Global ETD Search

101	The Transient Receptor Potential Canonical 3 (TRPC3) Channel: Novel Role in Endothelial Cell Apoptosis and its Impact on Atherosclerosis Ampem, Prince Tuffour 03 October 2017 (has links) No description available. Biomedical Research TRPC3 ER stress Unfolded protein response apoptosis Endothelial cells Atherosclerosis Calcium influx CAMKII STAT1 JNK Coronary artery disease lesion Thapsigargin Tunicamycin Pyr10 Apoe knockout transgenic mouse
102	Proteomic Analysis of Urinary Bladder Cancer : Aiming for Novel Biomarkers Lindén, Mårten January 2013 (has links) Urinary bladder cancer is a heterogeneous disease appearing in different forms, e.g. non-muscle invasive and muscle invasive. For all variants, the expression of proteins is interesting to analyze for diagnostic, predictive, prognostic and drug targeting purposes, since it reflects the altered gene expression causing the cancer. Since urothelial cells of the bladder are in direct contact with urine it is likely that this body fluid contains cancer-related proteins. In Paper I, unbiased analysis of proteins in urine from urinary bladder cancer patients and controls, using label-free quantification by mass spectrometry, was applied and four interesting proteins APOE, FGB, LRG and SERPINA1 were selected and further analyzed with western and dot blot. In Paper II, two more proteins, POLR1E and TOP2A, were validated as relevant proteins in bladder cancer urine. In Paper III and IV, the proteins GAL1 and STMN1 were investigated for their prognostic and therapeutic target potential in bladder cancer. In Paper II, III and IV, the expression of seven of the proteins were analyzed on tissue microarrays representing tumour tissue from 360 patients with different tumour stages. For the proteins identified by the urine screening approach, their protein expressions were confirmed in bladder cancer tissue. The expression level in tissue of five of the proteins, APOE, FGB, POLR1E (Paper II), GAL1 (Paper III) and STMN1 (Paper IV), increased with tumour stage, showing diagnostic relevance and three of the proteins, SERPINA1 (Paper II), STMN1 (Paper IV) and GAL1 (Paper III) had prognostic potential in urinary bladder cancer. In addition, GAL1 and STMN1 were demonstrated to be highly expressed in metastatic disease and inhibition of STMN1 reduced cell growth (Paper III and IV), indicating that these proteins are promising drug targets in urinary bladder cancer. In conclusion, the approach of this thesis has generated several candidate protein biomarkers in urine and tissue, validated with independent methods, which have the potential to improve the care for bladder cancer patients. urine APOE FGB GAL1 LRG1 POLR1E SERPINA1 STMN1 TOP2A biomarker diagnostic biomarker prognostic biomarker predictive biomarker mass spectrometry western blot dot blot immunohistochemistry IHC tissue microarray TMA urothelium antibody antibody-based urinblåsecancer biomarkör diagnos prognos urin proteomik masspektrometri immunohistokemi antikroppar
103	Genetische Suszeptibiliätstestung für sporadische Alzheimer-Demenz: Analyse medizinethischer Probleme im Spannungsfeld von Autonomie und Verantwortung / Genetic susceptibility testing for Alzheimer's disease: Analysis of biotehical issues Kogel, Friederike 20 June 2018 (has links) No description available. 610 late-onset Alzheimer’s dementia APOE genetic susceptibility testing Direct-to-consumer genetic testing medical ethics responsibility autonomy right to know clinical utility Medizin (PPN619874732)
104	Bridging the Gaps: Characterizing Alzheimer's Disease in Native Hawaiian and Pacific Islander Populations Tavana, Justina P. 15 December 2023 (has links) (PDF) This dissertation addresses critical gaps in dementia research in Native Hawaiian and Pacific Islander (NHPI) communities. Focusing on Samoan and Tongan communities, the study successfully adapted and validated the AD8 informant interview and the Clinical Dementia Rating (CDR) scale in native languages, establishing these instruments as reliable tools for detecting cognitive impairment in these populations. The research process prioritized meaningful community engagement and forged partnerships with indigenous professionals, ensuring alignment with and responsiveness to the specific needs of the community. These invaluable connections were the foundation of making this difficult work possible. Subjects assessed with these adapted instruments were enrolled in the largest NHPI dementia study to date. Evaluation of this cohort led to new Insights into dementia prevalence and potential risk factors among NHPIs including assessment of APOE isoform frequencies and other genetic data. The ɛ4 allele was found to be much more frequent in NHPIs than in other ethnic groups, and does not appear to show association with dementia risk. NHPI Early-onset Alzheimer's disease families were also studied using whole genome sequence data, setting a foundation for future genetic studies. Future efforts should focus on disseminating these adapted tools, expanding genetic studies across diverse NHPI sub-populations, and conducting longitudinal studies to track cognitive changes. Collaborations between clinical, scientific, and cultural experts are encouraged for comprehensive, culturally-sensitive research strategies. In summary, this dissertation serves as a bridge between current Alzheimer's research and a promising future for new efforts in NHPI populations. It also creates a roadmap for adapting other clinical and research instruments into new languages and cultures. Through linguistic adaptations, genetic insights, and epidemiological investigations, it demonstrates a more precise, culturally relevant approach to Alzheimer's research that can significantly impact healthcare practices and the overall well-being of NHPI communities. Alzheimer's disease Early-onset Alzheimer's disease Native Hawaiian and Pacific Islander cognitive health dementia AD8 Clinical Dementia Rating scale cognitive impairment APOE linguistic and cultural adaptations cognitive assessment tools Life Sciences
105	Electromagnetic field and neurological disorders Alzheimer´s disease, why the problem is difficult and how to solve it Lyttkens, Peter January 2018 (has links) No description available. Alzheimer oxidative stress EMF microwave VGCC ACh protein refolding APOE big data FINGER wifi DECT AChE DNA-damage mobile phone glucose metabolism demyelinating antioxidant defence defective proteins non thermal effects Alzheimer risk pathophysiology mechanism amyloid pathologies multifactor strategy diet exercise cognitive training vascular risk management exposure sleep disturbance circadian dysfunction neuropsychiatric symptom risk assessments Neurosciences Neurovetenskaper

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