Orientador: Paulo José Fortes Villas Boas / Resumo: Introdução: Atualmente a expectativa de vida mundial está aumentando significativamente. Avaliar a população assistida em centros de convivência permitirá ampliar a discussão acerca das atividades realizadas e propostas nesses locais, com ênfase na qualidade de vida dos idosos. Objetivo: Avaliar os idosos do Centro de Convivência do Idoso “Aconchego” em Botucatu quanto às síndromes geriátricas, capacidade funcional e uso de medicamentos. Métodos: Estudo observacional transversal, realizado entre o mês de janeiro de 2018 e abril de 2019, no Centro de Convivência do Idoso Aconchego, em Botucatu (SP). Foi realizada avaliação geriátrica amola quanto aos domínios capacidade funcional (escala de Katz, Pfeffer, escala de Lawton), cognição (Mini Exame do Estado Mental - MEEM), humor (escala de depressão geriátricade Yesavage), deficit sensorial dos idosos (teste da voz sussurrada e déficit visual), nutrição (índice de massa corpo- ral), fragilidade (índice Study of osteoporotic fracture e índice fenotípico de Linda Fried), continência urinária e questão social e familiar. Os idosos portadores de demência foram classificados quanto a gravidade pelo Clinical Dementia Ratio (CDR). Foi realizada análise descritiva, testes de associação (QuiQuadrado, T-stu- dent), sendo estatisticamente significativo quando o nível alfa foi < 0,05. Resultados: A amostra avaliada foi de 76 idosos, que tiveram a média de idade de 80,6 + 8,0 anos, sendo que 72,4% (55) eram do sexo feminino. 94,2% apresentava... (Resumo completo, clicar acesso eletrônico abaixo) / Abstract: Introduction: The current world life expectancy is increasing significantly. Assessing the population assisted in social centers will allow a broader discussion about the activities carried out and proposed in these places, with emphasis on the quality of life of the elderly. Objective: To evaluate the elderly of the Center for the Cohabitation of the Elderly "Aconchego" in Botucatu regarding geriatric syndromes, functional capacity and medication use. Methods: Cross-sectional observational study, conducted between January 2018 and April 2019, at the Aconchego Shelter Center in Botucatu (SP). A geriatric evaluation was carried out in relation to functional capacity domains (Katz scale, Pfeffer, Lawton scale), cognition (Mental State Mini Examination), humor (Yesavage geriatric depression scale), sensorial deficit of the elderly (Index of osteoporotic fracture and Linda Fried's phenotype index), urinary continence, and social and family issues. Elderly people with dementia were classified as severity by the Clinical Dementia Ratio (CDR). A descriptive analysis, association tests (Chi-Square, T-student) was performed, being statistically significant when the alpha level was <0.05. Results: The sample evaluated was 76 elderly, who had a mean age of 80.6 + 8.0 years, and 72.4% (55) were female. 94.2% had cognitive impairment by MMSE, and 47.4% had a previous diagnosis of dementia. 55.3% were classified as overweight / obese. 41.7% of the elderly were classified as mild dementia a... (Complete abstract click electronic access below) / Mestre

Introducción: Los adultos mayores institucionalizados (AMI), constituyen una población vulnerable porque pierden autonomía al adaptarse a un nuevo ambiente lo cual predispone la aparición de síntomas depresivos y dependencia funcional. El objetivo del estudio es determinar la asociación entre síntomas depresivos y funcionalidad en esta población. Materiales y Métodos: Estudio transversal analítico con la aplicación de instrumentos estandarizados para evaluar síntomas depresivos (Escala de depresión geriátrica de Yesavage) y dependencia funcional para actividades básicas de la vida diaria (Índice de Barthel) y la extracción de datos de historias clínicas en un Centro Geronto-Geriátrico en Lima- Perú durante Febrero- Abril del 2013. Resultados: 153 AMI fueron enrolados con una media de 80,8 ±7,3 años a predominio masculino, solteros, y de bajo nivel educativo. El 47,1% tenía algún grado dependencia funcional y el 62,1% algún síntoma depresivo. El coeficiente de Spearman entre los puntajes de Yesavage y Barthel mostró con una correlación negativa no significativa (-0,14, p=0,08). En el análisis de regresión lineal multivariado las covariables educación secundaria (p<0,01), hipertensión arterial (p<0,01), y dependencia funcional escasa (p=0,01) estuvieron asociadas a un mayor puntaje de sintomatología depresiva. Conclusiones: Existe asociación significativa entre los síntomas depresivos y dependencia funcional. Por ello, la identificación precoz de la dependencia funcional escasa en los AMI debe ser considerada como un indicador evitar la aparición de síntomas depresivos. / Introduction: Institutionalized Elderly (IE) constitute a vulnerable population because they lose their autonomy to adapt to a new environment which predisposes the onset of depressive symptoms and functional dependency. The aim of the study is determine the relationship between depressive symptoms and functional dependency in public old age homes. Materials and Methods: Analytical cross- sectional study using standardized scales to evaluate depressive symptoms (Yesavague’s Geriatric Depression Scale) and functional dependency on activities of daily living (Barthel Scale) and extracting data manually from medical records in a Gerontological- Geriatric Center in Lima Peru from February to April, 2013. Results: 153 IE were enrolled in the study with a mean age of 80.8, +/- 7.3 years. They were predominantly men, single and with low educational level, 47.1% had some degree of functional dependency and 62.09% some symptom of depression. The Spearman coefficient between Yesavage and Barthel illustrated non-significant negative correlation (-0.14, p=0.08). In the multivariate linear regression analysis, the covariates secondary education (<0.01), arterial hypertension (p<0.01) and functional dependency (p=0.01) were associated with a higher score of depressive symptoms. Conclusions: There is a significant association between depressive symptoms and functional dependency. Thus, the early identification of low functional dependency in IE should be considered as an early indicator to avoid depressive symptoms. / Tesis

Possibilities of prevention reflecting geriatric principles: Functional status and depressivity in old age Hana Vaňková, MD Abstract Background: Given the population ageing in Europe and in the Czech Republic, strategies aiming to prevent functional decline in older age are of great importance. Depression in old age increases functional decline and is also associated with increased morbidity, mortality and deterioration of quality of life (Anstey et al., 2007; Karakaya et al., 2009). Therefore, there is a need for a comprehensive intervention addressing both functional status and depressive symptoms. Methods: Using comprehensive geriatric assessment, the relationship between functional status and depressive symptoms was examined in 308 residents of long-term care facilities (RCFs) in the Czech Republic. Depressive symptoms were measured using the 15-item Geriatric Depression Scale. An additional randomized control trial (RCT) evaluated the effect of a dance-based therapy on depressive symptoms in 162 institutionalized older adults with average age over 80 years. Results: A multiple regression analyses adjusted for sociodemographic factors and for taking antidepressants found that cognitive function and functional limitation by pain were most strongly associated with depressive symptoms. The ability to...

Background: Older patients are vulnerable to chemotherapy-related toxicity (CRT). Therefore we evaluated screening tools in their power to predict CRT. Methods: Patients with cancer aged ≥65 years completed three screening questionnaires (G8, optimised G8 and Cancer and Ageing Research Group (CARG). Additionally, Comprehensive geriatric assessment (CGA) for verification of supportive care needs was undertaken on patients with impaired G8 scores. During chemotherapy treatment patients were assessed, capturing grade 0–5 CRT as defined by NCI CTCAE 4. Results: 104 patients with non-haematological cancers were included at three study sites. Median age was 73 years (range 65–85). Onco-geriatric screening detected 74% as impaired using G8 and optimised G8 questionnaires and 86% using CARG screening. Grade 3–5 toxicity affected 64.4% of all patients. G8 (OR 0.3 95% CI [0.1;1.0]) and optimised G8 (OR 0.4 95% CI [0.1; 1.5]) did not reliably predict CRT, whereas screening with CARG demonstrated a strong prediction of severe CRT: OR 4.2, 95% CI [1.1, 15.9]. CGA was undertaken on 66 patients, revealing deficiencies in nutritional (83%) and functional-status (54%) and occurrence of relevant comorbidity (53%). Conclusion: The CARG tool could be useful for predicting CRT. CGA showed clinically relevant supportive care needs in patients with a positive G8 screening.:1. Einleitung ..................................................................................................................................... - 3 - 1.1 Epidemiologie der Krebserkrankungen bei älteren Patienten .................................................. - 4 - 1.2 Herausforderungen der geriatrischen Onkologie ..................................................................... - 5 - 1.3 Status Quo ................................................................................................................................. - 7 - 1.4 Geriatrisches Assessment (GA)................................................................................................ - 11 - 1.6 Geriatrisches Screening ........................................................................................................... - 13 - 1.5 Chemotherapie assoziierte Toxizität ....................................................................................... - 15 - 2 Ableitung der Studienrationale ...................................................................................................... - 17 - 3 Publikationsmanuskript .................................................................................................................. - 18 - 4 Zusammenfassung der Arbeit ........................................................................................................ - 26 - 5 Literaturverzeichnis der Einleitung ................................................................................................ - 29 - 6 Anlagen ........................................................................................................................................... - 35 - 7 Abkürzungsverzeichnis ................................................................................................................... - 52 - 8 Erklärung über die eigenständige Abfassung der Arbeit ................................................................ - 53 - 9 Lebenslauf – David Immanuel Kotzerke ......................................................................................... - 54 - 10 Spezifizierung des eigenen Beitrages ........................................................................................... - 56 - 11 Danksagungen .............................................................................................................................. - 58 -

Possibilities of prevention reflecting geriatric principles: Functional status and depressivity in old age Hana Vaňková, MD Abstract Background: Given the population ageing in Europe and in the Czech Republic, strategies aiming to prevent functional decline in older age are of great importance. Depression in old age increases functional decline and is also associated with increased morbidity, mortality and deterioration of quality of life (Anstey et al., 2007; Karakaya et al., 2009). Therefore, there is a need for a comprehensive intervention addressing both functional status and depressive symptoms. Methods: Using comprehensive geriatric assessment, the relationship between functional status and depressive symptoms was examined in 308 residents of long-term care facilities (RCFs) in the Czech Republic. Depressive symptoms were measured using the 15-item Geriatric Depression Scale. An additional randomized control trial (RCT) evaluated the effect of a dance-based therapy on depressive symptoms in 162 institutionalized older adults with average age over 80 years. Results: A multiple regression analyses adjusted for sociodemographic factors and for taking antidepressants found that cognitive function and functional limitation by pain were most strongly associated with depressive symptoms. The ability to...

O Brasil está entre os países em desenvolvimento onde a faixa etária acima dos 80 anos é a que mais cresce. Este grupo tem sido pouco estudado em nosso meio, sobretudo no que tange às diferenças inter-regionais relacionadas à saúde. Trata-se de estudo epidemiológico comparativo e transversal, de idosos >= 80 anos residentes em duas comunidades. A amostra probabilística constou de dois grupos de idosos mais velhos: um de Ribeirão Preto (RP-SP), com 155 sujeitos e outro de Caxias do Sul (CS-RS), com 117 sujeitos. A coleta de dados se deu através de uma Avaliação Geriátrica Global, com entrevistas domiciliares realizadas entre maio de 2007 e setembro de 2008. O instrumento de coleta foi composto por dados demográficos e socioeconômicos, medidas antropométricas, Miniexame do Estado Mental (MEEM), Atividades Instrumentais de Vida Diária (AIVD), Medida de Independência Funcional (MIF), presença de comorbidades, Escala de Depressão Geriátrica (EDG) e estilo de vida (uso de álcool, tabagismo, nível de atividade física e avaliação da dieta). A média de idade foi de 84,4 (± 4,3) anos em RP e 85,0 (± 3,9) anos em CS. Houve predominância do sexo feminino (~ 67%), cor branca (~ 89%) e viúvos (~56%) em ambos os municípios, sem que houvesse diferenças significativas nestas variáveis. Não houve diferença importante na escolaridade média dos dois grupos, e a renda média do idoso foi maior (P = 0,020) em RP (R$ 978,2 ± 1.329,6) do que em CS (R$ 668,3 ± 596,1). Entretanto, em RP houve maior concentração de indivíduos tanto analfabetos como com alta escolaridade; bem como daqueles que recebiam tanto menos de um salário mínimo (SM) como mais de 3 SM. Verificou-se ainda uma proporção maior de idosos que utilizavam convênio de saúde em CS (63%) do que em RP (49%). Não houve diferença estatisticamente significativa no escore médio do MEEM entre os dois grupos (20,6 ± 7,5 em RP e 19,5 ± 6,3 em CS; P = 0,23), sendo que este foi significativamente menor para indivíduos do sexo feminino, com idade mais avançada e analfabetos. Verificou-se uma proporção maior de idosos independentes para as AIVD em RP (22%) do que em CS (7%; P = 0,001), bem como um escore maior na MIF naquele grupo (108,2 ± 24,3) do que em CS (102,9 ± 19,9; P = 0,058). Um melhor nível de independência em ambos os municípios foi observado para os idosos do sexo masculino, aqueles casados, de maior escolaridade e melhor renda. Houve uma tendência a uma maior proporção de idosos com sobrepeso e obesos em CS (41,9% e 21,4%, respectivamente) do que em RP (32,7% e 15,3%, respectivamente; P = 0,08). Verificou-se também maior número de comorbidades em CS (7,6 ± 2,9) do que em RP (5,9 ± 2,9; P < 0,001). Entretanto, RP apresentou maior escore na EDG (4,1 ± 2,9), com maior proporção de sujeitos depressivos (39,3%) do que CS (3,1 ± 2,8 e 22,8%, respectivamente; P = 0,005). Os idosos com menos sintomas depressivos foram aqueles do sexo masculino, casados, ou com maior escolaridade em ambos os grupos. Em ambos os municípios, após ajustar-se para idade e gênero, observouse que o grau de independência funcional (MIF) correlacionou-se positivamente com o MEEM e negativamente com o número de comorbidades e o escore na EDG. Quanto ao estilo de vida, não houve diferença significativa entre os dois grupos no que tange ao gasto energético em atividade física e ao consumo de cigarros. No entanto, em CS houve uma proporção maior de idosos que utilizam ou utilizavam bebida alcoólica, especialmente vinho. Os idosos de CS também apresentaram maior consumo calórico diário, inclusive de carboidratos, gorduras saturadas e sódio do que em RP (P < 0,001 para todos). Quando comparado a RP, embora os idosos de CS apresentem menor desigualdade educacional e de renda, além de menores índices de depressão, a dieta destes é menos saudável, há maior prevalência de obesidade e outras comorbidades e maior dependência funcional. Um adequado planejamento em termos de políticas de saúde, que melhor atendesse aos prérequisitos do envelhecimento bem-sucedido, poderia contribuir ao bem-estar dos idosos brasileiros mais velhos. / Brazil is one of the developing countries where the age range over 80 years is the fastest growing population group. This group has been little studied in our context, mainly with respect to interregional health-related differences. This comparative and cross-sectional epidemiological research looked at elderly >= 80 years of age living in two communities. The probabilistic sample comprised two groups of elder elderly: one in Ribeirão Preto (RP-SP), with 155 subjects; and another in Caxias do Sul (CS-RS), including 117 subjects. Data were collected through a Comprehensive Geriatric Assessment, involving home interviews carried out between May 2007 and September 2008. The data collection instrument consisted of demographic and socioeconomic data, anthropometric measures, the Mini-Mental State Examination (MMSE), Instrumental Activities of Daily Living (IADL), Functional Independence Measure (FIM), presence of comorbidities, Geriatric Depression Scale (GDS) and lifestyle (alcohol use, smoking, level of physical activity and diet assessment). The mean age was 84.4 (± 4,3) years in RP and 85,0 (± 3,9) years in CS. Female (~ 67%), white (~ 89%) and widowed (~56%) persons predominated in both cities, without any significant differences in these variables. No important difference was found between the two groups\' mean education level, and the elderly\'s mean income was higher (P = 0.020) in RP (R$ 978,2 ± 1,329,6) than in CS (R$ 668.3 ± 596,1). In RP, a greater concentration of both illiterate people and persons with a high education level was found; and of people receiving either less than one minimum wage (MW) or more than 3 MW. Also, the proportion of elderly people with health insurance found in CS (63%) was larger than in RP (49%). No statistically significant difference was found in the mean MMSE score between both groups (20.6 ± 7.5 in RP against 19.5 ± 6.3 in CS; P = 0.23), which was significantly lower for female, older and illiterate people. A larger proportion of independent elderly in terms of IADL was found in RP (22%) when compared with CS (7%; P = 0.001), and a higher score on the FIM in RP (108.2 ± 24.3) than in CS (102.9 ± 19.9; P = 0.058). In both cities, a higher level of independence was found for male, married elderly with higher education and income levels. A larger proportion of overweight and obese elderly was found in CS (41.9% and 21.4%, respectively) than in RP (32.7% and 15.3%, respectively; P = 0.08). Also, in CS, a larger quantity of comorbidities was found (7.6 ± 2.9) than in RP (5.9 ± 2.9; P < 0.001). However, RP displayed a higher score on the GDS (4.1 ± 2.9), with a larger proportion of depressive subjects (39.3%) than in CS (3.1 ± 2.8 and 22.8%, respectively; P = 0.005). In both groups, male, married elderly with higher education levels showed less depressive symptoms. In both cities, after adjusting for age and gender, a positive correlation was observed between the level of FIM and the MMSE, and a negative correlation with the number of comorbidities and the GDS score. As for lifestyle, no significant differences were found between both groups in terms of energy spent on physical activity and smoking. However, in CS, a larger proportion of elderly was found who were consuming or had consumed alcohol, especially wine. Elderly in CS also presented higher daily consumption levels of calories, carbohydrates, saturated fats and sodium than in RP (P < 0.001 for all). In comparison with RP, although elderly in CS demonstrated less inequality in terms of education and income and lower depression rates, their diet is less healthy and prevalence levels of obesity, other comorbidities and functional dependence are higher. Thus, efforts can me made to adequately plan health policies with a view to better complying with the prerequisites of successful aging and providing greater wellbeing to the Brazilian oldest-old.

Syftet var att granska sjuksköterskans dokumentation avseende intagningsorsak, andra identifierade problem/behov utefter CGA och vilka åtgärder det ledde till samt beskriva sjuksköterskans erfarenheter av att använda instrumentet CGA. Metod: Studien har en beskrivande design med kvantitativ och kvalitativ ansats. Totalt granskades 50 bedömningsinstrument och datajournaler. Frågeformulär utformades och 13 sjuksköterskor valde att delta. Journalgranskningarna utfördes med kvantitativ retrospektiv analys och frågeformulären analyserades enligt kvalitativ manifest innehållsanalys. Resultat: Under journalgranskningen framkom 11 olika intagningsorsaker där försämrat allmäntillstånd var den största gruppen. Totalt identifierades 205 problem/behov och 186 initierade åtgärder varav 7 åtgärder/person var högsta antal. Flest initierade åtgärder fanns inom nutrition, social bakgrund och fallrisk. Sjuksköterskornas erfarenheter av att använda CGA var att det fanns behov av tydliga arbetsrutiner gällande CGA, att CGA fungerade bra som checklista men var tidskrävande. De upplevde att CGA gav dubbelarbete men viljan fanns att använda CGA men däremot svårt att få det att fungera i arbetet samt att sjuksköterskorna identifierade problem/behov utan att använda CGA. Sjuksköterskorna upplevde inte att omhändertagandet förändrades men däremot fick teamet helhetsperspektiv på patientens livssituation. Samverkan med anhöriga och kommunen var viktigt. Slutsats: Studiens resultat visade att förutom inskrivningsorsak fanns även andra identifierade problem/behov utefter CGA som hade stor betydelse för att den äldre skulle uppleva hälsa. Sjuksköterskorna upplevde brister inom rutinen runt CGA samt erfor att sjuksköterskornas omhändertagande av den geriatriska patienten inte förändrades efter implementeringen av CGA. / Aim was to examine nurses documentation regarding admission cause, other identified problems/needs by the CGA and the actions that led to and describe nurses experiences of using the instrument CGA. Method: The study has a descriptive design with quantitative and qualitative approach. Total audited 50 assessment instruments and data records. Questionnaires were designed and 13 nurses chose to participate. Journal audits performed by quantitative retrospective analysis and the questionnaires were analyzed by the inspiration of qualitative manifest content analysis. Results: In the journal audit identified 11 different admission causes which reduced general condition was the largest group. Total identified 205 problems/needs and 186 initiated measures which 7 action/person was the highest number. Most measures were initiated in nutrition, social background and risk of falling. Nurses experiences of using the CGA was that there was a need for clear work procedures regarding the CGA, the CGA worked well as a checklist but was time consuming. They felt that the CGA gave duplication but the desire was to use the CGA but hard to make it work at work and the nurses identified problems / needs without using the CGA. The nurses did not feel that the care was changed but got the team holistic view of the patients life situation. Collaboration with families and the municipality was important. Conclusion: The study results showed that in addition the cause enrollment were other identified problems/needs along the CGA that had great importance for the elderly would experience health. The nurses experienced deficiencies in routine around the CGA and required that the nurses taking care of the geriatric patient did not change after the implementation of CGA.

O Brasil está entre os países em desenvolvimento onde a faixa etária acima dos 80 anos é a que mais cresce. Este grupo tem sido pouco estudado em nosso meio, sobretudo no que tange às diferenças inter-regionais relacionadas à saúde. Trata-se de estudo epidemiológico comparativo e transversal, de idosos >= 80 anos residentes em duas comunidades. A amostra probabilística constou de dois grupos de idosos mais velhos: um de Ribeirão Preto (RP-SP), com 155 sujeitos e outro de Caxias do Sul (CS-RS), com 117 sujeitos. A coleta de dados se deu através de uma Avaliação Geriátrica Global, com entrevistas domiciliares realizadas entre maio de 2007 e setembro de 2008. O instrumento de coleta foi composto por dados demográficos e socioeconômicos, medidas antropométricas, Miniexame do Estado Mental (MEEM), Atividades Instrumentais de Vida Diária (AIVD), Medida de Independência Funcional (MIF), presença de comorbidades, Escala de Depressão Geriátrica (EDG) e estilo de vida (uso de álcool, tabagismo, nível de atividade física e avaliação da dieta). A média de idade foi de 84,4 (± 4,3) anos em RP e 85,0 (± 3,9) anos em CS. Houve predominância do sexo feminino (~ 67%), cor branca (~ 89%) e viúvos (~56%) em ambos os municípios, sem que houvesse diferenças significativas nestas variáveis. Não houve diferença importante na escolaridade média dos dois grupos, e a renda média do idoso foi maior (P = 0,020) em RP (R$ 978,2 ± 1.329,6) do que em CS (R$ 668,3 ± 596,1). Entretanto, em RP houve maior concentração de indivíduos tanto analfabetos como com alta escolaridade; bem como daqueles que recebiam tanto menos de um salário mínimo (SM) como mais de 3 SM. Verificou-se ainda uma proporção maior de idosos que utilizavam convênio de saúde em CS (63%) do que em RP (49%). Não houve diferença estatisticamente significativa no escore médio do MEEM entre os dois grupos (20,6 ± 7,5 em RP e 19,5 ± 6,3 em CS; P = 0,23), sendo que este foi significativamente menor para indivíduos do sexo feminino, com idade mais avançada e analfabetos. Verificou-se uma proporção maior de idosos independentes para as AIVD em RP (22%) do que em CS (7%; P = 0,001), bem como um escore maior na MIF naquele grupo (108,2 ± 24,3) do que em CS (102,9 ± 19,9; P = 0,058). Um melhor nível de independência em ambos os municípios foi observado para os idosos do sexo masculino, aqueles casados, de maior escolaridade e melhor renda. Houve uma tendência a uma maior proporção de idosos com sobrepeso e obesos em CS (41,9% e 21,4%, respectivamente) do que em RP (32,7% e 15,3%, respectivamente; P = 0,08). Verificou-se também maior número de comorbidades em CS (7,6 ± 2,9) do que em RP (5,9 ± 2,9; P < 0,001). Entretanto, RP apresentou maior escore na EDG (4,1 ± 2,9), com maior proporção de sujeitos depressivos (39,3%) do que CS (3,1 ± 2,8 e 22,8%, respectivamente; P = 0,005). Os idosos com menos sintomas depressivos foram aqueles do sexo masculino, casados, ou com maior escolaridade em ambos os grupos. Em ambos os municípios, após ajustar-se para idade e gênero, observouse que o grau de independência funcional (MIF) correlacionou-se positivamente com o MEEM e negativamente com o número de comorbidades e o escore na EDG. Quanto ao estilo de vida, não houve diferença significativa entre os dois grupos no que tange ao gasto energético em atividade física e ao consumo de cigarros. No entanto, em CS houve uma proporção maior de idosos que utilizam ou utilizavam bebida alcoólica, especialmente vinho. Os idosos de CS também apresentaram maior consumo calórico diário, inclusive de carboidratos, gorduras saturadas e sódio do que em RP (P < 0,001 para todos). Quando comparado a RP, embora os idosos de CS apresentem menor desigualdade educacional e de renda, além de menores índices de depressão, a dieta destes é menos saudável, há maior prevalência de obesidade e outras comorbidades e maior dependência funcional. Um adequado planejamento em termos de políticas de saúde, que melhor atendesse aos prérequisitos do envelhecimento bem-sucedido, poderia contribuir ao bem-estar dos idosos brasileiros mais velhos. / Brazil is one of the developing countries where the age range over 80 years is the fastest growing population group. This group has been little studied in our context, mainly with respect to interregional health-related differences. This comparative and cross-sectional epidemiological research looked at elderly >= 80 years of age living in two communities. The probabilistic sample comprised two groups of elder elderly: one in Ribeirão Preto (RP-SP), with 155 subjects; and another in Caxias do Sul (CS-RS), including 117 subjects. Data were collected through a Comprehensive Geriatric Assessment, involving home interviews carried out between May 2007 and September 2008. The data collection instrument consisted of demographic and socioeconomic data, anthropometric measures, the Mini-Mental State Examination (MMSE), Instrumental Activities of Daily Living (IADL), Functional Independence Measure (FIM), presence of comorbidities, Geriatric Depression Scale (GDS) and lifestyle (alcohol use, smoking, level of physical activity and diet assessment). The mean age was 84.4 (± 4,3) years in RP and 85,0 (± 3,9) years in CS. Female (~ 67%), white (~ 89%) and widowed (~56%) persons predominated in both cities, without any significant differences in these variables. No important difference was found between the two groups\' mean education level, and the elderly\'s mean income was higher (P = 0.020) in RP (R$ 978,2 ± 1,329,6) than in CS (R$ 668.3 ± 596,1). In RP, a greater concentration of both illiterate people and persons with a high education level was found; and of people receiving either less than one minimum wage (MW) or more than 3 MW. Also, the proportion of elderly people with health insurance found in CS (63%) was larger than in RP (49%). No statistically significant difference was found in the mean MMSE score between both groups (20.6 ± 7.5 in RP against 19.5 ± 6.3 in CS; P = 0.23), which was significantly lower for female, older and illiterate people. A larger proportion of independent elderly in terms of IADL was found in RP (22%) when compared with CS (7%; P = 0.001), and a higher score on the FIM in RP (108.2 ± 24.3) than in CS (102.9 ± 19.9; P = 0.058). In both cities, a higher level of independence was found for male, married elderly with higher education and income levels. A larger proportion of overweight and obese elderly was found in CS (41.9% and 21.4%, respectively) than in RP (32.7% and 15.3%, respectively; P = 0.08). Also, in CS, a larger quantity of comorbidities was found (7.6 ± 2.9) than in RP (5.9 ± 2.9; P < 0.001). However, RP displayed a higher score on the GDS (4.1 ± 2.9), with a larger proportion of depressive subjects (39.3%) than in CS (3.1 ± 2.8 and 22.8%, respectively; P = 0.005). In both groups, male, married elderly with higher education levels showed less depressive symptoms. In both cities, after adjusting for age and gender, a positive correlation was observed between the level of FIM and the MMSE, and a negative correlation with the number of comorbidities and the GDS score. As for lifestyle, no significant differences were found between both groups in terms of energy spent on physical activity and smoking. However, in CS, a larger proportion of elderly was found who were consuming or had consumed alcohol, especially wine. Elderly in CS also presented higher daily consumption levels of calories, carbohydrates, saturated fats and sodium than in RP (P < 0.001 for all). In comparison with RP, although elderly in CS demonstrated less inequality in terms of education and income and lower depression rates, their diet is less healthy and prevalence levels of obesity, other comorbidities and functional dependence are higher. Thus, efforts can me made to adequately plan health policies with a view to better complying with the prerequisites of successful aging and providing greater wellbeing to the Brazilian oldest-old.

Objetivo: Determinar la Frecuencia de Depresión en el adulto mayor con síndrome de fragilidad según la Valoración Geriátrica Integral en el Hospital Nacional Almanzor Aguinaga Asenjo entre abril del año 2019 hasta marzo del 2020. Así mismo, determinar las características sociodemográficas y clínicas, y la frecuencia de los criterios de Fried en los adultos mayores frágiles con depresión según la Valoración Geriátrica Integral en el Hospital Nacional Almanzor Aguinaga Asenjo en este periodo. Diseño: Se realizo un estudio observacional, descriptivo, retrospectivo y transversal. Población: Son todos los Adultos Mayores con diagnóstico de Fragilidad según la Valoración Geriátrica Integral en el servicio de Geriatría del Hospital Nacional Almanzor Aguinaga Asenjo atendidos entre abril 2019 y marzo 2020. Desarrollo: Las personas sujeto a estudio se seleccionaron mediante muestreo censal, dando como resultado un total de 90. Resultados: La frecuencia de Depresión establecida fue de 75,6% (68 casos) frente a 24,4% (22 casos) de “No Depresión” (22/90) en el adulto mayor con síndrome de fragilidad. Las variables sociodemográficas y clínicas más frecuentes en adultos mayores con síndrome de fragilidad y depresión fueron: el rango octogenario (81 a 90 años) con un 54.4%; la población femenina con 67,6%; primaria completa con 75,0%; comorbilidad II en un 96,6%, y 51,5% tienen polifarmacia. En los criterios clínicos de fragilidad, la baja actividad física y la marcha lenta se reportaron como los más frecuentes con 100% y 98,5% respectivamente. / Today, the construction industry is focusing on the use of sustainable materials due to their environmental impact. because of their environmental impact. Concrete is widely used in construction due to its diverse properties, but one of its components, cement, composed mainly of clinker, causes significant CO2 pollution. clinker causes significant CO2 pollution. Therefore, the possibility of partially substituting this the possibility of partially substituting this material is being investigated. One example is calcined diatomaceous calcined diatoms, which are mainly composed of diatomite layers. The objective of this The objective of this study is to evaluate the properties of conventional concrete with the incorporation of calcined diatoms in proportions of 5%. calcined diatoms in proportions of 5%, 10% and 15%. For this purpose, tests were carried out in the fresh and hardened state. and hardened state. In general, the properties improve with respect to the standard mix for a 5% by weight substitution of cement with diatomaceous earth. 5% by weight replacement of cement by calcined diatomite. Calcined diatoms can be used in the production of lightweight concrete, since they reduce its density by 17 kg/m3. In terms of compressive strength, a 9% increase was observed with the addition of 5% calcined diatoms. of calcined diatomaceous earth compared to conventional concrete, thanks to its high pozzolanic activity. pozzolanic activity. In terms of durability, improvements were found when using 5% calcined diatomaceous earth as compared to conventional concrete, due to its high pozzolanic activity. calcined diatomaceous earth. The diatomite, despite increasing the production cost by 3% per cubic meter, improves the properties of the concrete. cubic meter, improves the properties of the concrete due to its low density, high pozzolanic and microscopic activity. pozzolanic activity and microscopic size.

京都大学 / 新制・課程博士 / 博士(医学) / 甲第24135号 / 医博第4875号 / 新制||医||1060(附属図書館) / 京都大学大学院医学研究科医学専攻 / (主査)教授 近藤 尚己, 教授 川上 浩司, 教授 阪上 優 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DFAM