Modelling and simulation of the human body during an impact situation such as a car accident, can lead to better designed safety features on vehicles. In order to achieve this, investigation into the material properties and the creation of a numerical model of cortical bone is needed. One approach to creating a material model of cortical bone suitable for these situations is to describe the material model as visco-elastic, as reported by Shim et al. [1], Bekker et al. [2] and Cloete et al. [3]. The work by Shim et al. and Bekker et al. developed three-dimensional models, but do not accurately capture the transition in behaviour in the intermediate strain rate region, while Cloete et al. developed a phenomenological model which captures the intermediate strain rate behaviour in one dimension. This work aims to verify and extend these models. The intermediate strain rate regime (1 s−1 to 100 s−1 ) is of particular interest because it is a key characteristic of the behaviour of cortical bone and several studies have been conducted to gather experimental data in this region [3, 4, 5, 6]. The behaviour can be captured using non-linear viscoelastic models. This dissertation focuses on the development and implementation of a material model of cortical bone based on non-linear visco-elastic models to capture the intermediate strain rate regime behaviour. The material model was developed using uni-axial test results from cortical bone. The model by Cloete et al. has been improved and extended, and issues of local and global strain rate with regards to the viscosity have been clarified. A hereditary integral approach was taken in the analysis and implementation of discrete models and was found to be consistent with mathematical models. The model developed was extended to three dimensions in a manner similar to that of Shim et al. and Bekker et al. for implementation in commercial finite element software (LS-Dyna and Abaqus).

The field of rhetorical aesthetics has a long and rich history. Despite that history, however, aesthetic artifacts have yet to be considered with the same weight that conventional rhetorical artifacts are. My project is to consider the rhetorical effectiveness of aesthetic artifacts, making a case for more inclusion of these types of artifacts in rhetorical theory. I will demonstrate the effectiveness of the aesthetic by performing a comparative analysis of both an aesthetic and conventional reaction to the 2019 fires at Notre Dame de Paris. By considering the constitutive power of the aesthetic, I will argue that the depth of analysis that the aesthetic allows makes it, in some cases, a more effective space for rhetorical analysis than conventional artifacts.

Transcription factors activated by exogenous or endogenous stimuli alter gene expression with major effects on chromatin accessibility and the epigenome. This thesis investigates that impact of environmental chemical and hormonal exposure on liver chromatin accessibility in a mouse liver model. Exposure to the constitutive androstane receptor (CAR)-specific agonist ligand 1,4-bis-[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP) induces localized changes in chromatin accessibility at several thousand DNase hypersensitive sites (DHS). Activating histone marks, associated with enhancers and promoters, were induced by TCPOBOP and were highly enriched at opening DHS. Opening DHS were highly enriched for CAR binding sites and nuclear receptor direct repeat-4 motifs. These DHS were also enriched for the CAR heterodimeric partner RXRA, binding by CEBPA and CEBPB, and motifs for other liver-specific factors. Thus, TCPOBOP alters the enhancer landscape through changes in histone marks and by mechanisms linked to induced CAR binding. In other studies, the impact of pituitary growth hormone (GH) secretion patterns on chromatin accessibility changes associated with sex-biased liver gene expression was examined. In adult male liver, the transcription factor STAT5 is directly activated by each successive plasma GH pulse. In female liver, STAT5 is persistently activated by the near-continuous stimulation by plasma GH. A majority of the ~4,000 GH-regulated, sex-biased DHS have chromatin marks characteristic of enhancers and were enriched for proximity to sex-biased gene promoters. Chromatin accessibility is thus a key feature of sex-differential gene expression. Two major classes of male-biased DHS were identified: dynamic male-biased DHS, almost all bound by STAT5, which undergo repeated cycles of chromatin opening and closing induced by each GH pulse; and static male-biased DHS, whose accessibility is unaffected GH/STAT5 pulses and whose sex bias results from these chromatin sites being more closed in female liver. Sites with STAT5 binding showed greater chromatin opening, many of which also contain the STAT5 motif. Finally, the effect of a single GH pulse on hypophysectomized male mouse liver was investigated to identify DHS responsive to the male, pulsatile-GH, secretion pattern. These studies demonstrate that widespread epigenetic changes associated with target gene expression are induced by xenobiotics and hormones regulating liver gene expression. / 2022-01-31T00:00:00Z

abstract: An orthotropic elasto-plastic damage material model (OEPDMM) suitable for impact simulations has been developed through a joint research project funded by the Federal Aviation Administration (FAA) and the National Aeronautics and Space Administration (NASA). Development of the model includes derivation of the theoretical details, implementation of the theory into LS-DYNA®, a commercially available nonlinear transient dynamic finite element code, as material model MAT 213, and verification and validation of the model. The material model is comprised of three major components: deformation, damage, and failure. The deformation sub-model is used to capture both linear and nonlinear deformations through a classical plasticity formulation. The damage sub-model is used to account for the reduction of elastic stiffness of the material as the degree of plastic strain is increased. Finally, the failure sub-model is used to predict the onset of loss of load carrying capacity in the material. OEPDMM is driven completely by tabulated experimental data obtained through physically meaningful material characterization tests, through high fidelity virtual tests, or both. The tabulated data includes stress-strain curves at different temperatures and strain rates to drive the deformation sub-model, damage parameter-total strain curves to drive the damage sub-model, and the failure sub-model can be driven by the data required for different failure theories implemented in the computer code. The work presented herein focuses on the experiments used to obtain the data necessary to drive as well as validate the material model, development and implementation of the damage model, verification of the deformation and damage models through single element (SE) and multi-element (ME) finite element simulations, development and implementation of experimental procedure for modeling delamination, and finally validation of the material model through low speed impact simulations and high speed impact simulations. / Dissertation/Thesis / Doctoral Dissertation Civil, Environmental and Sustainable Engineering 2019

京都大学 / 0048 / 新制・課程博士 / 博士(理学) / 甲第20924号 / 理博第4376号 / 新制||理||1628(附属図書館) / 京都大学大学院理学研究科地球惑星科学専攻 / (主査)教授 田上 高広, 教授 山路 敦, 教授 平原 和朗 / 学位規則第4条第1項該当 / Doctor of Science / Kyoto University / DGAM

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We introduce an elastic constitutive model of gravity that enables the interpretation of cosmological observations in terms of established ideas from Solid Mechanics and multiscale modeling. The behavior of physical space is identified with that of a material-like medium called "cosmic fabric," which exhibits constitutive behavior. This cosmic fabric is a solid hyperplate that is broad in the three ordinary spatial dimensions and thin in a fourth hyperspatial dimension. Matter in space is treated as fabric inclusions that prescribe in-plane (three-dimensional) strain causing the transverse bending of the fabric into the fourth hyperspatial dimension. The linearized Einstein-Hilbert action, which governs the dynamics of physical space, is derived from postulating Hooke’s Law for the fabric, and the Schwarzschild metric is recovered from investigating matterabric interactions. At the continuum length scale, the Principle of Relativity is shown to apply for both moving and stationary observers alike, so that the fabric’s rest reference frame remains observationally indistinguishable at such a length scale. Within the Cosmic Fabric paradigm, the structural properties of space at different hierarchical length scales can be investigated using theoretical notions and computational tools from solid mechanics to address outstanding problems in cosmology and fundamental physics. For example, we propose and offer theoretical support for the "Inherent Structure Hypothesis", which states that the gravitational anomalies currently attributed to dark matter may in fact be manifestations of the inherent (undeformed) curvature of space. In addition, we develop a numerical framework wherein one can perform numerical "experiments" to investigate the implications of said hypothesis.

Rutting failures are prominent in expedient airfields constructed with AM2 landing mats over soft existing subgrades. There are many issues that must be addressed when approaching this multiaceted problem. The load transfer mechanism occurring at interlocking mat joints and the mat-soil interface bonding condition affect near surface subgrade response. The repeated loading coupled with lateral aircraft wander causes significant principal stress rotation in the subgrade. This kneading action then causes variations in the excess pore-water pressure and a subsequent softening of the soil. The purpose of this study is to investigate the critical factors that lead to subgrade rutting failures in landing mats constructed over soft subgrades. A three dimensional finite element (3D FE) model of a landing mat system over soft subgrade is implemented under both static and pseudo-dynamic loading conditions with aircraft wander. To capture the complex stress histories induced by the simulated moving gear loads over the unique structural features of the AM2 mat system, an elastoplastic kinematic hardening constitutive model, the Multi-Mechanical Model, is developed, calibrated and used to represent the subgrade response. Under both static and pseudo-dynamic loading, the FE model results match very well with the stress and deformation results from full-scale instrumented testing of the AM2 mat over 6 CBR subgrade. Results show that incorporating the load transfer mechanism occurring at the mat joints and varying the mat-soil interface condition affect the near surface subgrade deformation and stress responses that contribute to rutting failures. Furthermore, rotation of the principal stress axes and changes in excess pore-water pressures occur in the subgrade because of the moving tire load. These phenomena contribute to extension of the field of deformation influence around the trafficked area in the subgrade and upheaval at the edges of the test section. Findings of this study show that although layered elastic analysis procedures are the basis of current airfield design methodologies, critical design features and the corresponding deformation responses can be better modeled using the FE approach. Furthermore, the proposed 3D modeling approach implementing aircraft wander can provide a reliable platform for accurately simulating the subgrade response under pseudo-dynamic loading conditions.

This study focuses on molecular dynamics (MD) simulations, coupled with a discrete mathematical framework, and crystal plasticity (CP) simulations to investigate micro void nucleation and the plastic spin. The origin and historical use of the plastic spin are discussed with particular attention to quantifying the plastic spin at the atomistic scale. Two types of MD simulations are employed: (a) aluminum single crystals undergoing simple shear and (b) aluminum triple junctions (TJ) with varying grain orientations and textures undergoing uniaxial tension. The high-angle grain boundary simulations nucleate micro voids at or around the TJ and the determinant of the deformation gradient shows the ability to predict such events. Crystal plasticity simulations are used to explore the stress-state of the aluminum TJ from uniaxial tension at a higher length scale with results indicating a direct correlation between CP stress-states and the location of micro void nucleation in the MD simulations.

The present study develops a phenomenological adaptation to an internal state variable (ISV) model that incorporates the influence of dynamic recrystallization (DRX) in a material’s evolving microstructure and flow stress response. During metal forming and joining processes that promote internal heat distributions and large strains, microstructural processes often occur that result in a transformation of the evolving microstructure away from the base distribution. In an effort to lower the stored energy accumulated in the material’s lattice and grain structure, the deformed material may undergo a type of dynamic recovery process, such as DRX. In this study, the ISV model’s flow stress output is modified to include a phenomenological DRX softening and hardening term internal to the isotropic hardening rate ISV. The flow stress thus directly includes the influence of microstructure evolution. The evolving grain size is modeled such that an inverse relation exists between strain hardening and average grain size.