The purpose of the dissertation "An optimalization of an external funding of the prospectus" is to examine financial analyses of particular business connected with the business development. The present study aims to explore actual finance of the particular business and asset of the business. Moreover the analytical report examine Business development strategy. The dissertation is engaged also in analysis of investment credit and finacial leasing offers and benchmarking of both. The main purpose of the financial analyses is suggestion of the financing of the prarticular company.

The Master’s thesis deals with the business performance assessment of DSB EURO, s. r. o. company by Balanced Scorecard method. The concept of the Balanced Scorecard method and its implementation is described in the theoretical part. The practical part is based on the theory described in the thesis and evaluates current situation of the company by financial and non-financial measures. The concept of the implementation into chosen company is designed from the analysis results. The final part is aimed on the risk summarization and concept contribution.

The Master’s thesis deals with question of strategic management. It is focused on performance measurement Invia.cz, a.s. using the Balanced Scorecard method. Theoretical part describes concept of the Balanced Scorecard and proces of its implementation. The next part of thesis includes strategic and financial analysis which serves as the basis of this concept. A major part includes proposal of concept implementation into the strategic management. At the end, possible risks and anticipated benefits of this method are evaluated

Indiana University-Purdue University Indianapolis (IUPUI) / Glycogen, a branched polymer of glucose, acts as an intracellular carbon and energy reserve in many tissues and cell types. The breakdown of glycogen by hormonally regulated degradation involving the coordinated action of glycogen phosphorylase and debranching enzyme has been well studied. However, the importance of lysosomal disposal of glycogen has been underscored by a glycogen storage disorder, Pompe disease. This disease destroys tissues by over-accumulating glycogen in lysosomes due to a genetic defect in the lysosomal acid α-glucosidase. Details of the intracellular trafficking of glycogen are not well understood. Starch-binding domain-containing protein 1 (Stbd1) is a protein of previously unknown function with predicted hydrophobic N-terminus and C-terminal CBM20 carbohydrate binding domain. The protein is highly expressed in the liver and muscle, the major repositories of glycogen. Stbd1 binds to glycogen in vitro and in vivo with a preference for less branched and more phosphorylated polysaccharides. In animal models, the protein level of Stbd1 correlates with the genetic depletion of glycogen. Endogenous Stbd1 is found in perinuclear compartments in cultured mouse and rat cells. When over-expressed in cells, Stbd1 accumulates and coincides with glycogen and GABARAPL1, the autophagy protein. They form enlarged perinuclear structures which are abolished by removing the hydrophobic N-terminus of Stbd1. Stbd1, with point mutations in the CBM20 domain, retains the perinuclear localization but without concentration of glycogen in this compartment. In cells that are stably over-expressing glycogen synthase, glycogen exists as large perinuclear deposits, where Stbd1 can also be present. Removing glucose from the culture leads to a breakdown of the massive glycogen accumulation into numerous smaller and scattered deposits which are still positive for Stbd1. Furthermore, the autophagy protein GABARAPL1 co-immunoprecipates and co-localizes with Stbd1 when co-expressed in cells. Point mutation or deletion of the autophagy protein interacting region on Stbd1 eliminates the interaction and co-localization with GABARAPL1 but not the characteristic perinuclear distribution of Stbd1. We propose that Stbd1 is involved in glycogen metabolism. In particular, it participates in the vesicular transfer of glycogen to the lysosome with the recruitment of autophagy related proteins GABARAPL1 and/or GABARAP, as these vesicles mature prior to lysosomal fusion.

Postpartum depression (PPD) is a prevalent, complex illness impacting 10% to 20% of mothers and their families. Treatments for PPD, such as medication and psychotherapy, are effective at reducing the severity of symptoms and generally improving quality of life for new mothers and their families. Unfortunately, many mothers with PPD go unrecognized due to a lack of standardized screening methods. Further, mothers regularly encounter barriers to accessible, evidence-based follow-up care to treatment even when symptoms of PPD are detected. The use of a stepped care protocol, set in a pediatric primary care clinic, is one proposed strategy to address the insufficient rates of screening, detection, and maternal contact with treatment. This study examines the feasibility of implementing a stepped care protocol to screen and provide brief therapeutic treatment to mothers reporting symptoms of PPD in one pediatric primary care clinic. The RE-AIM (reach, effectiveness, adoption, implementation, and maintenance) framework was used to evaluate implementation outcomes. Results suggest this stepped care protocol was feasibly implemented in one pediatric primary care clinic. The protocol was largely successful in screening mothers at a majority of well child checks (83.76%) for PPD and connecting them with resources based on the severity of symptoms reported. Future studies should further evaluate the impact brief onsite mental health treatments have on reports of PPD symptoms, longitudinal maternal and child outcomes as a result of the protocol, as well as the protocol’s replicability to pediatric practices elsewhere.

Amongst the breathtaking and mountainous landscapes of the Western Highlands is a highly indigenous Mayan population stricken with challenges of food insecurity and extreme poverty. Despite efforts by governmental and non-governmental organizations alike to combat these challenges, the results of chronic malnutrition have led to some of the highest child stunting rates in all of Guatemala, particularly in the department of Totonicapán, where this study took place. To date, information is limited regarding agricultural programs that utilize the rabbit as a model to reduce food insecurity in Guatemala. Thus, a novel agricultural education program, Guatemala Rabbit Project (GRP), was developed using a farm-to-fork and hands-on training approach to provide women with knowledge and skills needed to successfully raise rabbits for household consumption. The overarching purpose of this study is to evaluate the GRP as an agricultural intervention among women in three Western Highlands communities. The REAIM evaluation framework, developed for and widely utilized to evaluate public health interventions, was used to assess reach, effectiveness, adoption, implementation, and maintenance of the GRP among participants. The first aim of this study was to conduct a process evaluation utilizing reach, adoption, and implementation dimensions of RE-AIM. Findings suggest that the target population was reached, and adoption rates (84%) were promising. In general, GRP adopters adhered to the best management practices taught during the training, as reflected by observational scores across a variety of management topics indicating successful implementation. The second study aimed to evaluate the outcomes of the GRP utilizing effectiveness and maintenance dimensions of RE-AIM. Findings suggest that the GRP could serve as a household agricultural intervention based on the reported benefits and positive unintended outcomes discovered. Participants provided feedback about challenges that will be used to expand training content. Overall, findings provide evidence that the GRP could be a sustainable agricultural intervention, increasing access to animal protein while also providing households with an additional source of income.

Primary care within the United States’ health care system is evolving to address increases in chronic conditions across the lifespan that impact individuals’ daily lives, and the health care system’s performance and cost. Even as interprofessional primary care teams aim to manage a large majority of health needs over time, these teams often lack the skilled professionals necessary to address function in daily life. Occupational therapy’s distinct value as experts in evaluation and intervention for health-related occupational development, adaptation, prevention and management can address this problem. However, continued education and additional tools are necessary in order for occupational therapists to increase their knowledge of the profession’s role in primary care, increase self-efficacy in promoting occupational therapy to stakeholders, and increase self-efficacy to utilize resources for research and establishing occupational therapy in primary care settings. The proposed online course "Occupational Therapy in Primary Care: What, Why, Where, & How?" is specifically targeted to occupational therapists to addresses these outcomes. Theoretical and historical evaluation of occupational therapy in primary care in the United States and Canada supports understanding the problem and mechanisms that can help navigate efforts to include occupational therapy in primary care. Diffusion of Innovations and Adult Learning Theory guide the course’s two-phases of development and dissemination. This project is a timely contribution to the emerging area of occupational therapy in primary care that supports the Institute for Health Care Improvements’ (IHI) Triple Aim to improve the individual experience of care, health of populations and reduce per capita cost of care.

In today’s society, the majority of our population lacks knowledge about agriculture and its importance. Therefore, there is a demand for agricultural programs to increase a general knowledge of agriculture. This study aimed to develop, pilot test, and evaluate the Hybrid-Online Hatch-out Program. Due to limited resources with the current Hands-on Hatch-out program, this Hybrid-Online Hatch-out Program could reach a larger population of youth and aid in educating more youth about poultry (one of the largest sectors of agriculture). The RE-AIM framework (Reach, Effectiveness, Adoption, Implementation, and Maintenance) was utilized to guide the evaluation process. The program was pilot-tested in two elementary schools with 14 teachers and 172 students in Pre-K through first grade. Overall, teachers were satisfied with the program, indicated that it was feasible to implement, and planned to repeat the program in the future. Additionally, students’ pre- to post-program increase in poultry knowledge was statistically significant.

One-third of the American population is obese (1), and of those successful at losing weight, most return to their baseline weight within three to five years (2). In an effort to increase the success of weight loss maintenance (WTLM), research has focused on strategies that promote self-regulation (3). Self-regulation strategies, such as daily self-monitoring of body weight (4), increased step count (5, 6), and increased fruit and vegetable intake (7) have proven to be effective in long-term WTLM interventions. To date, increased water consumption has not been researched as a WTLM strategy, yet it has been shown to decrease meal energy intake (8, 9) and increase weight loss among middle-aged and older adults (10). The purpose of our first investigation was to determine if self-monitoring of increased water consumption facilitates WTLM over 12 months among middle-aged to older adults, when combined with other self-regulation strategies. Our second investigation was a review of WTLM literature to determine the translation potential published interventions using the RE-AIM (Reach, Efficacy/effectiveness, Adoption, Implementation, Maintenance) framework (11) to provide recommendations for future research. Our first main finding was that weekly tracking of these self-regulatory behaviors (self-weighing, step counts, fruit/vegetable intake) for 12 months promotes effective long-term WTLM among middle-aged and older adults. However, daily self-monitoring of increased water consumption (48 fl oz/day) did not appear to provide an additional benefit. Secondly, we have identified significant gaps in the WTLM literature that may hinder the translatability of existing effective interventions. Specifically, current WTLM research is limited in reporting important external validity factors (e.g. costs, adoption, participation rate). Available WTLM literature provided a more detailed overview of Reach, Efficacy, and Implementation, yet was little information on potential adoption, costs, or sustainability. Future work in this area should address these factors to increase the translation potential of WTLM interventions in clinical or community settings. / Ph. D.

Obesity, a condition of excess body fat, is one of the most complex problems facing health systems. Lifestyle management programs that combine diet, physical activity, and intensive behavioral therapy have been shown by research to support a degree of weight loss that produces health benefits (i.e., at least a 3-5% initial body weight). However, it has been difficult for research-developed programs to be delivered in typical practice to have a meaningful impact. Integrated research-practice partnerships that involve the coming together of academic researchers, health system administrators, and program delivery staff may help overcome this gap, especially during this transformational time in the healthcare sector. This dissertation aimed to develop an understanding of how using the integrated research-practice approach would facilitate and sustain evidence-based lifestyle management strategies across a health system to treat obesity among patients and employees. An integrated research-practice partnership with Carilion Clinic, a health system in western Virginia, served as an example for the study. From 2013-2016, the Carilion Clinic integrated research-practice partnership conducted a series of trials testing different strategies for delivering weight loss and weight loss maintenance support. An evaluation guided by the RE-AIM (Reach, Effectiveness, Adoption, Implementation, and Maintenance) framework was conducted to describe implementation processes and outcomes for each strategy. Lessons learned from the evaluation support the value of the integrated-research practice partnership approach as a solution for overcoming gaps in obesity care. A shared priority perspective between research and practice was identified as the powerful process for supporting facilitation and sustainability of strategies. In addition, findings from the evaluation produced evidence to inform the future development of a system for Carilion Clinic to help patients and employees lose weight and keep it off through lifestyle management. / Ph. D.