A contemporaneidade tem como uma de suas principais marcas o excesso de individualismo ou narcisismo. Além disso, traz consigo uma série de transformações nos níveis subjetivo, intersubjetivo, familiar e social, dentre os quais destacamos aqueles sentidos na esfera familiar. O atual avanço tecnocientífico é apontado como um fator de peso nessas transformações, desde o surgimento da televisão até o das mais recentes tecnologias da informação e da comunicação (TICs). Apesar de haver divergências na literatura, frequentemente a população idosa é apontada como prejudicada por esse avanço tecnológico e considerada excluída digital. Ao mesmo tempo, vivenciamos um aumento dessa população e da expectativa de vida, o que levou também a mudanças na função dos avós na família, numa diversidade de possibilidades. Diferentemente da psicanálise tradicional, que teve como foco as dinâmicas envolvidas entre pais e filhos, a psicanálise vincular, referencial aqui elegido, enfatiza aquelas implicadas na dimensão do entre, o que significa uma compreensão sobre a família mais ampla. Investigar se e como a TIC poderia estar influindo sobre o vínculo avós-netos na atualidade, partindo do pressuposto da transmissão psíquica geracional, foi o objetivo desta pesquisa. Para tanto, foi adotado o método clínico-qualitativo e realizadas entrevistas semidirigidas com quatro duplas de avós idosos e netos adolescentes que apresentassem algum contato virtual entre si, totalizando oito participantes; a forma de análise dos dados seguiu o método de estudo de caso. Os resultados encontrados mostraram que cada dupla fazia um determinado uso da TIC entre si, ainda que tenha havido aspectos em comum entre todas ou algumas delas. A inversão geracional e certa desconfiança na comunicação virtual foram duas constantes; bem como a constatação de que o uso que era feito da tecnologia se relacionava com determinadas características da dinâmica de funcionamento psíquico dos sujeitos, do vínculo entre eles ou mesmo da família. Em três duplas observou-se a geração de um efeito paradoxal causado pela interferência da tecnologia, qual seja, o fato de ela propiciar a aproximação entre as partes quando estavam distantes, mas seu afastamento quando estavam juntas, devido ao uso excessivo dela feito pelos netos, que então passavam a dispensar menos atenção aos respectivos avós. Nas duplas entrevistadas, a presença da tecnologia não pareceu comprometer o papel dos avós, uma vez que eles tinham uma posição bastante importante para os seus netos. Para alguns destes últimos, o papel dos avós ainda era visto relativamente a um lugar de saber e de superioridade. Em suma, pôde-se perceber que, em algumas situações, a TIC facilitava o vínculo das duplas e em outras o subtraía, e em outras ainda ela não passava de um mero complemento. Mesmo assim, observou-se que sua influência não tinha mais poder do que o vínculo em si mesmo, este, sim, fator suficiente e determinante para ditar a qualidade da relação da dupla, pelo menos no que se referiu a avós e netos / Contemporaneity has as one of its main brands the excess of individualism or narcissism. In addition, it brought several transformations on the subjective, intersubjective, family and social levels, among which we highlight those taking place in the family sphere. The current techno-scientific progress is key in these transformations, from the beginning of television to the recent information and communication technologies (ICTs). Although literature may differ, often the elderly population is seen as precluded by this technological advance and considered digitally excluded. On the same token, we experienced an increase in this population and a rise in life expectancy, leading to changes in the role of grandparents in the family, in a diversity of possibilities. Unlike traditional psychoanalysis, which focused on the dynamics between parents and children, the links psychoanalysis, referential chosen for this work, emphasizes the dynamics involved in the \"between\" dimension, implying a broader understanding about the family. The objective of this research was to investigate whether and how ICT could be influencing the link between grandparents and grandchildren in the current generation, based on the theory of the generational psychic transmission. For this purpose, the clinical-qualitative method was applied and semi-structured interviews were done with eight participants, consisting of four pairs of elderly grandparents and their adolescent grandchildren, both having virtual contact between them; the form of data analysis followed the case study method. The results showed that each pair made a particular use of ICT among themselves, although there have been aspects in common among all or some of them. The inversion of generations and a lack of trust in virtual communication were two constants, as well as the finding that the use of technology was related to certain characteristics of the subjects\' psychic dynamics, the relation between themselves or even the family. In three of the pairs a \"paradoxical effect\" was observed, being caused by the interference of technology, as it would bring the parties closer when they were distant, but set them apart when they were together, due to the excessive use of it by the grandchildren, who then paid less attention to their grandparents. For the interviewed pairs, the presence of technology did not seem to jeopardize the role of grandparents, since they held a very important position for their grandchildren. For some of the latter, the role of the grandparents was still seen as one of knowledge and superiority. In short, it was possible to perceive that in some situations ICT facilitated the bonding process between the pairs, while for others it would prejudice it, and even for some it was only a mere complement. Even so, it was noted that their influence had no more power than the bond in itself, factor sufficient and determinant to dictate the quality of the relationship between the pairs, at least when it comes to grandparents and grandchildren

It is commonly accepted nowadays that innovations are brought forward in an interactive process of knowledge generation and application. The business sector, the science sector, and policy actors are involved in this process as has been stressed in concepts such as innovation systems and the network approach. It is still unclear, however, as to what extent different kinds of innovation rely on specific knowledge sources and links. More advanced innovations on the one hand might draw more on scientific knowledge, generated in universities and research organizations. Such knowledge is often exchanged in personal interactions at a local or regional level. Incremental innovations and the adoption of new technologies, on the other hand, seem to occur often in interaction with partners from the business sector also at higher spatial levels. In this paper we analyze such patterns of knowledge links. After dealing with knowledge interactions from a conceptual view and reviewing the relevant literature, we present an empirical analysis for Austria. The findings show that firms introducing more advanced innovations are relying to a higher extent on R&D and patents, and that they are cooperating more often with universities and research organizations. Firms having introduced less advanced innovations rely more on knowledge links with business services. Furthermore, the employment of researchers was identified as a key factor enhancing knowledge interactions of firms with universities. (authors' abstract) / Series: SRE - Discussion Papers

Streptococcus pyogenes is an important human pathogen. One of the most prominent virulence factors produced by S. pyogenes is SfbI, a surface adhesin composed of three domains: thioester domain (TED), proline-rich repeat domain (PRR) and fibronectin-binding repeat domain (FnBD). The structures and functions of TED and PRR and their contributions to the pathogenesis of streptococcal diseases are unknown. The interaction between PRR and its putative target, the intracellular actin cytoskeleton regulator Arp2/3, was investigated by both in vitro and in vivo studies. PRR was shown to inhibit Arp2/3-dependent actin polymerisation. The expression of PRR in HeLa cells caused disruption to the cytoskeleton of the cells. All data point towards a role of PRR in inhibiting the Arp2/3 complex but more evidence is needed to support this. The N-terminal domain of SfbI (TED) and four homologous domains from S. pyogenes, group G streptococci and Streptococcus pneumoniae were characterised by mass spectrometry, NMR spectroscopy and biochemical assays. All were shown to possess intramolecular thioester bonds, spontaneously formed between sides chains of Cys and Gln residues. Fibrinogen (Fg) was identified as the first binding target of bacterial TEDs with direct evidence that the thioester bond was involved in the interaction with Fg. A pull-down experiment using human plasma showed Fg is a specific binding partner of SfbI-TED. The binding sites were narrowed down to the thioester-forming Gln of SfbI-TED and Lys residues in the Fg-Aα chain, and binding potentially occurred via covalent isopeptide linkage. The data presented here suggest two new roles for SfbI, previously unknown in bacterial pathogenesis. The PRR may be the first bacterial inhibitor of the actin cytoskeleton acting by inhibiting the Arp2/3 complex. Thioester domains appear to be a shared common feature of surface proteins of many Gram-positive pathogens. They may form covalent crosslinks between bacteria and host tissue.

No description available.

Diferentes sistemas do mundo real podem ser representados por redes. As redes são estruturas nas quais seus vértices (nós) representam entidades e links representam relações entre essas entidades. Além disso, as redes caracterizam-se por ser estruturas dinâmicas, o que implica na rápida aparição e desaparição de entidades e seus relacionamentos. Nesse cenário, um dos problemas importantes a serem enfrentados no contexto das redes, é da predição de links, isto é, prever a ocorrência futura de um link ainda não existente entre dois vértices com base nas informações já existentes. A importância da predição de links deve-se ao fato de ter aplicações na recuperação de informação, identificação de interações espúrias e, ainda, na avaliação de mecanismos de evolução das redes. Para enfrentar o problema da predição de links, a maioria dos métodos utiliza informações da vizinhança topológica das redes para atribuir um valor que represente a probabilidade de conexão futura entre um par de vértices analisados. No entanto, recentemente têm aparecido métodos híbridos, caracterizados por usar outras informações além da vizinhança topológica, sendo as informações das comunidades as normalmente usadas, isso, devido ao fato que, ao serem grupos de vértices densamente ligados entre si e esparsamente ligados com vértices de outros grupos, fornecem informações que podem ser úteis para determinar o comportamento futuro das redes. Assim, neste trabalho são apresentadas duas propostas na linha dos métodos baseados nas informações das comunidades para predição de links. A primeira proposta consiste em um novo índice de similaridade que usa as informações dos vértices pertencentes a mesma comunidade na vizinhança de um par de vértices analisados, bem como as informações dos vértices pertencentes a diferentes comunidades nessa mesma vizinhança. A segunda proposta consiste de um conjunto de índices obtidos a partir da reformulação de algumas propostas já existentes, porém, inserindo neles informações dos vértices pertencentes unicamente à mesma comunidade na vizinhança topológica de um par de vértices analisados. Experimentos realizados em dez redes complexas de diferentes domínios demonstraram que, em geral, os índices propostos obtiveram desempenho superior às abordagens usuais / Different real-world systems can be represented as networks. Networks are structures in which vertices (nodes) represent entities and links represent relationships between these entities. Moreover, networks are dynamic structures, which implies rapid appearance and disappearance of entities and their relationships. In this scenario, the link prediction problem attempts to predict the future existence of a link between a pair of vertices considering existing information. The link prediction importance is due to the fact of having different applications in areas such as information retrieval, identification of spurious interactions, as well as for understanding mechanisms of network evolution. To address the link prediction problem, many proposals use topological information to assign a value that represents the likelihood of a future connection between a pair of vertices. However, hybrid methods have appeared recently. These methods use additional information such as community information. Communities are groups of vertices densely connected among them and sparsely connected to vertices from other groups, providing useful information to determinate the future behavior of networks. So, this research presents two proposals for link prediction based on communities information. The first proposal consists of a new similarity index that uses information about the communities that the vertices in the neighborhood of a analyzed pair of vertices belong. The second proposal is a set of indices obtained from the reformulation of various existing proposals, however, using only the information from vertices belonging to the same community in the neighborhood of a pair of vertices analyzed. Experiments conducted in ten complex networks of different fields show the proposals outperform traditional approaches

[pt] Dentro do processo de publicação de dados na Web recomenda-se interligar os dados entre diferentes fontes, através de recursos similares que descrevam um domínio em comum. No entanto, com o crescimento do número dos conjuntos de dados publicados na Web de Dados, as tarefas de descoberta e seleção de dados tornam-se cada vez mais complexas. Além disso, a natureza distribuída e interconectada dos dados, fazem com que a sua análise e entendimento sejam muito demorados. Neste sentido, este trabalho visa oferecer uma arquitetura Web para a identificação de fontes de dados em RDF, com o objetivo de prover melhorias nos processos de publicação, interconex ão, e exploração de dados na Linked Open Data. Para tal, nossa abordagem utiliza o modelo de MapReduce sobre o paradigma de computa ção nas nuvens. Assim, podemos efetuar buscas paralelas por palavraschave sobre um índice de dados semânticos existente na Web. Estas buscas permitem identificar fontes candidatas para ligar os dados. Por meio desta abordagem, foi possível integrar diferentes ferramentas da web semântica em um processo de busca para descobrir fontes de dados relevantes, e relacionar tópicos de interesse denidos pelo usuário. Para atingir nosso objetivo foi necessária a indexação e análise de texto para aperfeiçoar a busca de recursos na Linked Open Data. Para mostrar a ecácia de nossa abordagem foi desenvolvido um estudo de caso, utilizando um subconjunto de dados de uma fonte na Linked Open Data, através do seu serviço SPARQL endpoint. Os resultados do nosso trabalho revelam que a geração de estatísticas sobre os dados da fonte é, de fato, um grande diferencial no processo de busca. Estas estatísticas ajudam ao usuário no processo de escolha de indivíduos. Um processo especializado de extração de palavras-chave é aplicado para cada indivíduo com o objetivo de gerar diferentes buscas sobre o índice semântico. Mostramos a escalabilidade de nosso processo de recomendação de fontes RDF através de diferentes amostras de indivíduos. / [en] In the Web publishing process of data it is recommended to link the data from different sources using similar resources that describe a domain in common. However, the growing number of published data sets on the Web have made the data discovery and data selection tasks become increasingly complex. Moreover, the distributed and interconnected nature of the data causes the understanding and analysis to become too prolonged. In this context, this work aims to provide a Web architecture for identifying RDF data sources with the goal of improving the publishing, interconnection, and data exploration processes within the Linked Open Data. Our approach utilizes the MapReduce computing model on top of the cloud computing paradigm. In this manner, we are able to make parallel keyword searches over existing semantic data indexes available on the web. This will allow to identify candidate sources to link the data. Through this approach, it was possible to integrate different semantic web tools and relevant data sources in a search process, and also to relate topics of interest denied by the user. In order to achieve our objectives it was necessary to index and analyze text to improve the search of resources in the Linked Open Data. To show the effectiveness of our approach we developed a case study using a subset of data from a source in the Linked Open Data through its SPARQL endpoint service. The results of our work reveal that the generation and usage of data source s statistics do make a great difference within the search process. These statistics help the user within the choosing individuals process. Furthermore, a specialized keyword extraction process is run for each individual in order to create different search processes using the semantic index. We show the scalability of our RDF recommendation process by sampling several individuals.

L'accès à Internet par satellite permet de connecter des régions isolées de la terre ou des utilisateurs en mouvement, pour lesquels une solution terrestre peut s’avérer couteuse voire impossible. L’utilisation de constellations de satellite en orbite basse permet de transmettre avec des délais similaires à ceux des transmissions terrestres, permettant l’utilisation des protocoles de transport classiques comme TCP. L’utilisation d’un tel environnement engendre cependant des contraintes spécifiques à ce type de réseau, comme des délais de transmission variables et un important taux d’erreur, principalement lors de la traversée de l’atmosphère. Pour compenser ces forts taux de pertes, des mécanismes de fiabilisation doivent être introduit au niveau des couche basse. Ces mécanismes ont toutefois un impact négatif sur les performances des protocoles de transport, notamment TCP, limitant grandement le débit. Le but de cette thèse est de comprendre dans un premier temps les interactions entre les mécanismes de fiabilisation et les protocoles de transport, pour ensuite proposer des solutions permettant d’améliorer la qualité des transmissions. / LEO satellite constellations allow to connect isolated or mobile users to the Internet, when terrestrial solutions are too expensive or impossible to deploy. Using such constellations allow to connect these areas with transmission delays close to terrestrial delays, and then to use the classic transport protocols such as TCP. However, this environment brings new impairments such as variable delays and important error rate between the satellite and the ground receiver. To counteract this high error rate, reliability schemes are introduced on the link between the satellite and the ground user. However, these schemes have a negative impact on the transport protocol (TCP), mitigating the throughput, and which has not been deeply studied yet. In this thesis, we first understand the impact of the reliability schemes on the transport layer, and then propose solutions to improve the efficiency of the transmissions.

Cette thèse revient sur les migrations diolas et les évolutions identitaires qui accompagnent ces populations au contact d’autres groupes, et à la faveur des déplacements de personnes.L'immigration diola très peu étudiée, est abordée dans cette thèse, à travers les associations, informelles ou celles qui relèvent de la loi 1901, pour celles légitimées par l’autorité préfectorale en France.Ces regroupements constituent un creuset par excellence, pour analyser les enjeux de pouvoirs chez des populations héritières d'une autre forme de pouvoir. Les liens envers le lieu d'origine questionnent au-delà des parcours migratoires, les histoires, les politiques et les identifications de ces immigrés et de leurs descendants.Les enjeux de pouvoir et les interactions entre les immigrés et leurs parents restés au pays seront donc analysées sous le prisme des migrations et des coopérations bilatérales. Le contexte politique et économique est un facteur très important dans cette étude.Mots clés : Migrations, enjeux de pouvoirs, Diolas, associations, identités. / This thesis deals with the diola migrations and the evolutions of their identities when they meet other groups by moving.The diola immigration, few studied, is considered in this thesis through the unformal associations or the legal associations ruled by the law of 1901 legitimated by French local authorities. These communities are the ideal place to analyze the challenges of power among people who have been ruled by other kinds of power. The links with the country of origin are questioned out of the migratory trajects and the stories, the policies and the didentifications of these immigrants and their descents are also studied.The power challenges and the interactions between the immigrants and their relatives living in the country of origine will be analyzed through the migrations and the bilateral cooperations. The politicla and economic context is an important factor in this research.Key words : migrations, power challenges, Diola, associations, identities

Thesis advisor: Joshua E. Greene / We construct taut foliations in every closed 3-manifold obtained by r-framed Dehn surgery along a positive 3-braid knot K in S^3, where r < 2g(K)-1 and g(K) denotes the Seifert genus of K. This confirms a prediction of the L--space conjecture. For instance, we produce taut foliations in every non-L-space obtained by surgery along the pretzel knot P(-2,3,7), and indeed along every pretzel knot P(-2,3,q), for q a positive odd integer. This is the first construction of taut foliations for every non-L-space obtained by surgery along an infinite family of hyperbolic L-space knots. We adapt our techniques to construct taut foliations in every closed 3-manifold obtained along r-framed Dehn surgery along a positive 1-bridge braid, and indeed, along any positive braid knot, in S^3, where r < g(K)-1. These are the only examples of theorems producing taut foliations in surgeries along hyperbolic knots where the interval of surgery slopes is in terms of g(K). / Thesis (PhD) — Boston College, 2020. / Submitted to: Boston College. Graduate School of Arts and Sciences. / Discipline: Mathematics.

[EN] Throughout the pages of this document, I present the results of the research that was carried out in the context of my PhD studies. During the aforementioned research, I studied the process of Traceability Links Recovery between natural language requirements and industrial software models. More precisely, due to their popularity and extensive usage, I studied the process of Traceability Links Recovery between natural language requirements and Business Process Models, also known as BPMN models. In order to carry out the research, I focused my work on two main objectives: (1) the development of the Traceability Links Recovery techniques between natural language requirements and BPMN models, and (2) the validation and analysis of the results obtained by the developed techniques in industrial domain case studies. The results of the research have been redacted and published in forums, conferences, and journals specialized in the topics and context of the research. This thesis document introduces the topics, context, and objectives of the research, presents the academic publications that have been published as a result of the work, and then discusses the outcomes of the investigation. / [ES] A través de las páginas de este documento, presento los resultados de la investigación realizada en el contexto de mis estudios de doctorado. Durante la investigación, he estudiado el proceso de Recuperación de Enlaces de Trazabilidad entre requisitos especificados en lenguaje natural y modelos de software industriales. Más concretamente, debido a su popularidad y uso extensivo, he estudiado el proceso de Recuperación de Enlaces de Trazabilidad entre requisitos especificados en lenguaje natural y Modelos de Procesos de Negocio, también conocidos como modelos BPMN. Para llevar a cabo esta investigación, mi trabajo se ha centrado en dos objetivos principales: (1) desarrollo de técnicas de Recuperación de Enlaces de Trazabilidad entre requisitos especificados en lenguaje natural y modelos BPMN, y (2) validación y análisis de los resultados obtenidos por las técnicas desarrolladas en casos de estudio de dominios industriales. Los resultados de la investigación han sido redactados y publicados en foros, conferencias y revistas especializadas en los temas y contexto de la investigación. Esta tesis introduce los temas, contexto y objetivos de la investigación, presenta las publicaciones académicas que han sido publicadas como resultado del trabajo, y expone los resultados de la investigación. / [CA] A través de les pàgines d'aquest document, presente els resultats de la investigació realitzada en el context dels meus estudis de doctorat. Durant la investigació, he estudiat el procés de Recuperació d'Enllaços de Traçabilitat entre requisits especificats en llenguatge natural i models de programari industrials. Més concretament, a causa de la seua popularitat i ús extensiu, he estudiat el procés de Recuperació d'Enllaços de Traçabilitat entre requisits especificats en llenguatge natural i Models de Processos de Negoci, també coneguts com a models BPMN. Per a dur a terme aquesta investigació, el meu treball s'ha centrat en dos objectius principals: (1) desenvolupament de tècniques de Recuperació d'Enllaços de Traçabilitat entre requisits especificats en llenguatge natural i models BPMN, i (2) validació i anàlisi dels resultats obtinguts per les tècniques desenvolupades en casos d'estudi de dominis industrials. Els resultats de la investigació han sigut redactats i publicats en fòrums, conferències i revistes especialitzades en els temes i context de la investigació. Aquesta tesi introdueix els temes, context i objectius de la investigació, presenta les publicacions acadèmiques que han sigut publicades com a resultat del treball, i exposa els resultats de la investigació. / Lapeña Martí, R. (2020). Traceability Links Recovery among Requirements and BPMN models [Tesis doctoral no publicada]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/149391 / TESIS