姚道生. / 論文(哲學碩士)--香港中文大學硏究院中國語言及文學學部,1994. / 參考文獻: leaves 206-211 / Yao Daosheng. / Chapter 第一章 --- 緖論 --- p.1 / Chapter 第一節 --- 「六朝」一詞的界定 --- p.1 / Chapter 第二節 --- 樂府考略 --- p.2 / Chapter 第三節 --- 採桑主題 --- p.14 / Chapter 第二章 --- 採桑主題產生的文化背景 --- p.26 / Chapter 第一節 --- 說「蠶」「桑」 ´ؤ´ؤ從「蠶」「桑」二字的古文字考釋看 先秦時代的蠶桑業 --- p.27 / Chapter 第二節 --- 從出土文物看先秦時代的蠶桑業 --- p.41 / Chapter 第三節 --- 採桑親蠶 --- p.57 / Chapter 第四節 --- 小結 --- p.72 / 附錄一 / 附錄二 / Chapter 第三章 --- 採桑樂府的流變 --- p.79 / Chapter 第一節 --- 漢代之作 ´ؤ´ؤ採桑樂府的原型 --- p.80 / Chapter 第二節 --- 後世模擬之作 ´ؤ´ؤ採桑樂府的因革 --- p.93 / Chapter 第三節 --- 總述 --- p.129 / Chapter 第四章 --- 比興的言志傳統與採桑女守禮形象的確立 --- p.141 / Chapter 第一節 --- 比興的言志傳統 --- p.142 / Chapter 第二節 --- 採桑女守禮形象的確立 --- p.147 / Chapter 第五章 --- 採桑樂府的寄託 --- p.166 / Chapter 第一節 --- 「以意逆志」的讀詩方法 ´ؤ´ؤ判別詩歌是否有寄託的讀詩法 --- p.167 / Chapter 第二節 --- 「知人論世」的讀詩方法 ´ؤ´ؤ尋求詩人的寄託 --- p.177 / Chapter 第六章 --- 餘論´ؤ´ؤ解釋與創作 --- p.198 / 參考書目及論文 --- p.206

陳建樑. / 稿本 / 論文(哲學碩士)--香港中文大學硏究院中國語言及文學部,1992. / 參考文獻: leaves 860-956 / Chen Jianliang. / Chapter 甲 --- 前言 --- p.1 / Chapter 乙 --- 本文 --- p.3 / Chapter 上篇: --- 服注采《公»«穀»義探論 --- p.3 / 前言 --- p.3 / Chapter (1) --- 服氏采《公»«穀»義之例 --- p.62 / Chapter (2) --- 采《公羊»義之例一 --- p.11 / Chapter (3) --- 采«公羊»義之例二 --- p.114 / Chapter (4) --- 采«公羊»義之例三 --- p.135 / Chapter (5) --- 采«公羊»義之例四 --- p.149 / Chapter (6) --- 采«穀梁»義之例 --- p.174 / 小結 --- p.199 / Chapter 下篇： --- 服注緩用群籍攷 --- p.208 / 前言 --- p.208 / Chapter (1) --- 援«禮記»為說 --- p.219 / Chapter a --- 援«禮記»為說之條一 --- p.222 / Chapter b --- 援«禮記»為說之條二 --- p.237 / Chapter c --- 援«禮記»為說之條三 --- p.250 / Chapter d --- 援«禮記»為說之條四 --- p.269 / Chapter e --- 援«禮記»為說之條五 --- p.279 / Chapter (2) --- 援«司馬法»為說 --- p.322 / Chapter a --- 援«司馬法»為說之條一 --- p.332 / Chapter b --- 援«司馬法»為說之條二 --- p.382 / Chapter c --- 援«司馬法»為說之條三 --- p.420 / Chapter d --- 援«司馬法»為說之條四 --- p.436 / Chapter (3) --- 援«國語»為說 --- p.473 / Chapter a --- 援«國語»為說之條一 --- p.473 / Chapter b --- 援«國語»為說之條二 --- p.490 / Chapter (4) --- 援«詩»為說 --- p.585 / Chapter a --- 援«詩»為說之條一 --- p.585 / Chapter b --- 援«詩»為說之條二 --- p.605 / Chapter (5) --- 援«易»為說 --- p.632 / Chapter (6) --- 援«周禮»為說 --- p.700 / Chapter (7) --- 援«兵法»為說 --- p.710 / Chapter (8) --- 援«魯連子»為說 --- p.735 / Chapter (9) --- 援«神異經»為說 --- p.770 / 小結 --- p.880 / Chapter 丙 --- 結語 --- p.881 / Chapter 丁 --- 參攷書文舉要 --- p.888

書名據目次前. / Thesis (M.A.)--香港中文大學. / Shu ming ju mu ci qian. / Manuscript. / Includes bibliographical references (leaves 400-427). / Thesis (M.A.)--Xianggang Zhong wen da xue. / 引言 --- p.1 / Chapter 第一章 --- 嚴復的生平 --- p.8 / Chapter 第一節 --- 早年的傳統教育 --- p.8 / Chapter 第二節 --- 船政學堂　 --- p.10 / Chapter 第三節 --- 海上游歷與留學英國 --- p.12 / Chapter 第四節 --- 由軍界轉至思想界 --- p.19 / Chapter 第五節 --- 繙譯事葉的肇始 --- p.24 / Chapter 第六節 --- 繙譯方面的貢獻 --- p.30 / Chapter 第七節 --- 繙譯時期的政論和動態 --- p.44 / Chapter 第二章 --- 嚴復繙譯天演論的動機　 --- p.70 / Chapter 第一節 --- 發出種族危機的警告 --- p.71 / Chapter 第二節 --- 發出本土文化危亡的警告 --- p.99 / Chapter 第三節 --- 宣傳人定勝天的價值　 --- p.123 / Chapter 第三章 --- 嚴復繙譯天演論而維護斯賓塞學說　 --- p.151 / Chapter 第一節 --- 斯賓塞在嚴復心目中的地位 --- p.151 / Chapter 第二節 --- 赫胥黎的倫理觀 --- p.164 / Chapter 第三節 --- 嚴復維護斯賓塞的社會有機體說　 --- p.177 / Chapter 第四章 --- 天演論譯本出版前嚴復進化思想的特質 --- p.221 / Chapter 第一節 --- 弱者的進化思想 --- p.221 / Chapter 第二節 --- 人定勝天的內涵 --- p.235 / Chapter 第三節 --- 邏輯條理上的統一　 --- p.254 / Chapter 第五章 --- 嚴復天演論對晚清思想界的影響　 --- p.279 / Chapter 第一節 --- 傳播程序 --- p.279 / Chapter （一） --- 文體與傳播的關係 --- p.279 / Chapter （二） --- 時局與傳播的關系　 --- p.296 / Chapter 第二節 --- 政治性的影響 --- p.318 / Chapter （一） --- 對君憲派的影響 --- p.320 / Chapter （二） --- 對革命派的影響　 --- p.333 / Chapter 第三節 --- 學術性的影響　 --- p.353 / Chapter （一） --- 以進化觀點治學 --- p.353 / Chapter （二） --- 西化思想的繼續輸入 --- p.365 / 應用資料 --- p.400 / 參考書目　 --- p.412 / 參考論文　 --- p.422

黃俊文. / "2002年7月" / 論文 (哲學碩士)--香港中文大學, 2002. / 參考文獻 (leaves 158-175) / 附中英文提要. / "2002 nian 7 yue" / Huang Junwen. / Lun wen (zhe xue shuo shi)--Xianggang Zhong wen da xue, 2002. / Can kao wen xian (leaves 158-175) / Fu Zhong Ying wen ti yao. / 緒論 --- p.1-2 / Chapter 第一章： --- 傅奕生平考訂 --- p.3-24 / Chapter 1. --- 籍貫 / Chapter 2. --- 生卒年 / Chapter 3. --- 家貧及爲道士 / Chapter 4. --- 仕宦 / Chapter 5. --- 小結 / Chapter 第二章： --- 《道德經古本篇》成書考 --- p.25-36 / Chapter 1. --- 傅奕所見的《道德經》版本 / Chapter 2. --- 《道德經古本篇》成書考 / Chapter 第三章： --- 傅奕本的流傳 --- p.37-44 / Chapter 第四章： --- 《道德經古本篇》避諱考 --- p.45-79 / Chapter 1. --- 引言 / Chapter 2. --- 隋唐諱 / Chapter 3. --- 魏晉南北朝諱 / Chapter 4. --- 漢諱 / Chapter 5. --- 秦諱 / Chapter 第五章： --- 《道德經古本篇》異文硏究 --- p.80-130 / Chapter 第六章： --- 傅、范本關係硏究 --- p.131-155 / 總結 --- p.156-157 / 參考書目 --- p.158-175 / 附錄 --- p.176-178

The synthetic chemotherapeutic agent, 5-FU, has been used for the treatment of a variety cancers, with colorectal cancer being among the most susceptible. Administration of 5-FU by continuous intravenous infusion has proven to yield greater antitumor efficacy and lower hematotoxicity compared to administration of 5-FU by intravenous bolus injections. Nevertheless, systemic application of 5-FU is often limited by its narrow therapeutic threshold, and therefore in certain situations, such as tumor resection, it may be more appropriate to provide local rather than systemic delivery of 5-FU. It was therefore proposed that 5-FU loaded PLGA millirods may be capable of providing sustained release of 5-FU at a local level which may have equivalent or greater antitumor activity and less cytotoxicity than the systemic or local delivery of soluble 5-FU. PLGA millirods loaded with 5-FU were successfully fabricated by a hot-melt extrusion technique and characterized for in vitro and in vivo release rates. It was demonstrated that percentage loading by weight of 5-FU could be adjusted to modify its release kinetics. It was also shown that millirods could be stably stored under a variety of conditions for at least 2 months. An optimal millirod formulation (PLGA 50:50 loaded with 5-FU (50% w/w)) was tested for antitumor activity and general toxicity in vivo. At the dose of 120 mg/kg 5-FU, millirods (delivered peritumorally) were efficacious (with 100% survival rates) against solid thymomas in tumor-challenged mice (causing complete regression). Whilst the soluble form of 5-FU (delivered intraperitoneally (IP) at 120 mg/kg) was also highly efficacious (90% survival rates) against thymomas it was also more hematotoxic. In addition, the millirod form provided significantly greater antitumor activity against colorectal tumors in mice compared to the soluble form of 5-FU. In terms of in vivo toxicity, surprisingly, the type of formulation did not have a significant effect on mouse weight despite both IP and subcutaneous (SC) delivery causing death of some mice. Importantly, it was found that 5-FU loaded PLGA millirods were significantly less hematotoxic than soluble 5-FU delivered by either IP or SC injection at the equivalent dose. Thus, locally implanted 5-FU loaded PLGA millirods appeared to be less toxic and possessed overall greater antitumor potency than soluble 5-FU delivered by IP or SC injection. This study further investigated whether the combination of 5-FU loaded PLGA millirods with eniluracil (in both thymoma and colorectal tumor models) or immune checkpoint inhibitors (in the colorectal tumor model) could enhance the antitumor efficacy of 5-FU millirods in mice challenged with colorectal tumors. It was found that the combination of 5-FU loaded PLGA millirods and eniluracil (millirod or solution forms) did not significantly enhance the antitumor efficacy of 5-FU millirods in either tumor models. It was also found that immune checkpoint inhibitors did not enhance the antitumor efficacy of 5-FU loaded PLGA millirods in the colorectal tumor model.

Le cancer colorectal représente un défi thérapeutique compte tenu de sa fréquence (38 000 nouveaux cas annuels dans notre pays), et de sa gravité (moins de 10 % de survie à 5 ans en situation métastatique). Sa prise en charge adéquate est avant tout multidisciplinaire associant les nouvelles techniques de chirurgie et de radiologie à la chimiothérapie. Celle-ci est représentée par trois cytotoxiques majeurs : le 5-Fluorouracile, pierre angulaire du traitement, l'oxaliplatine (L-OHP) et enfin l'irinotecan (CPT-11), auxquels se sont ajoutées ces dernières années les biothérapies ciblant le facteur angiogénique VEGF (bevacizumab) ou le récepteur épithélial de surface EGFR (cetuximab, panitumumab). Notre travail de Thèse d'Université a cherché à explorer, chez des patients atteints d'un cancer colorectal métastatique, le retentissement sur les taux de réponses, les survies et les toxicités, de génotypes enzymatiques impliqués dans les métabolismes des trois cytotoxiques principalement utilisés dans cette indication. Nos études translationnelles montrent l'optimisation des traitements à base de 5-FU par l'approche pharmacocinétique associée au dépistage préthérapeutique d'une population à haut risque de toxicité (DPYD mutés et/ou rapport UH2/U abaissé). Par ailleurs apparaissent de mauvais pronostic sur la survie globale et en cas de monochimiothérapie par 5-FU, les patients 3R/3R pour TYMS et homozygote sauvage pour MTHFR 1298 A>C ou 677 C>T, facteurs de risques génotypiques disparaissant avec l'adjonction de CPT-11. Concernant ce dernier, un schéma de traitement adapté au statut UGT 1A1, et combiné au cetuximab, aboutit à des taux de maladie contrôlée et de survie sans progression inégalés en deuxième ligne de traitement. Enfin, les patients homozygotes T/T pour ERCC1 118 C>T et C/C XPD 751 A>C apparaissent à risque de neurotoxicité chroniques à l'oxaliplatine. Considérant le génome tumoral, outre Kras et Braf, PI3KCA muté apparaît pour la première fois comme un facteur possible de résistance aux traitements anti-EGFR. En conclusion, la prise en compte des facteurs pharmacogénétiques et pharmacogénomiques devrait permettre à l'avenir une meilleure rationalisation des traitements de chimiothérapies en optimisant leurs efficacités tout en limitant leurs toxicités.

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Abstract The Hai-Wai-Chi Society, an overseas organization derived from the ¡§Chi Society¡¨ based in Shanghai, was initiated and founded by Hsu Fu-Yuan, one of the six poets of the Chi Society. Towards the end of the Hung Kung reign of the late Ming dynasty, in the wake of the defeat of the Sungchiang uprising staged by the society, Hsu continued to work for the recovery of the Ming legacy against the ruling Qing regime. At first, he left Shanghai to follow Emperor Lungwu in Fujian. After Emperor Lungwu was defeated, he proceeded to Choushan to follow King Lu and cooperated with Chang Huang-Yen. Later on, after Choushan was seized by the Qing army, Hsu accompanied King Lu under the shelter of Koxinga in Xiamen. It was at this point that the society came to its apex. When Koxinga took hold of Taiwan following his defeat at Nanjing battle, the society members began to enter the island along with the soldiers. Therefore, the literature of Hai-Wai-Chi Society is viewed as the beginning of Han Taiwanese literature. Taiwan Shih Cheng by Lien Heng refers to Hsu Fu-Yuan, Chang Huang-Yen, Lu Jo-Teng, Sheng Chuan-Chi, Chao Tsung-Lung, Chen Shih-Ching as ¡§The Six Poets of Hai-Wai-Chi Society.¡¨ This paper, entitled A Study of Three Poets in the Hai-Wai-Chi Society, is intended to follow the same way of thinking in its exploration of Hsu Fu-Yuan, Chang Huang-Yen, and Lu Jo-Teng through the existing anthology of the society. Meanwhile, the relevant literature concerning the other three poets will be reviewed for necessary references. The Hai-Wai-Chi Society is characterized by its composition of core members, mainly loyalists to King Lu, who followed Koxinga to Taiwan as a consequence of the fall of Choushan. Mourning over the end of the Ming empire, intellectuals of high morality and talent assembled to form a society of poetry to express their emotions toward the fatherland. The members of the Hai-Wai-Chi Society were actively involved in the fight against the Qing court. In spite of successive defeats, they would live and die in exile overseas rather than surrender as subjects of the Qing regime. The Introduction aims to explain the motivation of this study, the meaning and formation of The Hai-Wai-Chi Society, with a literature review of the three poets. The first chapter explores the public opinions of The Dong-Lin Party¡]ªFªLÄÒ¡^ and the Restoration Society¡]´_ªÀ¡^ in the Late Ming period, and the poetry of patriotism by Chen Tzu-Lung and Hsia Wang-Chun of The Hai-Wai-Chi Society, to be defined in this study as two typical kinds of heritage of The Hai-Wai-Chi Society. The second chapter gives an analysis of the historical background of South Ming royalists fighting against the Qing regime and the formation and development of The Hai-Wai-Chi Society. The third chapter is focused on the Tiao-Huang-Tang Manuscript by Hsu Fu-Yuan to study his overseas poems that express his uncompromising anti-Qing mentality and noble patriotic integrity. The fourth chapter represents the social reality of war-ridden Kinmen during the Koxinga period based on Niao-Yi Poetry and Liu-An Anthology by Lu Jo-Teng. The fifth chapter deals with Chi-Ling Grass, Ping-Tsa Collection, and Tsai-Wei Recitation by Chang Huang-Yen to distinguish him as a great noble Ming loyalist who had fought against the Qing power for 19 years overseas. The Conclusion sums up the poetry by the three poets as: (1) a reflection of history with a national concern, (2) an expression of opposition against invasion with a firm anti-Qing determination, and (3) a kind of oceanic literature with a universal sympathy.

Because of competing for the recreational needs of the new sound, it was resulting in long tones boom and changing the dominant status of the short term in Preceding Song Dynasty. Regarding Fu as Ci was learning the writing skills from Ci to expand the original technique of expression of Ci. It was the new practice in response to long tones or slow terms. The implication of this word "Fu" was based on the meaning of the repeated narrative, and both had the virtues of the Sao Fu, Xun Fu, prosaic Fu, antithetic Fu and metric Fu. Xin Qi-ji¡¦s actual performance on regarding Fu as Ci, and his repeated narrative used in the flow of time, ode to history and nostalgia, the category of thing, the entire space and the specific object, which were able to narrate with wonderful words, from that we can see the thousands of states. Excessive parallelism and antithesis not only reached to the effects of repeated narrative, but the antithesis caused by the double sentences and top word were both closed to the practice of metric Fu. It was also the example of lyricization. Stacks of allusions, the Fu requires itself to be very perfect, and it was appropriate for the poetry. The allusion-using of Xin¡¦s Ci, such as Congratulating the groom, was like the Hate Fu. Sao Fu and prosaic Fu were good at playing an active part in the imagination, and then falsely declared the otherness in order to modify. Xin¡¦s Ci of Magnolia slow used ¡§asking-God form¡¨ to issue continuously the contradictory questions, and they created the unreasonable and wonderful sense. It was the amazing performance of Xin Qi-ji¡¦s imagination. Hypothesized question and answer was able to use the third party to express the issues which were difficult to say directly. The one purpose was to be far from the conflict of interests, and the other purpose was to expound circuitously with superfluous words. The situation that the poets imitated the Fu by enchanting with the style of Fu writer, such as Liu Yong imitated Song Yu, and Xin Qi-ji liked to quote from Qu Yuan¡¦s Fu. By imitating deliberately the Fu, such as Water Dragon Verse was similar to Luo God Fu, with the use of rhyme ¡§xie¡¨. By completely imitating and shifting the words, with the use of famous sentences written by predecessors, it met one¡¦s own spirituality. The allegory of prosaic Fu focusd on the end of the article in order to boost the whole article¡¦s momentum, and because Xin Qi-ji had a sentimental mind, it was easy to see the allegory spirit appeared on the end of his Fu.

We gathered normal and colorectal cancer tissues from 18 patients after tumor surgery. The tumor tissues represent caner stages from T1 to T4 (TNM system).Two-dimensional electrophoresis and MALDI-TOF techniques were utilized to identify the differentially expressed proteins. Our studies showed that there are about 18 differentially expressed proteins in normal and tumor tissues (p<0.05) which 13 proteins increased in tumor were Keratin 8, Protein disuflde isomerase A3 precursor, Keratin 18, Fractalkine precursor, LDH-B, Tropomyosin alpha 4 chain, Tropomyosin alpha 3 chain, chloride intracellular channel protein 1, PTTG1(Pituitary tumor-transforming protein 1),