Yes / Widespread generation and analysis of omics data have revolutionized molecular medicine on Earth, yet its power to yield new mechanistic insights and improve occupational health during spaceflight is still to be fully realized in humans. Nevertheless, rapid technological advancements and ever-regular spaceflight programs mean that longitudinal, standardized, and cost-effective collection of human space omics data are firmly within reach. Here, we consider the practicality and scientific return of different sampling methods and omic types in the context of human spaceflight. We also appraise ethical and legal considerations pertinent to omics data derived from European astronauts and spaceflight participants (SFPs). Ultimately, we propose that a routine omics collection program in spaceflight and analog environments presents a golden opportunity. Unlocking this bright future of artificial intelligence (AI)-driven analyses and personalized medicine approaches will require further investigation into best practices, including policy design and standardization of omics data, metadata, and sampling methods. / H.C., R.H., J.B., D.B., S.G., T.E., and N.J.S. are members of the ESA Space Omics Topical Team, funded by the ESA grant/contract 4000131202/20/NL/PG/pt “Space Omics: Towards an integrated ESA/NASA –omics database for spaceflight and ground facilities experiments” awarded to R.H., which was the main funding source for this work. H.C. is also supported by the Horizon Center for Doctoral Training at the University of Nottingham (UKRI grant no. EP/S023305/1). S.G. is supported by the Swedish Research Council VR grant 2020-04864. L.A.R. and M.M. represent the Omics Subgroup of the Japan Society for the Promotion of Science KAKENHI funding group “Living in Space” and are supported by JP15K21745, JP20H03234, and 20F20382. L.A.R. is also supported by the JSPS postdoctoral fellowship P20382. We thank Dr. Sarah Castro-Wallace, the NASA GeneLab Animal AWG, ISSOP, ESA Space Omics Topical Team, ESA Personalized Medicine Topical Team, and Global Alliance for Genomic Health (GA4GH) for useful discussions.

Doctor of Philosophy / Department of Electrical and Computer Engineering / William B. Kuhn / Balasubramaniam Natarajan / Wireless body area networks (WBANs) are an important part of the developing internet of things (IOT). NASA currently uses space suits with wired sensors to collect limited biomedical data. Continuous monitoring and collecting more extensive body vital signs is important to assess astronaut health. This dissertation investigates wireless biomedical sensor systems that can be easily incorporated into future space suits to enable real time astronaut health monitoring. The focus of the work is on the radio-wave channel and associated antennas. We show that the space suit forms a unique propagation environment where the outer layers of the suit’s thermal micrometeoroid garment are largely radio opaque. This environment can be modeled as a coaxial one in which the body itself plays the role of the coax center conductor while the space suit shielding materials play the role of the outer shield. This model is then validated through simulations and experiments. Selecting the best frequency of operation is a complex mixture of requirements, including frequency allocations, attenuation in propagation, and antenna size. We investigate the propagation characteristics for various frequency bands from 315 MHz to 5.2 GHz. Signal attenuation is analyzed as a function of frequency for various communication pathways through 3D simulations and laboratory experiments. Small-scale radio channel results indicate that using lower frequency results in minimal path loss. On the other hand, measurements conducted on a full-scale model suggest that 433 MHz and 2400 MHz yield acceptable path loss values. Propagation between the left wrist and left ankle yielded the worst overall path loss, but signals were still above –100 dBm in raw measurements for a 0dBm transmission indicating that the intra-suit environment is conducive to wireless propagation. Our findings suggest that the UHF bands are best candidate bands since there is interplay between the body conductivity favoring lower frequencies, and the difficulty of coupling RF energy into and out of the channel using suitably sized antennas favoring higher frequencies. Finally, a new self-shielded folded bow-tie antenna is proposed that can be a promising choice for the general area of WBAN technologies as well as potential new space suit environments.

During an extravehicular activity (EVA), the role of an astronaut involves a multitude of complex tasks. Whether that task is a science experiment aboard the International Space Station, or traversing extraterrestrial terrain – attention, communication, and instruction are essential. As an aid, augmented reality (AR) can portray suit informatics and procedures within line-of-sight while minimizing attentional loss. Currently, there exists little research highlighting the human systems considerations to qualify AR systems for space suit applications. This study quantifies user interface (UI) and human performance measures for an AR prototype on the Mark III space suit. For user testing, 21 military pilots and personnel (11 men, 10 women) evaluated UI search tasks and completed a series of AR-instructed EVA dexterity tasks in an elevated luminosity, background clutter, and workload scenario. UI results suggest correlations for readability and usability; whereas, human performance results provide situational awareness, workload, and task performance data.

To leave Earth’s gravity well and ascend into Cislunar space takes ingenuity, and the engineering feats of many. Now to propel humanity further into space, rockets will need assistance to provide the large requirements of mass to be used for space structures. Tsiolkovsky’s Rocket Equation greatly limits the advantages of rockets and leaves an opening for Space Elevators to assist in a dual space access approach. By moving a large amount of mass routinely, efficiently, environmentally friendly and with daily launches towards space. Along with the apex anchor situated at 100,000 km for emergency assistance across all Cislunar space, and to act as both storage facilities and a construction zone. Space Elevators are the railway to space and can supplement rockets by transforming how mass is transported to Cislunar space and beyond. / Att lämna jordens gravitationsbrunn och stiga upp i Cislunar-rymden kräver uppfinningsrikedom och mångas ingenjörsprestationer. För att nu driva mänskligheten längre ut i rymden kommer raketer att behöva hjälp för att tillhandahålla de stora kraven på massa som ska användas för rymdstrukturer. Tsiolkovskys raketekvation begränsar i hög grad fördelarna med raketer och lämnar en öppning för rymdhissar för att hjälpa till med en dubbel rymdtillgång. Rymdhissar kan att flytta en stor mängd massa rutinmässigt, effektivt, miljövänligt och med dagliga uppskjutningar mot rymden. Apex-ankaret som ligger på 100 000 km kan fungera för nödhjälp över hela Cislunar-utrymmet och som både lagringsutrymmen och en konstruktionszon. Rymdhissar är järnvägen till rymden och kan komplettera raketer genom transformation hur massa transporteras till Cislunar rymden och bortom.

Musculoskeletal disorders, specifically low back pain, has been well documented andreported by astronauts throughout the space exploration era. Statistics from astronautmemoirs states that 52-68% of astronauts experience moderate to severe lower backpain after prolonged spaceflights. The main cause is atrophy in the paraspinal musclesof the lumbar region. No sufficient countermeasure exists in-flight currently and therehabilitation programs remain ineffective. This thesis presents the first attempt to designand develop a prototype robotic exoskeleton, actuated by pneumatic artificial muscles, asan active countermeasure in-flight where it will be utilised as an equipment for muscularhypertrophy and a supporting device for rehabilitation programs on Earth. It will bemanufactured by additive manufacturing methods for adaptability while remaining lowin weight.A thorough analysis of the spine and lumbar region as a biomechanical system wasmade. Appropriate assumptions was made to simplify the understanding of the complexsystem that is the human spine. The targeted muscles were: multifidus, erector spinaeiliocostalis and erector spinae longissimus. A force analysis of the human torso bendingin the sagittal plane was made, finding that the torques of the torso reaches 244 Nm.The complete exoskeleton design is presented with the parts that will be 3D-printed andthe working principle of the system. Thereafter an extensive model of the exoskeletonis established using Denavit-Hartenberg representation of manipulators as a serial linksystem. The model provides a fundamental understanding of exoskeleton and enablesthe possibility to simulate it accurately. The evaluation protocol for the validation testsis then presented. Active pressure will be tested at 0, 3 and 6 bar and loads of 5 and 11kg will be lifted.Subsequently the assembly, with all the hardware and software selected for the prototypeis demonstrated. Thereafter the results of the evaluation tests are presented followed bya discussion of the results; anomalies, faults and challenges are subjects discussed. Thediscussion concludes that the exoskeleton shows potential for both supporting the motionin a rehabilitation use and enabling muscular hypertrophy in the lumbar region for theresistive tests. Although an extensive heavy-duty evaluation needs to be performed totruly validate the exoskeleton.

The International Space Station utilizes many different forms of written and verbal communication between the flight crews and ground control personnel. This study analyzes the historical use of three regular communication methods, Daily Planning Conferences, Weekly Planning Conferences and written Daily Summaries, as well as specific, science and internal maintenance events for characteristics and perceived effectiveness across eight expeditions (4 ? 11). The results are recommendations for the continued use of, or substitution for, these methods for future long-duration human space missions, specifically to the Moon and to Mars. General conclusions are that most of the conference content could have been relayed through written/electronic methods, and that the Daily Summaries are considered succinct and effective as a communication cornerstone. Conclusions formed from the study of individual events involved the importance of well-written crew procedures, the effective stowage and retrieval of necessary materials and the selection of well-defined science experiments.

The PhD thesis "Russian Speaking Students (from Russia and Kazakhstan) in the Czech Republic: Educational Migration and the Role of the Family in it", examines the life of Russian speaking students, who come to the Czech Republic to obtain a university degree. It tries to answer several research questions. How is the decision taken to come to the Czech Republic? What kind of role does family play in the decision-making process and in further intentions/plans in the Czech Republic? What are the migration strategies of Russian speaking students in the Czech Republic? How do these strategies change over time? What connections exist between the life cycle of the student and the migration process? This is an anthropological, multisite field research, with participant observation being the core research method. As of 2015, 55 student research participants participated in the research (41 from Russia and 14 from Kazakhstan), with whom formal and informal interviews were made. Transnationalism and migration system theory have been used as theoretical concepts so as to better understand the student migration process.

The PhD thesis "Russian Speaking Students (from Russia and Kazakhstan) in the Czech Republic: Educational Migration and the Role of the Family in it", examines the life of Russian speaking students, who come to the Czech Republic to obtain a university degree. It tries to answer several research questions. How is the decision taken to come to the Czech Republic? What kind of role does family play in the decision-making process and in further intentions/plans in the Czech Republic? What are the migration strategies of Russian speaking students in the Czech Republic? How do these strategies change over time? What connections exist between the life cycle of the student and the migration process? This is an anthropological, multisite field research, with participant observation being the core research method. As of 2015, 55 student research participants participated in the research (41 from Russia and 14 from Kazakhstan), with whom formal and informal interviews were made. Transnationalism and migration system theory have been used as theoretical concepts so as to better understand the student migration process.