniennes. L’objectif de mon travail de thèse a été d’étudier l’impact immunitaire périphérique d’une injection sous-rétinienne, tout d’abord dans un contexte antigénique simple, puis dans le cadre d’un transfert de gène par virus adéno-associé recombinant. En utilisant un modèle murin, j’ai pu démontrer que l’injection sous-rétinienne de peptides induit une inhibition des réponses lymphocytaires Th1/Tc1, Th2/Tc2, Th17/Tc17 en périphérie, de manière similaire à l’ACAID. Néanmoins, ce privilège immunitaire de la zone sous-rétinienne présente ses limites puisque l’injection sous-rétinienne de fortes doses d’AAV8 induit une réponse anti-transgène pro-inflammatoire en périphérie, accompagnée d’une altération locale de la structure rétinienne. Ce travail de thèse ouvre par ailleurs des voies de recherche quant à des approches d’immuno-modulation spécifiques. A terme, ces résultats devraient permettre d’optimiser l’immuno-monitorage des patients dans les essais cliniques. / For over a century, the eye has been described as an immune privileged site : immune responses are tighly controlled locally and an immune deviation mechanism is induced in periphery after the injtection of antigens in the anterior chamber (ACAID, Anterior Chamber-Associated Immune Deviation). A better comprehension of the immune status of the eye, especially the retina, has become a major concern regarding emerging and innovative therapeutic approaches to treat retinal pathologies. The aim of my work was to study the peripheral immune consequences of a subretinal injection, first in an simple antigenic context, and second in the context of adeno-associated virus-mediated gene transfer. In a murine model, I have shown that the subretinal injection of peptides induces an inhbition of Th1/Tc1, Th2/Tc2, Th17/Tc17 immune responses, similarly to ACAID. However, such an immune privilege has its limits. Indeed, the subretinal injection of high doses of AAV8 induces a pro-inflammatory anti-transgene immune response, along with a local alteration of the retinal structure. This work also provides new leads for specific approaches of immune modulation. On the long term, these results should provide new insights in optimizing the immuno-monitoring of patients enrolled in clinical trials.

京都大学 / 0048 / 新制・課程博士 / 博士(理学) / 甲第19472号 / 理博第4132号 / 新制||理||1594(附属図書館) / 32508 / 京都大学大学院理学研究科物理学・宇宙物理学専攻 / (主査)教授 佐々 真一, 准教授 藤 定義, 准教授 武末 真二 / 学位規則第4条第1項該当 / Doctor of Science / Kyoto University / DFAM

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In der Arbeit werden normativ-technische und verfahrenstechnische Voraussetzungen zur Richtighaltung von Kreisformmessgeräten dargelegt. Dazu wird ein umfassendes Begriffssystem für die allgemeine Beschreibung von Bewegungsabweichungen von bewegten Bauteilen an Werkzeugmaschinen oder Formmessgeräten, z.B. Kreisformmessgeräten, als Grundlage für ihre Tolerierung und Messung vorgeschlagen. Bekannte Messverfahren zur Bestimmung von Rotationsabweichungen der Spindel von Kreisformmessgeräten werden theoretisch und praktisch untersucht. Es wird ein neues Messverfahren, das kontinuierliche Relativlagenmessverfahren, entwickelt und ebenfalls untersucht. Die untersuchten Messverfahren zur Bestimmung von Rotationsabweichungen ermöglichen verschiedene Messunsicherheiten bis zu weniger als 0,02 µm. Vorschläge für die Gestaltung des Prüfschemas zur Richtighaltung von Kreisformmessgeräten werden unterbreitet. auch unter: Zentralbibliothek/Magazin/MPF1443:Verzeichnis der verwendeten Abkuerzungen V Vorwort VII 1. Einleitung 1 2. Grundlagen der radiusbezogenen Kreisformmessung 2 2.1. Eliminierung der Exzentrizitaet 2 2.2. Messunsicherheit der Kreisformmessung 3 2.3. Bewegung eines rotierenden Teiles 3 3. Begriffe und Definitionen zur Bewegung eines Teiles 5 3.1. Allgemeine Bemerkungen 5 3.2. Internationaler Stand 9 3.2.1. Bekannte Begriffe und Definitionen fuer die Bewegung eines Teiles 10 3.2.2. Bekannte Begriffe und Definitionen fuer die Bewegung eines rotierenden Teiles 11 3.2.3. Einschaetzung 14 3.3. Aufgabenstellung zur Erarbeitung von Begriffen und Definitionen 15 3.4. Vorschlag fuer neue Begriffe und Definitionen 16 3.4.1. Vorbemerkungen 16 3.4.2. Begriffe fuer die Verschiebung eines Punktes eines bewegten Teiles 19 3.4.2.1. Begriffe fuer die allgemeine Bewegung 19 3.4.2.2. Begriffe fuer die Rotation 21 3.4.2.3. Begriffe fuer die Translation 23 3.4.2.4. Erlaeuterungen zu den Begriffen 25 3.4.3. Begriffe fuer die Verdrehung einer Strecke eines bewegten Teiles 31 3.4.3.1. Begriffe fuer die allgemeine Bewegung 31 3.4.3.2. Begriffe fuer die Rotation und Translation 37 3.4.3.3. Erlaeuterungen zu den Begriffen 37 3.5. Vergleich und Einschaetzung der neuen Definitionen 43 3.6. Zeichnungsangaben von Bewegungs- und Verdrehungsabweichungen 49 4. Messverfahren zur Bestimmung von Rotationsabweichungen 51 4.1. Theoretische Untersuchungen 52 4.1.1. Vergleichsmessverfahren 53 4.1.2. Mehrlagenmessverfahren 54 4.1.2.1. Umkehrmessverfahren 55 4.1.2.2. Relativlagenmessverfahren 57 4.1.2.2.1. Relativlagenmessverfahren mit zwei Messstellungen 58 4.1.2.2.2. Relativlagenmessverfahren mit punktweiser Berechnung 59 4.1.2.2.3. Relativlagenmessverfahren mit Fourier-Reihen- Berechnung 60 4.1.2.3. Kontinuierliches Relativlagenmessverfahren 61 4.1.3. Weitere Messverfahren 64 4.1.3.1. Frequenztrennmessverfahren 64 4.1.3.2. Fotodiodensignalmessverfahren 65 4.1.4. Einschaetzung 66 4.2. Messtechnische Untersuchungen 67 4.2.1. Relativlagenmessverfahren mit punktweiser Berechnung 68 4.2.2. Vergleichsmessverfahren 73 4.2.3. Kontinuierliches Relativlagenmessverfahren 76 4.2.4. Einschaetzung 86 4.3. Messverfahren zur Richtighaltung von Kreisformmessgeraeten 87 5. Metrologische Richtighaltung 88 5.1. Pruefschema fuer Kreisformmessgeraete 90 5.1.1. Spezialnormal der Laenge fuer die Kreisform 91 5.1.2. Referenznormale 91 5.1.3. Arbeitsmessmittel 92 5.2. Pruefvorschriften fuer Kreisformmessmittel 93 5.2.1. Pruefvorschriften fuer die Eichung der Haupt- normale 93 5.2.2. Betriebliche Pruefvorschriften fuer Kreisformmessgeraete 93 5.3. Einschaetzung 95 6. Weitere Aufgaben 95 Verzeichnis der Anmerkungen 97 Literaturverzeichnis 98 Verzeichnis der Abbildungen 105 Verzeichnis der Anlagen 108 Anlagen 110 Thesen

This report deals with detecting object position using sensor datausing three different types of sensors held at four corners of a givendimensional plate; two sensors of URM09 Analog, 1 of URM09 Ultrasonic and 1 of VL6180X ToF sensor. The accuracy of the sensors performance is investigated using relative standard deviation. The results show that the proposed solution allows to estimate the objectposition and size without significant error.

This research study examines the risk-adjusted performance and portfolio risk of 60 large cap equity funds - mutual funds - under Swedish management. These funds apply environmental, social and governance criteria in their investment strategies. The empirical context concerns the COVID-19 situation and the context is divided into three periods, before, during and after the COVID-19 crisis. The ESG concept, modern portfolio and stakeholder theories are used to develop a theoretical base for the study on which the hypotheses are based which are summarized in a conceptual model. Secondary data regarding ESG and risk-adjusted returns are collected for each fund based on which the sharpe ratios and standard deviations (total or portfolio risk) for each fund are calculated. While there are associations between ESG and portfolio risk, no associations are found between ESG and sharpe ratios. As a result, this confirms the fact that ESG could be characterized as a mechanism to protect against downside risk in poor economic times but no association was established that ESG could also be used as a mechanism to determine efficiency in terms of risk-adjusted performance

När det handlar om ROT-projekt (renovering, om- och tillbyggnad) är det viktigt för entreprenören att uppnå långsiktig lönsamhet. För att säkerhetsställa detta är det av stor vikt att upprätta noggranna kalkyler som håller under hela byggprojektet. I dagsläget finns små marginaler för eventuella kostnadsökningar därmed ytterst lite utrymme för misstag. Eftersom förutsättningarna vid ROT-projekt ständigt varierar beroende på typ av badrum och skadeorsak är det därför väldigt svårt att uppskatta och beräkna kostnader utifrån rådande förutsättningar.  Utifrån detta finns det ett behov hos entreprenören att förstå varför kalkylerna avviker och hur man kan undvika detta i framtida projekt. Examensarbetet innehåller både en analys av kalkylerade kostnader och dess verkliga utfall samt en analys av kalkylverktyget Meps. Då ROT-sektorn är stor och omfattande har vi valt att avgränsa oss till badrumsrenoveringar som en följd utav vattenskador. Utifrån analys av kalkyler och kalkylverktyget samt intervjuer med parter både från entreprenör och från beställarsidan har vi kommit fram till en rad slutsatser om hur företaget kan ta fram noggrannare kalkyler i framtiden. Framförallt anser vi att företaget ska föra en tätare dialog med försäkringsbolagen för att vara en del i utvecklingen av kalkylverktyget. Vi anser även att man bör avsätta resurser för att utveckla erfarenhetsåterföringen inom företaget. / It is important for the contractor to have an accurate calculation throughout the whole project, especially when it comes to ”ROT”-projects (renovation and reconstruction).There is very little room for mistakes since the budget is very tight. Since the conditions always differ from one project to another it’s very important to take this into account. Due to this there is a great need for the contractor to understand why the calculations do not add up in the end so they can avoid income losses in the future. This report contains both an analysis of the calculated costs and the outcome for five different projects and also an analysis of the program used for calculating the costs, Meps. Since the ROT-sector is big and comprehensive we have decided only to analyse bathroom renovations due to water damages. From the analysis of the calculations and Meps together with interviews with contractors and clients we have come to the following conclusions: First of all we suggest that the entrepreneur should have a closer dialogue with the insurance company to be a part of the development of Meps. We also suggest that they should devote more resources for feedback in the company.