Thesis (MPH) --University of Limpopo, 2007. / Aim of the study: To determine knowledge of CPR and heart attack or cardiac arrest signs and symptoms among university students. Study Design: A questionnaire based descriptive, cross – sectional study. Setting: University of Limpopo – Turfloop Campus in Limpopo Province of South Africa. Subjects: A total sample of 400 students participated in the study. The sample was selected randomly using simple random sampling techniques. Outcome measures: The faculty, age, gender and level of study were determined as well as the knowledge each student has on signs and symptoms of impending heart attack and CPR.Results: Of the 400 students only 26% (n=104) knew the signs and symptoms of an impending heart attack as well as out of hospital management of heart attack by performing CPR. There were differences between and within faculties, age groups, gender and level of study. Based on the Bonferroni test the student from faculty of Sciences, Health and Agriculture are more likely (p-value 0017) to know when to perform CPR compared to students from other faculties. Level of study is not associated (p-value 0128) with how much the students know about the timing and indications of CPR. Overall female students performed worse with 79% (n=123) responding incorrectly to the questions compared to 69% (n=169) males. Conclusion: Based on the results of this study it safely can be concluded that the students’ knowledge of signs and symptoms of an impending heart attack and CPR procedure is poor. It is therefore important for the university as a center of teaching and learning to consider including as part of university curriculum, basic life support and first aid courses which include CPR. The inclusion of basic life support and first aid in university curriculum will prepare students to be able to effectively manage out of hospital heart attack and reduce mortality resulting from the latter. The findings of this study might to a certain extent be reflecting what the public’s knowledge on the subject is, hence the need for the policy makers to take serious note of the findings when public health promotion programmes are developed.

[Truncated abstract] Cardiac surgery involving cardiopulmonary bypass is a complex procedure that results in significant changes to blood coagulation, fibrinolytic biochemistry, platelet number and function, and the vasculature. These are due to pharmacological agents which are administered, haemodilution and contact of the blood with artificial surfaces. Consequently there are significant risks of thrombosis and haemorrhage associated with this procedure. The research presented in this thesis utilises in vitro, in vivo, and a novel ex vivo model to investigate the nature of the haemostatic defect induced by cardiopulmonary bypass. The components studied include the drugs heparin, protamine sulphate, and aprotinin, different types of bypass circuitry (including heparin bonded circuits) and procedures such as acute normovolaemic haemodilution. Patient variables, such as Factor V Leiden, are also studied. Each of these components is assessed for the effects on a number of laboratory measures of haemostasis including activated partial thromboplastin time, prothrombin time, activated protein C ratio, antithrombin concentration, heparin concentration, thrombin-antithrombin complex formation, prothrombin fragment 1+2 formation, markers of platelet surface activation and secretion, activated clotting time, haemoglobin concentration and coagulation factor assays.

<p>Death from heart diseases is the most common type of mortality in western countries and the survival rate of cardiac arrest is dismally low. In the treatment of cardiac arrest, two therapeutic methods are most important: cardiopulmonary resuscitation (CPR; chest compressions and ventilations) and defibrillation (electrical shocks to restart a fibrillating heart).</p><p>An automated external defibrillator is commonly used for such shocks, and records and performs signal analysis on the electrocardiogram(ECG) in order to advice when to shock the patient. However, the mechanical activity during CPR introduces artifact components in the ECG. To perform reliable ECG signal analysis, CPR is therefore discontinued for a substantial time before the potential delivery of a shock. This wastes valuable therapy time, and if this hands-off time could be reduced or eliminated by removing these artifacts, it should improve the chance of return of spontaneous circulation.</p><p>We propose a method for removing CPR artifacts using a novel multichannel adaptive filter, the computationally efficient and numerically robust MultiChannel Recursive Adaptive Matching Pursuit(MC-RAMP) filter. Using the most realistic data set to date, human out-of-hospital cardiac arrest data of both shockable and non-shockable rhythms, we test MC-RAMP and evaluate the feasibility of ECG analysis during CPR. In our experiments we use a shock advice algorithm and individual ECG signal features to reach the conclusion that after CPR artifact filtering, ECG rhythm analysis during ongoing CPR is feasible. </p><p>Finally, we analyze and quantify the time intervals without blood flow (no flow time(NFT)) during external automatic defibrillation in cardiac arrest patients and show that these patients were not perfused around half of the time. We propose methods using CPR artifact filtering to reduce the NFT, and show their significant and promising potential. By introducing the proposed methods into defibrillators, the NFT would be significantly reduced, hopefully increasing the survival.</p>

<p>Aim: The aim was to investigate the ambulance nurses experiences during a specific ambulance missions that led to usage of LUCAS ™.Method: Participating ambulance nurses were randomly assigned from a total sample group of 12 women and 39 men. Five women and five men participated. Qualitative interviews were conducted, where the Critical Incident Technique approach was used. Collected interviews were valued using qualitative content analysis.Result: Interview texts were divided into three domains, 10 subcategories could be identified which were sorted into three categories. A theme was finally formulated.The initial alarm data from SOS Alarm is important for the ambulance nurses preparation. There where cardiac arrest situations when the work went well, as well as situations where problems arose. The informants expressed that they should practice on LUCAS ™ to a greater extent than they now are doing. Staff in the emergency room, some time was perceived as stressful and they did not listen. The informants expressed frustration with the major administrative tasks after a LUCAS™ case, on the other hand, the "team spirit" where highlighted, they solve the task together.Conclusion: Developments during ambulance missions where LUCAS ™ will be used depends on, alarm data, resources, situation at the scene, planning, roles, supervision, handling of LUCAS ™ and Case Report Form, relatives and viewer reactions, the receipt at the emergency department and finally that ambulance staff cooperates after the LUCAS ™ mission.</p> / <p>Syfte:<strong> </strong>Syftet var att undersöka ambulanssjuksköterskors upplevelser under ett bestämt ambulansuppdrag som ledde fram till begagnande av LUCAS™.</p><p>Metod: Deltagande ambulanssjuksköterskor lottades ur en total urvalsgrupp bestående av 12 kvinnor och 39 män. Fem kvinnor och<strong> </strong>fem män deltog. Kvalitativa intervjuer genomfördes, där Critical Incident Technique metoden användes. Insamlade intervjudata värderades med hjälp av kvalitativ innehållsanalys.</p><p>Resultat:<strong> </strong>Intervjutexten kunde delas in i tre domäner, 10 underkategorier kunde identifieras som sorterades i tre kategorier. Slutligen formulerades ett tema. De initiala larmuppgifter från SOS Alarm är viktiga för ambulanssjuksköterskornas förberedelser. Det förekom hjärtstoppssituationer där arbetet gick bra, likväl situationer där problem uppstod. Informanterna uttryckte att de borde öva på LUCAS™ i större utsträckning än de gör i nu läget. Vid en del situationer upplevdes mottagande personal på akutmottagningen som stressade och att de inte lyssnade. Betecknande för informanternas upplevelser vad gäller de administrativa uppgifterna efter LUCAS™ uppdraget var inte positivt, dock betonades "team work".</p><p>Slutsats: Utvecklingen under ambulansuppdrag där LUCAS™ kommer till användning är beroende av; larmfakta, resurser, situationen på plats, planering, roller, arbetsledning, hanterandet av LUCAS™ och Case Report Form, anhöriga och åskådares reaktioner, mottagandet på akutmottagningen och slutligen att ambulanspersonalen samarbetar efter LUCAS™ uppdraget.</p>

Laparoscopic liver surgery is complicated due to the structure of this organ with open sinusoids. A serious disadvantage is the risk of gas embolism (GE) due to CO2 pneumoperitoneum. CO2 can enter the vascular system through a wounded vein. A common opinion is that gas fluxes along a pressure gradient, e.g. CVP-intra abdominal pressure (IAP). The occurrence of GE could also be eased by entrainment, a ‘Venturi-like’ effect, due to cyclic differences in thoracic pressure and blood flow caused by mechanical ventilation at normal frequency. The aims of these studies were to survey, in a porcine model, the influence on respiratory and haemodynamic variables by GE, to determine at what frequency, severity and duration GE occurs during laparoscopic liver resection (LLR) and whether there are methods to influence the occurrence or severity of GE. Pulmonary and circulatory variables were monitored and measured as well as continuous blood gas monitoring. Transoesophageal echocardiogram was used to identify GE and, according to the amount of bubbles in the right outflow tract of the heart, GE was graded as 0, 1 and 2. Pneumoperitoneum was created by using CO2and IAP was set to 16 mm Hg. A single bolus dose of CO2 influenced respiratory and haemodynamic variables for at least 4 h. During LLR GE occurred in 65-70% of the animals, of which the more serious caused negative influence on cardiopulmonary variables. Elevated PEEP (15 cm H2O) increased CVP but GE occurred irrespective if CVP was lower than or exceeded IAP. In two last studies, a hepatic vein was cut and left open for 3 m before it was clipped. Interestingly, no signs of GE were seen despite an open vein and IAP &gt; CVP in 8 of 20 animals. In the last study high frequency jet ventilation was used in order to minimise the risk of entrainment. The duration of GE was shortened. The occurrence of GE seemed to be influenced by several different factors. The physiological reaction of a GE is impossible to predict for a specific patient, and depends among other factors on comorbidity, and amount, site and entrance rate of GE.

Death from heart diseases is the most common type of mortality in western countries and the survival rate of cardiac arrest is dismally low. In the treatment of cardiac arrest, two therapeutic methods are most important: cardiopulmonary resuscitation (CPR; chest compressions and ventilations) and defibrillation (electrical shocks to restart a fibrillating heart). An automated external defibrillator is commonly used for such shocks, and records and performs signal analysis on the electrocardiogram(ECG) in order to advice when to shock the patient. However, the mechanical activity during CPR introduces artifact components in the ECG. To perform reliable ECG signal analysis, CPR is therefore discontinued for a substantial time before the potential delivery of a shock. This wastes valuable therapy time, and if this hands-off time could be reduced or eliminated by removing these artifacts, it should improve the chance of return of spontaneous circulation. We propose a method for removing CPR artifacts using a novel multichannel adaptive filter, the computationally efficient and numerically robust MultiChannel Recursive Adaptive Matching Pursuit(MC-RAMP) filter. Using the most realistic data set to date, human out-of-hospital cardiac arrest data of both shockable and non-shockable rhythms, we test MC-RAMP and evaluate the feasibility of ECG analysis during CPR. In our experiments we use a shock advice algorithm and individual ECG signal features to reach the conclusion that after CPR artifact filtering, ECG rhythm analysis during ongoing CPR is feasible. Finally, we analyze and quantify the time intervals without blood flow (no flow time(NFT)) during external automatic defibrillation in cardiac arrest patients and show that these patients were not perfused around half of the time. We propose methods using CPR artifact filtering to reduce the NFT, and show their significant and promising potential. By introducing the proposed methods into defibrillators, the NFT would be significantly reduced, hopefully increasing the survival.

The Analysis of Ilan¡¦s Out-of-Hospital Cardiac Arrest (OHCA) Patients Abstract The study uses Ilan¡¦s out-of-hospital cardiac arrest (OHCA) patients as the research object to understand the variable backgrounds of OHCA patients how they are affected by first aid factors between the period of pre-hospital and post-hospital admission. The study also discusses whether there is a correlation between first aid factors and first aid prognosis among those OHCA patients during pre-hospital and post-hospital admission periods. The study is retrospective and based on the Utstein style format. It collects 284 out-of-hospital cardiac arrest (OHCA) patient cases with trauma and non-trauma (282 effective samples) in an example of a regional teaching hospital in Ilan from 2007 to 2009. It uses descriptive statistics, independent sample t test, and Chi-Square test as the statistical analysis to obtain the following conclusions: 1. There are 282 effective sample patients in the study. There are 57 patients ( 20.2 %) who were return of spontaneous circulation (ROSC) after cardiac arrest approximately 14.77 minutes on average. There are 33 patients (11.7 % ) who survived to be hospitalized for 15.36 days on average, and there are 6 patients ( 2.1 % ) who were discharged from the hospital. 2. Internal medicine disease is the major causative factor of out-of-hospital cardiac arrest. Among those internal medicine disease cases, the history showed hypertension, diabetes mellitus, and heart diseases are the main causes of out-of-hospital cardiac arrest. Patients who are older than 65 years old are the main age groups, accounting for 67.7% of these cases. 3. The pre-hospital admission factors which affect the prognosis after the Emergency Department (ED) are the place of the accident, whether there are witnesses, scene process time , total reaction time , whether automatic external defibrillation was used, and whether people at the scene used CPR. 4. The post-hospital admission factors which affect the prognosis after the ED are initial cardiac rhythm, body temperature, pupil size , dose of epinephrine, whether defibrillation was used, the time of applying emergency first-aid, and medical expense. 5. The percentages of return of spontaneous circulation and survival rates in the study are lower than those of past studies of Taipei City and National Taiwan University Hospital. The possible factors are probably related to differences between rural and urban areas in the quality of emergency medical service systems (EMSS), and healthcare training. 6. From now on, in addition to improving the first-aid continuous monitoring system, we should also enhance EMT related training, and actively educate people to understand and learn CPR, so that comprehensive first-aid systems are available everywhere to effectively increase the success rate of first-aid. Keywords¡GOut-of-hospital cardiac arrest (OHCA), Cardiopulmonary resuscitation

In this thesis an integrated, dynamic model for cardiovascular and respiratory systems has been developed. Models of cardiopulmonary system, airway mechanics and gas exchange that preexisted in literature have been reviewed, modified and combined. Combined model composes the systemic and pulmonary circulations, left/right ventricles, tissue/lung compartments, airway/lung mechanics and gas transportation. Airway resistance is partitioned into three parts (upper, middle, small airways). A collapsible airways segment and a viscoelastic element describing lung tissue dynamics and a static chest wall compliance are included. Frank-Starling Law, Bowditch effect and variable cerebral flow are also employed in the model. The combined model predictions have been validated by laboratory data collected from two healthy, young, male subjects, by performing dynamic bicycle exercise tests, using Vmax 229 Sensormedics, Cardiopulmonary Exercise Testing Instrument. The transition from rest to exercise under a constant ergometric workload is simulated. The initial anaerobic energy supply, autoregulation and the dilatation of pulmonary vessels are considered. Mean arterial blood pressure and the blood gas concentrations are assumed to be regulated by the controllers of the central nervous system namely, the heart rate and alveolar ventilation. Cardiovascular and respiratory regulation is modeled by a linear feedback control which minimizes a quadratic cost functional.

Diss. (sammanfattning) Umeå : Umeå universitet, 2009. / Härtill 5 uppsatser. Även tryckt utgåva.

Σκοπός: Η FEV1 αποτελεί μέτρο του βαθμού της απόφραξης των αεραγωγών και γι’ αυτό το λόγο χρησιμοποιείται για τη σταδιοποίηση της ΧΑΠ και του άσθματος. Οι μηχανισμοί που εμπλέκονται και προσδιορίζουν τη δυνατότητα ανοχής στην κόπωση αυτών των ασθενών είναι πλέον πολύπλοκοι και δεν καθορίζονται μόνο από το βαθμό απόφραξης των αεραγωγών . Σκοπός της μελέτης ήταν η αξιολόγηση 1. Του βαθμού που ο λειτουργικός έλεγχος που προηγείται της κόπωσης σχετίζεται με την ανοχή στην κόπωση 2. Της σχέσης που υπάρχει μεταξύ της ποιότητας ζωής και της ανοχής στην κόπωση σε ασθενείς με αποφρακτική πνευμονοπάθεια Υλικό-Μέθοδος: Μελετήθηκαν 163 ενήλικες (107 άνδρες, 56 γυναίκες), οι οποίοι παρακολουθούνται στο τακτικό Πνευμονολογικό Ιατρείο της Πανεπιστημιακής Παθολογικής Κλινικής του Πανεπιστημίου Πατρών. Στην μελέτη περιλήφθησαν 57 ασθενείς (44 άνδρες, 13 γυναίκες) με ΧΑΠ Επίσης περιλήφθησαν 29 ασθενείς με άσθμα (16 άνδρες, 13 γυναίκες). 77 (47 άνδρες, 30 γυναίκες) είχαν φυσιολογική σπιρομέτρηση και χρησιμοποιήθηκαν ως ομάδα ελέγχου. Όλοι οι ασθενείς πριν την έναρξη του λειτουργικού ελέγχου συμπλήρωσαν την ελληνική μετάφραση του ερωτηματολογίου για τις αναπνευστικές νόσους το St. George’s Respiratory Questionnaire και υπεβλήθησαν σε πλήρη λειτυργικό έλεγχο της αναπνοής. Αποτελέσματα: Οι ασθενείς με ΧΑΠ και βαρύτητα νόσου σταδίου Ι είχαν φυσιολογική ανταπόκριση στην άσκηση με φυσιολογική ικανότητα για άσκηση, οι ασθενείς σταδίου ΙΙ είχαν μειωμένη ικανότητα κόπωσης 70%, ενώ οι ασθενείς σταδίου ΙΙΙ και ΙV είχαν πολλή μεγαλύτερη μείωση της ικανότητας για άσκηση. Όσο αφορα τους ασθματικούς 28 από τους 29 ασθματικούς ασθενείς είχαν φυσιολογική VO2peak (109%) και είχαν επαρκείς αναπνευστικές εφεδρείες (>43%), δείγμα ότι το αναπνευστικό σύστημα γι’ αυτούς τους ασθενείς δεν αποτέλεσε περιοριστικό παράγοντα άσκησης. Η ποιότητα ζωής των ασθενών με ΧΑΠ και ιδιαίτερα οι δραστηριότητες τους εξαρτώνται από τη μέγιστη ικανότητα για άσκηση και επομένως από τον περιορισμό των εκπνευστικών ροών όπως αυτές περιγράφονται από την FEF25-75, από τη βλάβη που υφίστανται οι μηχανικές ιδιότητες του πνεύμονα όπως αυτές περιγράφονται από τον MVV καθώς επίσης και από το δείκτη επιφανείας σώματος. Συμπεράσματα: Με αρκετά σημαντική ακρίβεια είναι δυνατόν να προβλεφθεί η μείωση της ικανότητας για άσκηση των ασθενών με ΧΑΠ από τις τιμές του λειτουργικού ελέγχου που προηγείται της άσκησης, ενώ και η ποιότητα ζωής των ασθενών με ΧΑΠ φαίνεται να επηρεάζεται από λειτουργικές παραμέτρους που συμβάλουν στη μειωμένη αυτή ικανότητα για άσκηση που εμφανίζουν οι ασθενείς με αποφρακτική πνευμονοπάθεια. / Exercise tolerance in patients with airflow limitation (COPD and Asthma) has multiple determinants and is difficult to predict from measurements of resting pulmonary function. Measurements of maximum exercise tolerance have been reported to be useful in disability evaluation and determination of the cause of exertional symptoms. In addition, understanding the factors which predict exercise capacity will provide clues to a better understanding of physical activity limitations in patients with airflow limitation (COPD and asthma). Previous studies in patients with COPD have indicated that ventilatory limitation is a primary determinant of exercise tolerance. However, individual pulmonary function parameters as FEV1 explain only about half of the variance in measured exercise tolerance. For many patients with airflow limitation, psychosocial characteristics may interact with physiologic abnormalities to limit physical work capacity. To date, few published studies have closely examined the role of psychosocial variables in the prediction of peak VO2 in patients with COPD and asthma. The Global Initiative for Chronic Obstructive Pulmonary Disease (GOLD) statement and GINA statement recommended that chronic obstructive disease and asthma be staged on the basis of the percentage of predicted FEV1. Patients with COPD have restricted respiratory airflow, which predisposes them to dyspnea. To avoid dyspnea, patients develop a sedentary lifestyle that leads to a decreased exercise tolerance, which, in turn, aggravates the dyspnea. The decrease in exercise tolerance is marked by a reduced maximum oxygen consumption (VO2max) and lower ventilatory anaerobic threshold (Vth). This study uses data from a clinical trial of rehabilitation in COPD patient and from outpatient stable asthmatic patient. The purposes of the analysis were the following: to examine how well exercise tolerance, specifically PaO2 after exercise and VO2 peak, can be predicted from a combination of physiologic and psychosocial measurements, and to provide insight into factors determining and limiting exercise capacity in COPD and asthmatic patients. The other purpose of this study was to examine the relation between patients with airway limitation (COPD and Asthma) and health-related quality of life. A total of 57 outpatient stable COPD patients and 29 asthmatic stable patients underwent cardiopulmonary testing and filled in a form of Saint George’s Respiratory Questionnaire (SGRQ). We examined the correlation between GOLD criteria for staging COPD patients and health-related QoL throughout the performance of a cardiopulmonary exercise test. CONCLUSIONS According to our results, maximum exercise tolerance is predicted reasonably well from measurements of resting pulmonary function in COPD patients. The most consistent predictors of VO2 peak were measurements of expiratory airflow limitation (FEF2575) and inspiratory– expiratory strength (MVV); none of the psychosocial variables added significantly to the accuracy of the prediction of peak VO2. In addition, only symptoms (dyspnea) influenced maximum exercise performance and decreased it. The effect of symptoms on VO2max depended on the severity of the disease set by the GOLD guidelines. Our findings indicate that we will have to include additional parameters in GOLD stages, such as the SGRQ and probably ergometry test, when COPD patients are classified. The predicted value and FEV1/FVC <70%) minimally affects health-related QoL, whereas stage II (FEV1, 30% to 80% of the predicted value) and stage III (FEV1< 30% of the predicted value) disease is associated with profound deterioration in health-related QoL. The relation between FEV1 and health-related QoL reported that the QoL was not significantly associated with the percentage of predicted FEV1; Activities are impaired proportionally to GOLD stages in our study. This indicates that COPD patients in early stages do not reduce their activities, but in severe stages (continually diminishing FEV1) their activities are reduced. We found that in COPD patients, activities do not correlate with aximum exercise performance our findings indicate that we will have to include additional parameters in GOLD stages, like SGRQ and probably ergometry test, when COPD patients are classified.