<p>Artificial Intelligence driven approaches, especially  based on deep learning algorithms, provided an alternative perspective in summarizing the common features in large-scale and complex datasets and aided the human professions in discovering novel features in cross-domain research. In this dissertation, the author proposed his research of developing AI-driven algorithms to reveal the real relation of complex medical data. The author started to identify the abnormal structures from the radiology images. When the abnormal structure was detected, the author built a model to explore the domain layers or cell phenotype of the specific tissues. Finally, the author evaluated cell-cell communication for the downstream tasks.</p> <p><br></p> <p>In his first research, the author applied IResNet, a two-stage prediction-interpretation Convolution Neural Network, to assist clinicians in the early diagnosis of Autism Spectrum Disorders (ASD). IresNet first predicted the input sMRI scan to one of the two categories: (1) ASD group or (2) Normal Control group, and interpret the prediction using a \textit{post-hoc} approach and visualized the abnormal structures on top of the raw inputs. The proposed method can be applied to other neural diseases such as Alzheimer's Disease. </p> <p><br></p> <p>When the abnormal structure was detected, the author proposed a method to reveal the latent relation at the tissue level. Thus the author proposed SiGra, an unsupervised learning paradigm to identify the domain layers and cellular phenotype in a particular tissue slide based on the corresponding gene expression matrix and the morphology representations. SiGra outperformed other benchmarking algorithms in three different tissue slides from three commercialized single-cell platforms.</p> <p><br></p> <p>At last, the author measured the potential interactions between two cells. The proposed spaCI, measured the correlation of a Ligand-Receptor interaction in the high-dimension latent space and predicted the interactive $L-R$ pair for downstream analysis. </p> <p><br></p> <p>In summary, the author presented three end-to-end AI-driven frameworks to facilitate clinicians and pathologists in better understanding the latent connections of complex diseases and tissues. </p>

Functional magnetic resonance imaging (fMRI) technology has been used in the investigation of human brain functionality and assist in brain disease diagnosis. While fMRI can be used to model both spatial and temporal brain functionality, the analysis of the fMRI images and the discovery of patterns for certain brain diseases is still a challenging task in medical imaging. Deep learning has been used more and more in medical field in an effort to further improve disease diagnosis due to its effectiveness in discovering high-level features in images. Convolutional neural networks (CNNs) is a class of deep learning algorithm that have been successfully used in medical imaging and extract spatial hierarchical features. The application of CNNs in fMRI and the extraction of brain functional patterns is an open field for research. This project focuses on how fMRIs can be used to improve Autism Spectrum Disorders (ASD) detection and diagnosis with 3D resting-state functional MRI (rs-fMRI) images. ASDs are a range of neurodevelopment brain diseases that mostly affect social function. Some of the symptoms include social and communicating difficulties, and also restricted  and repetitive  behaviors. The  symptoms appear on early childhood and tend to develop in time thus an early diagnosis is required. Finding a proper model for identifying between ASD and healthy subject is a challenging task and involves a lot of hyper-parameter tuning. In this project a grid search approach is followed in the quest of the optimal CNN architecture. Additionally, regularization and augmentation techniques are implemented in an effort to further improve the models performance.

Rapid technological advances in artificial intelligence (AI), data analytics, big data, the semantic web, the Internet of Things (IoT), and cloud and mobile computing have given rise to a new generation of AI-driven recommendation agents (RAs). These agents continue to evolve and offer potential for use in a variety of application domains. However, extant information systems (IS) research has predominantly focused on user perceptions and evaluations of traditional non-intelligent product-brokering recommendation agents (PRAs), supported by empirical studies on custom-built experimental RAs that heavily rely on explicit user preference elicitations. To address the lack of research in the new generation of intelligent RAs (RAs 2.0), this dissertation aims to study consumer responses to AI-driven RAs using an affordance perspective. Notably, this research is the first in the IS discourse to link RA design artifacts, RA affordances, RA outcomes, and user continuance. It examines how actualized RA affordances influence user engagements with and evaluations of these highly personalized systems, which increasingly focus on user experiences and long-term relationships. This three-essay dissertation, consisting of one theory-building paper and two empirical studies, conceptually defines "RAs 2.0," proposes a comprehensive theoretical framework with testable propositions, and conducts two empirical studies guided by smaller carved-out models to test the validity of the comprehensive framework. The research is expected to enrich the IS literature on RAs and identify potential areas for future research. Moreover, it offers key implications for industry professionals regarding the effective system development of the new generation of intelligent RAs. / Doctor of Philosophy / Rapid technological advances in artificial intelligence (AI), data analytics, big data, the semantic web, the Internet of Things (IoT), and cloud and mobile computing have given rise to a new generation of AI-driven recommendation agents (RAs). These agents continue to evolve and offer potential for use in a variety of application domains. This three-essay dissertation, consisting of one theory-building paper and two empirical studies, conceptually defines "RAs 2.0," proposes a comprehensive theoretical framework with testable propositions, and conducts two empirical studies guided by smaller carved-out models to test the validity of the comprehensive framework. The research is expected to enrich the IS literature on RAs and identify potential areas for future research. Moreover, it offers key implications for industry professionals regarding the effective system development of the new generation of intelligent RAs.

The aim of this work is to enhance the detection and classification pipelines of an artificial intelligence (AI)-based decision support system (DSS) for diagnosing acanthamoeba keratitis (AK), a vision-threatening disease. The images used are taken with the in vivo confocal microscopy (IVCM) technique, a complementary tool for clinical assessment of the cornea that requires manual human analysis to support diagnosis. The DSS facilitates automated image analysis and currently aids in diagnosing AK. However, the accuracy of AK detection needs improvements in order to use it in clinical practice. To address this challenge, we utilize image brightness processing through multiscale retinex (MSR), and develop a custom-built image processing pipeline with deep learning model and rule-based strategies. The proposed pipeline replaces two deep learning models in original DSS, resulting in an overall accuracy improvement of 10.23% on average. Additionally, our improved pipeline not only enhances the original system’s ability to aid AK diagnosis, but also provides a versatile set of functions that can be used to create pipelines for detecting similar keratitis diseases.

Radio frequency interference (RFI) poses significant challenges for passive microwave radiometry used in climate studies and Earth science. Despite operating in protected frequency bands, microwave radiometers often encounter RFI from sources like air surveillance radars, 5G communications, and unmanned aerial vehicles. Traditional RFI detection methods rely on handcrafted algorithms designed for specific RFI types. This study proposes a deep learning (DL) approach, leveraging convolutional neural networks to detect various RFI types on a global scale. By learning directly from radiometer data, this data-driven method enhances detection accuracy and generalization. The DL framework processes raw moment data and Stokes parameters, dynamically labeled using quality flags, offering a robust and efficient solution for RFI detection. This approach demonstrates the potential for improved RFI mitigation in passive remote sensing applications.

<p>This thesis aims to design and develop the spatial adaptation approach through spatial transformers to improve the accuracy of human keypoint recognition models. We have studied different model types and design choices to gain an accuracy increase over models without spatial transformers and analyzed how spatial transformers increase the accuracy of predictions. A neural network called Widenet has been leveraged as a specialized network for providing the parameters for the spatial transformer. Further, we have evaluated methods to reduce the model parameters, as well as the strategy to enhance the learning supervision for further improving the performance of the model. Our experiments and results have shown that the proposed deep learning framework can effectively detect the human key points, compared with the baseline methods. Also, we have reduced the model size without significantly impacting the performance, and the enhanced supervision has improved the performance. This study is expected to greatly advance the deep learning of human key points and movement dynamics. </p>

Denna uppsats presenterar resultaten av en kvalitativ undersökning som syftar till att ge en djupare förståelse för användningen av AI inom radiologi, dess framtida påverkan på yrket och hur det används idag. Genom att genomföra tre intervjuer med personer som arbetar inom radiologi, har datainsamlingen fokuserat på att identifiera de positiva och negativa aspekterna av AI i radiologi, samt dess potentiella konsekvenser på yrket. Resultaten visar på en allmän acceptans för AI inom radiologi och dess förmåga att förbättra diagnostiska processer och effektivisera arbetet. Samtidigt finns det en viss oro för att AI kan ersätta människor och minska behovet av mänskliga bedömningar. Denna uppsats ger en grundläggande förståelse för hur AI används inom radiologi och dess möjliga framtida konsekvenser. / This essay presents the results of a qualitative study aimed at gaining a deeper understanding of the use of artificial intelligence (AI) in radiology, its potential impact on the profession and how it’s used today. By conducting three interviews with individuals working in radiology, data collection focused on identifying the positive and negative aspects of AI in radiology, as well as its potential consequences on the profession. The results show a general acceptance of AI in radiology and its ability to improve diagnostic processes and streamline work. At the same time, there is a certain concern that AI may replace humans and reduce the need for human judgments. This report provides a basic understanding of how AI is used in radiology and its possible future consequences.

Wireless sensor networks (WSNs) have become pivotal in precision agriculture, environmental monitoring, and smart healthcare applications. However, the challenges of energy consumption and security, particularly concerning the reliance on large battery-operated nodes, pose significant hurdles for these networks. Energy-harvesting wireless sensor networks (EH-WSNs) emerged as a solution, enabling nodes to replenish energy from the environment remotely. Yet, the transition to EH-WSNs brought forth new obstacles in ensuring reliable and secure data transmission. In our initial study, we tackled the intermittent connectivity issue prevalent in EH-WSNs due to the dynamic behavior of energy harvesting nodes. Rapid shifts between ON and OFF states led to frequent changes in network topology, causing reduced link stability. To counter this, we introduced the hybrid routing method (HRM), amalgamating grid-based and opportunistic-based routing. HRM incorporated a packet fragmentation mechanism and cooperative localization for both static and mobile networks. Simulation results demonstrated HRM's superior performance, enhancing key metrics such as throughput, packet delivery ratio, and energy consumption in comparison to existing energy-aware adaptive opportunistic routing approaches. Our second research focused on countering emerging threats, particularly the malicious energy attack (MEA), which remotely powers specific nodes to manipulate routing paths. We developed intelligent energy attack methods utilizing Q-learning and Policy Gradient techniques. These methods enhanced attacking capabilities across diverse network settings without requiring internal network information. Simulation results showcased the efficacy of our intelligent methods in diverting traffic loads through compromised nodes, highlighting their superiority over traditional approaches. In our third study, we developed a deep learning-based two-stage framework to detect MEAs. Utilizing a stacked residual network (SR-Net) for global classification and a stacked LSTM network (SL-Net) to pinpoint specific compromised nodes, our approach demonstrated high detection accuracy. By deploying trained models as defenses, our method outperformed traditional threshold filtering techniques, emphasizing its accuracy in detecting MEAs and securing EH-WSNs. In summary, our research significantly advances the reliability and security of EH-WSN, particularly focusing on enhancing the network layer. These findings offer promising avenues for securing the future of wireless sensor technologies.

This research study focuses on the application models of Data Mining and Machine Learning covering cellular network traffic, in the objective to arm Mobile Network Operators with full view of performance branches (Services, Device, Subscribers). The purpose is to optimize and minimize the time to detect service and subscriber patterns behaviour. Different data mining techniques and predictive algorithms have been applied on real cellular network datasets to uncover different data usage patterns using specific Key Performance Indicators (KPIs) and Key Quality Indicators (KQI). The following tools will be used to develop the concept: RStudio for Machine Learning and process visualization, Apache Spark, SparkSQL for data and big data processing and clicData for service Visualization. Two use cases have been studied during this research. In the first study, the process of Data and predictive Analytics are fully applied in the field of Telecommunications to efficiently address users’ experience, in the goal of increasing customer loyalty and decreasing churn or customer attrition. Using real cellular network transactions, prediction analytics are used to predict customers who are likely to churn, which can result in revenue loss. Prediction algorithms and models including Classification Tree, Random Forest, Neural Networks and Gradient boosting have been used with an exploratory Data Analysis, determining relationship between predicting variables. The data is segmented in to two, a training set to train the model and a testing set to test the model. The evaluation of the best performing model is based on the prediction accuracy, sensitivity, specificity and the Confusion Matrix on the test set. The second use case analyses Service Quality Management using modern data mining techniques and the advantages of in-memory big data processing with Apache Spark and SparkSQL to save cost on tool investment; thus, a low-cost Service Quality Management model is proposed and analyzed. With increase in Smart phone adoption, access to mobile internet services, applications such as streaming, interactive chats require a certain service level to ensure customer satisfaction. As a result, an SQM framework is developed with Service Quality Index (SQI) and Key Performance Index (KPI). The research concludes with recommendations and future studies around modern technology applications in Telecommunications including Internet of Things (IoT), Cloud and recommender systems. / Cellular networks have evolved and are still evolving, from traditional GSM (Global System for Mobile Communication) Circuit switched which only supported voice services and extremely low data rate, to LTE all Packet networks accommodating high speed data used for various service applications such as video streaming, video conferencing, heavy torrent download; and for say in a near future the roll-out of the Fifth generation (5G) cellular networks, intended to support complex technologies such as IoT (Internet of Things), High Definition video streaming and projected to cater massive amount of data. With high demand on network services and easy access to mobile phones, billions of transactions are performed by subscribers. The transactions appear in the form of SMSs, Handovers, voice calls, web browsing activities, video and audio streaming, heavy downloads and uploads. Nevertheless, the stormy growth in data traffic and the high requirements of new services introduce bigger challenges to Mobile Network Operators (NMOs) in analysing the big data traffic flowing in the network. Therefore, Quality of Service (QoS) and Quality of Experience (QoE) turn in to a challenge. Inefficiency in mining, analysing data and applying predictive intelligence on network traffic can produce high rate of unhappy customers or subscribers, loss on revenue and negative services’ perspective. Researchers and Service Providers are investing in Data mining, Machine Learning and AI (Artificial Intelligence) methods to manage services and experience. This research study focuses on the application models of Data Mining and Machine Learning covering network traffic, in the objective to arm Mobile Network Operators with full view of performance branches (Services, Device, Subscribers). The purpose is to optimize and minimize the time to detect service and subscriber patterns behaviour. Different data mining techniques and predictive algorithms will be applied on cellular network datasets to uncover different data usage patterns using specific Key Performance Indicators (KPIs) and Key Quality Indicators (KQI). The following tools will be used to develop the concept: R-Studio for Machine Learning, Apache Spark, SparkSQL for data processing and clicData for Visualization. / Electrical and Mining Engineering / M. Tech (Electrical Engineering)

This thesis addresses the challenge of denoising microscopy images captured under low-light conditionswith varying intensity levels. The study compares three deep learning models — N2V, CARE, andRCAN — against the collaborative filter BM4D, which serves as a reference point. The models weretrained on two distinct datasets: Endoplasmic Reticulum and Mitochondria datasets, both acquired witha lattice light-sheet microscope.Results show that BM4D maintains stable performance metrics and delivers superior visual quality,when compared to the noisy input. In contrast, the deep learning models exhibit poor performance onnoisy test images when trained on datasets with non-uniform noise levels. Additionally, a sensitivitycomparison of neural parameter between the same models was made. Revealing that supervised modelsare data-specific to some extent, whereas the self-supervised N2V demonstrates consistent neuralparameters, suggesting lower data specificity. / Denna uppsats tar upp problemet med att reducera brus i mikroskopibilder tagna under svagaljusförhållanden med varierande intensitetsnivåer. Studien jämför tre djupinlärningsmodeller – N2V,CARE och RCAN – mot det kollaborativa filtret BM4D, vilket agerar som en referenspunkt.Modellerna tränades på två olika dataset: Endoplasmic Reticulum och Mitochondria, båda tagna meden selektiv planbelysningsmikroskop (lattice light-sheet microscope).Resultaten visar att BM4D behåller stabila prestationsmått och levererar bättre visuell kvalitet, jämförtmed den brusiga input. Däremot visar djupinlärningsmodellerna bristande prestanda på brusigatestbilder när de tränats på data med icke-enhetliga brusnivåer. Dessutom gjordes enkänslighetsjämförelse av neurala parametrar mellan samma modeller. Detta visade att de övervakademodellerna är specifika för data i viss utsträckning, medan den självövervakade N2V-modellen visarlika neurala parametrar, vilket tyder på lägre dataspecificitet