Global ETD Search

1	Etude de la protéine CIRP et sa fonction dans le métabolime de l'ARNm De Leeuw, Frederic 15 January 2008 (has links) La protéine CIRP (Cold Induced RNA binding Protein) est une petite protéine de liaison à l’ARN de 172 acides aminés, qui est constituée du côté amino-terminal d’un domaine de liaison à l’ARN de type RRM (RNA recognition motif), et d’une partie carboxy-terminale riche en glycine et arginine qui comprend plusieurs motifs RGG. Elle a été identifiée comme étant inductible par hypothermie mais aussi par irradiation aux UV et par hypoxie. Nous avons analysé son expression et sa localisation en réponse à différents stress cellulaires. Nous avons montré qu’un traitement à l’arsénite qui induit un stress oxydant n’altère pas l’expression de CIRP provoque sa localisation dans les granules de stress (SG). Les SG sont des structures ribonucléoprotéiques cytoplasmiques contenant des complexes de pré-initiation incompétents pour la traduction, et qui s’accumulent dans les cellules exposées à un stress. Ces structures constituent des sites de triages des ARNm, dans lesquels les ARNm sont soit stockés en attente d’une réinitiation de la traduction une fois le stress surmonté, soit destinés à être dégradés. La protéine CIRP se localise dans les SG que ce soit suite à un stress cytoplasmique ou du réticulum endoplasmique. Nous avons montré également que la localisation de la protéine CIRP dans les SG se déroule indépendamment de la présence de la protéine TIA-1 qui a été décrite comme responsable de l’assemblage des SG. De plus la surexpression de la protéine CIRP conduit à la formation de SG. Nous suggérons donc qu’il existe plusieurs voies qui mènent à l’assemblage de ces structures. En outre, nous avons analysé la localisation de mutants par délétion de la protéine CIRP et avons montré que le domaine RRM et le domaine RGG peuvent indépendamment localiser la protéine dans les SG. Par contre, la méthylation des résidus arginine du domaine RGG est une modification nécessaire à la localisation de CIRP dans les SG. Ensuite, nous avons étudié la fonction de la protéine CIRP dans le métabolisme des ARN messagers. Nous avons montré par une méthode d’adressage, que CIRP est un répresseur de la traduction des ARNm et que le domaine carboxy-terminal est nécessaire et suffisant à cette fonction. traduction/translation granules de stress/stress granules CIRP
2	CIRP Expression on Growth and Productivity of CHO Cells Tan, Hong-Kiat, Yap, Miranda G.S., Wang, Daniel I.C. 01 1900 (has links) Mammalian cell culture is typically operated at the physiological temperature of 37°C. Low temperature cell culture at 30-33°C, in particular for CHO cells, increased the specific productivity of many recombinant proteins amongst many other benefits. However, the cell density is lower, thus reducing the total protein yield. Of the 17 mammalian cold-stress genes reported to be up- or down-regulated at low temperature, CIRP shows potential as a gene target for improving recombinant protein production, as its expression levels were reported to affect both growth and specific productivity. In this study, it was shown that over-expression of the cold-stress gene CIRP did not cause growth arrest in CHO cells, in contrast to previous reports. However, over-expression of CIRP successfully improved the specific productivity and total yield of a recombinant interferon-γ CHO cell-line at 37°C by 25%. / Singapore-MIT Alliance (SMA) CIRP cold-stress Interferon gamma productivity
3	Beyond Academic Reputation: Factors that Influence the College of First Choice for High Achieving Students Schoenherr, Holly J 05 March 2009 (has links) Studies that have investigated college choice factors for high-achieving students repeatedly cite academic reputation as one of the top indicators of choice but have not indicated why some high-achieving students choose to attend universities with a less prestigious reputation than the more highly prestigious options available to them. The purpose of this study was to examine whether differences exist between traditional-aged high achieving students who choose to attend higher-tiered universities and their peers who choose to attend lower-tiered universities. Independent variables were selected based upon Hossler and Gallagher's (1987) three-stage model and previous research findings in the literature and grouped according to: (1) students' individual and family characteristics, including ethnicity, gender, parents' education level, and family income; (2) institutional characteristics, including financial considerations and academic reputation; and (3) the influence of others, including parents, relatives, teachers and counselors. The sample was drawn from the 97 universities which administered the CIRP Freshman Survey in 2004. Data were used for students who were attending their first choice college located more than 100 miles from home. Data were used from students who had received scores at or above 660 on the SAT Verbal, and scores at or above 670 on the SAT Math. For students who did not report scores for both SAT verbal and SAT math, the researcher accepted data from students reporting an ACT composite score of 30 or higher. In addition, in order for their data to be used, students were required to have an A or A+ average in high school. Results were reported as (1) frequencies and descriptive statistics, (2) a correlation matrix, and (3) multiple regression models. The study found the availability of financial aid to be the most important factor in predicting whether students will attend a higher-tiered or lower-tiered university. Although college costs and academic reputation were found to be significant predictors of the tier level of university attended, they were of secondary importance compared with the attention to financial aid by high achieving students. CIRP College choice process Financial aid High academic achievement Selectivity American Studies Arts and Humanities
4	Political Identity of First-Year College Students: An Analysis of Student Characteristics Using Cooperative Institutional Research Program (CIRP) Data Mulberry, Stella L. 05 1900 (has links) This quantitative study utilized secondary self-reported data from the 2008 administration of the Cooperative Institutional Research Program (CIRP) Freshman Survey from two Texas public universities to investigate the pre-college demographic, academic, attitude, behavioral, and familial factors that may relate to students' self-reported political identities. The study design was correlational regarding the relationship of the demographic, academic, attitude, behavioral, and familial independent variables to the dependent variable of the students' political identities. ANOVA main effects for the independent variables were calculated, and statistical significance required the p < .05 level. The statistically significant demographic factors were native English-speaking status; enrollment status; citizenship status; religious preference; and race. The statistically significant academic factor was intended major. The statistically significant attitude factors were opinions regarding social issues such as criminal rights; abortion rights; the death penalty; the legalization of marijuana; homosexual relationships and same-sex marriage; racial discrimination; income taxes; affirmative action; military spending and voluntary military service; gun control; the environment; national health care; immigration; personal success; political dissent; and free speech. Other statistically significant attitude factors related to personal goals of making artistic and scientific contributions; being politically influential and politically knowledgeable; raising a family; participating in environmental programs and community action programs; developing a life purpose; promoting racial understanding; and promoting cultural understanding. The statistically significant behavioral factors were the frequency with which students participated in activities such as attending religious services; smoking; feeling overwhelmed or depressed; playing a musical instrument; discussing politics; and being involved in political campaigns. Other statistically significant behavioral factors were the frequency with which students participated in critical thinking activities such as using logical arguments to support their opinions; seeking alternative solutions to problems; researching scientific articles; exploring topics of personal interest; and accepting mistakes. The statistically significant familial factors were the religious preferences of the students' fathers and mothers. The results can give insight into the political characteristics of the students with whom student affairs professionals work. They can be used to inform the planning and implementation of educational programs that aid in students' political identity development. Political identity CIRP first-year College freshmen -- Texas -- Attitudes. Identity (Psychology) Political psychology.
5	Does Faith-Based Worldview Predict Confidence in College Major: A Quantitative Longitudinal Study at the University of Michigan Taylor, Kristy January 2012 (has links) No description available. Higher Education Major spirituality University of Michigan Historical overview of higher education faith-based worldview CIRP freshman survey service learning philosophy of life
6	Etude de la protéine CIRP et sa fonction dans le métabolisme des ARN messagers De Leeuw, Frédéric 15 January 2008 (has links) La protéine CIRP (Cold Induced RNA binding Protein) est une petite protéine de liaison à l’ARN de 172 acides aminés, qui est constituée du côté amino-terminal d’un domaine de liaison à l’ARN de type RRM (RNA recognition motif), et d’une partie carboxy-terminale riche en glycine et arginine qui comprend plusieurs motifs RGG. Elle a été identifiée comme étant inductible par hypothermie mais aussi par irradiation aux UV et par hypoxie. Nous avons analysé son expression et sa localisation en réponse à différents stress cellulaires. Nous avons montré qu’un traitement à l’arsénite qui induit un stress oxydant n’altère pas l’expression de CIRP provoque sa localisation dans les granules de stress (SG). Les SG sont des structures ribonucléoprotéiques cytoplasmiques contenant des complexes de pré-initiation incompétents pour la traduction, et qui s’accumulent dans les cellules exposées à un stress. Ces structures constituent des sites de triages des ARNm, dans lesquels les ARNm sont soit stockés en attente d’une réinitiation de la traduction une fois le stress surmonté, soit destinés à être dégradés. La protéine CIRP se localise dans les SG que ce soit suite à un stress cytoplasmique ou du réticulum endoplasmique. Nous avons montré également que la localisation de la protéine CIRP dans les SG se déroule indépendamment de la présence de la protéine TIA-1 qui a été décrite comme responsable de l’assemblage des SG. De plus la surexpression de la protéine CIRP conduit à la formation de SG. Nous suggérons donc qu’il existe plusieurs voies qui mènent à l’assemblage de ces structures. En outre, nous avons analysé la localisation de mutants par délétion de la protéine CIRP et avons montré que le domaine RRM et le domaine RGG peuvent indépendamment localiser la protéine dans les SG. Par contre, la méthylation des résidus arginine du domaine RGG est une modification nécessaire à la localisation de CIRP dans les SG. Ensuite, nous avons étudié la fonction de la protéine CIRP dans le métabolisme des ARN messagers. Nous avons montré par une méthode d’adressage, que CIRP est un répresseur de la traduction des ARNm et que le domaine carboxy-terminal est nécessaire et suffisant à cette fonction. / Doctorat en Sciences / info:eu-repo/semantics/nonPublished Sciences exactes et naturelles Biologie Messenger RNA -- Metabolism Proteins -- Synthesis Genetic translation Cytoplasmic granules ARN messager -- Métabolisme Protéines -- Synthèse Traduction génétique Granulations cytoplasmiques traduction/translation granules de stress/stress granules CIRP
7	Educationally At-risk College Students From Single-parent and Two-parent Households: an Analysis of Differences Employing Cooperative Institutional Research Program Data. Brown, Peggy Brandt 08 1900 (has links) Using factors of low income, parents' levels of education, and family composition as determinants of educationally at-risk status, study investigated differences between first generation, undergraduate college students from families in lowest quintile of income in the U.S, One group consisted of students from single-parent households and the other of students from two-parent households. Data were from CIRP 2003 College Student Survey (CSS) and its matched data from the Freshman Survey (Student Information Form - SIF). Differences examined included student inputs, involvements, outcomes, and collegiate environments. Included is portrait of low income, first generation college students who successfully navigated U.S. higher education. The number of cases dropped from 15,601 matched SIF/CSS cases to 308 cases of low income, first generation college students (175 from single-parent households and 133 from two-parent households). Most of the 308 attended private, 4-year colleges. Data yielded more similarities than differences between groups. Statistically significant differences (p < .05) existed in 9 of 100 variables including race/ ethnicity, whether or not English was first language, and concern for ability to finance education as freshman. Data were not generalizable to all low income, first generation college students because of lack of public, 4-year and 2-year colleges and universities in dataset. Graduating seniors' average expected debt in June 2003 was $23,824 for students from single-parent households and $19,867 for those from two-parent households. 32% from single-parent households and 22% from two-parent households expected more than $25,000 of debt. Variables used on SIF proved effective tools to develop derived variables to identify low income, first generation college students from single-parent and two-parent households within CIRP database. Methodology to develop derived variables is explained. College students -- United States. College attendance -- United States. Academic achievement -- United States. CIRP college students educationally at-risk first generation students low income students single-parent households two-parent households
8	Implicit Family Process and Couples Rules: A Comparison of American and Hungarian Families Gergely, Noemi 13 July 2006 (has links) (PDF) Family life is organized by rules, and most of them are unspokenly agreed-upon by family members and may be even out of awareness. Implicit family process and couple rules may facilitate or constrain family relationship and intimate couple relationship growth. Prevalence of family rules may be different across cultures. Family members may perceive their rules and family functioning differently according to their family position and gender. Married couples may view their relationship rules differently than couples who cohabit. This study utilized the Family Implicit Rules Profile (FIRP) and the Couples Implicit Rules Profile (CIRP) Questionnaires to answer these research questions. The questionnaires were translated into Hungarian, and the content validity of the Hungarian translation was established. Hungarian non-clinical families and couples were compared to American (U.S.) non-clinical families and couples to examine how prevalent implicit rules were in the two cultures. According to the findings, Hungarian families and couples scored lower on the total FIRP and CIRP scores. Hungarian families perceived implicit family rules regarding kindness and monitoring less prevalent, and rules regarding constraining their thoughts, feelings and self more prevalent than American families. No differences were found in expressiveness and connection and inappropriate caretaking of parents between the two cultures. Hungarian couples perceived their implicit relationship rules regarding kindness, expressiveness and connection and monitoring less prevalent than American couples. No differences in implicit rules about constraining thoughts, feelings and self and inappropriate caretaking of partner were found between the two cultures. Mothers in both cultures viewed their families in a more positive light than other family members, and female family members (mothers and daughters) were more positive than their male counterparts (fathers and sons) about rules in their families in both cultures. Sons in both cultures perceived more responsibility to protect their parents emotionally than did daughters. Married couples in both cultures perceived their relationship rules more favorably in terms of kindness and monitoring than cohabiting couples. Results were interpreted in the context of cultural differences between the American and the Hungarian cultures. Limitations and the possibility of future research are discussed. rule implicit unspoken family couple Hungary American gender parent father mother son daughter cohabiting married marital status questionnaire Family Implicit Rules Profile Couples Implicit Rules Profile FIRP CIRP kindness expression connection constraining caretaking monitoring culture relationship back-translation Family, Life Course, and Society
9	TU-Spektrum 3/2007, Magazin der Technischen Universität Chemnitz Steinebach, Mario, Thehos, Katharina, Häckel-Riffler, Christine, Brabandt, Antje, Chlebusch, Michael, Leithold, Nicole, Linne, Carina, Werner, Arne 04 December 2007 (has links) (PDF) dreimal im Jahr erscheinende Zeitschrift über aktuelle Themen der TU Chemnitz 3D-Koordinaten-Messgerät Altersquotient Briefmonopol Chemnitzer Linux-Tage 2008 Ehrungen Fotorallye Gustav Anton Zeuner Immatrikulation 2007 Initiative Pro Förderwerke Innenstadtbesuche älterer Menschen Internationales KOMSA Unternehmensgruppe Leichtbauverbundstrukturen Luftfahrtforschungsprogramm Mikrosystemtechnik-Kongress Neue Professoren an der TU Patentanmeldungen Patentinformationszentrum Professoren im Ruhestand Prorektoren Schüler-Uni Informatik Schülerpraktika Informatik Second-Life-Welt Sensordatenverarbeitung Sticksensor Stipendiaten Strategien für Veränderungsmanagement Strukturleichtbau Studienstiftungen Sächsisch-Tschechische Kooperationen Thailändische Prinzessin Sirindhorn Thailändische Promovenden Universitätspreise VIII. Chemnitzer Ostforum VW Sachsen Verstorben Webseiten-Ranking Weltkongress der Produktionstechnik CIRP Campus of Excellence Summer School 2007 ddc:050 Auslandsstudium Deutscher Akademischer Austauschdienst Ecuador Marktforschung Mexiko Nanolithographie Nanotechnologie Qualitätsmanagement Rektor Schwimmen Sport Staffellauf Universaldienst Verbraucherinsolvenzverfahren
10	TU-Spektrum 3/2007, Magazin der Technischen Universität Chemnitz Steinebach, Mario, Thehos, Katharina, Häckel-Riffler, Christine, Brabandt, Antje, Chlebusch, Michael, Leithold, Nicole, Linne, Carina, Werner, Arne 04 December 2007 (has links) dreimal im Jahr erscheinende Zeitschrift über aktuelle Themen der TU Chemnitz Campus of Excellence Summer School 2007 info:eu-repo/classification/ddc/050 ddc:050

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