The design of a microcomputer-based monitoring and display system for a cardiopulmonary bypass loop is discussed. Analog signals representing blood temperature and oxygen saturation of sample points entering and leaving the blood oxygenator, patient temperature, oxygenator heat exchanger water temperature and hemoglobin content are monitored and displayed. The hemoglobin content and oxygen saturation signals, input from a reflective-type hemoglobin meter and oximeter are corrected for blood temperature and operator input pH. The oxygen saturation is also corrected for hemoglobin content. Oxygen transfer to the patient is calculated and displayed to evaluate the effectiveness of the system in cardiopulmonary support. Alarms are issued for free gas in blood, no blood flow, and high oxygenator water temperature. The hardware and software design is described along with schematics and flowcharts. A complete software listing is included. The monitoring and display system is operational, but has not been tested with flowing blood. / M.S.

Bakgrund: I Sverige finns det inga lagar som reglerar beslut om livsupphållande behandling. I de etiska riktlinjerna och föreskrifter står läkarens roll tydligt definierat men inte sjuksköterskans. Ett ställningstagande till HLR är ett etiskt svårt beslut och när en patient inte är beslutsförmögen kan sjuksköterskans expertis i omvårdnad bidra med kunskap och väglednings i beslut om HLR Syfte: Att belysa sjuksköterskans upplevelser kring beslutsfattandet av att avstå hjärt- och lungräddning. Metod: Författarna har genomfört en litteraturöversikt vilket betyder att kunskap inom ett specifikt område har identifierats och analyserats. Resultat: I resultatet beskrivs sjuksköterskors attityder och upplevelser om de etiska dilemman som uppstår vid ställningstagandet och hur sjuksköterskor önskar att vara delaktiga i beslutsfattandet om HLR. Brist på information om HLR till patienter, personal emellan och olika synsätt på HLR kan orsaka konflikter. Sjuksköterskorna beskriver även hur vårdrelationen påverkas av HLR-beslut. Tre huvudteman och åtta subteman framkom. Diskussion: De mest framträdande delarna i resultatet visade på de etiska dilemman som kan uppstå vid ställningstagandet till HLR. De aspekter som påverkar är kommunikation, informella aspekter och värdering av livskvalitet. Olika handlingsalternativ diskuteras i förhållande till uppsatsens bakgrund, teoretisk utgångspunkt, vetenskaplig litteratur och vetenskapliga studier. / Background: In Sweden there are no laws governing the decision on life sustaining treatment. The ethical guidelines and regulations are clear about the physicians role but do not clarify the nurses role. A decision on CPR is ethically difficult and when a patient is not lucid nurse's expertise in nursing can contribute with knowledge and guidance in decisions about CPR. Aim: To explore the nurse’s experiences of decision-making regarding do-not-resuscitate orders. Method: The authors conducted a literature review which refers to knowledge in a specific area which was defined and analyzed. Results: The result describes nurses' attitudes and perceptions about ethical dilemmas that arise in the decision-making process of CPR and the wish to be involved in the decision. Lack of information on CPR to patients, between staff and different approaches to CPR can cause conflicts. The nurses also describe how the relationship is affected by the CPR decision. Three main themes and eight subthemes emerged. Discussion: The most prominent elements of the result showed the ethical dilemmas which may arise from the standpoint of CPR. The aspects that affect the decision-making process are communication, informal aspects and estimation of quality of life. Various choices are discussed in relation to the thesis background, theoretical basis, scientific literature- and studies.

O prognóstico após a parada cárdio-respiratória (PCR) e reanimação cardio-pulmonar (RCP) depende de intervenções críticas, particularmente, do tempo de resposta entre a chamada de socorro ou resgate, até a chegada ao local onde se encontra a vítima, além das compressões torácicas eficazes, da desfibrilação precoce e do suporte avançado de vida. Para avaliar a eficácia e a adequação dos procedimentos de RCP durante a PCR, entidades e associações científicas se reuniram e elaboraram o Utstein Style out-of-hospital, cujas definições e instrumento, usados para registro do evento, têm sido amplamente utilizadas em todo o mundo, bem como para estudos publicados sobre atendimento à parada cardíaca. A adoção de um instrumento de consenso internacional levou a uma grande evolução guidelines de reanimação e a progressos científicos, possibilitando a troca de informações mais efetivas para promover comparações internacionais em relação aos procedimentos de ressuscitação tendo como propósito codificar variáveis, mensurar aspectos do processo e avaliar resultados dos atendimentos na PCR fora do hospital. Apesar do grande numero de PCR que ocorre no Brasil, não há, até então, um instrumento em nosso idioma adaptado à nossa realidade. Este trabalho teve pro objetivos realizar a tradução e adaptação cultural do Utstein Style out-of-hospital, com base nos pressupostos metodológicos de Guillemin (2002). O instrumento foi, também, testado em dois centros de atendimento pré-hospitalar para verificar a viabilidade de sua utilização. Como resultado deste estudo metodológico obtivemos um instrumento traduzido para o idioma português, com algumas modificações necessárias para sua adaptação à cultura nacional, sugeridas por um comitê de juizes e cuja aplicação, ainda que em pré-teste, permitiu verificar que os resultados obtidos assemelham-se aos dados internacionais. O maior número de causas de PCR ocorreu em adultos do sexo feminino (58,8%), com idade acima de 29 anos. Grande parte das paradas cardíacas foi identificada por espectador (47,0%), pelo Serviço Médico de Emergência (35,5) e pelo médico (17,5%). Quanto à ocorrência da PCR, 82,4% foi por causa desconhecida e 17,6% por trauma / The prognostic after the cardiac arrest and cardio-pulmonary resuscitation (CPR) is dependent of critical interventions, particularly, time reply called until place, efficient chest compressions early defibrillation and the advanced life support. The definitions of the Utstein style and the instrument of register have been widely used in published studies of cardiopulmonary arrest (CPA), what it took to a great evolution and the progress for international consensuses on science and guidelines of resuscitation, making possible the exchange of information more effective to promote international auditorship in relation to the resuscitation procedures having as intention to codify variable, to measure aspects of the process and to evaluate resulted of the take care of in the CPA of the hospital. Currently several countries already use with this purpose. The Utstein was approved by the international committees. Although the great one number of CPA in Brazil, we did not possess an instrument in our language and adapted. This instrument underwent a process of translation into Portuguese, back-translation into its original language and finally analysis by a committee of judges to evaluate semantics, idiomatic, cultural and conceptual equivalences, with the authorization of the AHA, following the recommendations of Guillemin, revised in 2002. The instrument was tested in two centers the out-of-hospital attendance to verify the use of in the Brazilian country and making possible comparisons with international data, enriching adding the evolution of the CPR in the world. As result of this study we got an instrument translated into the Portuguese language, with some necessary modifications for its adaptation to the national culture, suggested for a committee of judges and whose application allowed verifying that the gotten results resemble it the international data. The biggest number of CPA causes occurred in adults, females (58.8%), with age above of 29 years. Great part of the CPA was identified by witness (47.0%), the Emergency Medical Service (35.5%) and by the physician (17.5%). Several occurrences of CPA, 82.4% it was for unknown cause and 17.6% for trauma

A parada cardiorrespiratória é um evento potencialmente letal, e a qualidade do atendimento prestado depende da agilidade, conhecimento e habilidade de toda a equipe envolvida. O desenvolvimento de um guia com os pontos relevantes a serem observados durante o atendimento à PCR intra-hospitalar surgiu em 1997, com a criação do In-Hospital Utstein Style por uma força tarefa de especialistas em atendimento e pesquisa em PCR. Trata-se de um guia que agrega informações acerca do atendimento à PCR, contendo um relatório padrão para coleta de dados, divido em variáveis: do paciente, do evento e de resultados, além de algumas informações adicionais. A criação de um relatório padrão de coleta de dados, permitiu uniformizar a linguagem, bem como o desenvolvimento de novas pesquisas, baseadas no mesmo modelo. Com a finalidade de disponibilizar o In-hospital Utstein Style para a realidade brasileira, este instrumento foi submetido ao processo de tradução e adaptação cultural, nas seguintes etapas: tradução para o português, retro-tradução para a língua de origem, análise por comitê de juízes para avaliação das equivalências semântica, idiomática, cultural e conceitual. O resultado deste processo gerou um instrumento para pré-teste, aplicado em 20 pacientes que sofreram PCR, com a finalidade de verificar o comportamento do instrumento em nossa realidade. As variáveis de resultado não foram coletadas, pois pressupõe o acompanhamento destes pacientes ao longo do tempo. A amostra foi constituída por 60,0% de homens, com idade média de 63 anos ±16,17. O ritmo de PCR mais comum foi atividade elétrica sem pulso (65,0%), o tempo médio para desfibrilar foi de 1,25 minutos. Assim como observado por pesquisadores internacionais, existem informações perdidas durante o atendimento, não registradas, prejudicando a coleta dos dados referentes a este momento. A análise dos dados, permite concluir que o instrumento é aplicável à realidade brasileira, tornando possíveis comparações com estudos internacionais, buscando melhor atendimento ao evento da PCR. A falta de preenchimento de alguns itens , principalmente aqueles referentes às variáveis do evento (coletados no momento da PCR), podem ser perdidos, por falta de preenchimento adequado do instrumento, por profissionais médicos e de enfermagem. O treinamento e incentivo para melhorar a quantidade e qualidade de registros, tornam possíveis, através da aplicação do Utstein Style conhecer cada atendimento feito e toda a assistência prestada, identificando prováveis falhas e principalmente investindo em qualidade de vida após o evento / Cardiopulmonary Arrest is a potentially lethal event in which the quality of the service rendered depends on agility, knowledge and the skills of all of the involved team. The development of the first guide identifying the significant points to be taken during the procedure of an in-hospital CPA appeared in 1997, with the creation of the In-Hospital Utstein Style by a task force of personnel specialized in attendance and research of CPA. This guide brings together information concerning CPA attendance and contains a standardized report for collecting data which is divided into the following variables: patient, event, and the outcome, as well as some other additional information. The creation of this standardized report for collecting data made it possible to standardize the language as well as to develop new research based on the same model. With the intended goal of making available, the In-hospital Utstein Style for Brazilian professionals, this instrument underwent a process of translation and cultural adaptation in the following steps: translation into Portuguese, back-translation into its original language and finally analysis by a committee of judges to evaluate semantics, idiomatic, cultural and conceptual equivalences. The outcome of this process resulted in a pre-test instrument applied to 20 patients who had had CPA in order to verify the behavior of this instrument according to our reality. The outcome variables were not collected, because it involved accompanying these patients over a lengthy period of time. The sample consisted of 60% men, with an average age of 63 years ±16, 17. The most common CPA rhythm was pulseless electrical activity (65%); the defibrillation average time was 1.25 minutes. Therefore, as verified by international researchers, there is a loss of information during the attendance, which is not-recorded, thus hindering the collection of data concerning the moment of the CPA. With the data analysis, we can conclude that the instrument is adaptable to the Brazilian reality, enabling further comparisons with international studies, therefore improving the care administered during the CPA event. The failure to complete some of the items principally those referencing the variables of the CPA event (that should have been collected at the CPA moment) could result in critical data being lost if not properly answered in the report done by attending medical and nursing personnel. Personnel trained and encouraged to improve the quantity and quality of date collection can make it possible, through the utilization of the Utstein Style, to better understand each attendance and assistance rendered, identifying possible failures and, above all, enabling further investments in quality of life after the arrest

O prognóstico após a parada cárdio-respiratória (PCR) e reanimação cardio-pulmonar (RCP) depende de intervenções críticas, particularmente, do tempo de resposta entre a chamada de socorro ou resgate, até a chegada ao local onde se encontra a vítima, além das compressões torácicas eficazes, da desfibrilação precoce e do suporte avançado de vida. Para avaliar a eficácia e a adequação dos procedimentos de RCP durante a PCR, entidades e associações científicas se reuniram e elaboraram o Utstein Style out-of-hospital, cujas definições e instrumento, usados para registro do evento, têm sido amplamente utilizadas em todo o mundo, bem como para estudos publicados sobre atendimento à parada cardíaca. A adoção de um instrumento de consenso internacional levou a uma grande evolução guidelines de reanimação e a progressos científicos, possibilitando a troca de informações mais efetivas para promover comparações internacionais em relação aos procedimentos de ressuscitação tendo como propósito codificar variáveis, mensurar aspectos do processo e avaliar resultados dos atendimentos na PCR fora do hospital. Apesar do grande numero de PCR que ocorre no Brasil, não há, até então, um instrumento em nosso idioma adaptado à nossa realidade. Este trabalho teve pro objetivos realizar a tradução e adaptação cultural do Utstein Style out-of-hospital, com base nos pressupostos metodológicos de Guillemin (2002). O instrumento foi, também, testado em dois centros de atendimento pré-hospitalar para verificar a viabilidade de sua utilização. Como resultado deste estudo metodológico obtivemos um instrumento traduzido para o idioma português, com algumas modificações necessárias para sua adaptação à cultura nacional, sugeridas por um comitê de juizes e cuja aplicação, ainda que em pré-teste, permitiu verificar que os resultados obtidos assemelham-se aos dados internacionais. O maior número de causas de PCR ocorreu em adultos do sexo feminino (58,8%), com idade acima de 29 anos. Grande parte das paradas cardíacas foi identificada por espectador (47,0%), pelo Serviço Médico de Emergência (35,5) e pelo médico (17,5%). Quanto à ocorrência da PCR, 82,4% foi por causa desconhecida e 17,6% por trauma / The prognostic after the cardiac arrest and cardio-pulmonary resuscitation (CPR) is dependent of critical interventions, particularly, time reply called until place, efficient chest compressions early defibrillation and the advanced life support. The definitions of the Utstein style and the instrument of register have been widely used in published studies of cardiopulmonary arrest (CPA), what it took to a great evolution and the progress for international consensuses on science and guidelines of resuscitation, making possible the exchange of information more effective to promote international auditorship in relation to the resuscitation procedures having as intention to codify variable, to measure aspects of the process and to evaluate resulted of the take care of in the CPA of the hospital. Currently several countries already use with this purpose. The Utstein was approved by the international committees. Although the great one number of CPA in Brazil, we did not possess an instrument in our language and adapted. This instrument underwent a process of translation into Portuguese, back-translation into its original language and finally analysis by a committee of judges to evaluate semantics, idiomatic, cultural and conceptual equivalences, with the authorization of the AHA, following the recommendations of Guillemin, revised in 2002. The instrument was tested in two centers the out-of-hospital attendance to verify the use of in the Brazilian country and making possible comparisons with international data, enriching adding the evolution of the CPR in the world. As result of this study we got an instrument translated into the Portuguese language, with some necessary modifications for its adaptation to the national culture, suggested for a committee of judges and whose application allowed verifying that the gotten results resemble it the international data. The biggest number of CPA causes occurred in adults, females (58.8%), with age above of 29 years. Great part of the CPA was identified by witness (47.0%), the Emergency Medical Service (35.5%) and by the physician (17.5%). Several occurrences of CPA, 82.4% it was for unknown cause and 17.6% for trauma

A parada cardiorrespiratória é um evento potencialmente letal, e a qualidade do atendimento prestado depende da agilidade, conhecimento e habilidade de toda a equipe envolvida. O desenvolvimento de um guia com os pontos relevantes a serem observados durante o atendimento à PCR intra-hospitalar surgiu em 1997, com a criação do In-Hospital Utstein Style por uma força tarefa de especialistas em atendimento e pesquisa em PCR. Trata-se de um guia que agrega informações acerca do atendimento à PCR, contendo um relatório padrão para coleta de dados, divido em variáveis: do paciente, do evento e de resultados, além de algumas informações adicionais. A criação de um relatório padrão de coleta de dados, permitiu uniformizar a linguagem, bem como o desenvolvimento de novas pesquisas, baseadas no mesmo modelo. Com a finalidade de disponibilizar o In-hospital Utstein Style para a realidade brasileira, este instrumento foi submetido ao processo de tradução e adaptação cultural, nas seguintes etapas: tradução para o português, retro-tradução para a língua de origem, análise por comitê de juízes para avaliação das equivalências semântica, idiomática, cultural e conceitual. O resultado deste processo gerou um instrumento para pré-teste, aplicado em 20 pacientes que sofreram PCR, com a finalidade de verificar o comportamento do instrumento em nossa realidade. As variáveis de resultado não foram coletadas, pois pressupõe o acompanhamento destes pacientes ao longo do tempo. A amostra foi constituída por 60,0% de homens, com idade média de 63 anos ±16,17. O ritmo de PCR mais comum foi atividade elétrica sem pulso (65,0%), o tempo médio para desfibrilar foi de 1,25 minutos. Assim como observado por pesquisadores internacionais, existem informações perdidas durante o atendimento, não registradas, prejudicando a coleta dos dados referentes a este momento. A análise dos dados, permite concluir que o instrumento é aplicável à realidade brasileira, tornando possíveis comparações com estudos internacionais, buscando melhor atendimento ao evento da PCR. A falta de preenchimento de alguns itens , principalmente aqueles referentes às variáveis do evento (coletados no momento da PCR), podem ser perdidos, por falta de preenchimento adequado do instrumento, por profissionais médicos e de enfermagem. O treinamento e incentivo para melhorar a quantidade e qualidade de registros, tornam possíveis, através da aplicação do Utstein Style conhecer cada atendimento feito e toda a assistência prestada, identificando prováveis falhas e principalmente investindo em qualidade de vida após o evento / Cardiopulmonary Arrest is a potentially lethal event in which the quality of the service rendered depends on agility, knowledge and the skills of all of the involved team. The development of the first guide identifying the significant points to be taken during the procedure of an in-hospital CPA appeared in 1997, with the creation of the In-Hospital Utstein Style by a task force of personnel specialized in attendance and research of CPA. This guide brings together information concerning CPA attendance and contains a standardized report for collecting data which is divided into the following variables: patient, event, and the outcome, as well as some other additional information. The creation of this standardized report for collecting data made it possible to standardize the language as well as to develop new research based on the same model. With the intended goal of making available, the In-hospital Utstein Style for Brazilian professionals, this instrument underwent a process of translation and cultural adaptation in the following steps: translation into Portuguese, back-translation into its original language and finally analysis by a committee of judges to evaluate semantics, idiomatic, cultural and conceptual equivalences. The outcome of this process resulted in a pre-test instrument applied to 20 patients who had had CPA in order to verify the behavior of this instrument according to our reality. The outcome variables were not collected, because it involved accompanying these patients over a lengthy period of time. The sample consisted of 60% men, with an average age of 63 years ±16, 17. The most common CPA rhythm was pulseless electrical activity (65%); the defibrillation average time was 1.25 minutes. Therefore, as verified by international researchers, there is a loss of information during the attendance, which is not-recorded, thus hindering the collection of data concerning the moment of the CPA. With the data analysis, we can conclude that the instrument is adaptable to the Brazilian reality, enabling further comparisons with international studies, therefore improving the care administered during the CPA event. The failure to complete some of the items principally those referencing the variables of the CPA event (that should have been collected at the CPA moment) could result in critical data being lost if not properly answered in the report done by attending medical and nursing personnel. Personnel trained and encouraged to improve the quantity and quality of date collection can make it possible, through the utilization of the Utstein Style, to better understand each attendance and assistance rendered, identifying possible failures and, above all, enabling further investments in quality of life after the arrest

Abstract Cardiac surgery with cardiopulmonary bypass (CPB) results in hemodilution, systemic inflammatory response, activation of coagulation and fibrinolysis, and microembolisation, which may all contribute to postoperative organ dysfunction. As an attempt to attenuate these side effects, the use of minimized cardiopulmonary bypass (MCPB) systems has increased. Compared to conventional CPB (CCPB), they are characterized with reduced artificial surface area and blood-air interface. The goal of these alterations has been to reduce systemic inflammation, preserve coagulation function and minimize the need for blood tranfusions. This study was aimed at determining whether or not MCPB attenuates the adverse effects of CPB. In study I, the safety, feasibility and effect on transfusion requirements of MCPB was investigated in unselected coronary artery bypass surgery (CABG) patients. In studies II and III, the incidence of retinal microembolism after CABG and aortic valve replacement (AVR) surgery with MCPB was compared to that of CCPB by means of fluorescein angiography. Furthermore, in studies II and III, the effect of MCPB on systemic inflammation, coagulation, endothelial activation and injury, as well as on platelet activity, was compared to those of CCPB. In study IV, the effect of MCPB on intestinal mucosal damage following CPB was compared to CCPB in a porcine model of prolonged CPB. MCPB appeared as safe and feasible as CCPB in unselected CABG patients (Study I). MCPB was associated with decreased retinal microembolism compared to CCPB in CABG patients (Study II). Conversely, the difference in retinal microembolism in AVR patients was not statistically significant (Study III). MCPB was associated with a decrease in neutrophil activation in CABG and AVR patients as compared to CCPB. However, there were no differences in coagulation, endothelial activation and injury, or in platelet activity (Studies II, III). There were no differences in markers of intestinal mucosal damage between MCPB and CCPB following prolonged CPB in the experimental model (Study IV). The results of this study suggest that MCPB may be used safely with CABG patients, with beneficial effects on hematocrit, and attenuated neutrophil activation. In CABG patients, MCPB is associated with reduced retinal microembolism, suggesting a decreased embolic load to the brain. The clinical feasibility of MCBP requires further technical evolution in the management of valve surgery. The results of the animal model support previous concerns regarding intestinal mucosal damage during CPB. / Tiivistelmä Sydänkeuhkokoneen käyttö aiheuttaa elimistössä hemodiluution, yleistyneen tulehdusvasteen ja hyytymisjärjestelmän aktivoitumisen sekä mikroembolisaatiota. Ilmiöt ovat yleensä lieviä ja ohimeneviä, mutta voivat johtaa elintoimintahäiriöihin ja pitkittyneeseen toipumiseen sydänleikkauksen jälkeen. Haittojen lievittämiseksi sydänkeuhkokonetta on pyritty kehittämään fysiologisemmaksi. Miniperfuusiolaitteistoissa kiertävän veren kontakti pintamateriaalien ja ilman kanssa jää pienemmäksi ja veren laimenemista tapahtuu vähemmän. Tutkimuksen tavoitteena oli selvittää voidaanko miniperfuusiolla lievittää sydänkeuhkokoneen haittoja. Ensimmäisessä osatyössä selvitettiin miniperfuusion käyttökelpoisuutta ja vaikutusta verensiirtotarpeeseen ohitusleikkauspotilailla valikoimattomassa aineistossa. Toisessa ja kolmannessa osatyössä selvitettiin silmänpohjan mikroembolioiden ilmaantuvuutta miniperfuusion ja perinteisen sydänkeuhkokoneen käytön jälkeen ohitusleikkauspotilailla ja aorttaläppäleikkauspotilailla. Toisessa ja kolmannessa osatyössä selvitettiin lisäksi miniperfuusion vaikutuksia yleistyneen tulehdusvasteen voimakkuuteen, hyytymisjärjestelmään sekä endoteelin aktivaatioon perinteiseen sydänkeuhkokoneeseen verrattuna. Neljännessä osatyössä verrattiin kokeellisessa mallissa miniperfuusion ja perinteisen sydänkeuhkokoneen vaikutuksia suoliston limakalvon eheyteen. Miniperfuusio ilmeni yhtä käyttökelpoiseksi kuin perinteinen sydänkeuhkokone ohitusleikkauspotilaiden hoidossa. Ohitusleikkauspotilailla ilmeni vähemmän silmänpohjan mikroembolioita miniperfuusion jälkeen, mutta aorttaläppäleikkauspotilailla ero ei ollut tilastollisesti merkitsevä. Miniperfuusion käyttöön liittyi vähemmän neutrofiilien aktivaatiota. Tekniikoiden välillä ei ilmennyt eroa hyytymisjärjestelmän eikä endoteelin aktivaatiota osoittavissa merkkiaineissa. Sydänkeuhkokoneen käyttö aiheutti saman tasoisen suoliston limakalvon vaurion miniperfuusiolla ja perinteisellä sydänkeuhkokoneella. Tutkimuksen perusteella miniperfuusiotekniikkaa voidaan käyttää turvallisesti ohitusleikkauspotilaiden hoidossa ja sen käyttö vähentää hemodiluutiota ja neutrofiilien aktivaatiota verrattuna perinteiseen sydänkeuhkokoneeseen. Miniperfuusiolla voidaan vähentää sydänkeuhkokoneen käytön aiheuttamaa silmänpohjan mikroembolisaatiota, joka saattaa viitata vähäisempään aivoverenkierron mikroembolisaatioon. Miniperfuusiotekniikoiden tulee edelleen kehittyä hyödyttämään enemmän myös aorttaläppäleikkauspotilaita. Löydökset koskien sydänkeuhkokoneen aiheuttamia suoliston limakalvovaurioita vahvistavat aiempaa olettamusta suoliston haavoittuvuudesta sydänleikkauksen jälkeen.

Master of Science / Department of Kinesiology / Craig A. Harms / In comparison to adults and adolescents, relatively little is known about ventilatory responses of prepubescent children to exercise. Children have smaller airways relative to lung size than adults and ventilate "out of proportion" to metabolic demands of exercise which may render them more susceptible to ventilatory limitations during exercise. It is also not known if there are any sex differences in ventilatory limitations during incremental exercise in children. Therefore, the purpose of this study was to determine the prevalence of ventilatory constraints (expiratory flow limitation, EFL) during incremental exercise to exhaustion in prepubescent (Tanner stage 1) boys and girls. Forty healthy, prepubescent boys (n = 20) and girls (n = 20) with no history of asthma completed baseline pulmonary function and lung volume tests. Subjects then completed an incremental cycle VO[subscript]2max test where workload was increased 10W every 90 sec until exhaustion. RPE, dyspnea ratings, and % EFL were recorded at the end of each exercise stage. EFL was determined by placing the exercising tidal volume loop inside a post-exercise maximal flow volume envelope. Ventilatory and metabolic data were recorded on a breath by breath basis throughout exercise via a metabolic cart. Arterial oxygen saturation was determined via pulse oximetry. Body composition was determined using dual-energy x-ray absorptiometry. Following 15 minutes of recovery, subjects exercised at 105% of their VO[subscript]2max workload until exhaustion to provide confident in the VO[subscript]2max measurement. There were no differences (p>0.05) in anthropometric measures (height, weight) or body composition (lean body mass, percent body fat) measures between boys and girls. At rest, boys had significantly higher lung volumes (TLC, boys = 2.6 + 0.5 L, girls = 2.1 + 0.5 L; FRC, boys = 0.9 + 0.3 L, girls = 0.7 + 0.3 L) and maximal flows (FVC, boys = 2.2 + 0.3 L, girls = 1.9 + 0.4 L; PEF, boys = 3.6 + 0.7 L/sec, girls = 2.9 + 0.6 L/sec; FEV1, boys = 1.9 + 0.2 L/sec, girls = 1.6 + 0.3 L/sec). At maximal exercise, boys had significantly higher VO[subscript]2max (boys = 35.4 + 7.5 ml/kg/min, girls = 29.5 + 6.6 ml/kg/min; boys = 1.2 + 0.2 L/min, girls = 1.0 + 0.2 L/min), VE (boys = 49.8 + 8.8 L/min, girls = 41.2 U+U 8.3 L/min), and VCO[subscript]2 (boys = 1.2 + 0.2 L/min, girls = 0.9 + 0.2 L/min) compared to girls. There were no differences (p>0.05) in VE/VCO2 (boys = 41.1 + 3.9, girls = 43.4 + 5.5), PETCO2 (boys = 35.5 + 2.5 mmHg, girls = 35.7 + 3.2 mmHg) maximal HR (boys = 174.4 + 23.1 bpm; girls = 183.4 + 16.6 bpm), RER (boys = 1.04 + 0.05, 1.03 + 0.08), or SaO2 (boys = 96.7 + 3.4%, girls = 97.7 + 1.3%) which was maintained within 3% of baseline throughout exercise for all subjects. EFL during exercise was present in 19 of 20 boys and 18 of 20 girls. Severity of EFL at VO2max, as judged by % overlap of tidal volume with maximal flow volume envelope, was not different between genders at any time during exercise (at VO[subscript]2max: boys = 58 + 7%, girls = 43 + 8%). There was no significant association between % EFL at VO[subscript]2max and aerobic capacity or total lung volume. A significant relationship existed between % EFL at VO[subscript]2max and the change in end-expiratory lung volume from rest to maximal exercise in boys (r = 0.77) and girls (r = 0.75). In summary, our data suggests that ventilatory constraints in the form of expiratory flow limitation are highly and equally prevalent in prepubescent boys and girls from moderate to maximal exercise which likely leads to an increased work of breathing, but not to decreases in arterial oxygen saturation.

Bakgrund: Tidigare har närstående inte tillåtits att närvara vid hjärt-lungräddning (HLR) men diskussionen har ökat i omfattning. European Resuscitation Council och American Heart Association förespråkar närståendes närvaro men trots detta tillåter många länder inte detta. Sveriges sjukhus inrapporterade 2586 hjärtstopp år 2014. Närstående upplever lidande när en nära blir sjuk, vilket kopplas till familjefokuserad omvårdnad där de närstående och patienten ska ses som en helhet. Här läggs det vikt vid socialt stöd som har betydelse för en individs hälsa, en sjuksköterska kan vara lämplig som stödjande person. Syfte: Syftet med denna litteraturöversikt var att beskriva sjuksköterskans uppfattningar av att ha närstående närvarande vid HLR. Metod: En litteraturöversikt har gjorts innehållande 12 vetenskapliga artiklar med både kvantitativ och kvalitativ ansats. Resultat: Sjuksköterskor känner oro för hur närstående påverkas av att bevittna HLR, att de ska ingripa i återupplivningsarbetet. Sjuksköterskor uppfattar stöd till närstående som väsentligt för att möjliggöra närvaro vid HLR. Närstående uppfattas påverka den sociala och fysiska miljön. Riktlinjer för sjuksköterskor behövs. Konklusioner: Sjuksköterskor uppfattar att det saknas förutsättningar för närstående att närvara vid HLR. Med en stödperson för de närstående och tydliga riktlinjer kan detta främjas. Däremot finns det hinder så som arbetsmiljö som försvårar möjligheten för närståendes närvaro. / Background: Earlier, relatives’ weren ́t allowed to be present at cardiopulmonary resuscitation (CPR) but nowdays the topic is highly relevant. European Resuscitation Council and American Heart Association recommends this practice. However, many countries don ́t allow this. In 2014, 2586 cardiac arrests were reported in Swedish hospitals. Relatives are suffering when loved ones becomes ill, which is linked to family-centered care where relatives and patient should be seen as a whole. This places emphasis on social support which ́s important to peoples health. A nurse may be suitable as a support person. Purpose: The purpose of this literature review was to describe nurses' perceptions of having relatives present during cardiopulmonary resuscitation. Method: A literature review was made containing 12 scientific articles with both quantitative and qualitative approach. Results: Nurses are concerned about how relatives are affected by witnessing CPR, that they may interfere in the resuscitation efforts. Nurses perceive that support for the relatives are essential. Relatives are perceived to have impact on the social and physical environment. Guidelines for nurses are needed. Conclusions: Nurses perceive that with staff who can support the family and with the availability of guidelines and a well-functioning work environment it ́s possible to have relatives present during CPR.

Syfte: var att undersöka vilken pedagogisk metod, instruktörsledd eller filmbaserad med facilitator som ger bäst kunskap såväl kortsiktigt som långsiktigt vid hjärt-lungräddningsutbildning (HLR) i årskurs sju. Syftet var även att undersöka elevers motivation till att ingripa i en akut hjärtstoppssituation. Teori Då lärande enligt läroplanen ska ske i social miljö, genom samspel har jag i studien valt att utgå från det sociokulturella perspektivet där kontexten är viktig i ett sammanhang, i kombination med praktikorienterad teori för att beskriva lärandet. Metod Datainsamling har skett genom en kombination av kvantitativ och kvalitativ metod. Åttio elever utförde treminuters praktiskt test direkt efter utbildningstillfället i HLR samt efter tre månader. Bedömning av medvetandekontroll och andningskontroll utfördes genom direktobservation. Kvalitet på utförd HLR registrerades via en övningsdocka kopplad till ett datorbaserat program, Leaerdal PC skill reporter. Insamlad data registrerades i en modifierad version av mätinstrumentet Cardiff Test. I testet bedömdes 13 variabler med total poängsumma 12-48 poäng. Primärt effektmått var den totala poängen med enskilda variabler som sekundär endpoints. En hypotes är att det inte är någon skillnad mellan utbildningsmetoderna gällande elevernas totalpoäng, vilket medför att den filmbaserade metoden är effektivare då den utförts i helklass. Semistrukturerade intervjuer genomfördes direkt efter utbildningstillfället för att undersöka elevers motivation till att göra en livräddande insats. Resultat: Ingen signifikant skillnad ses mellan utbildningsgrupperna beträffande kvalitetstestets totalpoäng, vare sig vid mätning direkt efter utbildningstillfället; instruktörsledd 33 poäng, DVD-baserad 34 poäng, eller vid tre månaders uppföljning; instruktörsledd 31 poäng, DVD-baserad 30 poäng. Vid tremånaders test utförde majoriteten av eleverna bröstkompressioner med handplacering för långt ned mot bröstbensspetsen, DVD-baserad 20 %, instruktörsledd 48 %. I den instruktörsledda gruppen sågs vid tre månaders uppföljning en signifikant ökning av andelen elever som utförde kompressioner med korrekt kompressionsdjup (5-6 cm), 7,5 % vs 32,5 %, DVD-baserad 10 % vs 25 %. Flertalet elever ansåg spontant att de hade tillräckliga kunskaper för att göra en livräddande insats. Vid följdfrågor framkom dock att flertalet av de intervjuade kände oro och rädsla för bristande kunskaper, dels för att skada den drabbade, dels för att göra fel vid en livräddande insats i verkligheten. Några elever beskrev att bekräftelse och återkoppling bidrog till att stärka elevens självkänsla till att våga ingripa i en verklig situation, vilket kan vara svårt att hinna med vid utbildning i stora grupper. En möjlig slutsats är att den filmbaserade metoden är effektivare sätt till antal utbildade deltagare, men med stöd av sociokulturell teori bör det i framtida utbildningar avsättas mer tid för gemensamt lärande, tillvaratagande av frågeställningar samt avsättning av tid för individuell och gemensam reflektion. / Aim: To compare students’ practical CPR skills and attitude to perform bystander CPR after instructor-led versus DVD-based training. Method:  Data was collected through a combination of quantitative and qualitative methods. CPR skills were assessed of 80 seventh grade students during a three minutes practical test, directly after training and at three months follow up by using a PC Skill Reporting System. For CPR skills a total score, 12-48 points, was calculated.  A hypothesis is that there is no difference between training methods regarding students' total score, which means that the DVD-based method is more efficient when performed with the whole class. Nine semi-structured interviews were conducted immediately after the training to investigate students' motivation to make a life-saving effort. Result: There were no significant differences between the instructor-led or the DVD-based group regarding CPR skills, a total score of 33 points versus 34 points directly after training and 31 points versus 30 points at three months, respectively.Most students felt spontaneously that they had enough knowledge to make a life-saving effort, but the follow-up questions showed that the majority of the responders, felt worry and fear of lack of sufficient knowledge, to harm the victim or to make mistakes in a life-saving situation. Some students described that feedback after the practical test, helped to strengthen the student's self-esteem, which can be difficult to find time for when training in large groups.One possible conclusion is that the DVD-based method is more efficient in number of participants trained, but with support of the socio-cultural theory, it should in future trainings aside more time for joint learning, valorization of issues and deposition of time for individual and collective reflection.