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The human brain acts as an intelligent sensor by helping in effective signal communication and execution of logical functions and instructions, thus, coordinating all functions of the human body. More importantly, it shows the potential to combine prior knowledge with adaptive learning, thus ensuring constant improvement. These qualities help the brain to interact efficiently with both, the body (brain-body) as well as the environment (brain-environment). This dissertation attempts to apply the brain-body-environment interactions (BBEI) to elevate human existence and enhance our day-to-day experiences. For instance, when one stepped out of the house in the past, one had to carry keys (for unlocking), money (for purchasing), and a phone (for communication). With the advent of smartphones, this scenario changed completely and today, it is often enough to carry just one's smartphone because all the above activities can be performed with a single device. In the future, with advanced research and progress in BBEI interactions, one will be able to perform many activities by dictating it in one's mind without any physical involvement. This dissertation aims to shift the paradigm of existing brain-computer-interfaces from just ‘control' to ‘monitor, control, enhance, and restore' in three main areas - healthcare, transportation safety, and cryptography. In healthcare, measures were developed for understanding brain-body interactions by correlating cerebral autoregulation with brain signals. The variation in estimated blood flow of brain (obtained through EEG) was detected with evoked change in blood pressure, thus, enabling EEG metrics to be used as a first hand screening tool to check impaired cerebral autoregulation. To enhance road safety, distracted drivers' behavior in various multitasking scenarios while driving was identified by significant changes in the time-frequency spectrum of the EEG signals. A distraction metric was calculated to rank the severity of a distraction task that can be used as an intuitive measure for distraction in people - analogous to the Richter scale for earthquakes. In cryptography, brain-environment interactions (BBEI) were qualitatively and quantitatively modeled to obtain cancelable biometrics and cryptographic keys using brain signals. Two different datasets were used to analyze the key generation process and it was observed that neurokeys established for every subject-task combination were unique, consistent, and can be revoked and re-issued in case of a breach. This dissertation envisions a future where humans and technology are intuitively connected by a seamless flow of information through ‘the most intelligent sensor', the brain.

As an extension of previous studies (Urbanczyk, Angel, & Kennelly, 1988) examining the effects of unimanual finger tapping on lateralized cognitive tasks, lateral body orienting was added to an established dual task paradigm to generate differential hemispheric activation and shifts of attention. One hundred twenty university students retained sequences of digits or spatial locations for 20 seconds either alone or during finger tapping. By turning both head and eyes left or right, the hemisphere congruent with the sequences (LH for digits, RH for locations) or incongruent (vice versa) was activated. Activation had little effect on retention means but greatly affected resource composition supporting task performance. Congruent orientation produced significantly higher positive correlations between digit and location tasks than incongruent orientation. Females showed higher sequence retention correlations than males across both orienting groups. For females, congruent activation enhanced tapping rates and retention-tapping correlations. For males, activation affected neither of these. Discussed in light of neuroanatomical research, these results suggest that congruent attentional orienting may integrate regions of the less activated hemisphere into networks of the more activated hemisphere. This unification may occur more readily across the female corpus callosum, producing a greater dependence upon a general attentional resource than for males, who appear to depend more upon hemispheric resources.

The effects of caffeine (250 mg) and placebo on healthy controls were studied in a double-blind, cross over study on 24 healthy subjects who performed a working memory n-back task. Reaction time and accuracy levels were tested using the n-back working memory measure in cognitive neuroscience. An experimental study tested on the 1, 2 and 3-back tasks under the placebo/coffee condition. Based on the empirical results obtained in this thesis it can be concluded that changes produced by caffeine ingestion support the hypothesis that caffeine acts as a stimulant. However, it cannot be proven that the stimulant translates into enhanced motor processes with an improvement in performance.

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A informação háptica fornecida pelo toque leve (TL) e pelas âncoras reduz a oscilação postural durante a postura em pé. No entanto, não está claro se esse benefício permaneceria na presença de tarefas cognitivas em adultos jovens e em idosos com e sem histórico de quedas. Assim, os objetivos foram: 1) investigar os efeitos das âncoras e de tarefas cognitivas visuais e auditivas no controle postural em adultos jovens em uma tarefa postural desafiadora (Estudo 1); 2) investigar o efeito das dicas hápticas fornecidas pelo TL e pelas âncoras durante a realização de uma tarefa cognitiva visual idosos com e sem histórico de quedas quando na postura em pé (Estudo 2). Sessenta e quatro indivíduos foram distribuídos em três grupos: adultos jovens (n=20), idosos caidores (n=22) e idosos não caidores (n=22). Para os adultos jovens (Estudo 1), a tarefa consistiu em permanecer em pé em uma trave de equilíbrio com pés distantes na largura dos ombros sem e com o uso das âncoras, sem e com tarefas cognitivas (teste visual de Stroop adaptado e tarefa auditiva de monitoramento de dígitos). Para os idosos (Estudo 2), a tarefa consistiu em permanecer na postura ereta com os pés unidos desempenhando seis condições experimentais combinando dicas hápticas (sem contato, TL e âncoras) e na presença ou ausência da tarefa cognitiva visual (teste visual de Stroop adaptado). Os resultados do estudo 1 mostraram que para os adultos jovens os benefícios do uso das âncoras não foram influenciados pelas tarefas cognitivas. Mesmo em superfície desafiadora, a oscilação postural foi reduzida para facilitar a execução das tarefas cognitivas. Os resultados do estudo 2 revelaram que os idosos com e sem histórico de quedas se beneficiaram igualmente da adição de dicas hápticas. A presença da tarefa cognitiva-visual reduziu a oscilação postural em ambos os grupos. De maneira geral, tanto o TL quanto as âncoras foram eficazes na redução da oscilação postural em adultos jovens e idosos com e sem histórico de quedas, sugerindo que a informação háptica foi capaz de beneficiar o controle postural mesmo em condições de tarefas cognitivas, demonstrando que jovens e idosos, particularmente aqueles com histórico de quedas, foram capazes de modular funcionalmente o controle postural de forma a facilitar a execução das tarefas cognitivas. / Haptic information provided by the light touch (LT) and the anchors reduce the postural sway during upright standing. It is unclear whether this benefit would remain in the presence of cognitive tasks in young and older adults with and without a history of falls. Thus, the aims were: 1) to investigate the effects of the anchors and the visual and auditory cognitive tasks on postural control in young adults in a challenging balancing task (Study 1); 2) to investigate the effect of haptic input provided by LT and anchors while performing a cognitive-visual task in older adults with and without a history of falls when standing upright (Study 2). Sixtyfour individuals were divided into three groups: young adults (n=20), faller older adults (n=22) and non-faller older adults (n=22). For the young adults (Study 1), the task consisted in standing upright on a balance beam with feet apart at shoulders width while performing 6 experimental conditions combining the anchors (with or without) and the cognitive tasks (none, the adapted visual Stroop test and the auditory digit monitoring task). For the older adults (Study 2), the task consisted in standing upright with feet together while performing six experimental conditions combining haptic cues (none, LT, and anchors) and the presence/absence of the cognitive-visual task (the adapted visual Stroop test). The results of the study 1 showed that the cognitive tasks did not affect the benefits of the anchors for the young adults. Even on a challenging surface, the postural sway reduced to facilitate the execution of the cognitive tasks. The results of the study 2 revealed that the older adults benefited similarly from the haptic cues, independently their history of falls. The presence of the cognitive-visual task reduced the postural sway in both groups. In general, both LT and anchors were effective to reduce postural sway in young and older (fallers and non-fallers) adults, suggesting that the haptic information was able to benefit the postural control even with cognitive tasks, demonstrating that young and older adults, particularly those with a history of falls, were able to functionally modulate their postural control to facilitate the execution of the cognitive tasks.

A informação háptica fornecida pelo toque leve (TL) e pelas âncoras reduz a oscilação postural durante a postura em pé. No entanto, não está claro se esse benefício permaneceria na presença de tarefas cognitivas em adultos jovens e em idosos com e sem histórico de quedas. Assim, os objetivos foram: 1) investigar os efeitos das âncoras e de tarefas cognitivas visuais e auditivas no controle postural em adultos jovens em uma tarefa postural desafiadora (Estudo 1); 2) investigar o efeito das dicas hápticas fornecidas pelo TL e pelas âncoras durante a realização de uma tarefa cognitiva visual idosos com e sem histórico de quedas quando na postura em pé (Estudo 2). Sessenta e quatro indivíduos foram distribuídos em três grupos: adultos jovens (n=20), idosos caidores (n=22) e idosos não caidores (n=22). Para os adultos jovens (Estudo 1), a tarefa consistiu em permanecer em pé em uma trave de equilíbrio com pés distantes na largura dos ombros sem e com o uso das âncoras, sem e com tarefas cognitivas (teste visual de Stroop adaptado e tarefa auditiva de monitoramento de dígitos). Para os idosos (Estudo 2), a tarefa consistiu em permanecer na postura ereta com os pés unidos desempenhando seis condições experimentais combinando dicas hápticas (sem contato, TL e âncoras) e na presença ou ausência da tarefa cognitiva visual (teste visual de Stroop adaptado). Os resultados do estudo 1 mostraram que para os adultos jovens os benefícios do uso das âncoras não foram influenciados pelas tarefas cognitivas. Mesmo em superfície desafiadora, a oscilação postural foi reduzida para facilitar a execução das tarefas cognitivas. Os resultados do estudo 2 revelaram que os idosos com e sem histórico de quedas se beneficiaram igualmente da adição de dicas hápticas. A presença da tarefa cognitiva-visual reduziu a oscilação postural em ambos os grupos. De maneira geral, tanto o TL quanto as âncoras foram eficazes na redução da oscilação postural em adultos jovens e idosos com e sem histórico de quedas, sugerindo que a informação háptica foi capaz de beneficiar o controle postural mesmo em condições de tarefas cognitivas, demonstrando que jovens e idosos, particularmente aqueles com histórico de quedas, foram capazes de modular funcionalmente o controle postural de forma a facilitar a execução das tarefas cognitivas. / Haptic information provided by the light touch (LT) and the anchors reduce the postural sway during upright standing. It is unclear whether this benefit would remain in the presence of cognitive tasks in young and older adults with and without a history of falls. Thus, the aims were: 1) to investigate the effects of the anchors and the visual and auditory cognitive tasks on postural control in young adults in a challenging balancing task (Study 1); 2) to investigate the effect of haptic input provided by LT and anchors while performing a cognitive-visual task in older adults with and without a history of falls when standing upright (Study 2). Sixtyfour individuals were divided into three groups: young adults (n=20), faller older adults (n=22) and non-faller older adults (n=22). For the young adults (Study 1), the task consisted in standing upright on a balance beam with feet apart at shoulders width while performing 6 experimental conditions combining the anchors (with or without) and the cognitive tasks (none, the adapted visual Stroop test and the auditory digit monitoring task). For the older adults (Study 2), the task consisted in standing upright with feet together while performing six experimental conditions combining haptic cues (none, LT, and anchors) and the presence/absence of the cognitive-visual task (the adapted visual Stroop test). The results of the study 1 showed that the cognitive tasks did not affect the benefits of the anchors for the young adults. Even on a challenging surface, the postural sway reduced to facilitate the execution of the cognitive tasks. The results of the study 2 revealed that the older adults benefited similarly from the haptic cues, independently their history of falls. The presence of the cognitive-visual task reduced the postural sway in both groups. In general, both LT and anchors were effective to reduce postural sway in young and older (fallers and non-fallers) adults, suggesting that the haptic information was able to benefit the postural control even with cognitive tasks, demonstrating that young and older adults, particularly those with a history of falls, were able to functionally modulate their postural control to facilitate the execution of the cognitive tasks.

The memory and spatial navigation are extremely important brain functions for humans, but they are often the question of life and death for animals. In humans, memory can be disrupted by various neuropsychiatric disorders. The patients suffering from Alzheimer's dementia (AD) have impaired working and long-term memory, spatial navigation, higher cognitive functions and social memory. The deficit of cognitive coordination (the skill to recognize the relevancy of incoming information) and disorientation belong to the symptomatology of schizophrenia. Intelectual disability appears in some patients with autism spectrum disorder. Unfortunately, it is not possible to cure these disorders efficiently because the etiology is not known in the majority of patients. The causes leading to development of these disorders could be revealed using animal models. This thesis contributes to the characterization of the cognitive skills disruptions - as well as other behavioral alterations - in selected rat models of AD (transgenic McGill rat, non-transgenic Samaritan rat) and schizophrenia (lipopolysaccharide model of early postnatal, or prenatal, bacterial infection). The thesis also discusses the validity and limitations of these models. Our results showed a severe deficit of spatial navigation, learning and...