Speech and language pathologists working with aphasia therapy regularly encounter close relatives of people with aphasia. A common observation is that close relatives discern a connection regarding how the person with aphasia manages communication difficulties, related to their communication style before suffering from stroke. It is uninvestigated whether premorbid communication style and functional communication in people with aphasia are related to each other. This study aims to explore if there is a relationship between premorbid communication style, cognitive functioning, and post-stroke functional communication in people with aphasia. Premorbid communication style, functional communication and cognitive functions were measured in 47 participants with severe aphasia. Correlation analyses were used to examine if these areas are related to each other. No relationship could be demonstrated between communication style and functional communication, which could be explained by the unreliable measurements that was used to measure communication style. However, there was a statistically significant positive relationship between cognitive function and functional communication. Additional research is needed to reliably measure communication style in future studies. This study contributes valuable information for continued research examining the relationship between premorbid communication style and functional communication in people with aphasia. / Logopeder som arbetar med afasibehandling möter ofta närstående till personer med afasi. En vanlig observation är att närstående ofta noterar en koppling gällande hur personen med afasi hanterar kommunikationssvårigheterna relaterat till sin kommunikationsstil före insjuknande i stroke. Det är outforskat huruvida premorbid kommunikationsstil och funktionell kommunikation hos personer med afasi är relaterade till varandra. Denna studie syftar till att utforska om det finns ett samband mellan premorbid kommunikationsstil, kognitiva funktioner och funktionell kommunikation för personer med afasi. Premorbid kommunikationsstil, funktionell kommunikation och kognitiva funktioner har mätts på 47 deltagare med grav afasi. Korrelationsanalyser har använts för att undersöka om det finns ett samband mellan dessa domäner. Inget samband kunde påvisas mellan premorbid kommunikationsstil och funktionell kommunikation, vilket skulle kunna förklaras av de mindre tillförlitliga mätningarna som gjordes för att mäta kommunikationsstil. Däremot fanns ett statistiskt signifikant positivt samband mellan kognitiv funktion och funktionell kommunikation. Ytterligare forskning behövs för att kunna mäta kommunikationsstil med pålitliga resultat. Denna studie bidrar med värdefull information inför fortsatt forskning om sambandet mellan premorbid kommunikationsstil och funktionell kommunikation för personer med afasi.

Abstract: Alzheimer’s Disease (AD) is a complex neurodegenerative disease that requires interprofessional collaboration. Pharmacological options are currently ineffective, increasing the need for preventative strategies to combat the rise of AD. Considerations of gut-targeted interventions have increased as a key component in the prevention of AD, based on the understanding that the state of the gut microbiome can impact cognitive function through the pathway known as the gut-brain axis. Methods: This scoping review explored information on the gut-brain axis in persons with AD. A comprehensive search was conducted in November 2023. Forty reviews and 13 human studies were analyzed. Results: There is an abundance of information supporting the role of the gut-brain axis in the development and prevention of AD. This information is complex and may deter healthcare professionals outside of neuroscience, medicine, and nutrition from engaging in the literature. Further research is needed from within the SLP’s scope of practice.

Episodic memory refers to the storage and retrieval of information about events in our past. According to dual process models, episodic memory is supported by familiarity which refers to the rapid and automatic sense of oldness about a previously encoded stimulus, and recollection which refers to the retrieval of contextual information, such as spatial, temporal or other contextual details that bring a specific item to mind. To be clear, familiarity is traditionally assumed to support recognition of item information, whereas recollection supports the recognition of associative information. Event Related Potential (ERP) studies provide support for dual process models, by demonstrating qualitatively distinct patterns of neural activity associated with familiarity (Mid-Frontal old/new effect) and recollection (Left-Parietal old/new effect). In the current thesis, ERPs were used to address two important questions regarding associative recognition – namely, the function of the neural signal supporting recollection and whether familiarity can contribute to the retrieval of novel associative information. The first series of experiments was aimed at addressing how recollection operates by employing a recently developed continuous source task designed to directly measure the accuracy of retrieval success. To date, the function of recollection has been fiercely debated, with some arguing that recollection reflects the operation of a continuous retrieval process, whereby test cues always elicit some information from memory. Alternatively, recollection may reflect the operation of a thresholded process that allows for retrieval failure, whereby test cues sometimes elicit no information from memory at all. In the current thesis, the Left Parietal effect was found to be sensitive to the precision of memory responses when recollection succeeded, but was entirely absent when recollection failed. The result clarifies the nature of the neural mechanism underlying successful retrieval whilst also providing novel evidence in support of threshold models of recollection. The second series of experiments addressed whether familiarity could contribute to the retrieval of novel associative information. Recent associative recognition studies have suggested that unitization (whereby multi-component stimuli are encoded as a single item rather than as a set of associated parts) can improve episodic memory by increasing the availability of familiarity during retrieval. To date, however, ERP studies have failed to provide any evidence of unitization for novel associations, whereas behavioural support for unitization is heavily reliant on model specific measures such as ROC analysis. Over three separate associative recognition studies employing unrelated word pairs, the magnitude of the Mid-Frontal old/new effect was found to be modulated by encoding instructions designed to manipulate the level of unitization. Importantly, the results also suggest that different encoding strategies designed to manipulate the level of unitization may be more successful than others. Finally, the results also revealed that differences in behavioural performance and modulation of the Mid-Frontal old/new effect between unitized and non-unitized instructions is greater for unrelated compared to related word pairs. In essence, the results suggest that unitization is better suited to learning completely novel associations as opposed to word pairs sharing a pre-existing conceptual relationship. Overall, the data presented in this thesis supports dual process accounts of episodic memory, suggesting that at a neural level of analysis, recollection is both thresholded and variable, whilst also supporting the assumption that familiarity can contribute to successful retrieval of novel associative information. The results have important implications for our current understanding of cognitive decline and the development of behavioural interventions aimed at alleviating associative deficits.

Cerebral small vessel disease (SVD) is identifiable by clinical, neuroimaging, neuropathological and cognitive findings. The aim of this thesis was to assess SVD and cerebral perfusion on magnetic resonance imaging (MRI) in a 75-year-old population and compare the findings with scars of myocardial infarctions, cardiovascular risk markers and cognitive function. In addition, the evolution of SVD over 5 years was studied. The study population included subjects from the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study. The subjects had been chosen in a randomized manner from the register of the municipality. MRI of the brain and the heart, cognitive tests and blood tests for cardiovascular risk factors were performed in 406 subjects at age 75 years and 250 of them were re-examined 5 years later at the age of 80. Paper 1 showed that unrecognized myocardial infarctions (UMIs) were found in 120 subjects (30%) and recognized myocardial infarctions (RMIs) in 21 (5%). Men with RMIs displayed an increased prevalence of cortical and lacunar cerebral infarctions, whereas women with UMIs more frequently had cortical cerebral infarctions. Paper 2 showed that one or more brain infarcts were seen in 23% of the subjects (20% had only lacunar infarcts, 1% had only cortical infarcts and 2% had both). Hypertension and obesity were significantly associated with an increased risk of infarction.  The newer risk markers investigated were not significantly associated with brain infarcts. Paper 3 showed that MRI manifestations of SVD progressed over 5 years. Relative cerebral blood flow (rCBF) was not associated with WMH volume or progression of WMH volume. Paper 4 showed that moderate to severe WMHs and incident lacunar infarcts on brain MRI were associated with a mild impairment of executive function. In conclusion, this longitudinal population based study compares MRI manifestations of SVD with clinical data, providing knowledge that may be used in further investigations of preventive interventions and for identification of disease in early stages.

Attention is a complex ability, which significantly contributes to the process of intentional learning. On the theoretical level, this thesis focuses on the types and theories of attention related to the effective management of school demands. More specifically, it focuses on the development period of older school age and adolescence, i. e. secondary school pupils. The paper analyzes the results of scientific studies that have been focused on the research of attention and its properties (e.g. stability, concentration or selectivity). The work is focused on examining whether a low-cost compensation aid - here earplugs - can improve concentration and stability of attention during learning. Furthermore, the work briefly mentions the physiological basis of the functioning of this cognitive process. The conclusion of the theoretical part of the paper maps the current possibilities of diagnostics of attention, especially in children and adolescents. There are also sporadic mentions of selected attention disorders (e.g. ADD, ADHD), which are closely related (not only) to learning. In the empirical part of the thesis, a quantitative research is described, using several different tests of attention. The research question is whether and how the attention (concentrating) and, where appropriate, the...

Thesis (Ph.D. (Physiotherapy))--University of the Witwatersrand, Faculty of Health Sciences, 2013. / Stroke impacts on a survivor’s ability to participate in community activities such as return to work (RTW) and affects people who are still within the working age. Return to work contributes to life satisfaction and social identity at least partly through independence gained from income-generation. The impact of RTW programmes for stroke survivors is limited and not generalisable to South Africa. This study aimed to bridge this gap in South Africa, and was conducted within the Gauteng province as it comprises the largest share of the South African population. Objectives and Methodology: The aim of the study was to determine the current practice in RTW intervention programmes for stroke survivors in the Gauteng Province of South Africa and to establish the effect of a workplace intervention programme on the rate of RTW of previously employed stroke survivors. This study had two stages: Stage one: A cross sectional survey was performed using a self administered questionnaire to establish current practice in RTW intervention programmes and the therapists’ perceived barriers and enablers of RTW after stroke. Stage two study included: a) a randomised controlled trial (RCT) to evaluate a six week RTW intervention, with follow-up at three and six months. The workplace intervention programme was tailored according to the functional ability and workplace challenges of each stroke survivor and was as follows: Week one: Assessment for work skill. The assessment included work modules which identified potential problems such as: visual discrimination; eye hand coordination; form and spatial perception; manual dexterity; colour discrimination; cognitive problems, and job specific physical demand factors. Week two: The therapist interviewed the stroke survivor and employer separately to establish perceived barriers and enablers of RTW. This was followed by a meeting between the therapist, stroke survivor and employer/supervisor to discuss and develop a plan to overcome identified barriers and to strengthen identified enablers based on consensus between stroke survivor and employer. Week three: A work visit for the stroke survivor to demonstrate what they did at work and identify what they could still do safely and what they could not do. This included vocational counselling and coaching; emotional support; adaptation of the working environment; advice on coping strategies to compensate for mobility and upper limb functional limitations; and fatigue management. Weeks four, five and six: continuation of the work visits, while monitoring progress, and making necessary adjustments as per stroke survivor and employer’s needs. This was done at the workplace while the participants continued with their usual therapy at the hospital. The control group received usual care. The primary outcome was RTW rate. The secondary outcomes included activities of daily living (measured with the Barthel Index); mobility (measured with the Modified Rivermead Mobility Index); basic cognitive function (measured with the Montreal Cognitive Assessment) and perceived quality of life (measured with the Stroke Specific Quality of life Scale). Another aim of stage two study was to: b) establish the stroke survivors’ and employers’ perceived barriers and enablers of RTW (this was done with the experimental group only); and to: c) identify predictors of RTW. Stage one study results: Thirty six (68%) of the 53 questionnaires sent to stroke rehabilitation facilities were returned. Seventeen (47%) of the 36 clinical settings referred stroke survivors to facilities offering RTW services; 12 (33%) facilities did not refer stroke survivors for RTW and did not offer RTW services; and seven (20%) facilities offered RTW services. Of the seven facilities that rendered RTW services for stroke survivors, five (71%) communicated with the employer to discuss reasonable accommodation and four (57%) did assessments for potential to RTW. The most common reason given by the 29 facilities for not offering RTW services was that they referred stroke survivors to other therapists who offered these services. The second most common reason was the unemployment status of the stroke survivor at the time of having stroke. The therapists’ most commonly perceived barriers of RTW were the severity of the stroke survivors’ physical impairments (n = 3) (36%) and their employment status (n = 11) (31%) at the time of having stroke. The most commonly perceived enablers were willingness of the employer to reasonably accommodate the stroke survivor at work (n = 12) (33%), family support (n = 8) (22%) and increased length of hospital stay to allow for intensive rehabilitation (n = 7) (19%). Stigma in the workplace was the only variable which had a statistically significant relationship with the type of clinical facility therapists worked at (p = 0.02). Stage two study results: The average age for the study group was 45 (SD: 8.7) years and the average stroke duration was 4.6 (SD: 1.8) weeks. There were 41 (51%) male stroke survivors and 39 (49%) female stroke survivors. Majority (55%) of the stroke survivors were breadwinners (63%), had a grade 11 to 12 educational level (64%), an income above R5000 (46%) and had a helper (74%) whom they did not have to pay (81%). Stroke survivors who returned to work had better quality of life at six months after stroke than those who did not RTW (p = 0.05). Results from the qualitative study indicated that the perceived enablers of RTW included: ability of the employer to provide reasonable accommodation and good interpersonal working relationships between stroke survivor, employer and co-workers. The perceived barriers of RTW included: unaffordable reasonable accommodation costs; inaccessible transport; having cognitive (memory and attention) and speech impairments and high unemployment rates. The overall RTW rate was 20% at three months follow-up and 40% at six months follow-up. Twenty seven percent of the stroke survivors in the intervention group returned to work at three months compared to 12% in the control group (p = 0.13). At six months, the majority of stroke survivors (60%) in the intervention group returned to work compared to 20% in the control group (p <0.001). The following factors were predictive of RTW: male gender (p = 0.03); fewer speech problems (p = 0.02); increased time off work post stroke (p = 0.001); ability to perform activities of daily living (p = 0.02); good mobility (p = 0.01) and good cognitive ability (p = 0.02). The stroke survivors in the intervention group were 5.2 times more likely to RTW than those in the control group at six months following stroke, and for every unit increase in the activities of the Barthel Index and Montreal Cognitive assessment score, the likelihood of RTW increased by 1.7 and 1.3 respectively. Conclusion: A RTW intervention consisting of workability assessments and workplace visits was effective in facilitating RTW for stroke survivors in Gauteng province, South Africa. Key predictors of RTW included male gender; increased time off work post stroke; ability to perform activities of daily living; good mobility and good cognitive ability and were identified as facilitating RTW; speech problems were identified as barriers to RTW. Overall, these results suggest the need to direct resources towards increasing work place intervention strategies after stroke.

Introdução: As doenças cerebrovasculares constituem-se um sério problema de saúde, e dados sobre sua prevalência mundial são alarmantes. A doença aterosclerótica dos vasos cervicais é um importante fator etiológico de isquêmica cerebral, por mecanismos que envolvem fenômenos embólicos e hipofluxo cerebral. Enquanto o manejo dos pacientes com estenose carotídea sintomática geralmente requer procedimentos cruentos como a endarterectomia e a angioplatia com stent carotídeo, não estão bem definidos o espectro clínico e o manejo adequado dos pacientes com estenoses carotídeas ditas assintomáticas (sem evidência de evento cerebrovascular ipsilateral). Neste contexto, é possível que a presença de déficits cognitivos e as alterações estruturais e funcionais na ressonância magnética cerebral possam ser úteis para a estratificação e o manejo destes pacientes. Objetivos: constitui objetivo principal do presente estudo investigar associações entre biomarcadores de ressonância magnética e desempenho cognitivo, em sujeitos com estenose carotídea assintomática unilateral. Métodos: foram incluídos na pesquisa 13 voluntários, com diagnóstico de doença aterosclerótica assintomática unilateral com comprometimento >= 70% da luz do vaso, recrutados nos ambulatórios de neurologia e cirurgia vascular, do Hospital das Clínicas, da Faculdade de Medicina de Ribeirão Preto - FMRP/ USP. Participaram do grupo controle 13 voluntários, sem antecedentes de doenças cerebrovasculares. A avaliação neuropsicológica consistiu na aplicação do Subteste Dígitos (WAIS); Trail Making Test; Stroop Test; Teste das Figuras Complexas de Rey; provas de fluência verbal fonêmica e categoria semântica; e o Mini Exame do Estado Mental, edições 1 e 2. Para a composição da avaliação de neuroimagem por ressonância magnética, foram inclusas: (1) imagens FLAIR (fluid attenuated inversion recovery) para avaliação de carga de lesão de substância branca; (2) imagens de ASL (arterial spin labeling), ponderadas em perfusão sanguínea, para quantificação do fluxo sanguíneo cerebral; e (3) imagens baseadas no contraste BOLD (blood oxygenation level dependent), em repouso, para avaliação da conectividade funcional. Análises estatísticas foram realizadas pelo Stata 15.1, em que as variáveis foram testadas para normalidade usando o teste de normalidade de Shapiro-Wilk. O teste t de amostras independentes e o teste U de Mann-Whitney foram utilizados para analisar as diferenças entre os grupos. As diferenças hemisféricas na carga de WMH foram testadas pelo teste t pareado, ou Wilcoxon. Testes Chi-squared ou Teste Exato de Fisher foram utilizados na análise de variáveis categóricas. Os coeficientes decorrelação de Pearson ou Spearman foram utilizados para explorar correlações entre escores cognitivos, volume de substância branca, carga de WMH, CBF e conectividade funcional. Resultados: O volume de substância branca (SB) em pacientes com estenose carotídea assintomática mostrou-se marcadamente reduzido, enquanto hiperintensidade de sinal em SB esteve significativamente aumentada em relação a indivíduos controles (p < 0,01). O hemisfério ipsilateral à estenose assintomática grave apresentou carga mais expressiva de lesão em SB (p = 0,01). Neste contexto, a presença de estenose assintomática esteve independentemente associada à hiperintensidade de SB. Análises de CBF não revelaram diferenças entre os grupos clínicos e controle, embora o CBF tenha sido associado ao desempenho das funções cognitivas em todos os domínios avaliados por este estudo. Não foram identificadas diferenças de fluxo sanguíneo global em territórios das artérias cerebrais anterior, média e posterior, entre sujeitos com estenose de artéria carótida assintomática e controles. Pacientes apresentaram prejuízos de conectividade em redes cerebrais de repouso (RSBNs), especialmente frontotemporal, saliência e rede atencional dorsal, em relação aos controles (p-FDR < 0,01). A performance cognitiva de pacientes com estenose carotídea foi inferior ao grupo controle, para todas as medidas, com diferenças significativas em domínios mnemônicos, atencionais e funções executivas (p<0.05), estes relacionados com RSBNs. Conclusões: Nós identificamos anormalidades pré-clínicas no volume de SB, CBF, conectividade funcional e no desempenho cognitivo de pacientes com estenose carotídea assintomática. Biomarcadores de neuroimagem na RM, combinados à avaliação cognitiva têm um grande potencial para identificação de pacientes com estenose carotídea assintomática sob risco elevado de AVC e declínio cognitivo. / Background: Cerebrovascular diseases are an important health problem worldwide with high prevalence, mortality and morbidity. Among its etiological subtypes, atherosclerotic disease involving the carotid artery is strongly associated with ischemic stroke due to arterial embolism and hemodynamic compromise. The management of symptomatic carotid stenosis generally requires carotid endarterectomy or stenting. Nevertheless, the management of asymptomatic carotid stenosis and patient selection for these procedures is still largely debated. It is possible that the presence of cognitive impairment, alterations on functional and structural magnetic resonance imaging (MRI) biomarkers of cerebrovascular disease could help the stratification and management of these patients. Objetives: to investigate the association between MRI biomarker of cerebrovascular disease and cognitive function in patient with unilateral asymptomatic carotid stenosis. Methods: we evaluated 13 patients with unilateral carotid stenosis >= 70% recruited from a tertiary academic outpatient clinic in Brazil and 13 control subjects without carotid stenosis or history of cerebrovascular diseases paired by age and sex. The neuropsycological evaluation included the WAIS, Trail Making Test; Stroop Test; Rey complex figures test; verbal fluency and categorical semantic fluency; and the minimental state 1 and 2. The MRI evaluation included: (1) FLAIR evaluation of white matter (WM) burden; (2) ASL evaluation of cerebral blood flow (CBF); (3) resting-state BOLD for evaluation of functional connectivity. Statistical analyses were performed with the Stata 15.1 package. Normality of the distribution of the variables was assessed with the Shapiro-Wilk test. We also used the student t test, Mann-whytney test, Chi-squared test and Fisher exact test as appropriate for univariate analyses. Pearson and Spearman correlation coefficients were used to explore the correlations among cognitive performance scores, WM volume, burden of WM hyperintensities, CBF and brain functional connectivity. Results: the global WM volume was markedly reduced and the global WM hyperintensity was significantly increased within the ipsilateral hemisphere in patients with unilateral carotid stenosis, when compared to controls (p < 0,01). CBF evaluated by ASL was associated with cognitive function but it was not significantly different between patients and controls within the arterial territories of the major intracranial arteries. Patients with carotid stenosis showed marked compromise of the brain connectivity within the frontotemporal, attentional and salience networks when compared to controls (p-FDR < 0,01). The cognitive performance was inferior for patients with unilateral carotid stenosis compared to controls in several cognitivedomains including executive function, attention and mnemonic domains. Conclusions: patients with asymptomatic carotid stenosis have high frequency of pre-clinical abnormalities on structural and functional MRI biomarkers and cognitive impairment. Evaluation of cognitive function, structural and functional MRI biomarkers of cerebrovascular disease may have a role to improve patient stratification and selection for interventions among patients with unilateral carotid stenosis.

Cognitive function disorders have an enormous impact on the life quality of a patient, his or her family and close people. It influences the patient's job, social interaction and independence. This diploma thesis focuses on the possibility of improving cognitive functions concerning multiple sclerosis with the help of facilitation physiotherapy. Twelve disordered volunteers participated a two-month physiotherapeutic programme (motor programs activating therapy), for 1 hour, twice per week. Before the beginning and after the end of the therapeutic programme an examination by a clinic test PASAT and the monitoring of functional magnetic resonance was done. The results of functional magnetic resonance were further compared with the results of group of healthy volunteers. Concerning clinic test, the results of the disordered patients have improved after the therapy. In functional magnetic resonance statistics the earlier start and change of a curve progress of brain activation was discovered, which portrays improving speed of processing information at multiple sclerosis disordered.

<p>Delirium is common among old patients admitted to hospital, but is often a neglected problem in patient care. The principal aim of this thesis was to evaluate aspects of delirium in relation to incidence, risk factors, behavioural changes, cognitive function and health-related quality of life (HRQOL). A further aim was to describe patients’ experiences of being delirious. The study was prospective, descriptive and comparative, with repeated measures (six-month follow up). The sample consisted of 225 consecutive patients, aged 65 years or older, who were to be operated on due to hip fracture or hip replacement. Exclusion criteria were serious cognitive disorder or delirium on admission. Data were collected via frequent daily observations, cognitive functioning tests (MMSE), HRQOL questionnaires (SF-36) and interviews. Delirium was assessed according to the DSM-IV criteria. A total of 45/225 became delirious, with an incidence of 24.3% among patients undergoing hip fracture surgery and 11.7% among those with hip replacement surgery. A predictive model for delirium included four factors: impaired hearing, passivity, low cognitive functioning, and waiting more than 18h for hip fracture surgery. Disorientation and urgent calls for attention were the most frequent behavioural changes in the prodromal phase prior to delirium. Delirium in connection with hip fracture revealed deteriorated HRQOL and cognitive functioning when measured at a six-month follow-up. The experience of being delirious was described by the patients as a sudden change of reality. Such an experience gave rise to strong emotional feelings, as did recovery from delirium. Nurses’ observations of behavioural changes in old patients with impaired cognitive function may be the first step in managing and reducing delirium. The predictive model of delirium ought to be tested further before use in clinical practice.</p>

<p>A total population of 4,479 children (7-15 years of age) attended school in Ludvika & Smedjebacken in 2000. All the school children and their parents were asked to fill in a questionnaire concerning different tics A three-stage procedure was used: tic identification, interview, and clinical assessment.</p><p>Tourette syndrome, according to DSM IV criteria was found in 25 (0.6%) of the children, another 34 (0.8%) suffered from chronic motor tics (CMT), 24 (0.4%) from chronic vocal tics (CVT) and 214 (4.8%) children had had transient tics (TT) during the last year. Altogether 297 (6.6%) children had or had had some tic disorder. </p><p>Twenty-five controls without tics and 25 children with TT of the same age, sex and school as the TS children were randomly chosen. They were together with the 34 children with CMT and the 24 children with CVT examined with use of a broad battery of instruments. </p><p>The mean age of the first symptoms of TS was significantly lower than the onset of chronic motor/vocal tics. A younger age of onset of TS indicated more severe tics. Eighty per cent had a first-degree relative with a psychiatric disorder such as tic disorder, obsessive-compulsive behaviour, attentiondeficit/hyperactivity disorder (ADHD), or depression. A non-significant increase with regard to reduced optimality score in the pre-, peri-, or neonatal periods was found in children with TS compared to controls. No differences were found concerning socio-economic status. Psychiatric comorbid disorders were found in 92% of the children with TS. ADHD was most common. Patterns of psychiatric comorbidity were similar in children with TS and CVT. Children with TS perform poorer than the population in general with respect to cognitive functioning and self-perception.</p><p>The results are discussed as they relate to the need for case identification, diagnosis, intervention, and treatment. </p>