<p>Problem kojim se doktorska disertacija bavi je politički aktivizam i sociokulturni faktori, koji ga određuju u uslovima tranzicije i krize u kojima se Srbija nalazi. Osnovna istraživačka pitanja od kojih se u radu po&scaron;lo su: na koji način funkcioni&scaron;e politički aktivizam u Srbiji, koji oblici političkog pona&scaron;anja su najzastupljeniji, kojim vrednosnim okvirima se političko pona&scaron;anje oblikuje, kao i koji sociokulturni faktori su najznačajniji prediktori političkog aktivizma. Teorijsku osnovu za istraživanje pružio je model socioekonomskog statusa u političkoj participaciji kojim se ističe značaj socioekonomskih pokazatelja u političkom aktivizmu kao &scaron;to su uzrast, &scaron;kolska sprema, zanimanje, životni standard. Istraživanje je vr&scaron;eno upitnikom koji se sastoji iz pet celina: prvi deo upitnika čine pitanja o sociodemografskim karakteristikama ispitanika, drugi deo se odnosi na politički aktivizam, treći na ispitivanje vrednosti i to modernističko-tradicionalističkih i autokratsko-demokratskih, četvrti deo upitnika meri teritorijalni identitet i naklonost određenim teritorijalnim celinama i peti se tiče odnosa prema religiji.<br />Uzorak istraživanja su činili članovi stranaka koje učestvuju u radu skup&scaron;tina u &scaron;est gradova u Vojvodini: Novom Sadu, Subotici, Somboru, Zrenjaninu, Pančevu i Sremskoj Mitrovici. Rezultati istraživanja su pokazali da su sociodemografski i sociokulturni faktori značajni za obja&scaron;njenje političkog aktivizma. Postavljene hipoteze su delimično potvrđene, jer se politički aktivizam u najvećoj meri iskazao u okviru već ponuđenih političkih de&scaron;avanja kao &scaron;to su izlazak na izbore, uče&scaron;će u partijskim skupovima i aktivnostima, a znatno manje kao samoinicijativne aktivnosti politički svesnih i odgovornih građana. Politička kultura koja se kroz aktivizam sagledala je pre svega podanička, sa elementima participativnog pona&scaron;anja.</p>

Mémoire numérisé par la Division de la gestion de documents et des archives de l'Université de Montréal.

O Distrito Aurífero de Lourenço, localizado na região centro-norte do Estado do Amapá, insere-se na Província Geocronológica Maroni-Itacaíunas, de idade Paleoproterozóica, onde ocorrem rochas supracrustais que foram afetadas por metamorfismo de alto grau e parcialmente migmatizadas, bem como complexos cálcio-alcalinos. O depósito de Salamangone hospeda-se em granitóides de composição tonalítica a granodiorítica, de caráter cálcio-alcalino, metaluminosos a levemente peraluminosos. Exibem concentrações relativamente elevadas de LILE e TR leves e baixas taxas de Nb, Ta, Ti e Zr, indicando que teriam sido gerados em ambiente de arco vulcânico. Análises U-Pb (zircão) em tonalito forneceram idade de cristalização de 2,16Ga, enquanto dados de Sm/Nd indicam idades modelo (\'T IND. DM\') da ordem de 2,34Ga (granodiorito) e 2,24Ga (tonalito), com valores positivos de \'\'épsilon\' IND. Nd\'(\'T IND. DM\'), +2,88 (granodiorito) e +3,02 (tonalito), permitindo interpretar que os protólitos desses granitóides foram diferenciados diretamente do manto, com pequena residência crustal, e estariam relacionados a arco juvenil Paleoproterozóico. A isócrona de referência Rb/Sr (rocha total) dos granitóides apontou uma razão inicial em torno de 0,702, indicando uma fonte mantélica (juvenil) para o magma gerador dessas rochas, corroborando os dados de geoquímica. A mineralização aurífera consiste em um sistema de veios de quartzo epigenéticos, enriquecidos em Au e As, controlado por uma zona de cisalhamento dúctil-rúptil. O sistema filoniano compreende três corpos principais, designados de Capa, Principal e Lapa, considerados como sendo veios de cisalhamento ou veios em falhas, tipificados por uma estrutura laminada ou em ribbon, a indicar episódios repetidos de fraturamentos e deposição mineral. A paragênese dos veios comporta 2 fases principais de mineralização: a Fase I, de maior deposição de quartzo, associada a processos de interação rocha-fluido, que provocou a sulfetação intensa na rocha tonalítica encaixante, e, predominantemente, em ribbons dentro dos veios, originando arsenopirita, lollingita, pirrotita e calcopirita, ressalvando-se que o ouro ocorre, principalmente, nos limites da arsenopirita e lollingita. Esta fase de mineralização se formou num intervalo de temperaturas, entre 400° e 565°C, estas calculadas por meio do geotermômetro arsenopirita. Datação Pb/Pb em cristais de arsenopirita desta Fase I forneceram uma isócrona Pb-Pb de referência de 2002 \'+ OU -\' 61 Ma e a composição isotópica sugere um reservatório crustal mais profundo para o Pb, entre as curvas, de evolução da crosta superior e de ambiente orogênico; a Fase II de mineralização constitui o episódio principal de deposição do ouro. Este ocorre sob a forma livre e associado à arsenopirita, pirita e galena e resultou de processos de remobilização, a partir de soluções aquosas de alta salinidade, atuantes ao longo da zona de cisalhamento. Os processos de alteração hidrotermal envolveram, principalmente, silicificação, sulfetação, saussuritização e cloritização da rocha tonalítica encaixante, desenvolvendo uma zona distal com pouca influência da mineralização, e uma zona proximal onde o balanço químico indica ganhos acentuados em As e Au, com pequena participação de MgO e CaO e perdas de \'Al IND. 2\'\'O IND. 3\', \'K IND. 2\'O e \'Na IND. 2\'O. Inclusões fluidas primárias, contendo soluções responsáveis pela Fase I de mineralização, não foram preservadas, tendo sido destruídas por vários episódios superpostos de deformação, responsáveis pela grande quantidade de planos de inclusões fluidas secundárias, observados nas amostras de quartzo. Uma solução aquosa complexa, contendo Ca \'+ OU -\' As(?), extremamente salina, aprisionada em inclusões fluidas, contidas em um conjunto de trilhas com direção entre N5° - 35°W, pode ter sido responsável pela remobilização e precipitação do ouro primário, durante a Fase II de mineralização. A recorrência de episódios de deformação com aporte e circulação de novos fluidos dentro da zona de cisalhamento, que hospeda o depósito de Salamangone, é demonstrada pela presença flagrante de soluções, essencialmente aquosas e com salinidades variadas, que indicam um amplo processo de mistura, envolvendo um fluido extremamente salino que evolui para termos com composições de salinas cada vez mais baixas. A origem dessas soluções pode, provavelmente, ser atribuída a uma mistura de salmouras profundas de natureza metamórfica, com fluidos hidatogênicos. Os dados isotópicos, disponíveis para a área de Lourenço e regiões vizinhas, na Guiana Francesa e Guiana, sugerem um modelo de evolução crustal geodinâmico, baseado no desenvolvimento de um arco magmático cálcio-alcalino, entre 2250 e 2000Ma. Este fato pode ser interpretado admitindo-se a subducção de uma litosfera oceânica, pré-colisão, entre massas continentais representadas, à época, pela Província Central Amazônica (Bloco Carajás-Iricoumé) e pelo Craton do Oeste Africano. Os períodos mais importantes de formação de depósitos de ouro orogênicos do Paleoproterozóico correlacionam-se, muito bem, com os episódios de crescimento da crosta continental juvenil, notando-se que os eventos de concentração de ouro se posicionam entre 2,1 e 1,8 Ga, incluindo a geração de importantes depósitos nos cratons do Oeste Africano e Amazônico e no Orógeno Trans-Hudsoniano (Goldfarb et al. 2001). Deste modo, Salamangone constituiria um depósito aurífero orogênico mesozonal, originado durante processos de deformações compressional a transpressional, em orógenos de acresção, associados à margem convergente Paleoproterozóica. / The Lourenço Au-District is located in the central portion of the State of Amapá, within the Maroni-Itacaiúnas Province, 2.2 - 1.95 Ga (Teixeira et al. 1989), of the Amazonian Craton. The Lourenço region is included within a Paleoproterozoic suite of high-grade partially migmatized metamorphic supracrustal rocks and calc-alkaline complexes. The Salamangone gold deposit lies within a calc-alkaline, metaluminous to slightly peraluminous tonalite to granodiorite pluton. It is characterized by high contents of incompatible trace elements and LREE, showing a geochemical signature of volcanic-arc granites. Zircons extracted from the tonalite were analyzed by the U-Pb method, and analytical points are plotted on a concordia diagram. The discordia calculated for 14 data points has an upper intersection at 2.16 \'+ OU -\' 0.13Ga, the inferred crystallization age of the tonalite, and a lower intercept 0.48 \'+ OU -\' 0.13Ga, respectively. The \'\'épsilon\' IND. Nd\' values were corrected using 2.16Ga age determined for the tonalite. The \'\'épsilon\' IND. Nd (2.16Ga)\' values vary from +2.88 to +3.02, which suggest that the magmatic source region was mainly a depleted mantle with little or no contamination from Archean crust. The low initial \'Sr ANTPOT. 87\'/\'Sr ANTPOT. 86\' ratios obtained for both contemporaneous granodiorite and tonalite vary from 0.702 to 0.703, in agreement with the Sm-Nd isotope data. The deposit, clearly related to the epigenetic style of mineralisation, mainly encompass tree ore bodies, named: Filão Principal, Filão Capa and Filão Lapa. A ductile-brittle shear zone striking N50°-60°W and dipping 55° to 70°NE controls all of these veins. The primary mineralisation consists of ribbon banded quartz veins enriched in Au and As, exhibiting relatively low enrichment of Ag, Pb, Cu, Bi. On the basis of the internal structure and texture, the veins can be classified as laminated. The alteration processes so far recognized are represented by silicification, sulphidation, saussuritization and chloritization of the host tonalite, producing a proximal alteration zone marked by enrichment in As and Au and a poorly mineralized distal zone. The textural and chronological relationships between the most common sulfide minerals, associated with the gold mineralisation, indicate a distinct paragenetic sequence, Stage I: arsenopyrite, pyrrotite, löllingite and chalcopyrite. Gold, located at grain boundaries between arsenopyrite and löllingite, is related to sulphidation hydrothermal processes. Temperatures yielded by the arsenopyrite thermometer are about 400 to 565°C. For directly date the ore minerals, age determinations were made on samples of arsenopyrite by stepwise leaching technique using Pb-Pb systematic. The analytical points define an isochron, which yield an age of 2002 \'+ OU -\' 61 Ma, consistent with the mineralisation stage I. The radiogenic Pb- Pb isotopic composition suggests a deep orogenic crustal source for the Pb. Stage II: arsenopyrite, pyrite and minor galena. It was the predominant period of gold deposition, which is related to remobilization processes. The primary stage I minerarization fluid inclusions are not at all preserved and recognized in the studied quartz samples, because they were destroyed by superposed episodes of deformation. However, abundant secondary aqueous healed fluid inclusions planes were observed. More complex N5°-35°W trending Ca \'+ OU -\' As (?) high salinity aqueous fluids, active during later stages of deformation within shear zone, are probably responsible for remobilization of gold from deeper levels, during stage II mineralization. The wide range of salinities recorded in the aqueous fluid inclusions might be referred to the mixture of high-salinity aqueous fluids with low-salinity fluids. These fluids were probably derived from a mixture of deep metamorphic brines with shallow meteoric waters of deep circulation. The isotopic data available for the Lourenço Au-District and neighboring regions in French Guiana and Guiana, strongly suggest a geodynamic crustal evolution model, based on the development of a calc-alkaline magmatic arc in the time interval (2.25-2.0 Ga). This can be explained by subduction of oceanic lithosphere in the beginning of the collision between two continental masses composed at that time by the Central Amazonian Province-Carajás-Iricoumé Block and the West African craton. The important periods of Archean and Paleoproterozoic orogenic gold-deposit formation correlate well with episodes of growth of juvenile continental crust, where the gold-forming events concentrated between 2.1 and 1.8 Ga, including deposition of the important ores, mainly, in the West Africa craton, Amazonian craton and Trans-Hudson orogen. In this way, the Salamangone gold deposit represents an orogenic mesozonal gold deposit, which was formed during compressional to transpressional deformation processes at Paleoproterozoic convergent plate margins in accretionary orogens.

Submitted by Caroline Xavier (caroline.xavier@pucrs.br) on 2017-12-15T13:19:36Z No. of bitstreams: 1 TES_TATIANA_GUTERRES_KAEHLER_COMPLETO.pdf: 2016956 bytes, checksum: b0fd61543fa1b3c26ae1a727287bfd0d (MD5) / Approved for entry into archive by Caroline Xavier (caroline.xavier@pucrs.br) on 2017-12-15T13:19:53Z (GMT) No. of bitstreams: 1 TES_TATIANA_GUTERRES_KAEHLER_COMPLETO.pdf: 2016956 bytes, checksum: b0fd61543fa1b3c26ae1a727287bfd0d (MD5) / Made available in DSpace on 2017-12-15T13:20:04Z (GMT). No. of bitstreams: 1 TES_TATIANA_GUTERRES_KAEHLER_COMPLETO.pdf: 2016956 bytes, checksum: b0fd61543fa1b3c26ae1a727287bfd0d (MD5) Previous issue date: 2017-06-30 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES / In bees, foraging flight can influence spatial characteristics of interactions in the community, which have consequences at ecosystem levels, such as nutrient transfer, seed dispersal and pollination. The pollination service performed by bees, in addition to influencing plant reproduction, positively affects about 90% of 107 global crops. One of the fundamental components for understanding populations persistence and interactions among species is the bees' foraging ranges, which can be determinant for population dynamics, genetic structure and life history. Considering this, the present work aims to analyze the foraging of Tetragonisca fiebrigi (Schwarz, 19838) using artificial feeders. In addition to determining the flight distance for the specie, the workers' space-time learning to the feeder is evaluated, the relation between the visitation rate and the quality of the food resources offered and the influence of the meteorological factors on the foraging. The experiments were carried out in the Botanical Garden of Porto Alegre, RS, Brazil, from December 2014 to April 2015 and from November to December 2016. To analyze bees? learning in relation to the feeder, during two days the resource was available at the entrance of the colony and the number of visiting workers was counted every 1 hour. Also, the influence of the meteorological factors in relation to the maximum distance reached by the workers was analyzed along with the relation to the visitation rate in the artificial feeder. In order to analyze the flight distance of the species, the feeder was arranged near the entrance of the hive and, from the bees? visitation, was moved every 30 min by 30m, 50m, 100m, 150m and so on until the maximum distance with foraging of workers. Five feeders containing sucrose solutions with different concentrations (10, 20, 30, 40, 50%) were simultaneously placed in front of each target colony to analyze the relationship between the quality of the resource and the visitation rate. These feeders were spaced apart at 10 m intervals and the number of visits counted at each distance for 30 min. The results showed that T. fiebrigi reached a forage distance of 600 m in the feeder. However, the number of visits decreased as the distance from the resource increased relatively to the colony. The sugar concentration in the syrup offered have influenced the workers? decision-making, that is, the quality of the resources was directly related to the visitation rate, since the workers increased visitation frequency at the highest concentrations, from 30 to 50%. At lower concentrations, 10 and 20%, the number of visits was lower and the workers stopped the foraging in a distance closer to the colony (80 m). Regarding the learning of the bees to locate the feeder, there was a visitation rate increase on subsequent days of availability of the resource. This study made it possible to relate visitation rate in relation to flight distance, meteorological factors and resource quality, enriching the understanding of the foraging pattern of T. friebrigi. Knowledge about the foraging of this species, as well as other bee species, allows inferences about migration, colonization, resource collection, pollination potential and the application of this information for management aimed at biodiversity conservation. In meliponiculture, this knowledge allows the spatial planning of the colonies according to the distribution and abundance of the resources present in the landscape. Similarly, knowledge about the foraging of bees is important in agriculture, due to the possibility of landscape planning, or even directed pollination, to increase the productivity of the crops dependent on those pollinators. / Nas abelhas o voo de forrageio pode influenciar as caracter?sticas espaciais das intera??es na comunidade, as quais t?m consequ?ncias em n?veis ecossist?micos, como na transfer?ncia de nutrientes, dispers?o de sementes e poliniza??o. O servi?o de poliniza??o efetuado pelas abelhas, al?m de influenciar na reprodu??o de plantas, afeta positivamente cerca de 90% de 107 culturas globais. Um dos componentes fundamentais para entender a persist?ncia de popula??es e as intera??es entre as esp?cies ? o raio de forrageio das abelhas, o qual pode ser determinante para a din?mica de popula??o, estrutura gen?tica e hist?ria de vida. Diante disto, o presente trabalho objetivou analisar o forrageio de Tetragonisca fiebrigi (Schwarz, 1938) utilizando alimentadores artificiais. Foi avaliado o aprendizado das oper?rias ao alimentador, a rela??o entre a taxa de visita??o e a qualidade dos recursos alimentares ofertados e a influ?ncia dos fatores meteorol?gicos no forrageio. Os experimentos foram realizados no Jardim Bot?nico de Porto Alegre, RS, Brasil, no per?odo de dezembro de 2014 a abril de 2015 e de novembro a dezembro de 2016. Para analisar o aprendizado das abelhas em rela??o ao alimentador, durante dois dias, o recurso era disponibilizado na entrada da col?nia e n?mero de visitas de oper?rias era contabilizado a cada hora. Tamb?m foi analisada influ?ncia dos fatores meteorol?gicos em rela??o a dist?ncia m?xima alcan?ada pelas oper?rias e ainda em rela??o a taxa de visita??o no alimentador artificial. Para analisar a dist?ncia de voo da esp?cie, o alimentador era disposto pr?ximo da entrada da colmeia e, a partir da visita??o de abelhas, era movido a cada 30 min em 30m, 50m, 100m, 150m e assim sucessivamente at? a dist?ncia m?xima com forrageamento de oper?rias. Para analisar a rela??o da qualidade do recurso com a taxa de visita??o foram dispostos, simultaneamente, em frente a cada col?nia alvo cinco alimentadores contendo solu??es de sacarose com diferentes concentra??es (10, 20, 30, 40, 50%). Estes alimentadores eram distanciados em intervalos de 10 m e o n?mero de visitas era contabilizado em cada dist?ncia por 30 min. Os resultados demonstraram que T. fiebrigi alcan?ou a dist?ncia de 600 m para forragear no alimentador. Entretanto, o n?mero de visitas diminuiu na medida que a dist?ncia do recurso aumentou em rela??o a col?nia. Com rela??o ao aprendizado das abelhas para localizar o alimentador verificou-se aumento da taxa de visita??o em dias subsequentes de disponibiliza??o do recurso. A concentra??o de a??car no xarope ofertado influenciou a tomada de decis?o das oper?rias, isto ?, a qualidade dos recursos teve rela??o direta com a taxa de visita??o, dado que as oper?rias aumentaram a frequ?ncia de visitas nas concentra??es mais elevadas, de 30 a 50%. Nas concentra??es inferiores, de 10 e 20%, o n?mero de visitas foi menor e as oper?rias cessaram o forrageamento em dist?ncia mais pr?xima da col?nia (80 m). Este estudo possibilitou relacionar a taxa de visita??o com rela??o a dist?ncia de voo, aos fatores meteorol?gicos e a qualidade dos recursos, enriquecendo a compreens?o sobre o padr?o de forrageio de T. friebrigi. O conhecimento sobre o forrageio desta, bem como de outras esp?cies de abelhas, permite infer?ncias sobre a migra??o, coloniza??o, coleta de recursos, potencial de poliniza??o e a aplica??o destas informa??es para o manejo dirigido ? conserva??o da biodiversidade. Na meliponicultura, esse conhecimento possibilita o planejamento espacial das col?nias de acordo com a distribui??o e abund?ncia dos recursos presentes na paisagem. De modo semelhante o conhecimento sobre o forrageamento das abelhas ? importante na agricultura, devido ? possibilidade de planejamento da paisagem, ou mesmo de poliniza??o dirigida, para o aumento da produtividade das culturas dependentes desses polinizadores.

Submitted by PPG Teologia (teologia-pg@pucrs.br) on 2018-06-25T13:54:58Z No. of bitstreams: 1 Mestrado - JOSU? DE ASEVEDO SOARES.pdf: 749863 bytes, checksum: f1a1d96aa3d3b08da1d8abfcf119a877 (MD5) / Approved for entry into archive by Sheila Dias (sheila.dias@pucrs.br) on 2018-06-29T14:48:15Z (GMT) No. of bitstreams: 1 Mestrado - JOSU? DE ASEVEDO SOARES.pdf: 749863 bytes, checksum: f1a1d96aa3d3b08da1d8abfcf119a877 (MD5) / Made available in DSpace on 2018-06-29T14:55:29Z (GMT). No. of bitstreams: 1 Mestrado - JOSU? DE ASEVEDO SOARES.pdf: 749863 bytes, checksum: f1a1d96aa3d3b08da1d8abfcf119a877 (MD5) Previous issue date: 2018-03-28 / CAPES / This dissertation reflects on the theme: ?And He also appeared to me?: Paul's vision of the resurrection after the encounter with Jesus on the road to Damascus. It will be sought to understand the importance of Jesus' resurrection in Paul's conversion and, at the same time, to understand how the resurrection of Jesus is at the center of Paul's preaching, his faith, his vision, and how he struck the New Testament Church to substantiate these questions, we go through a bibliographical analysis of the theories of biblical theologians and some theologians of systematic theology. / Esta disserta??o reflete sobre o tema: ?E Apareceu tamb?m a mim?: A vis?o de Paulo sobre a ressurrei??o, ap?s o encontro com Jesus no caminho de Damasco. Buscar-se-? compreender a import?ncia da ressurrei??o de Jesus na convers?o de Paulo, e, concomitantemente entender como a ressurrei??o de Jesus est? no centro da prega??o de Paulo, a sua f?, a sua vis?o e como atingiu a Igreja do Novo Testamento para fundamentar essas quest?es, percorremos atrav?s de uma an?lise bibliogr?fica o pensamento de te?logos da ?rea b?blica e alguns te?logos da teologia sistem?tica.

"In a wireless network environment, all the users are able to access the wireless channel. Thus, if malicious users exploit this feature by mimicking the characteristics of a normal user or even the central wireless access point (AP), they can intercept almost all the information through the network. This scenario is referred as a Man-in-the-middle (MITM) attack. In the MITM attack, the attackers usually set up a rogue AP to spoof the clients. In this thesis, we focus on the detection of MITM attacks in Wi-Fi networks. The thesis introduces the entire process of performing and detecting the MITM attack in two separate sections. The first section starts from creating a rogue AP by imitating the characteristics of the legitimate AP. Then a multi-point jamming attack is conducted to kidnap the clients and force them to connect to the rogue AP. Furthermore, the sniffer software is used to intercept the private information passing through the rogue AP. The second section focuses on the detection of MITM attacks from two aspects: jamming attacks detection and rogue AP detection. In order to enable the network to perform defensive strategies more effectively, distinguishing different types of jamming attacks is necessary. We begin by using signal strength consistency mechanism in order to detect jamming attacks. Then, based on the statistical data of packets send ratio (PSR) and packets delivery ratio (PDR) in different jamming situations, a model is built to further differentiate the jamming attacks. At the same time, we gather the received signal strength indication (RSSI) values from three monitor nodes which process the random RSSI values employing a sliding window algorithm. According to the mean and standard deviation curve of RSSI, we can detect if a rogue AP is present within the vicinity. All these proposed approaches, either attack or detection, have been validated via computer simulations and experimental hardware implementations including Backtrack 5 Tools and MATLAB software suite. "

The Notch signalling pathway plays an essential role in cell-fate decisions and morphogenesis, and is frequently ectopically activated in human cancers. The signal is initiated through DSL ligand-dependent Notch proteolysis, which releases its intracellular domain. However, over-expression of the E3 ubiquitin ligase Deltex can bypass the requirement for Notch ligands and ectopically activate Notch by directing it into the endocytic pathway. It has been shown that Deltex induced endocytic-Notch signalling, but not DSL-induced signalling, requires both HOPS and AP-3 complex components that mediate trafficking to lysosomes and related organelles. I showed through a combination of the analysis of the dxsm mutant allele and by expression of mutant forms of Deltex in cell culture, that the C-terminal region of Deltex is important for Notch signalling, but is not required for Notch endocytosis. This suggests that the C-terminal region contains an interaction site that may direct endocytosed Notch to the correct endocytic compartment. A key question however was whether this endocytic pathway is utilised for full Notch signaling in normal development alongside the canonical activation mechanism. I therefore investigated the expression of Drosophila midline single-minded (sim), which is a Notch signal reporter gene, and embryonic neurogenesis which is repressed by Notch signalling. I found that deltex, HOPS and AP-3 mutants displayed gaps in sim expression and also a neurogenic phenotype similar to Notch loss-of-function, and consistent with a role for ligand-independent Notch activation in normal development. I found that the penetrance of these phenotypes increased when flies were cultured at higher temperature. These results suggest that Dx/HOPS/AP-3-dependent Notch activation provides a developmental robustness to the Notch signalling network. It was also found that AP-3 and HOPS components have an additional role in regulating cell survival, which is partially separable in time using a temperature shift assay. I also revealed a requirement of maternal Notch for cell survival in early embryonic development, which may be related to the HOPS-dependent function. Comparison of deltex, AP-3 and HOPS mutant phenotypes suggested that there may be functional redundancy of deltex with components that regulate Notch endocytosis, and of AP-3 with proteins that mediate subsequent trafficking to the late endosome/lysosome. Finally I characterised the molecular lesions of an allele of the HOPS component light and the AP-3 component ruby and identified lesions which were consistent with the loss-of-function of these genes.

Made available in DSpace on 2011-03-23T21:19:46Z (GMT). No. of bitstreams: 0 / Item created via OAI harvest from source: http://www.bdtd.ufpa.br/tde_oai/oai2.php on 2011-03-23T21:19:46Z (GMT). Item's OAI Record identifier: oai:bdtd.ufpa.br:373 / This research work analizes tourism in the Cabo Orange National Park surrounding areas, in the State of Amapá, Brazil. A qualitative approach was used in order to understand the reality of two resident communities around the area: Vila Velha do Cassiporé and Vila Cunani, aiming at capturing their perception about tourism and assessing the role of the main governmental and non-governmental institutions which have tried to implement development policies for the National Park. Public Policies regarding the surrounding areas of the National Park were found to be incipient and a fragmentation of those two communities social tissue was noticed. Besides that, natural, historical and cultural potentialities were perceived, and yet there are no work projects contemplating such features. It is concluded, thefore, that limitations are greater than tourism development possibilities around the Cabo Orange National Park. Related institutions and the resident communities must exercise their participation rights in order to guarantee sustainability for tourism initiatives, making sure that they bring social inclusion and development, ensuring, at the same time, the conservation of natural and cultural resources in this environmental unit located in the State of Amapá. / Este trabalho de pesquisa analisou o turismo no entorno do Parque Nacional do Cabo Orange, no estado do Amapá. Para isso, utilizou-se de um enfoque qualitativo para compreender a realidade das duas comunidades residentes nesse entorno, Vila Velha do Cassiporé e Vila Cunani e suas percepções acerca de turismo, bem como entender o papel das principais instituições governamentais e não-governamentais que tentam implementar políticas de desenvolvimento nesse Parque Nacional. Diante disso, verificou-se que as políticas públicas direcionadas para o entorno dessa unidade de conservação ainda são incipientes, assim como há uma visível fragmentação do tecido social dessas duas comunidades tradicionais residentes. Ademais, percebeu-se que existem potencialidades naturais, históricas e culturais que podem ser trabalhadas no fomento de produtos turísticos, entretanto, ainda não há um trabalho voltado para tal fim. Portanto, concluiu-se que os limites são maiores do que as possibilidades no desenvolvimento do turismo nesse entorno do Parque Nacional do Cabo Orange. Dessa maneira, cabe às instituições competentes e comunidades residentes desse entorno exercitarem a participação como garantia de sustentabilidade para que o turismo possa a vir a ser uma possibilidade de inclusão social, desenvolvimento e indutor de conservação dos recursos naturais e culturais dessa unidade de conservação de uso integral no norte do estado do Amapá.

Klimatkrisen är ett faktum. Sverige har, genom egna initiativ och internationella konventioner, gjort åtaganden mot att bli ett fossilfritt land med delmålet att minska utsläpp av koldioxid med minst 60 procent fram till 2030, för att ge kommande generationer och pensionärer möjligheten till en hållbar framtid. Samtidigt investeras miljardbelopp, genom svenska pensionsmyndigheter, i de allra smutsigaste fossila bolagen som genom sin verksamhet är en stor del av orsaken till den globala uppvärmningen. Att våra gemensamma pensionsmedel som ska säkra framtida pensioner är med och finansierar klimatkrisen är en paradox. Undersökningen syftar till att ta reda på vilka eventuella målkonflikter som finns i AP-fondernas uppdrag, hur de ser ut samt hur de använder sig av kommunikationsstrategier för att legitimera investeringar i fossila bolag. För att förstå och analysera fallet används framförallt legitimitetsteorin och intressentteorin, vilka bygger på det nyinstitutionella perspektivet. Metoden som används är en kvalitativ innehållsanalys av årsredovisningar och hållbarhetsrapporter samt observationer under en hållbarhetspresentation och paneldebatt arrangerad av AP-fonderna. Resultatet pekar på att det finns en betydande målkonflikt mellan uppdraget att förränta kapital, med hänsyn till etik och miljö, och investeringar i fossila bolag. I analys och slutsats diskuteras vilka kommunikationsstrategier, motiv och metoder som används för att legitimera agerandet. Huvudstrategin för att behålla legitimitet är att argumentera för, samt påvisa, möjligheter till påverkan genom aktiv ägardialog genom att driva, eller åtminstone påstå att man driver, hållbarhetsfrågor framgångsrikt. AP-fonderna och Etikrådet verkar systematiskt använda CSR- arbete och olika kommunikationsstrategier för att behålla legitimitet och resultatet pekar på att greenwashing används för att legitimera investeringar och finansiering av fossila bolag.

This study investigates the effects of implementing a remediation program in a high school Advanced Placement Calculus AB course on student class grades and success in passing the AP Calculus AB exam. A voluntary remediation program was designed to help students understand the key concepts and big ideas in beginning Calculus. Over a period of eight years the program was put into practice and data on student participation and achievement was collected. Students who participated in this program were given individualized recitation activities targeting their specific misunderstandings, and then given an opportunity to retest on chapter exams that they had taken prior to remediation. Students were able to improve their scores on the original chapter exams and their grade in the class by demonstrating a greater understanding of the material after participating in the remediation sessions. This process was repeated for all chapter exams given during the academic year. In this study, a data analysis comparing the percent gain, after remediation, in each student’s overall class grade to their AP Calculus AB exam scores was conducted. Additionally, AP Calculus AB exam scores of students enrolled in these classes were compared to AP Calculus AB exam scores globally both pre and post implementation of the remediation program. The results of this study demonstrate that there is a substantial positive correlation between student participation in the remediation program and greater success on the AP Calculus AB exam. The average AP Calculus AB score for the students enrolled in AP Calculus AB during the eight-year period of implementing the remediation program increased by over 9%.