Made available in DSpace on 2016-03-15T19:39:55Z (GMT). No. of bitstreams: 1 Olivia Morgan Lapenta.pdf: 1151745 bytes, checksum: 91e51a2bad20664489c6aae6c59924b6 (MD5) Previous issue date: 2012-08-17 / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / The Mental Simulation theory suggests activation of the motor network during imagery and execution of movements, similarly to the activation during observation and execution of actions, which is mediated by the Mirror Neuron System. This activation can be measured using eletroencefalography register of Mu rhythm suppression. It is propose that motor network activation and therefore increase of cortical excitability at primary motor cortex and Mu dessynchronization are due to premotor Miror-Neuron System inputs. Transcranial direct current stimulation is a neuromodulation technique that induce facilitation and inhibition of neural firing leading to enhance or decrease in cortical excitability, respectively. Thus, we propose to evaluate the polarity dependent effects of this technique in the Mu rhythm during biological and non-biological movements observation and imagery tasks. Therefore we applied anodal, cathodal and sham stimulation in 21 male subjects (mean age 23.8+3,06), over left primary motor cortex (2mA for 20min) and immediately after we registered the electroencephalography considering the electrodes C3, C4 and surrounding C3 and C4 and Cz. Analyses of C3 and C4 showed significant effects according to Movement (p=0.005), and also for the interactions between type of stimulation and hemisphere (p=0.04) and type of stimulation, movement and hemisphere (p=0.02). Surrounding electrodes analyses revealed significant effect for the interaction between stimulation type, task condition and movement type (p=0.03). Thus, the main findings of this study were i. Mu suppression for biological movement (in both imagery and observation) of the hand region in the contralateral hemisphere after sham stimulation, ii. reverse effect for the surrounding electrodes during imagery condition and iii. polarity-dependent neuromodulation of the Mu rhythm. The results are discussed considering focal ERD/ surrounding ERS according to the type of task. We concluded that there are contralateral focal Mu dessynchronization during observation and imagery of biological movements together with syncronizarion of the motor areas not involved in the task only for the imagery condition and that transcranial direct current stimulation has a significant effect under the entire electrode and according to the applied polarity. The use of transcranial direct current stimulation followed by observation and imagery tasks might be an interesting intervention strategy for disturbances involving motor ability impairment as well as deficits related to imitation and comprehension of other s actions. / A teoria de simulação mental sugere ativação da rede neural motora durante mentalização e execução de movimentos, de maneira análoga à ativação em observação e execução de ações, o que é mediado pelo Sistema de Neurônios-Espelho. Esta ativação pode ser mensurada por supressão do ritmo Mu registrado por eletroencefalografia. É proposto que a ativação de áreas motoras e, portanto, o aumento de excitabilidade cortical em cortex motor primário e a dessincronização do ritmo Mu ocorram em consequência de insumo proveniente do Sistema Neurônios-Espelho pré-motor. A estimulação transcraniana por corrente contínua consiste numa técnica de neuromodulação por facilitação e inibição de disparo neuronal levando a aumento e redução de excitabilidade cortical, respectivamente. Assim, foi proposto avaliar os efeitos polaridade dependentes desta técnica sobre ritmo Mu durante tarefas de observação e mentalização de movimentos biológicos e não biológicos. Para tal, aplicamos estimulação anódica, catódica e placebo em 21 homens destros (idade média de 23.8+3,06), sobre córtex motor primário esquerdo (2mA por 20min) e, em seguida foi feito o registro eletroencefalográfico considerando os eletrodos C3, C4 e entorno de C3 e C4 e Cz. A análise de C3 e C4 apresentou efeitos significativos quanto ao tipo de Movimento (p=0.005) e ainda quanto as interações entre tipo de estimulação e hemisfério (p=0.04) e tipo de estimulação, de movimento e hemisfério (p=0.02). A análise dos eletrodos do entorno revelou efeito significativo para a interação entre tipo de estimulação, condição da tarefa e tipo de movimento (p=0.03). Assim, os principais achados do estudo foram i. supressão de Mu para movimento biológico (em mentalização e observação) da região da mão em hemisfério contralateral após estimulação placebo, ii. efeitos inversos para eletrodos de entorno em condição de mentalização e iii. neuromodulação polaridade dependente de ritmo Mu. Os resultados de oscilação de Mu são discutidos considerando ERD focal/ ERS entorno de acordo com o tipo de tarefa. Concluímos que há dessincronização contralateral focal de Mu durante observação e mentalização de movimentos biológicos, acompanhada por sincronização de áreas motoras não envolvidas na tarefa apenas na condição de mentalização e que a estimulação transcraniana por corrente contínua tem efeito sob toda a superfície do eletrodo e difere de acordo com a polaridade aplicada. O uso da estimulação transcraniana por corrente contínua combinada com tarefas de observação e mentalização pode conferir uma estratégia interessante de intervenção em distúrbios envolvendo comprometimento das habilidades motoras bem como comprometimento de habilidades de imitação e compreensão das ações do outro.

Made available in DSpace on 2016-03-15T19:40:18Z (GMT). No. of bitstreams: 1 Nathalia Ishikawa Baptista.pdf: 1435875 bytes, checksum: 8415993ce2a61757efe0d96f926c9095 (MD5) Previous issue date: 2014-08-05 / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / Verbal irony is a figurative form of communication between human beings, to understand it a specific ability to infer and predict the ironist intention is essential called Theory of Mind. Currently researches using spatial correlation techniques showed activation of the Medial Prefrontal Cortex (MPFC) on irony comprehension tasks. Thus, this thesis aimed to investigate the role of this area irony comprehension. Therefore the Transcranial direct current stimulation (tDCS) was used, i.e. the induction of low intensity electric current on specific cortical structures. The effects of stimulation depend on the current polarity, and thus, it is possible to investigate how the modulation of target area affects the performance in a cognitive task. Thus, 60 participants were recruited; they were all right handed and match the inclusion criteria. They were allocated to one of three groups of stimulation (anode, cathode or placebo), and received the tDCS for twenty minutes over the MPFC. After, the participants performed a test of verbal irony comprehension, with 204 stories visually presented. This phase was conducted during the EEG recording of the participants. Thus, the effects of tDCS over MPFC were accessed by: i. the behavioral test performance (measured by total score and average reaction time); ii. the brain activity underlying the task (measured by event-related evoked potentials - ERP - N400 and P600). The results indicate the involvement of the MPFC in semantic integration of affective aspects of figurative language. The increased cortical excitability of the area (anodal stimulation) resulted in a decrease of cognitive demand to integrate these aspects; in addition, it decreased the reaction time for the semantic incongruences. Thus, our results indicate that irony comprehension depends on the integration of information: cognitive and affective. Hence for a true appreciation of it s meaning is necessary to develop language skills as well the Theory of Mind. / A ironia verbal é uma forma figurada de comunicação entre seres humanos, para compreendê-la é fundamental a habilidade de inferir e predizer a intenção daquele que emite a ironia a chamada Teoria da Mente. Atualmente as pesquisas com técnicas de correlação espacial evidenciaram a ativação do Córtex Pré-frontal Medial (CPFM) na compreensão de ironia. Sendo assim, a presente dissertação teve como objetivo investigar o papel dessa estrutura na compreensão da ironia. Para isso, foi utilizada a técnica de Estimulação transcraniana por corrente contínua (ETCC), ou seja, a indução de corrente elétrica de baixa intensidade sobre estruturas corticais específicas. Os efeitos dessa estimulação dependem da polaridade da corrente, e desta forma, é possível verificar como a modulação da área-alvo interfere no desempenho em uma tarefa cognitiva. Sendo assim, foram recrutados 60 participantes de pesquisa, que deveriam ser destros e estarem de acordo com os critérios de inclusão. Eles foram alocados em um dos três grupos de estimulação (anódica, catódica ou placebo), e receberam a ETCC por vinte minutos em CPFM. Após esta fase, os participantes realizaram um teste de compreensão de ironia verbal, com 204 histórias apresentadas visualmente. Esta fase foi realizada durante o registro eletroencefalográfico (EEG) dos participantes. Desta forma, os efeitos da ETCC em CPFM foram verificados: i. no desempenho comportamental no teste (mensurado pelo total de acertos e média de tempo de reação/resposta); ii. assim como na atividade cerebral subjacente a tarefa (mensurada pelos Potenciais evocados relacionados a evento ERP N400 e P600). Os resultados indicam o envolvimento do CPFM na integração semântica de aspectos afetivos da linguagem figurada. O aumento da excitabilidade cortical desta área (estimulação anódica) resultou em uma menor demanda cognitiva para integrar estes aspectos, além disso, diminuiu o tempo de resposta para as incongruências semânticas. Desta forma, entende-se que a compreensão da ironia depende da integração de informações: cognitivas e afetivas. E para que haja a verdadeira apreciação de seu significado é necessário o desenvolvimento de habilidades linguísticas e de Teoria da Mente.

Introdução: A Estimulação Transcraniana por Corrente Contínua (ETCC) é uma intervenção não farmacológica com resultados discordantes quanto à sua eficácia para o tratamento do Episódio Depressivo Maior (EDM). Possivelmente devido a heterogeneidade dos estudos, as três meta-análises publicadas até agora sobre o assunto apontam para uma pequena vantagem a favor da técnica, dependendo da variável de desfecho analisada (melhora de depressão ou resposta). Todas essas meta-análises utilizaram dados agregados. Focamo-nos, no presente estudo, na realização de uma revisão sistemática da literatura e de uma meta-análise baseada em dados individuais de pacientes (MA-DIP) com Depressão Maior (DM) submetidos à ETCC na fase aguda. Este tipo de análise é mais preciso na avaliação da eficácia de uma intervenção e na obtenção dos preditores de respostas de tratamento, já que as características individuais de cada sujeito são consideradas ao invés das médias e frequências, como nas meta-análises de dados agregados. Objetivos: (1) avaliar a eficácia da ETCC na fase aguda da DM, (2) identificar preditores de resposta, remissão e melhora da depressão específicos e (3) avaliar a aceitabilidade da intervenção. Resultados: Os dados foram colecionados de 6 ensaios clínicos randomizados placebo controlados, totalizando 289 sujeitos. A ETCC ativa foi estatisticamente superior à estimulação simulada em relação à resposta (34% vs. 19%, respectivamente; RC=2,44, IC 95% = 1,38-4,32, NNT=7), remissão (23,1% vs. 12,7%, respectivamente; RC= 2,38, IC 95% = 1,22 - 4,64, NNT=9) e melhora da depressão (coeficiente = 0,35, IC 95% =0,12 0,57). Demonstrou-se que após ajustes para outros preditores e confundidores, depressão resistente a tratamento e doses mais altas de ETCC foram, respectivamente, inversa e diretamente associadas com a eficácia da ETCC. Conclusões: O tamanho de efeito do tratamento com ETCC foi comparável àqueles reportados, em outros estudos, para a Estimulação Magnética Transcraniana repetitiva (EMTr) e para o tratamento farmacológico (com antidepressivos tricíclicos e inibidores seletivos de recaptação de serotonina) na atenção primária para depressão. Os parâmetros mais importantes para otimização em ensaios clínicos futuros são a refratariedade da depressão e a dose da ETCC / Introduction: Transcranial direct current stimulation (tDCS) is a nonpharmacological intervention for depression. Randomised, sham-controlled clinical trials (RCTs) conducted hitherto have presented mixed results regarding its efficacy. Although recent meta-analyses suggest some efficacy when measuring depression symptoms using a continuous outcome, these meta-analyses were limited in their results as they used an aggregate data approach. We aimed therefore to perform an individual patient data (IPD) meta-analysis. In contrast to an aggregate data meta-analysis, an IPD approach uses the raw data of each participant within a study. IPD is more accurate in estimating the efficacy of an intervention since aggregate data meta-analyses present only summary estimates of efficacy. IPD meta-analysis is also superior to the aggregate data approach for obtaining predictors of treatment outcome, as the characteristics of each patient are assessed instead of the mean and frequency values obtained in the traditional aggregate data meta-analysis. Objectives (a) To provide precise estimates of tDCS efficacy based on continuous (depression improvement) and categorical (response and remission rates) outcomes, (b) to identify variables associated with tDCS efficacy and (c) to estimate the treatment acceptability. Results: Data were gathered from six randomised sham-controlled trials, enrolling 289 patients. Active tDCS was significantly superior to sham for response (34% v. 19%, respectively, odds ratio (OR) = 2.44, 95% CI 1.384.32, number needed to treat (NNT) = 7), remission (23.1% v. 12.7%, respectively, OR = 2.38, 95% CI 1.224.64, NNT = 9) and depression improvement ( coefficient 0.35, 95% CI 0.120.57). Mixed effects models showed that, after adjustment for other predictors and confounders, treatment-resistant depression and higher tDCS doses were, respectively, negatively and positively associated with tDCS efficacy. Conclusions: The effect size of tDCS treatment was comparable with those reported for repetitive transcranial magnetic stimulation (rTMS) and antidepressant drug treatment in primary care. The most important parameters for optimisation in future trials are depression refractoriness and tDCS dose

Modern interconnected power systems are becoming highly complex and sophisticated, while increasing energy penetrations through congested inter-tie lines causing the operating point approaching stability margins. This as a result, exposes the overall system to potential low frequency power oscillation phenomena following disturbances. This in turn can lead to cascading events and blackouts. Recent approaches to counteract this phenomenon are based on utilization of wide area monitoring systems (WAMS) and power electronics based devices, such as flexible AC transmission systems (FACTS) and HVDC links for advanced power oscillation damping provision. The rise of hybrid AC-DC power systems is therefore sought as a viable solution in overcoming this challenge and securing wide-area stability. If multiple FACTS devices and HVDC links are integrated in a scheme with no supervising control actions considered amongst them, the overall system response might not be optimal. Each device might attempt to individually damp power oscillations ignoring the control status of the rest. This introduces an increasing chance of destabilizing interactions taking place between them, leading to under-utilized performance, increased costs and system wide-area stability deterioration. This research investigates the development of a novel supervisory control scheme that optimally coordinates a parallel operation of multiple FACTS devices and an HVDC link distributed across a power system. The control system is based on Linear Quadratic Gaussian (LQG) modern optimal control theory. The proposed new control scheme provides coordinating control signals to WAMS based FACTS devices and HVDC link, to optimally and coherently counteract inter-area modes of low frequency power oscillations inherent in the system. The thesis makes a thorough review of the existing and well-established improved stability practises a power system benefits from through the implementation of a single FACTS device or HVDC link, and compares the case –and hence raises the issue–when all active components are integrated simultaneously and uncoordinatedly. System identification approaches are also in the core of this research, serving as means of reaching a linear state space model representative of the non-linear power system, which is a pre-requisite for LQG control design methodology.

No description available.

Transmission pricing and congestion management are two important aspects of modern power sectors working under a deregulated environment or moving towards a deregulated system (open access) from a regulated environment. The transformation of power sector for open access environment with the participation of private sector and potential power suppliers under the regime of trading electricity as a commodity is aimed at overcoming some of the limitations faced by the vertically integrated system. It is believed that this transformation will bring in new technologies, efficient and alternative sources of power which are greener, self sustainable and competitive. There is ever increasing demand for electrical power due to the changing life style of human beings fueled by modernization and growth. Augmentation of existing capacity, siting of new power plants, and a search for alternate viable sources of energy that have lesser impact on environment are being taken up. With the integration of power plants into the grid depending upon the type, loca- tion and technology used, the cost of energy production also differs. In interconnected networks, power can flow from one point to other point in infinite number of possible paths which is decided by the circuit parameters, operating conditions, topology of network and the connected loads. The transmission facility provided for power transfer has to recover the charges from the entities present in the network based on the extent of utilization. Since power transmission losses account for nearly 4 to 8% of the total generation, this has to be accounted for and shared properly among the entities depending upon the connected generation/load. In this context, this thesis aims to evaluate the shortcomings of existing tracing methods and proposes a tracing method based upon the actual operating conditions of the network taking into account the network parameters, voltage gradient among the connected buses and topology of the network as obtained by the online state estimator/load flow studies. The concept proposed is relatively simple and easy to implement in a given transactional period. The proposed method is compared against one of the existing tracing technique available in literature. Both active and reactive power tracing is handled at one go. The summation of partial contributions from all the sources in any given line of the system always matches with that of the respective base case ow. The AC power flow equations themselves are nonlinear in nature. Since the sum of respective partial flows in a given branch is always equal to the original ow, these are termed as virtual flows and the effect of nonlinearity is still unknown. The virtual flows in a given line are complex in nature and their complex sum is equal to the original complex power flows as in the base case. It is required to determine whether these are the true partial flows. To answer this, a DC equivalent of the original AC network is proposed and is called as the R - P equivalent model. This model consists of only the resistances as that of original network (the resistances of transformers and lines neglecting the series reactance and the shunt charging) only. The real power injections in a AC network i.e. sources into respective buses and loads (negative real power injections) are taken as injection measurements of this R P model and the bus voltages (purely real quantities) are estimated using the method of least squares. Complex quantities are absent in this model and only real terms which are either sums or differences are present. For this model, virtual flows are evaluated and it has been verified that the virtual real power contributions from sources are in near agreement with the original AC network. This implies that the virtual flows determined for the original network can be applied for day-to-day applications. An important feature of the virtual flows is that it is possible to identify counter ow components. Counter flow components are the transactions taking place in opposite direction to the net flow in that branch. If a particular source is produces counter flow in a given line, then it is in effect reducing congestion to that extent. This information is lacking in most of the existing techniques. Counter flows are useful in managing congestion. HVDC links are integrated with HVAC systems in order to transfer bulk power and for the additional advantages they offer. The incremental cost of a DC link is zero due to the closed loop control techniques implemented to maintain constant power transfer (excluding constant voltage or constant current control). Consequently, cost allocation to HVDC is still a problem. The proposed virtual power flow tracing method is extended to HVAC systems integrated with HVDC in order to determine the extent of utilization of a given link by the sources. Before evaluating the virtual contributions to the HVDC links, the steady state operating condition of the combined system is obtained by per-forming a sequential load flow. Congestion is one of the main aspects of a deregulated system, and is a result of several transactions taking place simultaneously through a given transmission facility. If congestion is managed by providing pricing signals for the transmission usage by the parties involved. It can also be due to the non-availability of transmission paths due to line outages as a result of contingencies. In such a case, generation active power redispatch is considered as a viable option in addition to other available controls such as phase shifters and UPFCs to streamline the transactions within the available corridors. The virtual power flow tracing technique proposed in the thesis is used as a guiding factor for managing congestions occurring due to transactions/contingencies to the possible extent. The utilization of a given line by the sources present in the network in terms of real power flow is thus obtained. These line utilization factors are called as T-coefficients and these are approximately constant for moderate increments in active power change from the sources. A simple fuzzy logic based decision system is proposed in order to obtain active power rescheduling from the sources for managing network congestions. In order to enhance the system stability after rescheduling, reactive power optimization has life systems to illustrate the proposed approaches. For secure operation of the network, the ideal proportion of active power schedule from the sources present in the network for a given load pattern is found from network [FLG] matrix. The elements of this matrix are used in the computation of static voltage stability index (L-index). This [FLG] matrix is obtained from the partitioned network YBUS matrix and gives the Relative Electrical Distance (RED) of each of the loads with respect to the sources present in the network. From this RED, the ideal proportion of real power to be drawn by a given load from different sources can be determined. This proportion of active power scheduling from sources is termed as Desired Proportion of Generation (DPG). If the generations are scheduled accordingly, the network operates with less angular separation among system buses (improved angular stability), improved voltage profiles and better voltage stability. Further, the partitioned K[GL] matrix reveals information about the relative proportion in which the loads should draw active power from the sources as per DPG which is irrespective of the present scheduling. Other partitioned [Y ′ GG] matrix is useful in finding the deviation of the present active power output from the sources with respect to the ideal schedule. Many regional power systems are interconnected to form large integrated grids for both technical and economic benefits. In such situations, Generation Expansion Planning (GEP) has to be undertaken along with augmentation of existing transmission facilities. Generation expansion at certain locations need new transmission networks which involves serious problems such as getting right-of-way and environmental clearance. An approach to find suitable generation expansion locations in different zones with least requirements of transmission network expansion has been attempted using the concept of RED. For the anticipated load growth, the capacity and siting generation facilities are identified on zonal basis. Using sample systems and real life systems, the validity of the proposed approach is demonstrated using performance criteria such as voltage stability, effect on line MVA loadings and real power losses.

Background: Transcranial Direct Current Stimulation (tDCS) is an emerging approach for improving capacity in activities of daily living (ADL) and upper limb function after stroke. However, it remains unclear what type of tDCS stimulation is most effective. Our aim was to give an overview of the evidence network regarding the efficacy and safety of tDCS and to estimate the effectiveness of the different stimulation types. Methods: We performed a systematic review of randomised trials using network meta-analysis (NMA), searching the following databases until 5 July 2016: Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, CINAHL, AMED, Web of Science, and four other databases. We included studies with adult people with stroke. We compared any kind of active tDCS (anodal, cathodal, or dual, that is applying anodal and cathodal tDCS concurrently) regarding improvement of our primary outcome of ADL capacity, versus control, after stroke. PROSPERO ID: CRD42016042055. Results: We included 26 studies with 754 participants. Our NMA showed evidence of an effect of cathodal tDCS in improving our primary outcome, that of ADL capacity (standardized mean difference, SMD = 0.42; 95% CI 0.14 to 0.70). tDCS did not improve our secondary outcome, that of arm function, measured by the Fugl-Meyer upperextremity assessment (FM-UE). There was no difference in safety between tDCS and its control interventions, measured by the number of dropouts and adverse events. Conclusion: Comparing different forms of tDCS shows that cathodal tDCS is the most promising treatment option to improve ADL capacity in people with stroke.

Background: Eating disorders are psychiatric illnesses whose treatment is difficult and usually the classic procedures fail. Recently, the number of researches in neuromodulatory methods has increased. I present an overview of basic stimulation methods, their use in the treatment of anorexia nervosa (AN), bulimia nervosa and binge-eating and the results of our study focused on the treatment of AN by transcranial direct current stimulation (tDCS). Methods: It was a randomized, double-blind, sham-controlled trial. Forty-three inpatients with AN were divided to receive either active (n=22) or sham (n=21) tDCS over the left DLPFC (anode F3/cathode Fp2, 2mA for 30 minutes). All patients filled the Eating Disorder Examination Questionnaire (EDE-Q) and Zung depression scale (ZUNG), we measured them the thermal pain threshold, the objective dissatisfaction with their own body by Anamorfic program and evaluated BMI before the first and after the last tDCS. Follow-up was after 2 and 4 weeks. It was evaluated using ANOVA and OPLS model. Results: Compared to sham tDCS, active tDCS improved self-evaluation based on one's body shape (p < 0,05) and significantly decreased the need of excessive control over calorie intake (p < 0,05) in 4-week follow-up (questions 4 and 23 in EDE-Q). Question 21 in EDE-Q was more...

Direct current motors and stepping motors are very often used for electric drives in cars. The most frequent representatives of direct current motors are electric starter and wind- screen wiper motor. Stepping motors are very often used for electric regulating of outsides driving mirrors and seats. This study is focused on innovation and DC permanent magnet motor. The disadvanage of direct current motors is so called „sliding contact“. A possible compensation of direct current motor are EC (electronically commutator) motors that do not need sliding contact for their work.

Electric drives used in automotive industry are often based on standard DC motor as it is widely recognised as mature and reliable technology. The most common applications of DC motors in automotive industry are starters and wind screen wiper motors. Aim of this thesis is to provide design overview of typical automotive DC motor therefore main parts and features of the machine will be described in detail. Main disadvantage of DC motor is „sliding contact“ between commutator and carbon brushes which introduces source of electromagnetic disturbance and requires regular maintenance. Within this project different aspects of DC motor design and innovation are expected to be tackled including examples of loss calculation.