Les charges réelles d'applications sont souvent dynamiques. Ainsi, le dimensionnement statique de ressources est voué soit au gaspillage, s'il est basé sur une estimation du pire scénario, soit à la dégradation de performance, s'il est basé sur la charge moyenne. Grâce au modèle du cloud computing, les ressources peuvent être allouées à la demande et le dimensionnement adapté à la variation de la charge. Cependant, après avoir exploré les travaux existants, nous avons trouvé que la plupart des outils d'élasticité sont trop génériques et ne parviennent pas à répondre aux besoins spécifiques d'applications particulières. Dans le cadre de ce travail, nous utilisons des boucles autonomiques et diverses techniques d'élasticité afin de rendre élastiques différents types d'applications, à savoir un service de consolidation, un intergiciel de messagerie et une plateforme de traitement de données en temps-réel. Ces solutions élastiques ont été réalisées à partir d'applications libres et leur évaluation montre qu'ils permettent d'économiser les ressources utilisées avec un surcoût minimal. / Real world workloads are often dynamic. This makes the static scaling of resourcesfatally result in either the waste of resources, if it is based on the estimatedworst case scenario, or the degradation of performance if it is based on the averageworkload. Thanks to the cloud computing model, resources can be provisioned ondemand and scaling can be adapted to the variations of the workload thus achievingelasticity. However, after exploring the existing works, we find that most elasticityframeworks are too generic and fail to meet the specific needs of particularapplications. In this work, we use autonomic loops along with various elasticitytechniques in order to render different types of applications elastic, namelya consolidation service, message-oriented middleware and a stream processingplatform. These elastic solutions have been implemented based on open-sourceapplications and their evaluation shows that they enable resources’ economy withminimal overhead.

Hostile sexism is the antipathetic expression of sexism, in which men are antagonistic towards women who threaten their superiority. Benevolent sexism is the patriarchal expression of sexism, where men express protective, yet restrictive, attitudes towards women. Both forms of sexism originate from the view that women are inferior, frail, and only suited for nurturing or domestic responsibilities. Benevolent sexism may be more harmful to women because coping is thwarted by observers' underestimation of its effects (Bosson, Pinel, & Vandello, 2009). The present study aimed to examine women's responses to and recovery from hostile and benevolent sexism utilizing measures of cardiovascular reactivity and recovery. I predicted that women would exhibit greater reactivity to hostile sexism, but impaired recovery to benevolent sexism. Participants were 124 undergraduate women (50% Caucasian, age M = 18.92), with no history of cardiovascular health issues. Sexism condition - benevolent, hostile, or no sexism - was manipulated by exposing participants to comments made by a male experimenter. Cardiovascular responses were obtained during rest, task, and recovery periods. As predicted, women exhibited greater cardiovascular reactivity after exposure to hostile sexism, and women who experienced benevolent sexism showed impaired recovery, compared to the other two conditions. Findings illustrate that hostile sexism elicits immediate responses that resolve relatively quickly. However, benevolent sexism may be more pernicious in terms of psychological and physical health due to its prolonged effects.

Cloud Computing is emerging as a new paradigm that aims at delivering computing as a utility. For the cloud computing paradigm to be fully adopted and effectively used it is critical that the security mechanisms are robust and resilient to malicious faults and attacks. Securing cloud is a challenging research problem because it suffers from current cybersecurity problems in computer networks and data centers and additional complexity introduced by virtualizations, multi-tenant occupancy, remote storage, and cloud management. It is widely accepted that we cannot build software and computing systems that are free from vulnerabilities and that cannot be penetrated or attacked. Furthermore, it is widely accepted that cyber resilient techniques are the most promising solutions to mitigate cyberattacks and change the game to advantage defender over attacker. Moving Target Defense (MTD) has been proposed as a mechanism to make it extremely challenging for an attacker to exploit existing vulnerabilities by varying different aspects of the execution environment. By continuously changing the environment (e.g. Programming language, Operating System, etc.) we can reduce the attack surface and consequently, the attackers will have very limited time to figure out current execution environment and vulnerabilities to be exploited. In this dissertation, we present a methodology to develop an Autonomic Resilient Cloud Management (ARCM) based on MTD and autonomic computing. The proposed research will utilize the following capabilities: Software Behavior Obfuscation (SBO), replication, diversity, and Autonomic Management (AM). SBO employs spatiotemporal behavior hiding or encryption and MTD to make software components change their implementation versions and resources randomly to avoid exploitations and penetrations. Diversity and random execution is achieved by using AM that will randomly "hot" shuffling multiple functionally-equivalent, behaviorally-different software versions at runtime (e.g., the software task can have multiple versions implemented in a different language and/or run on a different platform). The execution environment encryption will make it extremely difficult for an attack to disrupt normal operations of cloud. In this work, we evaluated the performance overhead and effectiveness of the proposed ARCM approach to secure and protect a wide range of cloud applications such as MapReduce and scientific and engineering applications.

The power consumption of data centers and cloud systems has increased almost three times between 2007 and 2012. The traditional resource allocation methods are typically designed for high performance as the primary objective to support peak resource requirements. However, it is shown that server utilization is between 12% and 18%, while the power consumption is close to those at peak loads. Hence, there is a pressing need for devising sophisticated resource management approaches. State of the art dynamic resource management schemes typically rely on only a single resource such as core number, core speed, memory, disk, and network. There is a lack of fundamental research on methods addressing dynamic management of multiple resources and properties with the objective of allocating just enough resources for each workload to meet quality of service requirements while optimizing for power consumption. The main focus of this dissertation is to simultaneously manage power and performance for large cloud systems. The objective of this research is to develop a framework of performance and power management and investigate a general methodology for an integrated autonomic cloud management. In this dissertation, we developed an autonomic management framework based on a novel data structure, AppFlow, used for modeling current and near-term future cloud application behavior. We have developed the following capabilities for the performance and power management of the cloud computing systems: 1) online modeling and characterizing the cloud application behavior and resource requirements; 2) predicting the application behavior to proactively optimize its operations at runtime; 3) a holistic optimization methodology for performance and power using number of cores, CPU frequency, and memory amount; and 4) an autonomic cloud management to support the dynamic change in VM configurations at runtime to simultaneously optimize multiple objectives including performance, power, availability, etc. We validated our approach using RUBiS benchmark (emulating eBay), on an IBM HS22 blade server. Our experimental results showed that our approach can lead to a significant reduction in power consumption upto 87% when compared to the static resource allocation strategy, 72% when compared to adaptive frequency scaling strategy, and 66% when compared to a multi-resource management strategy.

Quatre microélectrodes ont été insérées dans le ganglion stellaire gauche (GS) de préparations canines in vivo pour évaluer la décharge des potentiels d’action dans les neurones situés dans ce ganglion périphérique durant un état cardiovasculaire stable et suivant des injections systémiques et locales de nicotine. Durant les périodes de contrôle, des changements mineurs ont été observés dans la pression artérielle systolique, dans le rythme cardiaque et dans le temps de conduction atrio-ventriculaire. L’activité générée par les neurones du GS est demeurée relativement constante à l’intérieure de chaque chien, mais variait entre les préparations. L’administration de nicotine systémique a altéré les variables physiologiques et augmenté l’activité neuronale. Même si différents changements au niveau des variables physiologiques ont été observés entre les animaux, ces changements demeuraient relativement constants pour un même animal. La dynamique de la réponse neuronale était similaire, mais l’amplitude et la durée variaient entre et au sein des chiens. L’injection de nicotine dans une artère à proximité du GS a provoqué une augmentation marquée des potentiels d’action sans faire changer les variables physiologiques. La technique d’enregistrement permet donc de suivre le comportement de multiples populations de neurones intrathoraciques situés dans le GS. La relation entre l’activation neuronale du GS et les changements physiologiques sont stables pour chaque chien, mais varient entre les animaux. Cela suggère que le poids relatif des boucles de rétroaction impliquées dans la régulation cardiovasculaire peut être une caractéristique propre à chaque animal. / Four micro-electrodes were inserted in the left stellate ganglion (SG) of in vivo canine preparations to evaluate the firing of neuronal somata located in this peripheral ganglion during stable cardiovascular state and following local and systemic injection of nicotine. During control periods, minor changes were observed in systolic arterial pressure, the heart rhythm and the atrioventricular conduction time. The activity generated by SG neurons remained relatively constant within each dog, but the firing rate was variable among the preparations. Systemic nicotine administration altered the physiological variables and increased the neuronal activity. Although different patterns of physiological changes were observed among the preparations, it remained invariant upon successive injections in each animal. The behaviour of the neuronal response was similar but varies in amplitude and duration both within and between the dogs. Local injections of nicotine in an artery close to the SG induced a brief and huge burst of neuronal firing, but did not influence the physiological response. The recording technique thus permit to follow the behaviour of multiple intrathoracic neuronal populations located in the SG. The relation between the SG firing and the physiological changes is stable in each dog, but differed between the animals. It suggests that the weight of the different feedback loops involved in the cardiovascular regulation might be a characteristic feature of each animal and/or the position of the electrodes in the SG is critical, since different neuronal populations are present and could react differently.

Intrakardinė nervų sistema atlieka svarbų vaidmenį reguliuodama širdies ritmą, miokardo laidumą ir susitraukimo jėgą bei vainikinių arterijų tonusą. Neišnešiotų kūdikių intrakardinės inervacijos topografija yra svarbi, atliekant perkateterinę radijodažninę abliaciją, taikomą medikamentiniam gydimui rezistentiškų supraventrikulinių bei atrioventrikulinių reciprokinių tachikardijų atvejais. Tyrėjų duomenys, apie mazgų topografiją bei struktūrinę organizaciją, yra gana skirtingi ir, kad žmogaus vaisių širdies intrakardinis nervinis rezginys iš tiesų nėra pakankamai ištirtas. Todėl darbo tikslas buvo ištirti žmogaus epikardinių nervinių mazgų topografiją ir morfologij�� įvairaus amžiaus vaisių širdyse. Disertacinio darbo rezultatai rodo, kad (1) žmogaus epikardiniai nerviniai mazgai yra lokalizuoti definityvinėse vietose jau penkiolikos savaičių vaisiaus širdyje; (2) epikardinių mazgų skaičius ir pasklidimas žmogaus 15-40 savaičių vaisiuose nėra susijęs su amžiumi; (3) epikardinių nervinių subrezginių mazgų laukų topografija yra pastovi tirtose vaisių širdyse; (4) epikardinių nervinių subrezginių mazgų laukų struktūra – ganglijų skaičius ir jų sritinė lokalizacija yra individualiai kintantys; (5) epikardinių mazgų ir mazginių neuronų dydis, o taip pat mazgų forma bei tarpmazginių nervų skaičius yra susiję su vaisių amžiumi. / Intrinsic cardiac nervous system plays a crucial role in regulation of heart rate, contractility and tone of the coronary vessels. In neonates and infants, the intrinsic neural pathways are considered to be important for radiofrequency ablation that is performed in cases of incessant supraventricular and atrioventricular nodal reentrant tachycardia. Findings regarding to topography of intrinsic cardiac ganglia in the human fetuses differ substantially and deserves a further examination. The aim of this study was to investigate the topography and morphology of the human epicardiac neural ganglia during prenatal period. Results of the present study show, that: (1) the human fetal epicardiac ganglia are in their definitive location already from 15 weeks of gestation; (2) the number of the fetal epicardiac ganglia does not age-dependent and does not differ significantly between the fetal and the adult humans; (3) the distribution of the fetal epicardiac ganglia does not age-dependent; (4) the variability of the neural ganglionated fields, including both the ganglion number and the regional ganglion density, vary substantially from heart to heart; (5) the sizes of epicardiac ganglia in the human fetuses differ substantially from the adult ones, and that the ganglion structure, ganglion size and the number of interganglionic nerves are dependent on gestation stage of the human fetuses.

L’insomnie, une condition fréquemment retrouvée dans la population, se caractérise d’abord par une difficulté à initier ou à maintenir le sommeil et/ou par des éveils précoces le matin ou encore par un sommeil non-réparateur. Lorsqu’elle n’est pas accompagnée par des troubles psychiatriques ou médicaux ou un autre trouble de sommeil et qu’elle perdure plus de 6 mois on parle alors d’insomnie primaire chronique. Selon certains, cette condition serait associée à un état d’hyperéveil caractérisé par une augmentation de l’activité autonome sympathique durant le sommeil et l’éveil. Le baroréflexe est un important mécanisme de contrôle à court terme des fluctuations de la tension artérielle (TA) et de la fréquence cardiaque agissant sur le cœur et les vaisseaux sanguins par l’entremise du système nerveux autonome. On appelle sensibilité baroréceptive (SBR) la capacité du baroréflexe de réagir et de contrôler les fluctuations de TA en modulant le rythme cardiaque. De manière générale, la SBR serait augmentée durant la nuit par rapport à la journée. Aussi, il semblerait que le baroréflexe soit impliqué dans le phénomène de baisse physiologique de la TA pendant la nuit. Or, des données de notre laboratoire ont démontré une augmentation de la TA systolique au cours de la nuit ainsi qu’une atténuation de la baisse nocturne de TA systolique chez des sujets avec insomnie primaire chronique comparé à des témoins bons dormeurs. De plus, il a été démontré que le baroréflexe était altéré de façon précoce dans plusieurs troubles cardiovasculaires et dans l’hypertension artérielle. Or, il semblerait que l’insomnie soit accompagnée d’un risque accru de développement de l’hypertension artérielle. Ces études semblent aller dans le sens d’une altération des mécanismes de régulation de la TA dans l’insomnie. Par ailleurs, une réduction de la SBR serait aussi impliquée dans des états associés à une augmentation de l’activité autonome sympathique. Ainsi, nous nous sommes demandé si le baroréflexe pouvait constituer un des mécanismes de contrôle de la TA qui serait altéré dans l’insomnie et pourrait être impliqué dans l’augmentation de l’activité sympathique qui semble accompagner l’insomnie. Jusqu’à présent, le baroréflexe reste inexploré dans l’insomnie. L’objectif principal de ce mémoire était d’évaluer de façon non-invasive la SBR à l’éveil et en sommeil chez 11 sujets atteints d’insomnie primaire chronique comparé à 11 témoins bons dormeurs. L’évaluation du baroréflexe a été effectuée de façon spontanée par la méthode de l’analyse en séquence et par le calcul du coefficient alpha obtenu par l’analyse spectrale croisée de l’intervalle RR et de la TA systolique. De façon concomitante, les paramètres de la variabilité de l’intervalle RR en sommeil et à l’éveil ont aussi été comparés chez ces mêmes sujets. Aucune différence significative n’a été notée au niveau des index de la SBR entre le groupe d’insomniaques et celui des bons dormeurs, à l’éveil ou en sommeil. Cependant, on observe des valeurs légèrement plus faibles de la SBR chez les insomniaques ayant mal dormi (efficacité de sommeil (ES) < 85%) comparés aux insomniaques ayant bien dormi (ES≥ 85%) à la nuit expérimentale durant l’éveil et en sommeil. Par ailleurs, aucune différence n’a été notée entre le groupe d’insomniaques et celui des bons dormeurs au niveau des paramètres de la variabilité RR considérés (intervalle RR, PNN50, LF et HF en valeurs normalisées). En effet, les insomniaques tout comme les bons dormeurs semblent présenter une variation normale de l’activité autonome en sommeil, telle que représentée par les paramètres de la variabilité RR. Ces résultats préliminaires semblent suggérer que les mécanismes du baroréflexe sont préservés chez les sujets atteints d’insomnie primaire chronique tels que diagnostiqués de manière subjective. Cependant, il est possible qu’une altération des mécanismes du baroréflexe ne se révèle chez les insomniaques que lorsque les critères objectifs d’une mauvaise nuit de sommeil sont présents. / Insomnia, one of the most common sleep complaint in the general population, is characterised firstly by a difficulty initiating or maintaining sleep and/or early awakenings or non-restorative sleep. Insomnia is defined as primary when not principally due to another medical or psychiatric condition or other sleep disorder, whereas a minimum of 6 months duration is required to define chronic insomnia. Some authors have hypothesized that insomnia is associated with a state of hyperarousal characterized by increased sympathetic activity during sleep and wakefulness. The arterial baroreflex is an important mechanism providing continuous short term regulation of heart rate and blood pressure (BP) by means of the autonomic nervous system influences over the pacemaker and the peripheral circulation. Baroreflex sensitivity (BRS) is the baroreflex’s capacity to react and control BP changes by adjusting the heart rate. BRS is known to be heightened during the night compared to daytime. Also, it seems that the baroreflex could be involved in the physiological day-to-night BP fall. Previous data from our laboratory demonstrated in subjects with chronic primary insomnia, higher night-time systolic BP and a significant attenuation of the physiologic day-to-night systolic BP fall compared to good sleepers. Besides, the baroreflex has been shown to be altered early in several cardiovascular diseases and to precede hypertension. Subjects with insomnia have been shown to have a higher likelihood to develop daytime hypertension. All of these findings point in the direction of altered BP regulatory mechanisms in insomnia. Furthermore, a reduction of BRS could be implicated in states where higher sympathetic autonomic activity is observed. We hypothesised that the baroreflex could be one of the BP control mechanisms which are altered in insomnia and could be involved in the heightened sympathetic activity observed in insomnia. To our knowledge, the baroreflex has never been investigated previously in insomnia. The primary goal of this study was to investigate non-invasively BRS during wakefulness and sleep in 11 subjects with chronic primary insomnia compared to 11 good sleepers. Baroreflex was investigated spontaneously by the sequence method and by the calculation of the alpha coefficient obtained by cross spectral analysis of RR interval and systolic BP. Simultaneously, RR interval variability components were also compared during wakefulness and sleep between the two groups. No significant differences were found for indices of BRS between insomniacs and good sleepers during wakefulness and sleep. However, slightly lower values of BRS during wakefulness and sleep were noted in insomniacs with poor sleep (sleep efficiency (SE) <85%) versus those with good sleep (SE≥ 85%) at the experimental night. As a secondary finding, no differences were found between the insomniacs and the good sleepers for any of the RR variability components considered (RR interval, PNN50, LF and HF in their normalized units). Indeed, insomniacs like good sleepers exhibited normal variation of autonomic activity during sleep as depicted by the RR variability components. Our preliminary results suggest that baroreflex mechanisms are preserved in subjects with a subjective complaint of chronic primary insomnia. Nevertheless, certain impairment may occur in insomniacs as a function of objective measures of poor sleep.

Playing violent video games may provoke aggression. Psycho-physiological methods may provide knowledge about the underlying psychological processes. Most previous studies have been performed in laboratory settings at daytime with adults. Thus the aim of this thesis was to investigate psycho-physiological (autonomic and HPA related reactions), sleep-related and emotional responses in teenage boys to playing a violent and a non-violent video game at home before going to sleep. In Study I the autonomic responses differed between the violent and the non-violent game during playing and more distinctly during sleep. In Study II the HPA axis was not affected by video gaming at all. In Study III, the effect of habits of playing violent games was assessed (≤ 1h/day and ≥ 3h/day). High versus low experience of violent gaming were related to different autonomic, sleep-related and emotional processes at exposure to a violent and a non-violent game, during playing and during sleep. The present thesis demonstrated that violent and non-violent games induce different autonomic responses during playing and – more distinctly – during sleep. Frequent gaming seems to influence physiological, sleep-related and emotional reactions, possibly as an expression of desensitization processes.

Implementing self-management for enterprise systems is difficult. First, the scale and complexity of such systems makes it hard to understand and interpret system behavior or worse, the root causes of certain behaviors. Second, it is not clear how the goals specified at a system-level translate to component-level actions that drive the system. Third, the dynamic environments in which such systems operate requires self-management techniques that not only adapt the system but also adapt their own decision making processes. Finally, to build a self-management solution that is acceptable to administrators, it should have the properties of tractability and trust, which allow an administrator to both understand and fine-tune self-management actions. This dissertation work introduces, implements, and evaluates iManage, a novel system state-space based framework for enabling self-management of enterprise-scale systems. The system state-space, in iManage, is defined to be a collection of monitored system parameters and metrics (termed system variables). In addition, from amongst the system variables, it identifies the variables of interest, which determine the operational status of a system, and the controllable variables, which are the ones that can be deterministically modified to affect the operational status of a system. Using this formal representation, we have developed and integrated into iManage techniques that establish a probabilistic model relating the variables of interest and the controllable variables under the prevailing operational conditions. Such models are then used by iManage to determine corrective actions in case of SLA violations and/or to determine per-component ranges for controllable variables, which if independently adhered to by each component, lead to SLA compliance. To address the issue of scale in determining system models, iManage makes use of a novel state-space partitioning scheme that partitions the state-space into smaller sub-spaces thereby allowing us to more precisely model the critical system aspects. Our chosen modeling techniques are such that the generated models can be easily understood and modified by the administrator. Furthermore, iManage associates each proposed self-management action with a confidence-attribute that determines whether the action in question merits autonomic enforcement or not.

Background: Despite advances in the treatment of atherosclerosis, cardiovascular disease is the leading cause of death worldwide. With the population getting older and more obese, the burden of cardiovascular disease may further increase. Premenopausal women are relatively protected against cardiovascular disease compared to men, but the reasons for this sex difference are partly unknown. Redistribution of body fat from peripheral to central depots may be a contributing factor. Central fat is associated with hyperlipidemia, hyperglycemia, hypertension, and insulin resistance. Two possible mediators of these metabolic disturbances are tissue-specific production of the stress hormone cortisol and adipose tissue blood flow (ATBF). The aim of this thesis was to determine the adipose tissue production of cortisol by the enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) and to investigate the regulation of ATBF. Materials and Methods: Cortisol release was estimated by labeled cortisol infusions and tissue-specific catheterizations of subcutaneous and visceral adipose tissue (VAT) in men. We investigated ATBF by 133Xe-washout and its relation to autonomic activity, endothelial function, adipose tissue distribution, and adipokines in different groups of women. We further investigated the effect of two diets and of weight loss on ATBF in women. Results: We demonstrated significant cortisol release from subcutaneous adipose tissue in humans. Splanchnic cortisol release was accounted for entirely by the liver. Cortisol release from VAT (to the portal vein) was not detected. ATBF decreased according to increasing weight and postmenopausal status, and the level of blood flow was associated with nitric oxide (NO) activity and autonomic activity. ATBF was also highly associated with leptin levels and both subcutaneous adipose tissue and VAT areas. After 6 months of diet and weight reduction, a significant difference in ATBF was observed between diet groups. Conclusions: Our data for the first time demonstrate the contributions of cortisol generated from subcutaneous adipose tissue, visceral tissues, and liver by 11β-HSD1. ATBF is linked to autonomic activity, NO activity, and the amount of adipose tissue (independent of fat depot). Postmenopausal overweight women exhibited a loss of ATBF flexibility, which may contribute to the metabolic dysfunction seen in this group. Weight loss in a diet program could not increase the ATBF, although there were ATBF differences between diet groups. The results will increase understanding of adipose tissue biology and contribute to the development of treatment strategies targeting obesity and obesity-related disorders.