Submitted by Daniella Sodre (daniella.sodre@ufpe.br) on 2015-04-15T14:24:56Z No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) Dissertação Amanda Vieira.pdf: 3996035 bytes, checksum: 9afa8afb1a2006dfe656cc0f16741ce8 (MD5) / Made available in DSpace on 2015-04-15T14:24:56Z (GMT). No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) Dissertação Amanda Vieira.pdf: 3996035 bytes, checksum: 9afa8afb1a2006dfe656cc0f16741ce8 (MD5) Previous issue date: 2013-02-25 / CAPEs / O LPSF/GQ-130 é uma tiazolidinodiona que apresentou atividade anti-inflamatória promissora em estudos in vivo, porém, sua insolubilidade aquosa repercute em dissolução e absorção inadequada no organismo. Assim, este trabalho objetivou incrementar esta propriedade através da técnica de dispersões sólidas (DS). A caracterização química e físico-química do protótipo permitiu a confirmação da molécula através das técnicas espectrométricas tradicionais, bem como a determinação da sua faixa de fusão (171,3 a 176,5°C) e pureza (99,37% ± 0,19), através da análise térmica. A obtenção da cinética de degradação térmica não isotérmica elucidou sua energia de ativação (95,14 KJ.mol-1), ordem de reação (0) e temperatura de decomposição térmica (238,3 a 297,4°C). Estudos preliminares de estabilidade identificaram intensa susceptibilidade a degradação em condições básicas e oxidativas. Os aspectos físicos da NEQ envolvem estruturas cristalinas (5,5; 16,3 e 44,18° 2ϴ), de formato acicular, com diâmetro médio dos aglomerados de 12,48 μm. A validação do método de doseamento por Cromatografia Líquida de Alta Eficiência (CLAE-DAD) foi realizada em coluna C18 (25 cm x 4mm , 5μm ) fase reversa, com fase móvel composta por acetonitrila:H2O (85:15) e fluxo de 2 mL.min-1, sendo a solubilidade aquosa do protótipo inferior ao limite de quantificação do método (0,0001 μg.mL-1). O desenvolvimento do método de dissolução apresentou o meio de pH 1,2 com 1% de lauril sulfato de sódio como condição ótima para a execução das análises. As dispersões sólidas foram obtidas través do método do solvente (diclorometano), utilizando como matriz a hidroxipropilmetilcelulose (HPMC). O lote HPMC02 apresentou incremento de 28,57 e 11% na eficiência de dissolução (ED%) da DS binária (120 min), em comparação ao LPSF/GQ-130 isolado à mistura física (MF), respectivamente. A solubilidade da DS em água e em meio de dissolução foi incrementada em 7,7x106% e 1,99x103%, respectivamente. A obtenção dos sistemas ternários demonstrou maior ED% para a MF do que para a DS (47,45 e 44,97, respectivamente). Assim, pode-se concluir que o método empregado na obtenção da DS foi eficiente para a obtenção de DS binárias, entretanto, não repercutiu em melhoras para o sistema ternário. Ambos os sistemas constituem matérias-primas aperfeiçoadas para o desenvolvimento tecnológico de formas farmacêuticas a base deste protótipo.

The United States Air Force (USAF) trains C-130H Loadmaster students at Little Rock Air Force Base (AFB) through a civilian contract. The Aircrew Training System (ATS) contractor utilizes a Fuselage Trainer (FuT) to provide scenarios for the Loadmaster students to practice loading and unloading a simulated aircraft. The problem was the USAF does not have enough training devices and these devices are not at a high enough fidelity to accomplish many of the aircraft functions to meet the training objectives before flying on the actual aircraft. The ATS has moved the pilot's initial training into the Weapon System Trainer (WST). The WST has nearly eliminated all the aircraft flights for pilot initial instrument training because the simulator is life-like enough to accomplish the training tasks to qualify the students in the device. The Loadmaster student flights are scheduled based upon the pilot's flight training, thus forcing the Loadmaster students to utilize some other type of simulator device for their initial training. The goal was to investigate an efficient and effective AR training system to instruct Loadmaster skills before they train on the aircraft. The investigation examined the use of a prototype Helmet Mounted Display (HMD) AR device attached to the Loadmaster's helmet. Three scenarios provided a basis to evaluate the different aspects of hardware and software needed to utilize an HMD as a Loadmaster training tool. The scenarios tested how the AR device may improve the C-130H Loadmaster training capabilities to learn normal and emergency procedures to students in the FuT. The results show a way to save the government thousands of dollars in fuel cost savings and open the eyes of the training contractor to a new way of training students using AR.

No description available.

This diploma thesis has been elaborated within the Master's study of department 2307 that submits a production hooped component. The material of the component is steel ČSN 15 130. Single – part as far as small–lot production. On the basis of the literary study problems bend tubing was sugested the method: rotary draw bending. For this method was sugested mechanical bending machine with mandrel support arm, for bending with mandrel and exact bends in three – dimensional.

Le Dieu chrétien est-ll un Dieu vraiment présent à l’être humain? Pour répondre à cette question bien actuelle, nous avons puisé aux sources de notre foi. Notre but était de montrer qu'lrénée de Lyon peut nous aider à comprendre comment le Dieu des chrétiens est un Dieu de présence. Notre méthode a consisté à analyser rigoureusement l'œuvre principale d’Irénée, l’Adversus Haereses. Pour ce faire, nous avons conçu une grille de lecture qui a permis d’exploiter la dimension narrative de l’ouvrage étudié. Les éléments ainsi révélés par le texte ont fourni les matériaux de la lecture particulière d’Irénée qui constitue cette thèse. Dans une première partie, nous avons constaté que l'approche hérésiologique d’Irénée l’a amené à comprendre l’économie gnostique comme une expérience d’absence de la divinité. Le dieu gnostique lui apparaît en effet comme isolé par une multiplicité d’intermédiaires, et non intervenant dans la création; malgré l’apparente révélation qu’apporte la gnose, la divinité gnostique est présentée par Irénée comme inaccessible; et, au plan de l'achèvement, nous avons conclu à une fondamentale irrelation entre ce dieu et les autres êtres. Dans une deuxième partie, nous avons vu que la démonstration d’Irénée montre l’économie chrétienne orthodoxe comme une expérience de présence de Dieu. Nous avons rencontré un Dieu créateur qui se fait proche de ses créatures par l’intermédiaire de ses deux "Mains". Irénée nous a présenté un Dieu éducateur qui "accoutume" les humains à l’alliance avec lui par la médiation du Verbe incarné et de l’Esprit prophétique. Enfin, nous avons vu qu’au terme, le Dieu Père entre en communion d’amour avec ses enfants par l’intermédiaire du Verbe récapitulateur et le don de l’Esprit de vie. Oui, Irénée de Lyon, témoin du Ile siècle, homme de relation, peut contribuer à rendre à notre époque l’espérance en un Dieu toujours présent.

Depuis le début des temps, l'homme est confronté à sa propre finitude. Aussi, faut-il s'étonner que plusieurs philosophies et religions perçoivent le corps comme étant celui qui nous fait tendre vers le mal et le péché. Influencée par le platonisme, l'Église catholique n'a pas été à l'abri de la pensée dualiste. Pour les jansénistes des siècles derniers, le corps incarnait le mal, oubliant que le Christ s'était lui-même incarne. Le présent ouvrage laisse parler Irénée qui donne, à sa façon, une dignité incontestable au corps. Pour mieux comprendre la pensée irénéenne, les deux premiers chapitres présentent respectivement un bref historique du contexte irénéen, puis lèvent le voile sur le gnosticisme qui avait force Irénée à prendre la plume. Le troisième chapitre survole la théorie sémiotique (en se limitant au premier Greimas), ce qui permet, dans le chapitre quatre, de faire une étude sémiotique d'un extrait de l'Adversus Haereses. Enfin, la conclusion formule quelques déductions théologiques amenées par l'étude.

<p>This thesis is one part of a overall task of designing a module for frequency shift keying (FSK) to be used in an Ultra Wide Band (UWB) system. The FSK system has a Direct Digital Synthesizer (DDS) and Digital-to-Analog (DAC). The DACs differential current signals are directly fed to a RF (Radio Frequency) unit that generates the UWB RF signal.</p><p>The focus of this thesis is on DAC while the DDS is developed in VHDL as another thesis work. This thesis demonstrates a low-power, ultra wide band 10 bit DAC with an update frequency of 24 MSPS(Mega Samples Per Second). The DAC uses a L-fold linear interpolation architecture. It includes a 16-tap voltage controlled delay line and a 10 bit binary-weighted DAC with a time interleaved structure. The linear interpolation technique improves the attenuation of mirror components and also reduces the glitch. This helps to relax the analog filter requirements and sometimes an off chip capacitor is enough as low pass filter. The attenuation of image components is doubled in decibels(dB) compared with that of conventional DAC.</p><p>In this work various DAC architectures are studied. The current-steering DAC is chosen due to its high speed and high resolution. A binary weighted architecture is chosen to reduce the digital circuits. This helped in reducing the power consumption. The design and simulation is done with help of Cadence. The layout is done in Cadence Virtuoso and the DDS is integrated with the DAC. The chip is to be manufactured in 130 nm CMOS process.</p>

This thesis is one part of a overall task of designing a module for frequency shift keying (FSK) to be used in an Ultra Wide Band (UWB) system. The FSK system has a Direct Digital Synthesizer (DDS) and Digital-to-Analog (DAC). The DACs differential current signals are directly fed to a RF (Radio Frequency) unit that generates the UWB RF signal. The focus of this thesis is on DAC while the DDS is developed in VHDL as another thesis work. This thesis demonstrates a low-power, ultra wide band 10 bit DAC with an update frequency of 24 MSPS(Mega Samples Per Second). The DAC uses a L-fold linear interpolation architecture. It includes a 16-tap voltage controlled delay line and a 10 bit binary-weighted DAC with a time interleaved structure. The linear interpolation technique improves the attenuation of mirror components and also reduces the glitch. This helps to relax the analog filter requirements and sometimes an off chip capacitor is enough as low pass filter. The attenuation of image components is doubled in decibels(dB) compared with that of conventional DAC. In this work various DAC architectures are studied. The current-steering DAC is chosen due to its high speed and high resolution. A binary weighted architecture is chosen to reduce the digital circuits. This helped in reducing the power consumption. The design and simulation is done with help of Cadence. The layout is done in Cadence Virtuoso and the DDS is integrated with the DAC. The chip is to be manufactured in 130 nm CMOS process.

Constructing description logic ontologies is a difficult task that is normally conducted by experts. Recent results show that parts of ontologies can be constructed from description logic interpretations. However, these results assume the interpretations to be free of errors, which may not be the case for real-world data. To provide some mechanism to handle these errors, the notion of confidence from data mining is introduced into description logics, yielding confident general concept inclusions (confident GCIs) of finite interpretations. The main focus of this work is to prove the existence of finite bases of confident GCIs and to describe some of theses bases explicitly.

In this study, two sample sets from Zeugma Archaeological Area had been examined. The sample Set I includes 7 sediment, 18 stone, 4 brick/roof tile, 9 mortar, 4 plaster samples and the sample Set II consists of 24 mural painting samples. Samples were examined to get their raw material characteristics, mineralogical and chemical compositions, and microstructural properties using various analytical techniques such as Optical Microscopy, XRD, FTIR, PED-XRF, SEM-EDX and Raman Spectroscopy. In addition, mikroclimatic monitorings for temperature and relative humidity were also performed in that area. Sediments were calcereous soils of Eocene. Rock types of stones were mainly limestone which had 3 subgroups: micritic, biomicritic and recrytallised micritic limestones. The source of the limestones should be from the local formation. The firing temperature of brick/roof tile samples were estimated as 800-850&deg / C. Binder of mortar samples were mainly lime. Aggregate materials of brick/roof tiles, mortars, plasters and mural paintings may come from the river deposites of Euphrates. Mural painting samples have one intonaco layer, and single or double arriccio layers. The mural painting technique was fresco technique. Calcite was common mineral identified for all pigments. The sources of white, black and green coloured pigments were found as vaterite, graphite and malachite respectively. The sources of yellow coloured pigments were identified as ankerite, siderite and goethite. The red colours were identified as hematite, jasper and red earth/ochre. Jasper and vaterite, jasper and calcite, red earth/ochre and calcite, and hematite were the colour forming minerals of pink coloured pigments.