Esta tese é resultado de pesquisa que teve o objetivo de compreender o processo de desenvolvimento do Território Bico do Papagaio, no estado do Tocantins (TBP-TO), com base na implantação de projetos PROINFs, vinculados aos Programas PRONAT e PTC, visando explicitar efeitos, avanços e limites das políticas públicas territoriais em regiões com baixos índices de desenvolvimento. Nesta pesquisa utilizou-se de múltiplas estratégias para a coleta e análise de dados, seguindo os princípios e técnicas da triangulação, que constitui uma das formas de combinar métodos qualitativos entre si e de articular métodos quantitativos e qualitativos. Foi realizada, por meio de estudo de caso, em sete projetos implantados no TBP-TO. Uma questão importante, do ponto de vista metodológico, foi a oportunidade de fazer uma imersão no contexto investigado, observando e participando diretamente com os atores envolvidos na implantação e execução dos projetos PROINFs no referido território. Lançou-se mão de informações obtidas por observações, entrevistas, participação em reuniões, seminários, conversa com diferentes atores territoriais, moradores e membros do colegiado, gestores e beneficiários destes projetos. Os resultados levaram a uma compreensão das diferentes dimensões do desenvolvimento territorial e seus efeitos na vida dos beneficiários e na região. Os indicadores de desenvolvimento territorial, do ponto de vista econômico, foram avaliados entre ruins e críticos, dando a entender que a operacionalização da política territorial no TBP-TO reflete a própria história das relações de poder e dominação já existentes. Por outro lado, do ponto de vista social, foi observado o empoderamento da sociedade civil, especialmente nos casos das duas Escolas Família Agrícola (EFAs). Nesse sentido, esta tese contribuiu, não só para entender as dimensões do desenvolvimento territorial, seus desafios e possibilidades, mas para demonstrar que se não houver maior diálogo entre poder público (nas esferas municipal, estadual e federal), sociedade civil e os beneficiários dos projetos, o desenvolvimento territorial pode ficar comprometido. Diante dos resultados da pesquisa conclui-se que, nesse momento de retrocesso da política de desenvolvimento territorial, é necessário repensá-la, especialmente em relação ao exercício do poder e à autonomia dos Colegiados Territoriais. A organização dos colegiados territoriais e a união de seus membros em torno de objetivos comuns podem ser consideradas o motor propulsor da consolidação das EFAs, possibilitando a educação profissional de seus jovens. Esta organização é o maior indicador de desenvolvimento, na dimensão social, observado na pesquisa. / This thesis is the result of research that aims to understand the development process of the Parrot´s Beak Territory in the State of Tocantins (PBT-TO), based on the implantation of PROINFs projects, linked to PRONAT and PTC programs with the goal of clarifying effects, advances and limits of territorial public policies in regions with low levels of development. In this research, it was used multiple strategies for data collection and analysis, following the principles and techniques of triangulation, which is one of the ways to combine qualitative methods among themselves and to articulate quantitative and qualitative methods. The research was done through the case study in seven projects implanted in PBT-TO. An important thing, from the methodological point of view, was the opportunity to do an immersion in the context investigated by observing and participating directly with the actors involved in the implementation and execution of the projects PROINFs, in that territory. It was used the information obtained by observations, interviews, participation in meetings, seminars, talking with different territorial actors, residents and members of the board, managers and beneficiaries of these projects. The results led to an understanding of the different dimensions of territorial development and its effects on the lives of beneficiaries and in the region. The indicators of territorial development, from an economic point of view, were evaluated between bad and critical, implying that the operationalization of territorial policy in the PBT-TO reflect the history of the relationships of power and domination that exists. On the other hand, from the social point of view, it was observed the empowerment of civil society, especially in the cases of the Escolas Família Agrícola (EFAs). In this sense, this thesis has contributed not only to understand the dimensions of territorial development, its challenges and opportunities, but to demonstrate that if there is no greater dialogue between public authorities (in all spheres: Municipal, State and Federal), civil society and the beneficiaries of the projects, the territorial development may be compromised. On the research results it is concluded that, in this moment of backsliding of territorial development policy, it is necessary to rethink it, especially in relation to the exercise of power and the autonomy of Territorial governance bodies. The Organization of territorial governance bodies and the Union of its members around common goals, can be considered the impeller motor on consolidation of EFAs enabling professional education of their young. This organization is the greatest indicator of development in the social dimension, observed in the survey.

Esta tese é resultado de pesquisa que teve o objetivo de compreender o processo de desenvolvimento do Território Bico do Papagaio, no estado do Tocantins (TBP-TO), com base na implantação de projetos PROINFs, vinculados aos Programas PRONAT e PTC, visando explicitar efeitos, avanços e limites das políticas públicas territoriais em regiões com baixos índices de desenvolvimento. Nesta pesquisa utilizou-se de múltiplas estratégias para a coleta e análise de dados, seguindo os princípios e técnicas da triangulação, que constitui uma das formas de combinar métodos qualitativos entre si e de articular métodos quantitativos e qualitativos. Foi realizada, por meio de estudo de caso, em sete projetos implantados no TBP-TO. Uma questão importante, do ponto de vista metodológico, foi a oportunidade de fazer uma imersão no contexto investigado, observando e participando diretamente com os atores envolvidos na implantação e execução dos projetos PROINFs no referido território. Lançou-se mão de informações obtidas por observações, entrevistas, participação em reuniões, seminários, conversa com diferentes atores territoriais, moradores e membros do colegiado, gestores e beneficiários destes projetos. Os resultados levaram a uma compreensão das diferentes dimensões do desenvolvimento territorial e seus efeitos na vida dos beneficiários e na região. Os indicadores de desenvolvimento territorial, do ponto de vista econômico, foram avaliados entre ruins e críticos, dando a entender que a operacionalização da política territorial no TBP-TO reflete a própria história das relações de poder e dominação já existentes. Por outro lado, do ponto de vista social, foi observado o empoderamento da sociedade civil, especialmente nos casos das duas Escolas Família Agrícola (EFAs). Nesse sentido, esta tese contribuiu, não só para entender as dimensões do desenvolvimento territorial, seus desafios e possibilidades, mas para demonstrar que se não houver maior diálogo entre poder público (nas esferas municipal, estadual e federal), sociedade civil e os beneficiários dos projetos, o desenvolvimento territorial pode ficar comprometido. Diante dos resultados da pesquisa conclui-se que, nesse momento de retrocesso da política de desenvolvimento territorial, é necessário repensá-la, especialmente em relação ao exercício do poder e à autonomia dos Colegiados Territoriais. A organização dos colegiados territoriais e a união de seus membros em torno de objetivos comuns podem ser consideradas o motor propulsor da consolidação das EFAs, possibilitando a educação profissional de seus jovens. Esta organização é o maior indicador de desenvolvimento, na dimensão social, observado na pesquisa. / This thesis is the result of research that aims to understand the development process of the Parrot´s Beak Territory in the State of Tocantins (PBT-TO), based on the implantation of PROINFs projects, linked to PRONAT and PTC programs with the goal of clarifying effects, advances and limits of territorial public policies in regions with low levels of development. In this research, it was used multiple strategies for data collection and analysis, following the principles and techniques of triangulation, which is one of the ways to combine qualitative methods among themselves and to articulate quantitative and qualitative methods. The research was done through the case study in seven projects implanted in PBT-TO. An important thing, from the methodological point of view, was the opportunity to do an immersion in the context investigated by observing and participating directly with the actors involved in the implementation and execution of the projects PROINFs, in that territory. It was used the information obtained by observations, interviews, participation in meetings, seminars, talking with different territorial actors, residents and members of the board, managers and beneficiaries of these projects. The results led to an understanding of the different dimensions of territorial development and its effects on the lives of beneficiaries and in the region. The indicators of territorial development, from an economic point of view, were evaluated between bad and critical, implying that the operationalization of territorial policy in the PBT-TO reflect the history of the relationships of power and domination that exists. On the other hand, from the social point of view, it was observed the empowerment of civil society, especially in the cases of the Escolas Família Agrícola (EFAs). In this sense, this thesis has contributed not only to understand the dimensions of territorial development, its challenges and opportunities, but to demonstrate that if there is no greater dialogue between public authorities (in all spheres: Municipal, State and Federal), civil society and the beneficiaries of the projects, the territorial development may be compromised. On the research results it is concluded that, in this moment of backsliding of territorial development policy, it is necessary to rethink it, especially in relation to the exercise of power and the autonomy of Territorial governance bodies. The Organization of territorial governance bodies and the Union of its members around common goals, can be considered the impeller motor on consolidation of EFAs enabling professional education of their young. This organization is the greatest indicator of development in the social dimension, observed in the survey.

The male house sparrows has two assumed visible sexual traits which are 1) the colouration (or brightness) of the beak and 2) the size of the black badge on the bird’s throat and chest. Earlier research has shown that the testosterone concentration play an important part in determine the beak colour, with a higher testosterone concentration giving the bird a darker beak and as such making the male more attractive to females.     Even though stress has been counted for as a changing factor of phenotypes and behaviour it is not certain how vast effect stress has on different animals. This study is focusing on how and if the individuals fundamental stress level (fundamental corticosterone concentration) is affecting the morphological appearance, in this case the visible sexual traits (beak colour and badge size) and mask (an indicator of age), within the house sparrows in the Lundy Island population. In this study there was no relationship between beak colour and corticosterone concentrations, stating that beak brightness is not determined by fundamental stress. Likewise there was no relationship between the corticosterone concentrations and the size of the badge. Mask measurements in relationship to corticosterone showed no significant effect. These results indicate that there is no relationship between the corticosterone concentration in the blood and the mask size or the beak colour and badge size as visible sexual traits. / Många forskare är ense om att gråsparvshannen använder sig av två synliga karaktärsdrag för att attrahera honor. Den första är mörkhetsgraden på näbben och den andra är storleken på hannens svarta bröstlapp, placerad på hals och bröst. Tidigare forskning har visat att näbbfärgen påverkas kraftigt av hannens testosteron nivå och att en högre testosteron nivå leder till en mörkare näbb, vilket är mer attraktivt för honorna.    Även om stress har visat sig påverka både fenotyp och beteende hos många olika djurgrupper är det fortfarande oklart hur stor effekt stress har på olika djur. Denna studie fokuserar på hur och om den individuella fundamentala stressnivån (den fundamentala kortikosteron nivån) påverkar de synliga attraherande karaktärsdragen (näbbfärg och bröstlappsstorlek) hos gråsparvshannarna. I denna rapport analyseras även hannarnas masker, vilka fungerar som åldersindikatorer, i relation till de individuella kortikosteron koncentrationerna. Inget samband kunde hittas mellan näbbfärg och kortikosteron nivå hos de analyserade individerna. Likaså kunde inget samband hittas mellan kortikosteron nivån och storleken på hannens bröstlapp. Inte heller maskstorleken visade samband med kortokosteron nivån. Resultatet indikerar således att stress inte påverkar hannens sexuellt attraktiva karaktärsdrag eller mask.

Many previous studies in evolutionary genetics have been based on few model organisms that can be reared at ease in the laboratory. In contrast, genetic studies of non-model, natural populations are desirable as they provide a wider range of adaptive phenotypes throughout evolutionary timescales and allow a more realistic understanding of how natural selection drives adaptive evolution. This thesis represents an example of how modern genomic tools can be effectively used to study adaptation in natural populations. Atlantic herring is one of the world’s most numerous fish having multiple populations with phenotypic differences adapted to strikingly different environments. Our study demonstrated insignificant level of genetic drift in herring that resulted in minute genetic differences in the majority of the genome among these populations. In contrast, a small percentage of the loci showed striking genetic differentiation that were potentially under natural selection. We identified loci associated with adaptation to the Baltic Sea and with seasonal reproduction (spring- and autumn-spawning) and demonstrated that ecological adaptation in Atlantic herring is highly polygenic but controlled by a finite number of loci. The study of Darwin’s finches constitutes a breakthrough in characterizing their evolution. We identified two loci, ALX1 and HMGA2, which most likely are the two most prominent loci that contributed to beak diversification and thereby to expanded food utilization. These loci have played a key role in adaptive evolution of Darwin’s finches. Our study also demonstrated that interspecies gene flow played a significant role in the radiation of Darwin’s finches and some species have a mixed ancestry. This thesis also explored the genetic basis for the remarkable phenotypic differences between three male morphs in the ruff. Identification of two different versions of a 4.5 MB inversion in Satellites and Faeders that occurred about 4 million years ago revealed clues about the genetic foundation of male mating strategies in ruff. We highlighted two genes in the inverted region; HSD17B2 that affects metabolism of testosterone and MC1R that has a key role in regulating pigmentation, as the major loci associated with this adaptation.

Ce travail de thèse, réalisé dans le cadre des projets de recherche ROSIRIS (IRSN) et Geant4-DNA, porte sur la construction d’une simulation multi-échelle dédiée au calcul des dommages radio-induits précoces à l’ADN qui peuvent apparaître suite à l’irradiation d’un noyau cellulaire. L’outil développé s’appuie sur une version modifiée du code de Monte Carlo Geant4-DNA et est capable de simuler dans le détail le transport et les interactions physiques entre l’irradiation ionisante et la matière biologique (étape physique), la création d’espèces chimiques (étape physico-chimique) et les réactions et processus de diffusion de ces dernières (étape chimique). Durant la simulation de ces trois étapes, un modèle géométrique de l’ADN, décrivant l’ensemble du génome humain avec une précision moléculaire, est généré avec un nouveau logiciel développé dans le cadre de cette thèse : DnaFabric. Les premiers résultats obtenus pour des irradiations avec des protons et des ions alpha sont détaillés et comparés à des données de la littérature. Un bon accord est observés avec ces dernières illustrant ainsi la cohérence de l’ensemble de la simulation. L’influence très significative du critère de sélection utilisé pour identifier les dommages à l’ADN est également démontrée. / This work was performed in the frame of the ROSIRIS (IRSN) and Geant4-DNA research projects and describes the development of a simulation tool to compute radioinduced early DNA damages in a cell nucleus. The modeling tool is based on a modified version of the Monte Carlo code Geant4-DNA and is able to simulate the physical interactions between ionizing particles and the biological target (physical stage), the creation of chemical species within the cell nucleus (physico-chemical stage) as well as the reactions and diffusion processes of these chemical species (chemical stage). During all the simulation, a geometrical model that describes the DNA content of a human diploid cell nucleus is taken into account. This model was generated with a new software (DnaFabric) developed in the frame of this work and has a molecular level of detail.The first results (in term of DNA strand breaks) obtained with this tool are detailed and compared with experimental data from the literature. The good agreement between the simulation results and those data shows the coherence of our modeling. The significant influence of the selection criteria used to identify the DNA damages is also demonstrated.