Doctorat en philosophie et lettres / info:eu-repo/semantics/nonPublished

Ce mémoire est une contribution à l'étude critique de la chronique latine du règne de Charles VI (1380-1422) rédigée par Michel Pintoin, religieux de Saint-Denis. Nous examinons ce que son témoignage peut nous apprendre au sujet du rôle et de la pratique de l'art oratoire dans la société française du Moyen Âge tardif. Nous montrons d'abord comment le chroniqueur hisse l'éloquence au rang des qualités indispensables à tout homme public; cette valorisation appuyée de l'art de persuader apparaît comme un trait majeur de la transformation, au cours des XIVe et XVe siècles, de la conscience politique "médiévale" en conscience politique "moderne". Nous analysons ensuite les discours contenus dans la chronique: alors que certains sont des constructions rhétoriques de Michel Pintoin, dont ils reflètent la culture et les idées, d'autres offrent un écho des deux principaux genres oratoires pratiqués en France au tournant de 1400: Yarenga et le sermon "thématique", apparus tous deux au XIIIe siècle. / Québec Université Laval, Bibliothèque 2013

This thesis is a study of self-knowledge in the writings of Catherine of Siena. The introductory chapter clarifies the kind of self-knowledge she is describing, viz. metaphysical self-knowledge which, in the case of mystics such as Catherine, blossoms into mystical self-knowledge. Catherine is then situated within the framework of her own era. A survey of catherinian literature follows. Since her major symbol for self-knowledge is the cell, the concept of the cell in the Church tradition of the West, and its influence on Catherine, is explored. The major aspect of the enquiry is the tracing of the chronological unfolding of Catherine's doctrine of self-knowledge, working with the texts themselves. This is done under the headings of her three main symbols for self-knowledge, la eel/a (the cell), la casa (the house) and la citta dell'anima (the city of the soul). Each of these sections is concluded with an interpretation of the significance of the unfolding of that symbol within Catherine's thought and the chapter itself is rounded off by an interpretation of the three symbols for self-knowledge in their integration and interconnectedness. Catherine communicates her experience of mystical self-knowledge by means of a complex system of images and symbols, all of which fit together to form a whole. This warrants an investigation into the role of the imagination, imagery and symbol in mysticism, and explores Catherine's use of imagery and symbol. The study shows Catherine's own gradual integration of mystical experience and ministry as it takes place within her experience and in the development of her thought. What we are able to see, by studying the texts, is the formation and strengthening of the underlying unity in Catherine between the inner movement of mystical love and outgoing concern for others which is redemptive love. These two are really one. / Christian, Spirituality, Church History and Missiology / D. Th. (Religious Studies)

Made available in DSpace on 2016-04-28T19:34:45Z (GMT). No. of bitstreams: 1 Adriana Alves Moraes de Souza.pdf: 767217 bytes, checksum: 889c80bf275cc4ad0a61ebf5ca34b67a (MD5) Previous issue date: 2010-05-28 / Fundação de Amparo a Pesquisa do Estado de Minas Gerais / The theme of this dissertation is the process of referenciality and the objective of analyzing the direct and indirect anaphoric processes for the (re) construction of discourse objects and of these to the meaning of the text, in chronicles produced in the Middle Ages by Fernão Lopes. The research, under the viewpoint of Textual Linguistics, justifies itself through the relevance of the theme, mainly due to a lack of works of this textual sort, which circulated during the Middle Ages. Keeping the objective of the research in mind, two of Fernão Lopes chronicles were chosen, having as their theme the romance between D. Pedro I and Inês de Castro, in which the direct and indirect anaphoras used in the construction of the discourse objects were analyzed, for the understanding of the text as a whole, seeing that such objects are built from a determined historical context. The results indicate that Fernão Lopes, in his chronicles, after having introduced the references, keeps us bound predominately by using pronominalizations, repetitions, defined nominal expressions and elipses, ensuring the flow of the text and the textual coherence. Indirect and associative anaphoras are used with less frequency / Nesta dissertação, temos por tema o processo de referenciação e por objetivo analisar os processos anafóricos diretos e indiretos para a (re)construção dos objetos de discurso e destes para o sentido do texto, em crônicas produzidas na Idade Média por Fernão Lopes. A pesquisa, sob o ponto de vista da Linguística Textual, justifica-se pela relevância do tema, principalmente dada a falta de trabalhos em torno desse gênero textual, que circulava na Idade Média. Tendo-se em vista o objetivo da pesquisa, selecionamos duas crônicas de Fernão Lopes, tendo como tema o romance entre D. Pedro I e Inês de Castro, em que foram analisadas as anáforas diretas e indiretas empregadas na construção dos objetos de discurso, para a compreensão do texto como um todo, já que tais objetos são construídos a partir de um determinado contexto histórico. Os resultados indicam que Fernão Lopes, em suas crônicas, após a introdução dos referentes, mantém-nos ressaltados predominantemente por meio de pronominalizações, repetições, expressões nominais definidas e elipses, garantindo a progressão do texto e a coerência textual. As anáforas indiretas e associativas são utilizadas com menor frequência

This thesis is a study of self-knowledge in the writings of Catherine of Siena. The introductory chapter clarifies the kind of self-knowledge she is describing, viz. metaphysical self-knowledge which, in the case of mystics such as Catherine, blossoms into mystical self-knowledge. Catherine is then situated within the framework of her own era. A survey of catherinian literature follows. Since her major symbol for self-knowledge is the cell, the concept of the cell in the Church tradition of the West, and its influence on Catherine, is explored. The major aspect of the enquiry is the tracing of the chronological unfolding of Catherine's doctrine of self-knowledge, working with the texts themselves. This is done under the headings of her three main symbols for self-knowledge, la eel/a (the cell), la casa (the house) and la citta dell'anima (the city of the soul). Each of these sections is concluded with an interpretation of the significance of the unfolding of that symbol within Catherine's thought and the chapter itself is rounded off by an interpretation of the three symbols for self-knowledge in their integration and interconnectedness. Catherine communicates her experience of mystical self-knowledge by means of a complex system of images and symbols, all of which fit together to form a whole. This warrants an investigation into the role of the imagination, imagery and symbol in mysticism, and explores Catherine's use of imagery and symbol. The study shows Catherine's own gradual integration of mystical experience and ministry as it takes place within her experience and in the development of her thought. What we are able to see, by studying the texts, is the formation and strengthening of the underlying unity in Catherine between the inner movement of mystical love and outgoing concern for others which is redemptive love. These two are really one. / Christian, Spirituality, Church History and Missiology / D. Th. (Religious Studies)

Die Autoimmunenzephalitis ist eine kürzlich beschriebene entzündliche Erkrankung des zentralen Nervensystems, die Gedächtnisdefizite, Psychosen, oder epileptische Anfälle hervorrufen kann. Derzeit ist hingegen noch nicht ausreichend verstanden, welche pathologischen Veränderungen zu den kognitiven Defiziten führen und welche neuropsychologischen und bildgebenden Langzeitoutcomes zu erwarten sind. Anhand von strukturellen und funktionellen Bildgebungsanalysen zeigt diese Dissertation, dass kognitive Defizite auch nach der akuten Phase der Autoimmunenzephalitis fortbestehen können. Bei der LGI1-Enzephalitis gehen Gedächtnisdefizite mit fokalen strukturellen Läsionen im Hippocampus einher. Durch eine funktionelle Störung der Resting-State-Konnektivität des Default-Mode- und Salienznetzwerkes beeinträchtigen diese Hippocampusläsionen auch Hirnregionen außerhalb des limbischen Systems. Bei Patient:innen mit NMDA-Rezeptor-Enzephalitis finden sich in der longitudinalen neuropsychologischen Untersuchung trotz guter allgemeiner Genesung auch noch mehrere Jahre nach der Akutphase persistierende Defizite des Gedächtnisses und exekutiver Funktionen. Zuletzt zeigt eine transdiagnostische Analyse, dass der anteriore Hippocampus eine erhöhte Vulnerabilität gegenüber immunvermittelten pathologischen Prozessen aufweist. Diese Ergebnisse legen nahe, dass kognitive Symptome auch noch nach der Entlassung aus der stationären Behandlung fortbestehen können. Sowohl umschriebene strukturelle Hippocampusläsionen als auch Veränderungen in makroskopischen funktionellen Hirnnetzwerken tragen zur pathophysiologischen Erklärung dieser Symptome bei. Zudem erlauben diese Ergebnisse einen Einblick in neuroplastische Veränderungen des Gehirns und haben weitreichende Implikationen für die Langzeitversorgung und das Design zukünftiger klinischer Studien. / Autoimmune encephalitis is a recently described inflammatory disease of the central nervous system that can cause memory deficits, psychosis, or seizures. The trajectory of cognitive dysfunction and the underlying long-term imaging correlates are, however, not yet fully understood. By using advanced structural and functional neuroimaging, this thesis shows that cognitive deficits persist beyond the acute phase. In LGI1 encephalitis, MRI postprocessing revealed that memory deficits are related to focal structural hippocampal lesions. These hippocampal lesions propagate to brain areas outside the limbic system through aberrant resting-state connectivity of the default mode network (DMN) and the salience network. In NMDA receptor encephalitis, a longitudinal analysis of neuropsychological data describes persistent cognitive deficits, especially in the memory and executive domains, despite good physical recovery several years after the acute disease. Lastly, a transdiagnostic analysis reveals that the anterior hippocampus is particularly vulnerable to immune-mediated damage. In conclusion, these results demonstrate that cognitive symptoms in autoimmune encephalitis can persist beyond discharge from neurological care. Both discrete structural hippocampal damage and changes in macroscopic functional networks shed light on the pathophysiological basis of these symptoms. These findings help to explain how the brain responds to pathological damage and have substantial implications for long-term patient care and the design of future clinical studies.

Die flexible Anwendung von Wissen in neuen Alltagssituationen ist eine notwendige kognitive Fähigkeit. Bisherige Studien betonen die zentrale Rolle des Hippocampus beim Lernen und Verknüpfen neuer Informationen mit bereits vorhandenem Wissen. Die funktionelle Integrität des Hippocampus ändert sich jedoch im Laufe des Lebens bzw. wird durch neuropsychiatrische Erkrankungen häufig beeinflusst. Die betroffenen Personen müssen deswegen adaptive Strategien entwickeln, um behaviorale Ziele weiter zu erreichen. Daher befasst sich meine Doktorarbeit mit Adaptationsprozessen im sich entwickelnden Gehirn und im vollständig entwickelten Gehirn mit einer hippocampalen Dysfunktion. Diese Synopsis umfasst dazu drei Studien: (1) zu behavioralen Strategien im sich entwickelnden Gehirn, (2) zu behavioralen Strategien im vollständig entwickelten Gehirn nach einer Läsion und (3) zu strukturellen Veränderungen im vollständig entwickelten Gehirn nach einer Läsion. Studie 1 zeigt einen altersgebundenen Wechsel beim assoziativen Gedächtnis: Kinder, Jugendliche und junge Erwachsene benutzen verschiedene Gedächtnisstrategien beim Integrieren von Gedächtnisinhalten. Studie 2 zeigt, dass die beobachteten Gedächtnisbeeinträchtigungen bei Patienten mit rechtsseitigen hippocampalen Läsionen sich nicht alleine durch ein Defizit des assoziativen Gedächtnisses erklären lassen, sondern auf einen zusätzlichen hippocampalen Beitrag zur Gedächtnisintegration zurückzuführen sind. Studie 3 zeigt, dass sich postoperative Adaptationsprozesse auf struktureller Ebene in überraschend kurzer Zeit ereignen und dass die strukturelle Reorganisation nicht nur im Hippocampus, sondern auch in entfernteren Hirnregionen, die mit dem Hippocampus verbunden sind, stattfindet. Zusammenfassend zeigen die Ergebnisse der drei Studien, dass Adaptationsprozesse im sich entwickelnden Gehirn sowie bei Erwachsenen mit einer hippocampalen Dysfunktion sowohl auf der behavioralen als auch auf der strukturellen Ebene auftreten. / Applying knowledge flexibly to new situations is a cognitive faculty that is necessary in every-day life. Previous findings emphasise the crucial role the hippocampus plays in learning and linking new information with pre-existing knowledge. However, the functional integrity of the hippocampus changes over the lifespan and is frequently affected by neuropsychiatric disorders. The affected subjects must, therefore, develop adaptive strategies to achieve behavioural goals. Thus, my doctoral thesis deals with adaptation processes in the developing brain and in adult brains with a hippocampal dysfunction. This synopsis encompasses three studies on: (1) behavioural strategies in the developing brain, (2) behavioural strategies in the lesioned fully developed brain, and (3) structural changes in the lesioned fully developed brain. Study 1 suggests an age-related shift in the associative memory: Children, adolescents, and young adults use different memory strategies when integrating information. Study 2 suggests that the memory deficits observed in patients with right-sided hippocampal lesions are not merely a consequence of an impaired associative memory but rather result from an additional hippocampal contribution to the memory integration. Study 3 suggests that postoperative structural adaptation processes occur on a surprisingly short time-scale, and this structural reorganisation happens not only in the hippocampus but also in distant brain areas connected to the hippocampus. In conclusion, findings from these three studies show that adaptation processes in the developing brain and in adult brains with hippocampal dysfunction occur on both the behavioural and the structural level.