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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

CMV-Infektion mit gastrointestinaler Manifestation: Vergleich der diagnostischen Möglichkeiten von endoskopischer, pathologischer und virologischer Untersuchung

Claussen, Marie 24 September 2012 (has links) (PDF)
Cytomegalievirus (CMV) ist bei immunsupprimierten Patienten nach Organ- oder Stammzelltransplantation sowie bei Patienten mit chronisch entzündlichen Darmerkrankungen und nicht immunsupprimierten kritisch kranken Patienten ein ernstzunehmender Risikofaktor für eine manifeste CMV-Infektion. Diese ist durch eine hohe Morbidität und Letalität gekennzeichnet. Daher ist eine zeitnahe und zuverlässige Diagnosestellung für die Einleitung einer adäquaten Therapie und damit für das klinische Ergebnis der Patienten von entscheidender Bedeutung. Ziel dieser retrospektiven Arbeit war es, die diagnostischen Verfahren der endoskopischen, pathologischen und virologischen Untersuchung bezüglich ihrer Treffsicherheit bei der gastrointestinalen CMV-Infektion zu untersuchen. Dafür wurde eine quantitative molekularvirologische Nachweismethode für CMV aus formalinfixiertem, in Paraffin eingebettetem Gewebe etabliert. Des Weiteren wurde das Procedere der Entnahme und der Verteilung der Biopsien an die Institute für Virologie und Pathologie evaluiert und die Ergebnisse von endoskopischer und molekularvirologischer Untersuchung in Blut- und Gewebeproben miteinander verglichen. In einem weiteren Schritt konnte die Korrelation der molekularvirologischen mit den immunhistochemischen Ergebnissen untersucht werden. Für die genannten Fragestellungen wurde CMV spezifisches Genom aus Blutproben und Gewebeproben des Gastrointestinaltraktes von 164 Patienten im Zeitraum von Oktober 2008 bis September 2010 quantitativ ausgewertet. Insgesamt wurden 860 Gewebeproben und 2550 Plasma- und Serumproben untersucht. Basierend auf den Ergebnissen der Datenerhebung zeigt die vorliegende Arbeit, dass ohne eine Anpassung der Vorgehensweise einer von vier Fällen mit gastrointestinaler CMV-Infektion nicht diagnostiziert werden würde und es wird macht einen Vorschlag zur weiteren Optimierung des diagnostischen Procedere.
2

Evaluation of cytomegalovirus treatment in transplant patients before and during the foscarnet nationwide shortage

Doehnert, Deborah, Hattrup, Allison, Leadbetter, Maggie January 2012 (has links)
Class of 2012 Abstract / Specific Aims: To compare and evaluate the therapies prescribed, the incidence of adverse drug events, and the time to clinical cure in transplant patients with a cytomegalovirus (CMV) infection at an academic medical center before and during the foscarnet nationwide shortage. Methods: This study was a retrospective chart review to compare CMV treatment prescribed and clinical outcomes in pediatric and adult transplant patients at an academic medical center. Transplant patients were evaluated over a 16 month time period between December 2009 and March 2011. The average dose (mg/kg) and prevalence ganciclovir, foscarnet, and cidofovir prescribed in transplant patients with CMV infection were evaluated. Additionally, the incidence of adverse drug events including acute renal dysfunction and myelosuppression were characterized. Main Results: There were 30 subjects diagnosed with CMV disease during the evalutaion period. Of all of the patients treated for CMV before the shortage, 79% received ganciclovir, 43% received foscarnet, and 21% received cidofovir. Following the shortage in September 2010, the usage of the antiviral agents changed to 100%, 25%, and 13% respectively. Overall the usage of ganciclovir increased while the usage of foscarnet decreased when there was a shortage of medication. Conclusions: The antiviral prescribing patterns changed significantly during the foscarnet shortage. The average dose and incidence of ganciclovir increased which likely contributed to serious adverse events. Due to the limited amount of patients treated for CMV and the short time frame, clinical cure could not be determined at this time. Drug shortages are a serious problem and significantly influence patient outcomes.
3

Congenital cytomegalovirus infection : a study of a British population

Preece, Philip Milburn January 1988 (has links)
No description available.
4

Cytomegalovirus infection in pregnancy : outcome and risk factors

Tookey, Patricia Ann January 2000 (has links)
No description available.
5

Evaluation of Cytomegalovirus Treatment in Transplant Patients Before and During the Foscarnet Nationwide Shortage

Doehnert, Deborah, Hattrup, Allison, Leadbetter, Maggie, Matthias, Kathryn, Yost, Sarah January 2012 (has links)
Class of 2012 Abstract / Specific Aims: To compare and evaluate the therapies prescribed, the incidence of adverse drug events, and the time to clinical cure in transplant patients with a cytomegalovirus (CMV) infection at an academic medical center before and during the foscarnet nationwide shortage. Methods: This study was a retrospective chart review to compare CMV treatment prescribed and clinical outcomes in pediatric and adult transplant patients at an academic medical center. Transplant patients were evaluated over a 16 month time period between December 2009 and March 2011. The average dose (mg/kg) and prevalence ganciclovir, foscarnet, and cidofovir prescribed in transplant patients with CMV infection were evaluated. Additionally, the incidence of adverse drug events including acute renal dysfunction and myelosuppression were characterized. Main Results: There were 30 subjects diagnosed with CMV disease during the evalutaion period. Of all of the patients treated for CMV before the shortage, 79% received ganciclovir, 43% received foscarnet, and 21% received cidofovir. Following the shortage in September 2010, the usage of the antiviral agents changed to 100%, 25%, and 13% respectively. Overall the usage of ganciclovir increased while the usage of foscarnet decreased when there was a shortage of medication. Conclusions: The antiviral prescribing patterns changed significantly during the foscarnet shortage. The average dose and incidence of ganciclovir increased which likely contributed to serious adverse events. Due to the limited amount of patients treated for CMV and the short time frame, clinical cure could not be determined at this time. Drug shortages are a serious problem and significantly influence patient outcomes.
6

Role of antiretroviral therapy exposure host genetics on cytomegalovirus infection status and association with gut microbiome profiles among pregnant black African women

Mhandire, Doreen Zvipo 11 February 2021 (has links)
Cytomegalovirus (CMV) is an important antenatal infection that is prevalent in the developing world. The disabling and potentially fatal effects of CMV acquisition or reactivation during pregnancy on the developing foetus and or neonate are known but, factors predisposing pregnant women to CMV are not well studied. CMV has a wide host cell tropism that includes gut epithelial cells. CMV infection in the gut epithelial cells results in a leaky gut and potential gut microbial dysbiosis. In this study, we set out to determine the prevalence of CMV infection as well as factors associated with CMV reactivation in a cohort of pregnant Zimbabwean women. We also aimed to determine the role of CMV infection and CMV susceptibility host genetics on gut bacterial profiles. Seroprevalence of CMV was determined using the enzyme-linked immunosorbent assay. A high prevalence of previous exposure to CMV, as denoted by the presence of anti-CMV IgG antibodies in participants' sera, was observed. Anti-CMV IgM antibodies that denote active CMV infection were detected in the sera of 4.6% (n=35/524) study participants. Prevalence of CMV was also determined using real time PCR, CMV reactivation was higher (6.7%) when using PCR than when using immunological assays (4.6%). The presence of CMV DNA was significantly associated with HIV positivity (p=0.04). PCR is the gold standard for CMV diagnosis, thus, CMV DNA positivity was used to denote CMV infection status in this thesis. The second objective was to determine if the differential effect of CMV acquisition or reactivation among HIV infected participants was due to variability in plasma efavirenz containing antiretroviral therapy (ART) exposure. Efavirenz (EFV) plasma concentrations were determined using high performance liquid chromatography (HPLC). Single nucleotide polymorphisms (SNPs) in the CYP2B6 gene, which encodes the main EFV metabolizing enzyme were genotyped. Carriers of CYP2B6 poor metaboliser (PM) genotypes (c.516T/T and c.983T/C) had significantly higher mean plasma EFV concentration compared to carriers of CYP2B6 fast metabolizer genotypes (i.e., c.516G/G and c.983T/T). CYP2B6 PM genotype carriers were significantly less likely to be positive for CMV DNA when compared with fast metabolizer genotype carriers (pC (p=0.002), TLR7 rs179008A>C (pC (p=0.003). In contrast, presence of the IL6 rs10499563T>C polymorphism was inversely correlated with CMV infection (p=0.002). The reported genetic variants are reported to modulate proteins involved in immune responses against viral infections, thus, their association with susceptibility to CMV infection. Such findings may assist in the designing of a muchneeded candidate CMV vaccine. Lastly, we set out to determine the possible role of CMV infection in shaping gut microbiota profiles. We report on a significant difference (p=0.001) in the beta diversity of gut bacterial profiles between HIV- and age-matched CMV-infected (cases) and CMVuninfected (controls) participants. Using linear discriminant analysis (LDA) effect size (LefSe), significant differences in the relative abundance of specific bacterial taxa were observed between cases and controls (p2). Significantly lower abundance of Lactobacillus reuteri and Roseburia, genera associated with lower microbial translocation was observed in cases than controls. Lower relative abundance of Lactobacillus and Roseburia, is consistent with microbial translocation and heightened inflammation, respectively, hence higher likelihood of microbial translocation and inflammation occurring in cases than controls. Furthermore, Prevotella copri, a species that has been association with cytokine release and chronic inflammation was significantly more abundant in cases than controls. CMV is a known chronic inflammatory condition, and this study provides further confirmation through the higher relative abundance of P.copri in cases than controls. Biomarker identification has proven to be a successful means of translating molecular data into clinical practice, such as vaccine development in the case of CMV infection. Overall, this study reports the possible interaction of various host factors in facilitating CMV acquisition or reactivation during pregnancy. In the setting of HIV-CMV coinfection, our findings emphasise on the need for genotype guided drug dosage to achieve therapeutic EFV so as to maintain the balance between host and coinfecting microbes in HIV management. Comprehensive genotype guided drug dosage, if taken as a once-off test should be affordable especially in resource-limited settings. This is particularly important in pregnant women who are at a risk of vertically transmitting infection to the immunologically immature foetus and or neonate. Data from this study may assist in curbing the host associated challenges in designing an effective CMV vaccine. Moreover, the biomarkers reported may assist in diagnosis and management of potential CMV acquisition or reactivation during pregnancy. However, bigger prospective, functional studies would be needed to confirm the exact roles of the biomarkers identified in this study in the diagnosis, prognosis and therapeutics of CMV infection.
7

Caractérisation d'un modèle d'infection cérébrale in utero par le cytomégalovirus chez le rat : conséquences post-natales et rôle de l'activation microgliale

Cloarec, Robin 17 December 2015 (has links)
L’infection par le cytomégalovirus (CMV) au cours de la grossesse est fréquente et représente la première cause de pathologie neurodéveloppementale. En dépit de cette importance médicale, il n’existe à ce jour aucun traitement préventif ou curatif satisfaisant, et les mécanismes physiopathologiques mis en jeu, en particulier au niveau du cerveau foetal, restent mal connus. Des découvertes récentes sur les modèles murins d’infection cérébrale par le CMV, principalement réalisées pendant la période néonatale, ont apporté des données convergentes sur la physiopathologie de ces infections cérébrales ; notamment, le rôle joué par les cellules immunitaires périphériques dans la résolution de l’infection, et l’implication du système immunitaire cérébral (SIC) au cours du processus infectieux. Afin de compléter et préciser les résultats précédemment obtenus dans différents modèles murins, et de comprendre le rôle joué par le SIC, le premier objectif de ma thèse a consisté à mettre au point et à caractériser un nouveau modèle d’infection cérébrale par le CMV au cours du développement in utero chez le rat. Dans l'ensemble, nos résultats confirment l'altération du SIC au cours de l'infection par le CMV du cerveau en développement, et suggèrent fortement, dans ce modèle, un rôle majeur joué par le système microglie/macrophage dans l'émergence de troubles neurologiques semblables à ceux observés dans la pathologie humaine correspondante. / Cytomegalovirus (CMV) infection during pregnancy is the leading cause of neurodevelopmental disorders (polymicrogyria, microcephaly) and may lead to severe sensorineural consequences (deafness, epilepsy, cerebral palsy and hearing loss). Despite this medical importance, no preventive or curative treatment is satisfactory to date, and the pathophysiological mechanisms, notably in the fetal brain, remain poorly understood. Recent findings in murine brain CMV infection, mostly in neonatal models, have brought converging insights into the pathogenesis of these infections; the possible role played by peripheral immune cells against infection and the involvement of the brain immune system (BIS) have been proposed. The actual roles of BIS during in utero infection, and more specifically that of microglial cells and macrophages, remain unclear. In order to expand and precise the data previously obtained in the murine models, and to clarify the role of BIS, the first objective of my thesis was to design and to characterize a novel model of CMV infection during the fetal development of the rat brain. Overall, our datas confirm the altered state of BIS as a consequence of CMV infection of the developing brain, and strongly suggest, in the rat model studied here, that the microglia/macrophages system plays critical role in the pathogenesis of neurological manifestations similar to those classically seen after human congenital CMV infection.
8

Estudo histopatologico, imunoistoquimico e de hibridização ¿in situ¿ das glandulas submandibular e sublingual em pacientes autopsiados com aids em fase avançada / Histopathological, immunohistochemical, and in situ hybridization study of the submandibular and sublingual glands of autopsied patients with advanced AIDS

Leon, Jorge Esquiche 14 February 2008 (has links)
Orientador: Pablo Agustin Vargas / Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba / Made available in DSpace on 2018-08-10T01:33:44Z (GMT). No. of bitstreams: 1 Leon_JorgeEsquiche_D.pdf: 14373006 bytes, checksum: 92ef59d2c370853b3a5a566177688788 (MD5) Previous issue date: 2008 / Resumo: Os objetivos do presente estudo foram descrever as características histopatológicas, immunoistoquímicas e de hibridização "in situ" (HIS) das lesões encontradas nas glândulas submandibular e sublingual de pacientes autopsiados com AIDS entre 1996 e 1999 no Serviço de Verificação de Óbitos da Capital (SVOC) - Faculdade de Medicina da Universidade de São Paulo (FMUSP). Dados referentes ao gênero, idade, contagem de células TCD4 e história clínica foram obtidos dos prontuários clínicos de 105 pacientes, destes 103 casos corresponderam às glândulas submandibulares e 92 casos às sublinguais. Todas as glândulas foram examinadas macroscopicamente e no estudo histopatológico utilizamos colorações de H&E, Gomori-Grocott; Ziehl-Neelsen e Mucicarmin. Análise imunoistoquímica foi realizada para detectar os agentes infecciosos (CMV, LMP-EBV, HSV-l, HSV-2, p24-HIV e BCG) e caracterizar as sialadenites (CD3, CD4, CD8, CD20 e CD68), já a HIS analizou a presença do VEB (EBER1/2). A média de idade dos pacientes e o nível de células TCD4 nos casos das glândulas submandibular e sublingual foi de 36,62 '+ ou ¿ ¿ 11,18 anos e 74,37 '+ ou ¿ ¿ 112,82 células/¿mu'L, e 35,93 '+ ou ¿ ¿ 0,2 anos e 78,75 '+ ou ¿ ¿ 118,98 células/¿mu'L, respectivamente. Foram considerados microscopicamente normais .51 (49,5%) casos da glândula submandibular e 54 (58,7%) casos da sublingual. As lesões infecciosas foram as mais freqüentes na glândula submandibular (n=35), seguida pela sialadenite crônica inespecífica em ambas as glândulas (n=25). Micobacteriose (11 e 07 casos nas glândulas submandibular e sublingual, respectivamente), citomegalovirose (14 e 02 casos nas glândulas submandibular e sublingual, respectivamente) e criptococose (03 e 04 casos nas glândulas submandibular e sublingual, respectivamente) foram freqüentemente detectadas. A análise imunoistoquímica mostrou que todos os casos em ambas as glândulas foram negativos para LMP-EBV, HSV-l e HSV-2, enquanto BCG mostrou intensa imunopositividade somente nos casos de micobacteriose com padrão macrofágico difuso (n=2). Dos 16 casos de citomegalovirose, apenas 06 casos (05 e 01 caso nas glândulas submandibular e sublingual, respectivamente) foram detectados pela imunoistoquímica. A proteína p24-HIV (02 e 01 caso nas glândulas submandibular e sublingual, respectivamente) e EBER1/2 (09 e 04 casos nas glândulas submandibular e sublingual, respectivamente), este último avaliado somente nos casos de sialadenités, foram expressas somente em escassos histiócitos e linfócitos, respectivamente, indicando que a participação destes vírus na etiopatogênese das sialadenites é pouco provável e precisa ser ainda melhor definida. As sialadenites crônicas inespecíficas foram principalmente compostas por linfócitos TCD8 (p=0,323); enquanto as sialadenites granulomatosas, as sialadenites macrofágicas difusas associada com micobacteriose e as sialadenites macrofágicas difusas inespecíficas apresentaram grande quantidade de macrófagos CD68+ (p=0,99) permeados por numerosos linfócitos TCD8, em ambas as glândulas. Além disso, um caso de linfoma não-Hodgkin difuso de grandes células B afetou ambas as glândulas. Estes resultados mostram que as glândulas submandibular e sublingual foram principalmente acometidas por lesões infecciosas disseminadas e sialadenite crônica inespecífica. Similarmente, as glândulas parótidas, num estudo previamente publicado por nossa equipe, foram acometidas por lesões infecciosas sistêmicas. Sendo assim, os clínicos devem estar atentos à ocorrência destas lesões em glândulas salivares maiores de pacientes com AIDS em fase avançada / Abstract: This study describes the histopathological, immunohistochemical (lHC), and in situ hybridization (ISH) features found in the submandibular (n=103) and sublingual (n=92) glands of autopsied patients who died with AIDS between 1996 and 1999 in the SVOC FMUSP (Medical School of São Paulo University). Sex, age, CD4 cell count, and clinical history were obtained from the clinical records of 105 patients, of them 103 cases corresponded to the submandibular glands and 92 cases to the sublingual glands. All glands were examined for macroscopical alterations and stained using H&E, Gomori-Grocott, Ziehl-Neelsen, and Mucicarmine. IHC analysis to detect infectious agents (CMV, LMP-EBV, HSV-l, HSV-2, HIV-p24, and BCG) and to characterize the sialadenitis (CD3, CD4, CD8, CD20, and CD68) was performed, while the ISH assessed the presence of EBV (EBERl/2). The mean age of the patients and CD4 cell count of the cases of the submandibular and sublingual glands were 36,62 '+ or ¿ ¿ 11,18 years and 74,37 '+ or ¿ ¿ 112,82 cells¿mu¿L POT .-1¿, and 35,93 '+ or ¿ ¿ 10,2 years and 78,75 '+ or ¿ ¿ 118,98 cells¿mu¿¿L POT .-1¿, respectively. There were no histological alterations in 51 (49,5%) and 54 (58,7%) cases of the submandibular and sublingual glands, respectively. The infection conditions were the most common in the submandibular gland (n=35), followed by chronic non-specific sialadenitis in both glands (n=25). Mycobacteriosis (11 and 07 cases of the submandibular and sublingual glands, respectively), cytomegalovirosis (14 and 02 cases of the submandibular and sublingual glands, respectively), and cryptococcosis (03 and 04 cases of the submandibular and sublingual glands, respectively) were found frequently. The IHC analysis did not show immunoreactivity for LMP-EBV, HSV-l, and HSV-2; while BCG displayed strong immunopositivity only in cases of chronic diffuse macrophagic infiltrate associated to mycobacteriosis (n=2). Six out of 16 cases of cytomegalovirosis (05 and 01 case of the submandibular and sublingual glands, respectively) were detected for IHC analysis only. The p24-HIV protein (02 and 01 case of the submandibular and sublingual glands, respectively) and EBERl/2 (09 and 04 cases of the submandibular and sublingual glands, respectively), this latter evaluated only in the sialadenitis cases, were expressed only in macrophages and lymphocytes, respectively, indicating that the participation of these viruses in the etiopathogenesis of the sialadenitis is still unc1ear. Chronic non-specific sialadenitis revealed CD8+ T-lymphocytes predominance (p=0,323), hile the granulomatous, diffuse macrophagic associated to mycobacteriosis, and chronic non-specific diffuse macrophagic sialadenitis showed great amount of CD68+ macrophages (p=0,99) surrounded by numerous CD8+ T-lymphocytes, in both glands. Moreover, one case of diffuse large B-celllymphoma affected both glands. These results indicate that both submandibular and sublingual glands were affected mainly by infectious diseases and chronic non-specific sialadenitis. Similarly, the parotid glands in a study previously published by our team, were mainly affected for systemic infectious diseases. Therefore, c1inicians should consider more carefully the occurrence of these lesions in major salivary glands of patients with advanced AIDS / Doutorado / Patologia / Doutor em Estomatopatologia
9

Cytomégalovirus Humain : variabilité, Recombinaison et Protéine pUL40 / Human Cytomegalovirus : variability, Recombination and Protein pUL40

Faure-Della Corte, Muriel 13 December 2010 (has links)
Le cytomégalovirus humain (CMV) appartient à la sous-famille des Betaherpès virus. L’homme est son seul réservoir et il infecte 40 à 90% de la population mondiale. Ce virus, rarement dangereux pour le sujet immunocompétent, représente une réelle menace chez le patient immunodéprimé comme le transplanté d’organe. Après la primo-infection, le CMV diffuse dans tout l’organisme et alterne des phases de latence et de réactivation. Il consacre 20% de son génome à diverses stratégies d’échappement immunitaire.Les objectifs de notre travail sont de décrire dans une première partie 1- la variabilité de six gènes, codant quatre protéines immunomodulatrices (UL18, UL40, UL111a et US3) et deux protéines immunodominantes (IE1 et pp65), dans des souches de CMV directement séquencées à partir de sang total ou du LBA de patients infectés et immunodéprimés, 2- le mécanisme conduisant à cette variabilité 3- la répartition des souches virales dans le sang total et le LBA (compartimentation).La deuxième partie est consacrée à l’expression de la protéine immunomodulatrice pUL40.Nos travaux ont permis de confirmer l’existence d’un polymorphisme notable, supérieur à ce qui est déjà décrit. Des conséquences fonctionnelles pourraient en découler dans les protéines correspondantes. L’étude in silico de la variabilité du CMV met en lumière le rôle clé de la recombinaison comme mécanisme évolutif majeur. Nous n’avons pas mis en évidence de compartimentation des souches virales dans les échantillons analysés.Nos résultats préliminaires indiquent la faisabilité de la sur-expression de la protéine pUL40, permettant ultérieurement de mieux comprendre ses fonctions. / Human Cytomegalovirus (CMV) belongs to the Betaherpesviruses sub-family. Human beings are its sole reservoir and it infects 40 to 90% of the world population. This virus is rarely dangerous for the immunocompetent host, but represents a problematic opportunistic agent in immunocompromised patients, such as transplant recipients. After primary infection, CMV spreads widely in the organism and alternates latency and reactivation phases. CMV dedicates 20% of its genome to various immune escape strategies.Our aims were to describe, in a first part, 1- the variability of six CMV genes, which encode 4 immunomodulatory proteins (UL18, UL40, UL111a and US3) and two immunodominant proteins (IE1 and pp65), after direct amplification and sequencing from whole blood and bronchoalveolar lavages (BAL) taken from infected immune compromised patients, 2- the mechanism responsible for this variability 3- the distribution of CMV strains in whole blood and BAL (compartmentalization).In a second part, we attempted pUL40 expression.Our results confirmed the existence of a noticeable polymorphism, superior to what was previously described. Functional consequences could arise for the corresponding proteins. Our in silico study of CMV variation indicated a key role for recombination as a major evolutionary mechanism. We have observed little CMV compartmentalization among the investigated samples. Our preliminary results indicated pUL40 may be over-expressed, which could allow a better understanding of its functions in a near future.
10

Maskinstyrning i vält och vilken påverkan det har för lönsamhet och kvalitet.

Brännström, Oscar, Rova, Olle January 2022 (has links)
Machine control for a roller is a tool that can be applied by contractors during compactionwork. The machine control includes a function that can sense how packed a surface the rollerpasses is, the degree of compaction is then reported in a dimensionless Compaction MeterValue (CMV) number. With the help of the compaction function, it is possible to reduce thenumber of static plate loads that must be carried out in accordance with the Swedish TransportAdministration's requirements. From a cost point of view, it is positive if the number of plateloads decreases as they are very resource demanding, the machine control can thereforecontribute to a cost saving. The roller's machine control also includes a function that can sensethe height coordinate of the compacted road surface, which can reduce an engineer’s time outon projects.NCC's road and construction department in Umeå city applied machine control on one of itsprojects carried out on behalf of the Swedish Transport Administration. The project is aEuropean road E09 which is 136,000 square meters. According to the Swedish TransportAdministration's requirements, for traditional statistical acceptance control, five to eight staticplate loads must be performed every 5000 m2 of road area. For an acceptance control withmachine control instead of performing the traditional acceptance control, the number ofmeasuring points is reduced to one or two measuring points per 5000 m2 of road.From identified literature, it becomes clear that the advantages of machine control outweighthe few disadvantages identified. Literature states that when applying machine control, it ispossible to reduce costs associated with packing work by 54 percent, it also leads to anincreased quality assurance where 100 percent of the road body can be controlled. Fortraditional statistical acceptance control, only 1 percent of the road's bearing capacity ischecked with random plate loads.In the study, the impact of machine control on quality and quality work has been explored.Statistical acceptance control is performed with a maximum of eight randomly selected pointcontrols on a surface that can be up to 5000 m2. If this is compared with the roller’s compactionwork where the entire control object is being validated with the compaction computer in theroller first, in addition the weakest point or points are also checked. Then it is possible to makea reasoning that about 1 percent of the control object is checked during statistical acceptancecontrol while 100 percent of the control object is inspected during acceptance control with themachine control system. This reasonably entails a higher quality of the control object. However,there are uncertainties with the measured value CMV, which does not hold any dimension andis completely dependent on how the roller is calibrated. This means that CMV cannot becompared between different rollers on different projects if they are not calibrated equally.Therefore, we suggest that contractors should always calibrate their rollers in the samemanners.vA profitability calculation has been performed where NCC's projects are evaluated and it iscalculated how the usage of machine control has affected the project, an estimated cost isestablished for the use of machine control and a cost if it had not been applied. The calculationis based on interviews with relevant people within construction companies as they haveexpertise in handling the equipment.The profitability calculation showed that the realistic outcome for the project meant a saving of35 percent regarding costs that can be attributed to compaction work. The literature statedthat savings could reach up to 54 percent, it seems to be in the upper range as the reasonableoutcome is lower by 19 percentage points. Machine control still contributes to improvedprofitability but not as strongly as research claims, it may also be due to the fact that theprofitability calculation is based on an individual project, to get more reliable data moreprojects would have had to be evaluated.

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