published_or_final_version / abstract / toc / Philosophy / Doctoral / Doctor of Philosophy

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Series: Working Papers / Abteilung Gender and Diversity in Organizations

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In this thesis, I discuss a group of compositionally related 'core' chapters within the Yi Zhou shu, a collection of 59 texts from ancient China that has received very limited attention in scholarship. The texts in this collection are difficult to read and interpret because of their poor preservation and the lack of concise commentaries. I develop a methodological strategy for the identification of philologically related texts within the collection, which allows me to single out a group of texts related by compositional structures, rhetorical patterns and characteristic formulaic expressions. I call such chapters 'kingly consultations', considering that most of such texts are presented as speeches involving sage rulers of the Western Zhou (mid. 11th century - 771 BC), in which they share the fundamental wisdoms of kingship. I argue that these texts are remnants of an important ritualised textual practice, which has left traces not only in the Yi Zhou shu, but also in other collections, such as the Liu tao (Six Bow Cases), which is commonly classified among 'military' texts. I reconstruct elements of the socio-political context of the kingly consultations using comparative insight. I examine the numerical lists used for systematisation of knowledge against similar lists in the Pali canon. I also explain the significance of the expressions that emphasise the secretive transmission of texts against better known esoteric textual communities in China and Japan. Such comparison allows me to preliminarily identify the communities behind the kingly consultations as based on strict knowledge-based hierarchy, but prone to segmentation. Finally, I position the kingly consultations within the broader context of the practice of treasure texts. This practice is an important development in ancient China that led to the emergence of a new type of textual authority by 'detaching' earlier epigraphic texts from their precious material carriers and introducing them into novel environment of manuscript culture.

The thesis searches for the roots of the Chinese appreciation for the concepts contained in the early Mādhyamika texts in the currents in Chinese philosophy and the political climate in China during the Eastern Chin and Liu Sung periods. We also seek to account for the characteristic emphasis in hsüan-hsüeh thought on descriptions of a hypothetical sage-ruler and of "Non-being" (and in Buddhist thought on the divine saviour and the eternal life of the "spirit") in the social/political situation in China during this period. We examine the many points of correspondence and similarities between Taoist philosophy and concepts originating in the Prajnāpāramitā texts. Selected translations from the Ming-fo-lun (Treatise Illuminating the Buddha) by Tsung Ping (375-443) are used as examples of a Chinese layman's appraisal of the Buddhist "Path" vis-a-vis those of the philosophical Taoists and Confucianists and to give an overall picture of the philosophical climate of the period. The thesis concludes that there is a wealth of similarity between the Buddhist ideas being introduced to Chinese in the Post-Han period, and China's own philosophical output before and during this period. A continuity is identified between the tenets of hsüan-hsüeh and these Buddhist ideas. We further conclude that the Chinese interest in the limitless powers of the Buddha--like the emphasis in hsüan-hsüeh thought on the qualities of the sage-ruler--can be attributed to the social strife in the period and the erosion of faith in mundane political philosophies. The life of the "spirit" and the countenance of the Buddha offered truly lasting stability and reassurance which the more worldly doctrines had been unable to provide. As a final note, the thesis considers the common appreciation for Buddhism among Indians and Chinese as indicative of universal features of religious systems. We conclude that as common components of the Mādhyamika system practiced in India and China, the recognition of an all powerful deity and transcendent realm coupled with the idea of men's potential to interact and identify with these may be acknowledged as two of the fundamental features of a particular religious doctrine shared for a time by these two ancient civilizations. / Arts, Faculty of / Asian Studies, Department of / Graduate

Les mutations germinales activatrices de la voie RAS sont responsables de maladies rares regroupées sous le nom de RASopathies : le Syndrome de Noonan, le Syndrome de Noonan avec de Multiples Lentigines, la Neurofibromatose de type 1, le Syndrome de Malformations Capillaires et Malformations Artério-Veinseuses, le Syndrome Cardio-Facio-Cutané, le Syndrome de Legius et le Syndrome de Costello. Cette thèse s’intéresse au syndrome de Costello causé par une mutation hétérozygote de novo du gène HRAS. Ce syndrome est révélé dans les premiers mois de la vie et se caractérise par un retard de croissance postnatal, des traits du visage épais, un déficit intellectuel, des anomalies cutanées, ainsi qu’une prédisposition à développer des tumeurs. De plus, les patients atteints du syndrome de Costello développent une cardiomyopathie hypertrophique, de l’hypertension, une hypotonie et une myopathie d'origine moléculaire inconnue. En lien avec une association de malade et le service de génétique du CHU de Bordeaux, nous avons mené une exploration des anomalies protéomiques dans les tissus d’une souris modèle du syndrome de Costello ainsi que dans des fibroblastes de patients et des cellules modèles exprimant les formes mutées de HRASG12S et HRASG12A. Cette analyse globale et sans a priori a révélé des altérations au niveau du métabolisme énergétique et plus particulièrement de la composition des mitochondries. Le déficit fonctionnel des mitochondries, centrale énergétique du corps humain, a été caractérisé par des approches de biochimie, de bioénergétique et de biologie cellulaire. De plus, l’analyse des données ‘omiques’ a permis de suggérer une nouvelle hypothèse dans la physiopathologie du syndrome de Costello. Cette hypothèse considère l’implication d’un micro-ARN, le miR-221* dans l’inhibition du métabolisme oxydatif. Les analyses génétiques réalisées sur les cellules de patients et les cellules modèles ont démontré l’inhibition de l’expression de la protéine AMPK, un régulateur majeur du métabolisme mitochondrial, par le miR-221* sous le contrôle de HRASG12S et HRASG12A. Ces découvertes ont permis d’élaborer une stratégie thérapeutique visant à réduire la cardiomyopathie dans le syndrome de Costello. Les analyses précliniques effectuées sur les modèles cellulaires et le modèle murin ont permis d’évaluer l’efficacité d’une stimulation pharmacologique du métabolisme mitochondrial. Cette thèse révèle donc l’implication des mitochondries dans le syndrome de Costello et l’analyse moléculaire réalisée propose une série de données ‘Omiques’ qui permettront de progresser dans la compréhension de cette maladie rare. / Germline activating mutations of the RAS pathway are responsible for rare diseases grouped under the name of RASopathies: Noonan Syndrome, Noonan Syndrome with multiple Lentigines, Type 1-neurofibromatosis, Capillaries malformations and arteriovenous malformations syndrome, Cardio-Facio-Cutaneous Syndrome, Legius Syndrome and Costello Syndrome. This Ph.D thesis focuses on Costello syndrome that is caused by a heterozygous de novo mutation of the HRAS gene. This syndrome is revealed in the first months of life and is characterized by postnatal growth retardation, thick facial features, intellectual deficit, skin abnormalities, and a predisposition to developing tumors. In addition, patients with Costello syndrome develop hypertrophic cardiomyopathy, hypertension, hypotonia and myopathy of unknown molecular origin. In connection with a patients association and the genetics department of Bordeaux University Hospital, we conducted an exploration of proteomic abnormalities in the tissues of a mouse model of the Costello syndrome as well as in patients’ fibroblasts and cell models expressing mutated forms of HRASG12S and HRASG12A. This global and unbiased analysis revealed alterations in energy metabolism and more particularly in the composition of mitochondria. The functional deficiency of mitochondria, energy plants of the human body, has been characterized by biochemistry, bioenergetics and cell biology approaches. In addition, the 'omic' analysis of Costello syndrome suggested a new pathophysiology hypothesis that considered the involvement of a microRNA, miR-221* in the alteration of oxidative metabolism. Functional genetic analyzes performed on patient cells and cell models demonstrated the inhibition of the expression of the major mitochondrial metabolism regulator AMPK protein by miR-221* under the control of HRASG12S and HRASG12A. These findings led to the development of a preclinical therapeutic strategy to reduce cardiomyopathy in Costello syndrome. Preclinical investigations performed on the cellular models and the murine model made it possible to evaluate the efficacy of a pharmacological stimulation of mitochondrial metabolism. This thesis thus reveals the involvement of mitochondria in Costello syndrome and the molecular analysis carried out makes available a series of 'Omics' data that will allow progress in the understanding of this rare disease.

陳煒舜. / 論文(哲學博士)--香港中文大學, 2003. / 參考文獻 (p. 501-528). / 中英文摘要. / Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Electronic reproduction. Ann Arbor, MI : ProQuest Information and Learning Company, [200-] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Mode of access: World Wide Web. / Chen Weishun. / Zhong Ying wen zhai yao. / Lun wen (zhe xue bo shi)--Xianggang Zhong wen da xue, 2003. / Can kao wen xian (p. 501-528).

published_or_final_version / Chinese / Doctoral / Doctor of Philosophy

In recent years, through the process of narrative and literary criticism, scholars have begun suggesting that satire is present in specific texts of the Old Testament. Thus the primary function of this thesis is to analyse the validity of these arguments alongside suggesting different places where satire may be found. To achieve this goal, the thesis begins by analysing and defining satire as a concept. A clear definition provides the thesis with the method needed to identify satire in texts which predate any defined understanding of the concept. The thesis also uses satirical works from throughout history as templates for understanding similar types of satire within the biblical works. Once this methodology has been established, different genres of the Old Testament form the different chapters of the thesis. It identifies four different places where satire is deployed. Thus it examines satire in narratives, the book of Jonah, prophetic texts and wisdom literature. Each chapter combines new ideas with the analysis of previous scholastic arguments concerning the presence of satire. Within each genre a different type of satire with a range of complexity is deployed. The idol critiques in prophetic texts show simplistic satire. Narrative satire shows both situational and character-based satire. The book of Jonah is an example of hypocritical satire. Finally, satire in the wisdom literature contains a range of different satirical styles. The thesis concludes that satire is present within the texts of the Old Testament. This has implication to the field of satire. It affirms the existence of pre-Hellenistic satire. Alongside this, it shows that satire is a subconscious human technique, deployable even when the proponent has no defined understanding of the concept. In the field of Old Testament studies it provides an alternative reading of many familiar texts. A satirical reading provides clear insight into authorial intent as well as offering different interpretations of the texts which are examined.