Using the concept of the build-up cavity for second harmonic generation to produce 243nm laser light, an innovative cavity is theoretically explored using a 15mm length CLBO crystal. In order to limit the losses of the cavity, the number of effective optical surfaces is kept to only four and the use of a MgF2 crystal is adopted to separate the harmonic and fundamental laser beam from each other. The cavity is shown to have an expected round trip loss of five tenths of a percent or better, resulting in a conversion efficiency greater than 65%.

Melanoma, the most lethal form of skin cancer, arises from altered cells in the melanocyte lineage, but the mechanisms by which these cells progress to melanoma are unknown. To understand the early cellular events that contribute to melanoma formation, we examined melanocytes in melanoma-prone zebrafish strains expressing BRAFV600E, the most common oncogenic form of the BRAF kinase that is mutated in nearly 50% of human melanomas. We found that, unlike wild-type melanocytes, melanocytes in transgenic BRAFV600Eanimals were binucleate and tetraploid. Furthermore, melanocytes in p53-deficient transgenic BRAFV600Eanimals exhibited 8N and greater DNA content, suggesting bypass of a p53-dependent arrest that stops cell cycle progression of tetraploid melanocytes. These data implicate tetraploids generated by increased BRAF pathway activity as contributors to melanoma initiation. Previous studies have used artificial means of generating tetraploids, raising the question of how these cells arise during actual tumor development. To gain insight into the mechanism by which BRAFV600E generates binucleate, tetraploid cells, we established an in vitro model by which such cells are generated following BRAFV600E expression. We demonstrate thatBRAFV600E-generated tetraploids arise via cytokinesis failure during mitosis due to reduced activity of the small GTPase RhoA. We also establish that oncogene-induced centrosome amplification in the G1/S phase of the cell cycle and subsequent increase in the activity of the small GTPase Rac1, partially contribute to this phenotype. These data are of significance as recent studies have shown that aneuploid progeny of tetraploid cells can be intermediates in tumor development, and deep sequencing data suggest that at least one third of melanomas and other solid tumors have undergone a whole genome doubling event during their progression. Taken together, our melanoma-prone zebrafish model and in vitro data suggest a role for BRAFV600E-inducedtetraploidy in the genesis of melanomas. To our knowledge, this is the first in vivo model showing spontaneous rise of tetraploid cells that can give rise to tumors. This novel role of the BRAF oncogene may contribute to tumorigenesis in a broader context.

This document elaborates on the subject of video interlacing and its removal. It describes the interlacing of video, its history and the reasons that led to its use. The document also explains why it is necessary to remove interlacing and the basic methods that are used for it. It describes the proposed deinterlacing algorithm and its implementation, including description of inpainting and block matching. Included are also test results of both quality and speed of my deinterlacing algorithm. The final chapter describes the implementation as a console application and a DLL library.

In this thesis we study radial weights on Rn. We study two radial weights with different exponent sets. We show that they are both 1-admissible by utilizing a previously shown sufficient condition, for radial weights to be 1-admissible, together with some results connecting exponent sets and Ap weights. Furthermore applying a similar method on a more general radial weight, we manage to improve the previously shown sufficient condition for radial weights to be 1-admissible. Finally we show for one of these two weights that even though it is 1-admissible, whether or not it belongs to some class Ap depends both on the value of p and on the dimension n. Additionally, both of these weights as well as another simple weight are, at least in some dimensions n, not A1 even though they are 1-admissible.

Orchestrierung wurde bisher hauptsächlich auf eine intuitive, non-verbale musikalische Art und Weise unterrichtet und Traktate zur Orchestrierung widmen sich vor allem den Instrumenten (Instrumentenkunde). Der Komponist und Professor für Orchestrierung am nationalen Konservatorium in Paris, Marc-André Dalbavie (1961–), und einige seiner ehemaligen Studierenden haben seit den 1990er Jahren unter dem Begriff ›funktionale Orchestrierung‹ allgemeine und verbalisierte Prinzipien der Orchestrierung entwickelt, die meisten davon basierend auf Akustik, Psychoakustik und üblicher Praxis. Ich präsentiere im Folgenden eine Auswahl dieser Funktionen und einige damit in Verbindung stehende Beispiele aus der Literatur. / Orchestration has been mainly taught in a quite intuitive and non-verbalized musical way, and treatises in orchestration are mostly treatises on instruments. Since the 90’s, under the name ›functional orchestration‹, the composer and orchestration professor at the national Paris conservatory, Marc-André Dalbavie (1961–), and a few of his former students have developed some general and verbalized principles of orchestration, mostly based on acoustics, psychoacoustics and common practice. I briefly present some of these functions and a few related examples from the literature.

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<p dir="ltr">This study investigates the production of dative clitic doubling among Spanish heritage speakers and English-speaking L2 learners of Spanish. Dative clitic doubling, a grammatical structure in Spanish, is challenging for bilingual speakers (Montrul, 1998; Cuervo, 2007; Escobar-Alvarez, 2017). The study examines the extent to which heritage speakers of Spanish and L2 learners demonstrate knowledge of dative clitic doubling in Spanish with ditransitive verbs across four conditions: psych verbs, wh-questions, double object constructions, and inalienable possession. The results from an online Elicited Production Task reveal that L2 learners exhibit crosslinguistic influence from their L1, characterized by the omission of the dative clitic in the analyzed structures. Heritage speakers also show some degree of crosslinguistic influence, often preferring prepositional constructions over dative clitic doubling. The findings are discussed in the context of the current discourse on the roles of proficiency, language use, and exposure.</p>

Kapaciteter kan vara till stor nytta, bland annat då partiella differentialekvationer ska lösas. Kapaciteter är dock i många fall väldigt svåra att beräkna exakt, speciellt i viktade rum. Vad som istället kan göras är att försöka uppskatta kapaciteterna, vilket för ringar runt en fix punkt kan utföras med hjälp av fyra olika exponentmängder, \underline{Q}_0, \underline{S}_0, \overline{S}_0 och \overline{Q}_0, som beskriver hur vikten beter sig i närheten av denna punkt och i viss mån ger rummets lokala dimension. För att kunna dra nytta av exponentmängderna är det bra att veta vilka kombinationer av dessa som kan förekomma. För att få fram nya kombinationer använder vi olika sätt att mäta volym av klot med varierande radier. Dessa mått är definierade genom olika vikter. Det har tidigare funnits ett fåtal exempel på hur olika kombinationer av exponentmängderna kan se ut. Variationerna består av hur avstånden är i förhållande till varandra och om ändpunkterna tillhör mängderna eller inte. I denna rapport har vi tagit fram ytterligare fem nya kombinationer av mängderna, bland annat en där \underline{Q}_0 är öppen. / Capacities can be of great benefit, for instance when solving partial differential equations. In most cases, capacities can be difficult to calculate exactly, in particular on weighted spaces. In these cases, it can be sufficient with an estimation of the capacity instead. For annuli around a given point, the estimation can be done using four exponent sets \underline{Q}_0, \underline{S}_0, \overline{S}_0 and \overline{Q}_0, which describe how the weight behaves in a neighbourhood of that point and in some sense define the local dimension of the space. To be able to use the exponent sets, it is useful to know which combinations of them can exist. For this we use various measures, which are a way to measure volumes of balls with varying radii in Rn. These measures are defined by different weights. Earlier, there existed a few examples giving different combinations of exponent sets. The variations consist in their relationship to each other and if their endpoints belong to the set or not. In this thesis we present five new combinations of the exponent sets, amongst them one where \underline{Q}_0 is open.

This study develops a new approach to agreement variation in Standard Arabic (SA) and Rural Jordanian Arabic (RJA) based on the Probe-Goal framework of Chomsky (2000, 2001). The key patterns investigated are the variation in fullness of agreement in the SV and VS word orders, the relationship between agreement and clitic doubling, and the patterning of agreement with conjoined subjects. The thesis argues for a connection between agreement, clitic doubling, and word order. Full agreement on T (in person, number, and gender) causes the subject to move to [Spec, TP], deriving SV order. However, partial agreement on T (lacking person) creates only a partial copy of the subject in [Spec, TP]. This partial copy is realized as a pronominal clitic in some contexts (giving CLsVS word order) and as null pro in other contexts (giving VS word order). This approach enables a unified account of various differences in the patterning of agreement in SA and RJA. Turning to the more complex case of agreement with conjoined subjects, both varieties exhibit full resolved agreement with preverbal conjoined subjects. With postverbal conjoined subjects, however, there is variation: SA allows only partial agreement with the first conjunct while RJA allows partial agreement either with the first conjunct or with the entire conjoined phrase, depending on the features and the order of the conjoined nominals. The Probe-Goal framework augmented with Multiple Agree and the Continuity condition (Nevins 2007, 2011) will be employed to account for the choice between these two options in RJA. The more general theoretical conclusion is that the variation in agreement patterns is constrained by the internal hierarchical structure of φ-features on the probe. I propose that the probe has the same hierarchical structure as a pronoun (i.e. a DP). This proposal makes predictions about the range of possible variation in the features that are active in agreement and connects to broader issues such as the Pronominal Argument Hypothesis (Jelinek 1984) and the diachronic relationship between pronouns and agreement markers. / May 2017

The effect of uncertainty in gas composition on the accuracy of gas-phase thermometry using Laser-Induced Thermal Grating Spectroscopy, LITGS, is studied. Temperatures are obtained from measurements of the sound speed derived from the frequency of oscillations &fnof;_OSC imposed upon the LITGS signal arising from the transit of acoustic waves across the density modulation feature. The dependence of the sound speed, c_s on &radic;&gamma;/m, where &gamma; is the ratio of specific heats and m is the mean molecular mass leads to a dependence upon gas composition. LITGS signals were generated in acetone vapour in a variety of gas mixtures in a temperature controlled cell at 4 bar total pressure using pump pulses from a frequency quadrupled Q-switched Nd:YAG laser at 266 nm and a cw diode pumped solid state probe laser at 671 nm. Studies were undertaken of the variation in &fnof;_OSC with gas composition using gas mixtures of O₂ and N₂ with component concentrations in the range 0-100 &percnt;, and was found to agree with theoretical predictions. Measurement precision of the data (one standard deviation in 50 measurements) was found to be typically &plusmn; 1.7 &percnt; for measurements at 4 bar total pressure. The effect of varying concentrations in exhaust gas residuals (EGR) typical of pre-ignition gases in a spark ignition internal combustion engine were studied using synthetic air (N₂/ O₂ mixtures) containing variable amounts of simulated EGR components, CO₂ and H₂O. The effect of variation in CO₂ concentration in dry synthetic air was measured at 4 bar and 30&deg;C and found to agree with theoretical predictions. Experiments conducted at 30&deg;C, with the addition of a saturated vapour pressure of water indicate that the effect of a saturated vapour pressure of water on the oscillation frequency in synthetic EGR is on the borderline of resolution. The effect of variable amounts of typical hydrocarbon fuel vapour on &fnof;_OSC was studied using 2,2,4-trimethyl-pentane in gas mixtures composed of synthetic air and variable amounts of EGR and water vapour at 80&deg;C. Kinetic theory was used in order to model the dependence of the oscillation frequency &fnof;_OSC on various gas compositions containing fuel and EGR, in order to construct an error surface for comparison with experimental measurements. Experimental data were found to agree with the model predictions to within experimental error for a representative data set within the range of calculated values. The results indicate that uncertainties in temperature values derived from LITGS thermometry can be estimated with confidence within reasonable estimates of composition variations in an internal combustion engine, and should lead to absolute temperature accuracy of within 2-3 &percnt;.