Administration of armies has been sadly neglected in historical studies but the ability of the AIF to develop an efficient system of administration and to fit into the equally efficient British system, had much to do with the success of the AIF, especially late in the war. The various Empire governments had made some preparations for an alliance system of fighting in the event of a major war, but in practice these needed a great deal of adjustment. This thesis examines the manner in which the dominions and Britain planned for a possible war and the way in which changes had to be made in practice. It examines the manner in which the AIF developed a system and the many facets of this system, which had developed a remarkable degree of efficiency by the end of the war. Because the AIF and CEF were so alike in size, composition and in the problem they faced, a recurring theme of the thesis is a comparison between the two. It embraces the following: a. Prewar preparation for a combined empire army. b. The organisation of the administrative system of the AIF and the manner this improved through the war. c. The organisation and problems of the CEF administrative system d. The development of a system of capitation to pay for the services supplied to the AIF and CEF. e. Supply of equipment. f. Manner in which both forces worked to maintain their forces. g. The manner in which both forces catered for the needs of the individual soldiers. h. Supply in the field i. Medical administration in the AIF j. The administration in the AIF k. The administration of discipline in the AIF l. The demobilisation of the AIF.

In speech communication systems such as voice-controlled systems, hands-free mobile telephones and hearing aids, the received signals are degraded by room reverberation and background noise. This degradation can reduce the perceived quality and intelligibility of the speech, and decrease the performance of speech enhancement and source localization. These problems are difficult to solve due to the colored and nonstationary nature of the speech signals, and features of the Room Impulse Response (RIR) such as its long duration and non-minimum phase. In this dissertation, we focus on two topics of speech enhancement and speaker localization in noisy reverberant environments. A two-stage speech enhancement method is presented to suppress both early and late reverberation in noisy speech using only one microphone. It is shown that this method works well even in highly reverberant rooms. Experiments under different acoustic conditions confirm that the proposed blind method is superior in terms of reducing early and late reverberation effects and noise compared to other well known single-microphone techniques in the literature. Time Difference Of Arrival (TDOA)-based methods usually provide the most accurate source localization in adverse conditions. The key issue for these methods is to accurately estimate the TDOA using the smallest number of microphones. Two robust Time Delay Estimation (TDE) methods are proposed which use the information from only two microphones. One method is based on adaptive inverse filtering which provides superior performance even in highly reverberant and moderately noisy conditions. It also has negligible failure estimation which makes it a reliable method in realistic environments. This method has high computational complexity due to the estimation in the first stage for the first microphone. As a result, it can not be applied in time-varying environments and real-time applications. Our second method improves this problem by introducing two effective preprocessing stages for the conventional Cross Correlation (CC)-based methods. The results obtained in different noisy reverberant conditions including a real and time-varying environment demonstrate that the proposed methods are superior compared to the conventional TDE methods. / Graduate / 0544 / 0984 / saeed.mosayyebpour@gmail.com

In speech communication systems such as voice-controlled systems, hands-free mobile telephones and hearing aids, the received signals are degraded by room reverberation and background noise. This degradation can reduce the perceived quality and intelligibility of the speech, and decrease the performance of speech enhancement and source localization. These problems are difficult to solve due to the colored and nonstationary nature of the speech signals, and features of the Room Impulse Response (RIR) such as its long duration and non-minimum phase. In this dissertation, we focus on two topics of speech enhancement and speaker localization in noisy reverberant environments. A two-stage speech enhancement method is presented to suppress both early and late reverberation in noisy speech using only one microphone. It is shown that this method works well even in highly reverberant rooms. Experiments under different acoustic conditions confirm that the proposed blind method is superior in terms of reducing early and late reverberation effects and noise compared to other well known single-microphone techniques in the literature. Time Difference Of Arrival (TDOA)-based methods usually provide the most accurate source localization in adverse conditions. The key issue for these methods is to accurately estimate the TDOA using the smallest number of microphones. Two robust Time Delay Estimation (TDE) methods are proposed which use the information from only two microphones. One method is based on adaptive inverse filtering which provides superior performance even in highly reverberant and moderately noisy conditions. It also has negligible failure estimation which makes it a reliable method in realistic environments. This method has high computational complexity due to the estimation in the first stage for the first microphone. As a result, it can not be applied in time-varying environments and real-time applications. Our second method improves this problem by introducing two effective preprocessing stages for the conventional Cross Correlation (CC)-based methods. The results obtained in different noisy reverberant conditions including a real and time-varying environment demonstrate that the proposed methods are superior compared to the conventional TDE methods. / Graduate / 2015-04-23 / 0544 / 0984 / saeed.mosayyebpour@gmail.com

Perfusion magnetic resonance imaging is modern diagnostic method used mainly in oncology. In this method, contrast agent is injected to the subject and then is continuously monitored the progress of its concentration in the affected area in time. Correct determination of the arterial input function (AIF) is very important for perfusion analysis. One possibility is to model AIF by multichannel blind deconvolution but the estimated AIF is necessary to be scaled. This master´s thesis is focused on description of scaling methods and their influence on perfussion parameters in dependence on used model of AIF in different tissues.

About 3850 men of the First Australian Imperial Force were captured on the Western Front in France and Belgium between April 1916 and November 1918. They were mentioned only briefly in the volumes of the Official Histories, and have been overlooked in many subsequent works on Australia and the First World War. Material in the Australian War Memorial has been used to address aspects of the experiences of these neglected men, in particular the Statements that some of them completed after their release This thesis will investigate how their experiences ran counter to the narratives of CEW Bean and others, and seeks to give them their place in Australia???s Twentieth Century experience of war.

About 3850 men of the First Australian Imperial Force were captured on the Western Front in France and Belgium between April 1916 and November 1918. They were mentioned only briefly in the volumes of the Official Histories, and have been overlooked in many subsequent works on Australia and the First World War. Material in the Australian War Memorial has been used to address aspects of the experiences of these neglected men, in particular the Statements that some of them completed after their release This thesis will investigate how their experiences ran counter to the narratives of CEW Bean and others, and seeks to give them their place in Australia???s Twentieth Century experience of war.

Cerebral blood flow quantification is a vital diagnostic tool for disease monitoring and used for diagnosing a variation of pathological conditions. The human brain requires roughly about 20 % of the total cardiac output to sustain normal functioning, hence the perfusion of blood is an important factor to deliver oxygenated blood. The golden standard for quantifying the cerebral blood flow follows by measurement with dynamic positron emission tomography of 15O-labelled water modelled by tracer kinetic compartments. For implementation, knowledge of an input function must exist which is in general being sampled through arterial cannulation of the radial artery with a continuous sampling instrument. The core of this thesis is to establish if two sampling instruments contradicts in comparison to each other when sampling the data to the input function.  In total 22 subjects underwent a 10-minute dynamic  15O-labeled water brain PET scan on two imaging modalities PET/CT and PET/MR. Continuous arterial sampling was performed either by a Veenstra on PET/CT or a Swisstrace on PET/MR during a baseline scan. In two subjects the two sampling instruments were coupled in series and imaged solely on the PET/CT.  Cerebral blood flow analysis was done comparing varying dispersion times, the two imaging modalities compared each other and comparing the calculated and measured blood flows obtained through this study with the values obtained prior. To be able to compare the values showing inconsistency to the values obtained through this thesis, a comparison between two different iterative reconstruction methods was done. Here the method of ordered subsets expectation maximum was compared to a Bayesian penalized-likelihood method. To further compare the two sampling instruments an image derived input function was constructed and compared with the blood sampled input function. The results showed that there was no significant difference between measured cerebral blood flow between the two imaging modalities with the currently used reconstruction method based on Bayesian penalized likelihood but presented in the earlier data there was an inconsistency. A dispersion analysis with variation on the external dispersion time shows that if the time was chosen to low or to high compared to the standard time used it introduced distorted fitted models of the activity curves. This distortion creates further errors in the calculation of the cerebral blood flow, however with the analysis the standard dispersion time could be confirmed as an accurate fit. Subjects imaged with the two sampling instruments in series showed no significant difference except for the measured values on Veenstra to be slightly higher. Lastly the correlation between the image derived input function and the blood sampled input function showed poorly performance. Only a R2 value of 0.42 was achieved on the PET/CT while a meagre R2 value of 0.18 was achieved on the PET/MR. Although the correlation was poorly, the plotted activity curves from the two functions showed a representable appearance between each other. / Kvantifiering av det cerebrala blodflödet är ett nödvändigt diagnostiskt verktyg som används för att kontrollera och diagnostisera en variation av patologiska sjukdomstillstånd. Den mänskliga hjärnan kräver kring 20 %av den totala produktionen från hjärtat för att upprätthålla normal funktion, följaktligen är perfusion av blod en viktig faktor för att distribuera syrerikt blod runt om i kroppen. Den gyllene standarden för kvantifiering av det cerebrala blodflödet följer som undersökning med dynamisk positron emission tomografi av 15O-märkt vatten, modellerat  med kinetisk kompartment teori. För att kunna implementera detta måste information om en input-funktion erhållas, generellt erhålls detta genom att blod tags genom arteriell kanylering av antingen den radiella artären med ett kontinuerligt samplings instrument. Målet med detta arbete är att fastställa om två samplings instrument motsäger varandra vid mätning av data till input-funktionen. Totalt deltagande är 22 patienter som genomgick en 10-minuters dynamisk 15O-märkt vatten PET undersökning av hjärnan på två bildtagningsmodaliteter PET/CT och PET/MR. Kontinuerlig blodtagning genomfördes antingen med en Veenstra sampler instrument på PET/CT eller en Swisstrace sampler instrument på PET/MR tillsammans med en baseline undersökning. Vid två undersökningar seriekopplades de två instrumenten och patienterna blev endast undersökta vid PET/CT. För ytterligare kunna utvärdera de två instrumenten, konstruerades en bild framtagen input-funktion som sedan kunde jämföras med den blod samplade input-funktionen. Cerebrala blodflödes analyser gjordes med olika dispersions tider, även för att kunna jämföra de två bildtagningsmodaliteterna mot varandra och jämföra erhållna värden framtagna under denna studie med en tidigare studie. För att kunna jämföra avvikelserna i de uppmätta värdena har även två olika rekonstruerings metoder studerats. Resultaten visar ingen signifikant skillnad mellan de uppmätta cerebrala blodflödena mellan de två bildtagningsmodaliteterna rekonstruerade med den nuvarande standarden. Dispersions analysen med varierande extern dispersions tid visar att om tiden är för kort eller för lång jämfört med standardtiden, introduceras en osann anpassning av aktivitets kurvorna. Denna förvrängning av datat resulterar till fler avvikelser i beräkningarna av blodflödet, likväl var det möjligt att bekräfta standardtiderna som används. Patienter som undersöktes med instrumenten i seriekoppling visade ingen signifikant skillnad förutom att det uppmättes en aningens högre värden hos patienter med Veenstra som blod sampler. Slutligen, korrelationen mellan den bild framtagna input-funktionen och den blod samplade input-funktionen visade ett dåligt resultat. Endast ett R2 värde på 0.42 erhölls för PET/CT medan endast ett R2 värde på 0.18 på PET/MR erhölls. Trotts att korrelationen var dålig, visade de plottade aktivitets kurvorna ett representativt utseende mellan de två typerna av input funktion.

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L'activació sostinguda de Hog1 porta a una inhibició del creixement cel·lular. En aquest treball, hem observat que el fenotip de letalitat causat per l'activació sostinguda de Hog1 és parcialment inhibida per la mutació del complexe SCFCDC4. La inhibició de la mort causada per l'activació sostinguda de Hog1 depèn de la via d'extensió de la vida. Quan Hog1 s'activa de manera sostinguda, la mutació al complexe SCFCDC4 fa que augmenti l'expressió gènica depenent de Msn2 i Msn4 que condueix a una sobreexpressió del gen PNC1 i a una hiperactivació de la deacetilassa Sir2. La hiperactivació de Sir2 és capaç d'inhibir la mort causada per l'activació sostinguda de Hog1. També hem observat que la mort cel·lular causada per l'activació sostinguda de Hog1 és deguda a una inducció d'apoptosi. L'apoptosi induïda per Hog1 és inhibida per la mutació al complexe SCFCDC4. Per tant, la via d'extensió de la vida és capaç de prevenir l'apoptosi a través d'un mecanisme desconegut. / Sustained Hog1 activation leads to an inhibition of cell growth. In this work, we have observed that the lethal phenotype caused by sustained Hog1 activation is prevented by SCFCDC4 mutants. The prevention of Hog1-induced cell death by SCFCDC4 mutation depends on the lifespan extension pathway. Upon sustained Hog1 activation, SCFCDC4 mutation increases Msn2 and Msn4 dependent gene expression that leads to a PNC1 overexpression and a Sir2 deacetylase hyperactivation. Then, hyperactivation of Sir2 is able to prevent cell death caused by sustained Hog1 activation. We have also observed that cell death upon sustained Hog1 activation is due to an induction of apoptosis. The apoptosis induced by Hog1 is decreased by SCFCDC4 mutation. Therefore, lifespan extension pathway is able to prevent apoptosis by an unknown mechanism.