Bakgrund Att förlösas med kejsarsnitt fortsätter att öka internationellt och något nationellt och är även förenligt med risker. Kejsarsnittsfrekvensen varierar stort i Sveriges olika län och tros delvis bero på att kriterier och rutiner för kejsarsnitt skiljer sig åt. Syfte Att beskriva hur operationssjuksköterskans roll i det interprofessionella teamet vid kejsarsnitt framställs i riktlinjer vid svenska sjukhus som utför kejsarsnitt Metod En totalundersökning av Sveriges sjukhus riktlinjer vid kejsarsnitt ledde till att en tvärsnittsstudie med kvantitativ deskriptiv design användes. Riktlinjerna färgkodades utifrån ett systemteoretiskt perspektiv och en granskningsmall gjordes för att enhetligt kunna beskriva hur operationssjuksköterskans roll framställs i respektive riktlinje. Ett reliabilitetstest på mallen gjordes och Cronbach’s alfa beräknades till 0,891. Resultat 29 av 41 av Sveriges sjukhus som utför kejsarsnitt är representerade i studien. Operationssjuksköterskans roll identifierades slutligen utifrån fyra strukturer; direkt omnämnd, indirekt omnämnd, del i det interprofessionella teamet och beskriven utifrån variabler. Vid analys av riktlinjerna utifrån granskningsmallen, framkom det att i elektiva riktlinjer var det 4 sjukhus som hade över 75 % av variablerna i sina riktlinjer, vid akuta 8 och urakuta 11. Slutsats Riktlinjerna är mer samstämmiga i beskrivningen av operationssjuksköterskans roll vid urakuta riktlinjer dock inte alltid med en arbetsbeskrivning. En tydlig framställning av operationssjuksköterskans roll skulle kunna uppnås genom att använda variabler i den framtagna granskningsmallen och därmed bidra till ökad patientsäkerhet och mer likvärdig vård. / Background Cesarean delivery continues to increase internationally and somewhat nationally and also includes risks. The frequency varies greatly in Sweden's counties and is believed to be partly due to that the criteria and routines for cesarean sections differ. Aim To describe how the operating room nurse in the interprofessional team in cesarean section is stated in guidelines at Swedish hospitals that perform cesarean sections.  Method A total survey of Sweden's hospital guidelines for cesarean sections led to the use of a cross-sectional study with a quantitative descriptive design. The guidelines were color-coded based on a systems theory perspective and a review template was made to be able to uniformly describe how the operating room nurse is presented in each guideline. A reliability test on the template was done and Cronbach's alpha was calculated to be 0.891. Result 29 of 41 of Sweden's hospitals that perform cesarean sections are represented in the study. The operating room nurse was ultimately identified based on four structures; directly mentioned, indirectly mentioned, part of the interprofessional team and described based on variables. When analyzing the guidelines based on the review template, it emerged that in elective guidelines, there were 4 hospitals that had over 75 percent of the variables in their guidelines, in acute 8 and in emergency 11.  Conclusion The guidelines are more consistent in the description of the operating room nurse in emergency procedures, although not always with a work description. A clear presentation of the operating room nurse could be achieved by using variables in the developed review template and thus contribute to increased patient safety and more equal care.

No description available.

Thesis (MPH.) -- University of Limpopo, 2022 / The burden of labour and delivery-related complications are health problems that are life-threatening for the fetus and pregnant women. Mokopane hospital in Waterberg of Limpopo Province reports many maternal health complications. There has not been an investigation into the burden of delivery complications and therefore this study aims to investigate the burden of labour and delivery complication experienced by women giving birth at Mokopane hospital of Limpopo province. Purpose: of this study was to explore the burden of labour and delivery-related complications among pregnant women at Mokopane hospital of Limpopo province. Methods: A cross-sectional, retrospective descriptive study was conducted. The study followed a quantitative approach and the researcher completed a questionnaire using clinical records from all delivery files of mothers delivered at maternity between January 2017 to December 2019 Mokopane hospital. Findings: The major finding of this study was the majority of women were at a low risk of pregnancy (69%) followed by a high risk of pregnancy (24%). The study further revealed that (73.7%) of women at Mokopane hospital were delivered through the normal virginal procedure and (25.8%) delivered through Caesarean section. Moreover, about 86% of the mothers were normal after delivery whilst 14% were sick or had complications. Conclusion: This study, therefore, recommends that educational programs about labour and delivery-related complications and related programs should be prioritised for pregnant women. KEY CONCEPTS The burden: Is the intensity or severity of disease and its possible impact on daily life (Gidron 2013). In the context of this study, the burden will refer to the death and loss of health due to labour and delivery-related complications among pregnant women at Mokopane hospital of Limpopo Province. Labour: This is the process of rhythmic uterine contractions which results in cervical dilatation, a descent of the presenting part; and delivery of the fetus, placenta, and membrane. (Anthony & Van Der Spuy, 2002; Clark, Van de Velde, & Fernando, 2016). In the context of this study, labour will be defined as a physiologic process during which the fetus, membranes, umbilical cord, and placenta are expelled from the uterus. Delivery related complication: Is an acute condition arising from a direct cause of maternal death, such as antepartum or postpartum haemorrhage, obstructed labour, postpartum sepsis, a complication of abortion, pre-eclampsia or eclampsia, ectopic pregnancy and ruptured uterus, or indirect causes such as anaemia, malaria and tuberculosis. (WHO, 2018). In the context of this study, delivery related complications will include amongst others severe antenatal bleeding, Postpartum haemorrhage, nonconvulsive hypertensive disorder of pregnancy (pre-eclampsia), Eclampsia: preeclampsia plus convulsions, Convulsions, Prolonged labour, Premature rupture of the membranes, Retained placenta. Pregnant women: Is a woman who is in the period from conception to birth in which the egg is fertilised by a sperm and then implanted in the lining of the uterus then develops into the placenta and embryo, and later into a foetus (Martin, 2015). In the context of this study, a pregnant woman will be described as a woman who is carrying a developing embryo or fetus within her body.

Actualmente, los partos por cesárea suelen ser frecuentes, y en su mayoría uno de cada tres neonatos proviene de cesárea. Generalmente se suministra antibióticos antes o en la intervención quirúrgica con el fin de disminuir el riesgo de adquirir infecciones, sin embargo, algunas gestantes padecen de estas complicaciones. Siendo una de cada cuatro, así como, una de cada diez gestantes adquiere una infección del útero (endometritis) u originan una complicación en la incisión en la piel. Las complicaciones repercuten en la mejoría de la cirugía y pudiendo perjudicar la suficiencia de la progenitora para atender a su neonato. Por lo tanto, necesitarían de mayores intervenciones para disminuir mucho más el peligro de infecciones del útero, así como las complicaciones de la herida post parto por cesárea. (13) Esta exploración crítica, encontró que la higiene de la vagina con una solución antiséptica rápidamente antes del parto por cesárea disminuyo el peligro de la infección del útero postcesárea. Mostrando un mayor beneficio cuando la gestante realizó ruptura prematura de membranas. A su vez, esta inspección no implicó que la higiene vaginal aminorara en la totalidad de féminas que manifestaban fiebre o complejidades de la herida postoperatoria. El antiséptico fue yodopovidona, y en la observación se careció de eventos adversos de la preparación vaginal con dicha solución, tales como, irritación o alergia. La preparación vaginal con solución de yodopovidona en el preoperatorio inmediato de una cesárea disminuye el peligro de endometritis postoperatoria. Este resultado beneficioso, particularmente se indica para gestantes con ruptura de membranas siendo inducidas al parto por cesárea. Siendo un procedimiento sencillo y de costo bajo, los profesionales de la salud debemos contemplar la viabilidad de desarrollar la higiene vaginal preoperatoria con yodopovidona antes de efectuar los partos por cesárea. / Nowadays, cesarean deliveries are frequent, and most of them one out of three neonates are delivered by cesarean section. Antibiotics are usually administered before or during the surgical intervention in order to reduce the risk of acquiring infections, however, some pregnant women suffer from these complications. One in four, as well as, one in ten pregnant women acquire an infection of the uterus (endometritis) or originate a complication in the skin incision. Complications have repercussions on the improvement of the surgery and may impair the sufficiency of the mother to take care of her newborn. Therefore, further interventions would be needed to further reduce the risk of uterine infections as well as post cesarean wound complications (13). This critical exploration found that hygiene of the vagina with an antiseptic solution promptly before cesarean delivery decreased the danger of post cesarean uterine infection. It showed a greater benefit when the pregnant woman had premature rupture of membranes. In turn, this inspection did not imply that vaginal hygiene was reduced in all the women who manifested fever or postoperative wound complexities. The antiseptic was iodopovidone, and in the observation there were no adverse events of vaginal preparation with this solution, such as irritation or allergy. Vaginal preparation with iodopovidone solution in the immediate preoperative period after cesarean section reduces the risk of postoperative endometritis. This beneficial result is particularly indicated for pregnant women with ruptured membranes being induced to delivery by cesarean section. Being a simple and low-cost procedure, health professionals should consider the feasibility of developing preoperative vaginal cleansing with iodopovidone before performing cesarean deliveries.

Introduktion: Omedelbart kejsarsnitt är ett akut kirurgiskt ingrepp som utförs när det finns medicinska komplikationer som kräver omgående intervention för att skydda modern eller barnets liv. Proceduren utförs under tidspress och nästan alltid med generell anestesi, vilket innebär att de preoperativa förberedelserna ofta är begränsade. Anestesisjuksköterskans roll är avgörande i dessa situationer för att säkerställa en effektiv hantering av ingreppet. Stressfaktorer för anestesisjuksköterskor är påtagliga i dessa akuta situationer där snabba och korrekta beslut måste fattas under press. Metod: En kvalitativ intervjustudie har utförts med induktivt förhållningssätt för att beskriva anestesisjuksköterskors erfarenhet av omedelbart kejsarsnitt. Data analyserades med hjälp av en kvalitativ innehållsanalys. Resultat: Anestesisjuksköterskors erfarenheter vid omedelbart kejsarsnitt kan delas in i fyra kategorier: att känna stress och adrenalinpåslag när larmet går, att samarbeta under operation, att hantera stressmoment, och att arbeta strukturerat och vara förberedd. Diskussion: Studien betonar behovet av tydlig kommunikation och samarbete för att minska stress och förbättra resultatet vid omedelbara kejsarsnitt. Simuleringsövningar och kompetensbaserad utbildning är centrala för att stärka beredskapen hos anestesisjuksköterskan. Slutligen kan personlighetsdrag och emotionell intelligens påverka hur anestesisjuksköterskor hanterar stressiga situationer som vid omedelbart kejsarsnitt. Slutsats: Anestesisjuksköterskor var i aktuell studie väl förberedda och kapabla att hantera omedelbara kejsarsnitt tack vare kunskap och kommunikation, tydliga rutiner och standardisering, erfarenhet och personliga egenskaper. Det visar att förberedelse, kompetens, rutiner och samarbete är avgörande för hantering av dessa akuta situationer. Ytterligare forskning behövs för att optimera hanteringen genom träningsprogram samt förbättra kommunikation och rutiner för att öka anestesisjuksköterskans beredskap inför omedelbart kejsarsnitt.

Os objetivos deste estudo foram: avaliar as freqüências de partos vaginais e cesáreas em mulheres portadoras de cardiopatias, bem como a distribuição dos partos nos diferentes subgrupos de doenças cardíacas: arritmias (A), cardiopatias congênitas (CC) e cardiopatias adquiridas (CA); analisar os fatores clínicos e obstétricos que estiveram relacionados à determinação da via de parto no grupo total de cardiopatas e também nos subgrupos, e avaliar a associação entre o tipo de parto e complicações clínicas e obstétricas. Foram analisados retrospectivamente os dados referentes a 571 gestações de 556 mulheres internadas para parto na Clínica Obstétrica do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo entre 2001 e 2005. A composição dos grupos foi: A - 57 casos (10%), CC - 163 casos (28,6%) e CA - 351 casos (61,4%). A taxas de cesárea foram 57,2% (total), 45,6% (A), 64,2% (CC) e 55,7% (CA). A indicação da cesárea foi obstétrica em 77% dos casos. Analisando os 425 casos sem cesáreas anteriores, as taxas de cesárea foram: 47,1% (total), 37,8% (A), 57,8% (CC) e 43,3% (CA). A probabilidade de parto cesáreo esteve relacionada à presença de cesárea anterior, idade gestacional no parto inferior a 37 semanas, presença de intercorrências obstétricas, diagnóstico de cardiopatia congênita, insuficiência cardíaca classe funcional (CF) III ou IV, e uso de medicamentos de ação cardiovascular. A paridade maior ou igual a um diminuiu a probabilidade de cesárea. A presença de cesárea anterior foi o principal fator relacionado à probabilidade de parto cesáreo nesta população. Nos subgrupos de cardiopatia (sem cesárea anterior) a probabilidade de cesárea esteve aumentada na presença dos seguintes fatores: A - uso de medicação cardiovascular; CC - CF III/IV e intercorrências obstétricas; CA -intercorrências obstétricas e idade gestacional no parto inferior a 37 semanas. A ocorrência de complicações obstétricas foi 6,8% (total), sendo maior em A (18,6%) e nos partos vaginais (10,7%); complicações clínicas maiores ocorreram em 2,5% dos casos e foram mais freqüentes nos casos de cesárea (3,8%). Conclusão: As taxas de cesárea observadas em gestante com cardiopatia foram elevadas (em especial nos casos de cardiopatia congênita) e correlacionadas à presença de cesárea anterior, insuficiência cardíaca CF III/IV, uso de medicamentos de ação cardiovascular, presença de intercorrências obstétricas e idade gestacional no parto inferior a 37 semanas. / This study reviewed the data of 571 pregnancies in 556 pregnant women with heart disease admitted for delivery in a tertiary university hospital between 2001 and 2005. The objectives were to assess the prevalence of cesarean sections and vaginal births among the whole group of cases and in three subgroups: patients with arrhythmias (A - 57 cases / 10%), congenital diseases (CD - 163 cases / 28,6%) and acquired diseases (AD - 351 cases / 61,4%), and to determine the clinical and obstetrical factors related to the mode of delivery in the whole population and in the subgroups, as well as the association between the mode of delivery and clinical and obstetrical complications. The frequencies of cesarean sections were: 57,2% (whole population), 45,6% (A), 64,2% (CD) and 55,7% (AD); the cesarean sections were performed due to obstetrical reasons in 77% of the cases. In the 425 cases with no previous cesarean sections, the frequencies of c-sections deliveries were 47,1% (whole group), 37,8% (A), 57,8% (CD) and 43,3% (AD). The factors related to a higher probability of cesarean section were: previous cesarean section, gestational age at delivery of less than 37 weeks, presence of obstetrical events, diagnosis of congenital heart disease, heart failure (NYHA functional class III/IV) and use of cardiovascular drugs. The parity above 1 was related to a lesser probability of csections, and previous cesarean was the main factor related to the risk of abdominal delivery. In the cases with no previous cesarean sections, according to the subgroups of heart disease, the probability of cesarean section was heightened in the presence of the following factors: group A: use of cardiovascular drugs, CD: functional class III/IV and obstetrical events and AD: obstetrical events and gestational age in delivery less than 37 weeks. The rate of obstetrical complications was 6,8%, most of them in group A and in vaginal birth. Major clinical complications occurred in 2,5% of the cases, and were more related to cesarean sections (3,8%). Conclusion: the rates of cesarean sections observed in pregnant women with heart disease were high (mainly in the CD group), and related to previous cesarean sections, heart failure, use of cardiovascular drugs, presence of obstetrical events and gestational age at delivery less than 37 weeks.

Os objetivos deste estudo foram: avaliar as freqüências de partos vaginais e cesáreas em mulheres portadoras de cardiopatias, bem como a distribuição dos partos nos diferentes subgrupos de doenças cardíacas: arritmias (A), cardiopatias congênitas (CC) e cardiopatias adquiridas (CA); analisar os fatores clínicos e obstétricos que estiveram relacionados à determinação da via de parto no grupo total de cardiopatas e também nos subgrupos, e avaliar a associação entre o tipo de parto e complicações clínicas e obstétricas. Foram analisados retrospectivamente os dados referentes a 571 gestações de 556 mulheres internadas para parto na Clínica Obstétrica do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo entre 2001 e 2005. A composição dos grupos foi: A - 57 casos (10%), CC - 163 casos (28,6%) e CA - 351 casos (61,4%). A taxas de cesárea foram 57,2% (total), 45,6% (A), 64,2% (CC) e 55,7% (CA). A indicação da cesárea foi obstétrica em 77% dos casos. Analisando os 425 casos sem cesáreas anteriores, as taxas de cesárea foram: 47,1% (total), 37,8% (A), 57,8% (CC) e 43,3% (CA). A probabilidade de parto cesáreo esteve relacionada à presença de cesárea anterior, idade gestacional no parto inferior a 37 semanas, presença de intercorrências obstétricas, diagnóstico de cardiopatia congênita, insuficiência cardíaca classe funcional (CF) III ou IV, e uso de medicamentos de ação cardiovascular. A paridade maior ou igual a um diminuiu a probabilidade de cesárea. A presença de cesárea anterior foi o principal fator relacionado à probabilidade de parto cesáreo nesta população. Nos subgrupos de cardiopatia (sem cesárea anterior) a probabilidade de cesárea esteve aumentada na presença dos seguintes fatores: A - uso de medicação cardiovascular; CC - CF III/IV e intercorrências obstétricas; CA -intercorrências obstétricas e idade gestacional no parto inferior a 37 semanas. A ocorrência de complicações obstétricas foi 6,8% (total), sendo maior em A (18,6%) e nos partos vaginais (10,7%); complicações clínicas maiores ocorreram em 2,5% dos casos e foram mais freqüentes nos casos de cesárea (3,8%). Conclusão: As taxas de cesárea observadas em gestante com cardiopatia foram elevadas (em especial nos casos de cardiopatia congênita) e correlacionadas à presença de cesárea anterior, insuficiência cardíaca CF III/IV, uso de medicamentos de ação cardiovascular, presença de intercorrências obstétricas e idade gestacional no parto inferior a 37 semanas. / This study reviewed the data of 571 pregnancies in 556 pregnant women with heart disease admitted for delivery in a tertiary university hospital between 2001 and 2005. The objectives were to assess the prevalence of cesarean sections and vaginal births among the whole group of cases and in three subgroups: patients with arrhythmias (A - 57 cases / 10%), congenital diseases (CD - 163 cases / 28,6%) and acquired diseases (AD - 351 cases / 61,4%), and to determine the clinical and obstetrical factors related to the mode of delivery in the whole population and in the subgroups, as well as the association between the mode of delivery and clinical and obstetrical complications. The frequencies of cesarean sections were: 57,2% (whole population), 45,6% (A), 64,2% (CD) and 55,7% (AD); the cesarean sections were performed due to obstetrical reasons in 77% of the cases. In the 425 cases with no previous cesarean sections, the frequencies of c-sections deliveries were 47,1% (whole group), 37,8% (A), 57,8% (CD) and 43,3% (AD). The factors related to a higher probability of cesarean section were: previous cesarean section, gestational age at delivery of less than 37 weeks, presence of obstetrical events, diagnosis of congenital heart disease, heart failure (NYHA functional class III/IV) and use of cardiovascular drugs. The parity above 1 was related to a lesser probability of csections, and previous cesarean was the main factor related to the risk of abdominal delivery. In the cases with no previous cesarean sections, according to the subgroups of heart disease, the probability of cesarean section was heightened in the presence of the following factors: group A: use of cardiovascular drugs, CD: functional class III/IV and obstetrical events and AD: obstetrical events and gestational age in delivery less than 37 weeks. The rate of obstetrical complications was 6,8%, most of them in group A and in vaginal birth. Major clinical complications occurred in 2,5% of the cases, and were more related to cesarean sections (3,8%). Conclusion: the rates of cesarean sections observed in pregnant women with heart disease were high (mainly in the CD group), and related to previous cesarean sections, heart failure, use of cardiovascular drugs, presence of obstetrical events and gestational age at delivery less than 37 weeks.

L’objectif de cette étude est de caractériser les gestes, les pratiques et les rituels entourant la mort des enfants dans les provinces romaines d’Afrique Proconsulaire, de Numidie et de Maurétanie césarienne aux trois premiers siècles de notre ère. La documentation disponible provient de nombreuses publications de nécropoles, plus ou moins bien documentées en fonction de la date des fouilles, et de la nécropole de Pupput (Hammamet) qui offre pour la première fois un corpus suffisamment important pour être statistiquement crédible. En raison de leur disparité, les données sont présentées sous différents catalogues mais elles sont en revanche analysées simultanément lorsqu’elles renseignaient la même séquence des funérailles. Il a été opté d’étudier dans un premier temps la gestion des corps, de l’emplacement de la sépulture à sa fermeture, puis dans un second temps, les rituels réalisés dans et autour de la sépulture. Le postulat de départ est que les différentes pratiques funéraires adoptées par les familles responsables de l’enterrement de leurs enfants dépendaient d’un certain nombre de facteurs. Parmi eux, l’âge des enfants qui déterminait en grande partie le statut du défunt a été mis en évidence. D’après les données archéo-anthropologiques étudiées, les âges de 6 mois, 3 ans et 7 ans marquaient des étapes importantes dans la socialisation de l’enfant dans sa famille et la société africaine. / The aim of this study is to characterize the gestures, practices and rituals about the children’s death in the Roman provinces of Africa Proconsularis, Numidia and Mauretania cesarean in the first three centuries AD. The available documentation is divided between numerous publications of cemeteries, more or less well documented depending on the date of excavation, and unpublished literature of the necropolis of Pupput (Hammamet), which provides for the first time a corpus large enough to be statistically credible. Because of their differences, the data are presented in various catalogs but analyzed simultaneously when associated to the same funeral sequence. At first, it was decided to study how corpses were managed from the localization of burial to its closure, then in a second time, the rituals performed in and around the grave. The initial postulate is that different burial practices adopted by families in charge of the funeral of their children depended on a number of factors. Among them, the children's age that determined the status of the deceased has been identified. According to archaeological and anthropological data studied, the ages of 6 months, 3 years and 7 years marked important steps in the socialization of the child in his family and the African society.

Introdução: A leucemia linfoblástica aguda (LLA) é a neoplasia pediátrica com maior incidência no mundo. Sua etiologia é resultante de múltiplas interações entre herança genética e exposição a agentes ambientais potencialmente carcinogênicos nos períodos pré-natal, nascimento e pós-natal. O parto cesáreo tem sido apontado como fator de risco para LLA em crianças. No Brasil, país com altas taxas de cesariana, são poucos os estudos que avaliaram a associação de cesariana com LLA na infância. Objetivos: Investigar a associação de cesariana e condições pré-natal e pós-natal com LLA em crianças nascidas no estado de São Paulo. Métodos: Estudo caso-controle de base populacional. Os casos de LLA, crianças nascidas no estado de São Paulo a partir de 1999, foram recrutados em oito hospitais de 2003 a 2009. Os controles foram emparelhados com os casos por sexo, idade e cidade de nascimento. As informações utilizadas nesse estudo foram obtidas em entrevistas com as mães ou responsáveis pelas crianças por meio de questionário estruturado. Informações adicionais foram adquiridas no banco de Declarações de Nascidos Vivos (DNV), que integra o Sistema de Informações de Nascidos Vivos (SINASC) da Secretaria Municipal de Saúde de São Paulo e do Ministério da Saúde. Após o linkage probabilístico dos bancos de dados, a amostra final comporta 133 casos e 459 controles, relação de 3,4 controles por caso. Análises de regressão logística não condicional e condicional foram conduzidas para estimar a associação entre cesariana, condições pré-natal e pós-natal e LLA, com estimava dos odds ratios (OR) e respectivos intervalos de 95% de confiança (IC 95%). Três modelos de regressão logística foram elaborados: 1) ajuste por idade e sexo da criança, idade e escolaridade da mãe; 2) ajuste pelas variáveis anteriores, mais raça e número de consultas; 3) ajuste por todas as variáveis anteriores e a inclusão de idade gestacional e peso ao nascer. Resultados: A análise de regressão logística não condicional, com base no Modelo 2, revelou discreto risco de LLA na exposição à cesariana (OR=1,10; IC95% 0,71-1,70), proteção na condição de mãe com 12 ou mais anos de escolaridade (OR=0,46; IC95% 0,24-0,89) e idade da criança de 6 a 8 anos no diagnóstico (OR=0,30; IC95% 0,13-0,67). Resultados similares foram observados na análise de regressão logística condicional no Modelo 2: cesariana (OR=1,18; IC95% 0,69-2,00), mães com 12 ou mais anos de escolaridade (OR=0,56; IC95% 0,25-1,24). Conclusões: Há uma tênue associação entre cesariana e LLA na infância, sem significância estatística. Alta escolaridade da mãe e crianças na faixa etária entre 6 e 8 anos foram fatores de proteção para LLA. Crianças com síndrome de Down apresentaram seis vezes o risco de LLA. Os resultados obtidos por análise regressão logística condicional foram similares aos da regressão logística não condicional. / Introduction: Acute lymphoblastic leukemia (ALL) is the most common pediatric neoplasia worldwide. Its etiology results from multiple interactions between genetic inheritance and exposure to potentially carcinogenic environmental agents during the prenatal, birth, and postnatal periods. Cesarean section has been identified as a risk factor for ALL in children. In Brazil, a country with high Cesarean section rates, few studies have evaluated the association of Cesarean section with ALL in childhood. Objectives: To investigate the association of Cesarean section, prenatal and postnatal conditions with ALL in children born in the state of São Paulo. Methods: Population-based case-control study. The cases of ALL, children born in the state of São Paulo from 1999, were recruited in eight hospitals from 2003 to 2009. Controls were matched with cases by sex, age and city of birth. The information used in this study were obtained through interviews with mothers or guardians of the children, using a structured questionnaire. Additional information were get from the Live Births Database, stored in the Live Birth Information System at the São Paulo Municipal Health Department and at the Brazilian Ministry of Health. After the databases probabilistic linkage, the final sample entails 133 cases and 459 controls, 3.4 controls per case ratio. Non-conditional and conditional logistic regression analyzes were conducted to estimate the association between cesarean section, pre- and postnatal conditions, and ALL with estimation of odds ratios (OR) and respective 95% confidence intervals (95% CI). Three models of logistic regression were elaborated: 1) adjustment by age and sex of the child, age and schooling of the mother; 2) adjustment for the previous variables, more race and number of queries; 3) adjustment for all previous variables and the inclusion of gestational age and birth weight. Results: The nonconditional logistic regression analysis, based on Model 2, revealed a slight risk of ALL on cesarean section exposure (OR = 1.10, 95% CI 0.71-1.70), protection on the condition of mothers with 12 or more years of schooling (OR = 0.46, 95% CI 0.24-0.89), and age of child from 6 to 8 years at diagnosis (OR = 0.30, 95% CI, 0.13-0, 67). In the conditional logistic regression analysis in Model 2, similar results were observed: cesarean (OR = 1.18, 95% CI 0.69-2.00), mothers with 12 or more years of schooling (OR = 0.56, 95% CI, 0.25-1.24). Conclusions: There is a weak association between cesarean section and ALL in childhood, with no statistical significance. Mother with high education level and children in the age range between 6 and 8 years were protective factors for ALL. Children with Down syndrome had a six-fold risk of ALL. The results obtained by conditional logistic regression analysis were similar to those of non-conditional logistic regression.

INTRODUÇÃO: O Brasil ocupa o primeiro lugar entre os países com maiores taxas de cesariana no mundo. Pouco se sabe a respeito das consequências futuras deste procedimento, sobre a saúde materna. Este estudo investigou a influência da técnica anestésico-cirúrgica e analgesia pós-operatória, no aparecimento de dor crônica após a cesariana. Procuramos também identificar os fatores de risco de dor crônica pós-cesariana. MÉTODO: Este estudo prospectivo com distribuição aleatória foi conduzido em 443 pacientes que foram submetidas à cesariana (eletivas e emergenciais), com diferentes doses de bupivacaína 0,5% hiperbárica e opioides na raquianestesia, bem como uso de anti-inflamatórios não esteroidais peri-operatório. Os grupos foram: G8SMA- 8 mg bupivacaína hiperbárica + 2,5 mcg sufentanil + 100 mcg morfina; G10SMA- 10 mg bupivacaína hiperbárica + 2,5 mcg sufentanil + 100 mcg morfina; G12,5MA- 12,5 mg bupivacaína hiperbárica + 100 mcg morfina; G15MA- 15 mg bupivacaína hiperbárica + 100 mcg morfina; G12,5M - 12,5 mg bupivacaína hiperbárica + 100 mcg morfina. Somente as pacientes do grupo G12,5M não receberam AINE no peri-operatório. Dor em repouso e em movimento foram avaliadas no pós-operatório imediato. Fatores peri-operatórios, cirúrgicos e obstétricos foram investigados. Contato telefônico foi realizado, após três e seis meses do procedimento cirúrgico, para identificação das pacientes com dor crônica. RESULTADOS: A incidência de dor crônica nos grupos foi: G8SMA= 20%, G10SMA= 13%; G12,5MA= 7,1%; G15MA= 2,2% e G12,5M= 20,3%. Pacientes que apresentaram escores de dor mais elevados no período pós- operatório imediato, que referiram doenças crônicas em tratamento, que apresentaram maior tempo em trabalho de parto sem analgesia, tiveram maior incidência de dor crônica (p<0,05). CONCLUSÃO: A incidência de dor crônica diminui com emprego de doses maiores de anestésicos locais e uso de anti-inflamatórios não esteroidais. Escores mais elevados de dor no período pós-operatório imediato tiveram associação com aparecimento de dor crônica após a cesariana. Os fatores de risco encontrados foram: doença crônica em tratamento, maior tempo em trabalho de parto sem analgesia e escores de dor elevados no pós- operatório imediato / INTRODUCTION: Brazil holds first place in cesarean section rate in the world. Little is known about the consequences upon maternal health. This study investigated the influence of anesthetic, surgical techniques and postoperative analgesia on chronic pain after cesarean section. We also tried to identify risk factors for chronic pain after cesarean section. METHODS: A prospective randomized study was conducted among 443 patients who underwent elective or emergency cesarean section with different doses of hyperbaric bupivacaine 0.5% and opioids in spinal anesthesia, associated or not to non steroidal anti-inflamatory drugs. The groups were: G8SMA- 8mg hyperbaric bupivacaine + 2.5 mcg sufentanil + 100 mcg morphine; G10SMA- 10 mg hyperbaric bupivacaine + 2.5 mcg sufentanil + 100 mcg morphine; G12.5MA- 12.5 mg hyperbaric bupivacaine + 100 mcg morphine; G15MA- 15 mg hyperbaric bupivacaine + 100 mcg morphine; G12.5M- 12.5 mg hyperbaric bupivacaine + 100 mcg morphine (only in this group, non-steroidal anti-inflammatory drug was not used). Pain at rest and during movement were evaluated on the first two postoperative days using the verbal numerical rating scale. Perioperative, surgical and obstetric factors were investigated. Phone survey was conducted after three and six months to identify patients with chronic pain RESULTS: Incidences of chronic pain in groups were: G8SMA= 20%, G10SMA= 13%; G12.5MA= 7.1%; G15MA= 2.2% and G12.5M= 20.3 %. Patients with co-morbidities, and who had been more than 15 hours in labor before the cesarean (without analgesia) had more chance to have chronic pain than those who did not have pain. Patients who had higher pain scores on the two postoperative days were associated to chronic pain (p<0.05).!! CONCLUSION: The incidence of chronic pain decreases with higher doses of local anesthetic and the use of non-steroidal anti-inflammatory drugs. Patients who had higher pain scores in the immediate postoperative period were more likely to develop chronic pain. The only predictors of chronic pain were: previous history of disease, longer time in labor, intensity of postoperative pain and the use of lower doses of local anesthetic in spinal anesthesia