This article provides an evaluation and overview of the Personal Digital Assistant (PDA) version of the evidence-based medicine database, InfoRetriever. Both the Pocket PC and Palm OS version are evaluated in this article. Topics covered are the access and installation of InfoRetriever for both PDA operating systems, the design and interface of InfoRetriever, the ease of access of the database contents, and its importance as a tool for point-of-care medicine.

Although data is often used to estimate parameters for models in calculus and differential equations, the models themselves are seldom justified. In this paper, the data itself is used to motivate mathematical models in introductory mathematics courses. In doing so, various regression and optimization techniques are illustrated.

This diploma thesis analyses the influence of the change to the vehicle’s center of gravity on its after-impact movement. The theoretical part of the thesis describes the basic methods which are used in investigation of the transverse, lengthwise and height position of center of gravity or the influence of center of gravity’s vehicle position to its stability and handling. Next part of the thesis deals with basic division of the road accidents and briefly describes the methods used in its analysis. Problematic maneuvers and everyday road traffic situations are stated in this thesis. Chosen situations were simulated in Virtual CRASH and PC crash programmes. Influence of the transverse, lengthwise and height position of center of gravity was investigated in these programmes with regards to the after-impact behaviour of vehicle. The obtained results were evaluated in the final chapter.

This diploma thesis analyses the influence of the changes to the vehicle’s center of gravity on its after-impact movement. The theoretical part of the thesis describes the basic methods which are used in investigation of the transverse, lengthwise and height position of center of gravity or the influence of center of gravity’s vehicle position to its stability and handling. Next part of the thesis deals with basic division of the road accidents and briefly describes the methods used in its analysis. Problematic maneuvers and everyday road traffic situations are stated in this thesis. Chosen situations were simulated in Virtual CRASH and PC crash programmes. Influence of the transverse, lengthwise and height position of center of gravity was investigated in these programmes with regards to the after-impact behaviour of vehicle. The obtained results were evaluated in the final chapter.

京都大学 / 0048 / 新制・論文博士 / 博士(工学) / 乙第12924号 / 論工博第4117号 / 新制||工||1625(附属図書館) / 32134 / (主査)教授 宮川 豊章, 教授 三村 衛, 教授 西山 峰広 / 学位規則第4条第2項該当 / Doctor of Philosophy (Engineering) / Kyoto University / DFAM

There are multiple games which can be classified as “first-person stealth” and an early game in this genre called Thief Gold has been directly influential in it. Defining the genre through certain qualifiers and using games which have directly been stated tohave been influenced by Thief Gold, Thief Gold has here beencompared to six subsequent games in the genre. What has been discovered is that while core similarities always exist, the same problems have different solutions depending on the overall designfor individual games.

This research, focusing mainly on tocotrienols, includes two parts. The first part concerns the uptake and growth inhibition of tocotrienols in PC-3 cells. The second part is a study of the physiochemical properties of Vitamin E. In the cellular study our results suggested that position 5 of chroman head and side-chain are very important in determining the uptake of tocotrienols and growth inhibition of PC-3 cells. The uptake and growth inhibition are not necessarily related to the antioxidant properties of tocotrienols. Of the physiochemical studies, the results suggested that the antioxidant properties of vitamin E are due to the phenolic O-H group. In ethanol solution, each tocotrienol has a higher oxidation potential than its corresponding tocopherol. The oxidation potentials of vitamin E are in the order ofα-form < γform < δ-form. The theoretical calculations show that the side chains of tocotrienols are less ordered than those of tocopherols.

A major problem in prostate cancer (PCa) management is the development of drug resistance. It is known that there are changes in PCa biology upon prolonged treatment with drugs, including anti-androgen drugs that alter cellular signaling processes leading to the development of castration resistant PCa. MicroRNAs (miRNAs) are regulatory molecules that modulate gene expression through inhibition of protein translation and modulate cellular functions. Altered expression of miRNAs is often noted in drug resistant cancer including PCa. Studies from our laboratory have identified a number of down-regulated miRNAs in PCa, including miR-l 7-92a miRNAs. Frabin (FGD4) is a target of the miR-l 7-92a cluster that was found to be up-regulated in PCa cells. For this paper’s investigation, an FGD4 knockdown approach was used to identify the effects on cell viability, cell cycle progression, cell migration and drug sensitivity. Two PCa cells lines, LNCaP-104S (androgen sensitive) and PC-3 (androgen independent), were used for our studies. MTS assays for both cell lines showed significant reduction in cell viability following knockdown of FGD4 compared to transfection with control siRNAs. Cell cycle analysis revealed an arrest in the G2/M phase of the cells that were transfected with FGD4 siRNAs. Cell migration assays revealed a decrease in migration rate of PC-3 cells after knockdown, which supports the involvement of FGD4 in actin- cytoskeleton rearrangement. Treatments with anti-mitotic drug Docetaxel (PC-3) or androgen receptor antagonist bicalutamide/Casodex (LNCaP-104S) showed improved sensitivity of the FGD4 siRNA treated cells to these drugs. Our results suggest the potential for FGD4 knockdown to be used in combination with currently used drugs, increasing the effectiveness of frontline chemotherapeutics.

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