Antiretroviral treatment pre-exposure prophylaxis (PrEP) is an effective daily prevention medicine to reduce risks of HIV infections in high-risk populations. The current study examined PrEP uptake among gay men using the integrative model of behavioral prediction (IMBP) as the theoretical framework. Briefly, the IMBP states that attitude, norms, and behavioral control predict intention, which then predicts behavior. The intention-behavior relationship is moderated by actual control variables: skills and environmental constraints. To examine how IMBP variables affect PrEP uptake among gay men, I first conducted formative elicitation interviews with gay men; then I used the results from the interviews to construct the main survey. Then, the project recruited 500 gay men to participate in the survey, half of whom were PrEP takers and half of whom were not. The results of path modeling showed that attitudes and norms predicted behavioral intention, and intention predicted PrEP uptake among gay men. Results of moderation analyses testing the influence of skills and environmental constraints showed that HIV knowledge, lack of access to a doctor(s), and lack of health care system knowledge were significant moderators between intention and PrEP uptake. The practical implications, theoretical contributions, and empirical advancements were discussed.

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京都大学 / 0048 / 新制・課程博士 / 博士(情報学) / 甲第19851号 / 情博第602号 / 新制||情||105(附属図書館) / 32887 / 京都大学大学院情報学研究科知能情報学専攻 / (主査)教授 美濃 導彦, 教授 石田 亨, 教授 岡部 寿男 / 学位規則第4条第1項該当 / Doctor of Informatics / Kyoto University / DFAM

Complex realistic human motion sequences satisfying environmental constraints can be created by motion capture, which is a reliable way to reproduce human motions. However, motion capture data is difficult to modify in order to obtain variant motion sequences for multiple tasks. In this thesis, a system for synthesizing complex realistic human motion sequences based on a small group of sample motions to satisfy constraints is proposed. Methods are proposed for the system to preprocesses raw motion capture data to create sample motions that can be easily modified for the purpose of meeting specific requirements, while maintaining the subtleties of the origin motion capture data. Methods for the system to scan user-input constraints, to choose the best sample motion and synthesize the motion sequence based on route affected by the constraint are also proposed. Each generated motion piece is blended with the default motion, and thus a motion sequence composed of several pieces of motion based on constraints will be generated. Artifacts that arise during motion generation are identified and handled properly. Experimental results will show that the system can create cyclical sample motions from motion capture data, generate motion pieces based on environmental constraints, and synthesize complex realistic human motion sequences.

As the ¿War on Terror¿ evolves into the ¿Long War¿ against Islamo-fascism, it demands an enduring commitment to ensuring the security of the United States and its allies. This policy is based on the requirement to maintain control in a fractured and unpredictable global environment, while paying little attention to the underlying issues that lead to insecurity. It is an approach that is manifestly failing, as the continuing problems in Afghanistan and Iraq demonstrate. Moreover, ¿control¿ implies the maintenance of a global order that focuses on power remaining in the hands of a transnational elite community, principally focused on North America and Western Europe, but extending worldwide. This elite largely ignores socio-economic divisions and environmental constraints, and sees continuing stability as being best achieved by the maintenance of the status quo, using force when necessary. This collection of essays by Professor Paul Rogers argues that this post-Cold War security paradigm is fundamentally misguided and unsustainable. It concludes with two new essays on the need for a new conception of global security rooted in justice and emancipation.

En conditions de stress biotiques et abiotiques la production de plusieurs espèces réactives de l’oxygène (ERO) dans différents compartiments spécialisés de la cellule végétale est inévitable. L’oxygène singulet (1O2) a été identifié comme la principale ERO produite dans le chloroplaste au cours d’un stress lumineux. Cette ERO est très réactive et a une durée de vie courte d’environ 3 s dans les tissus biologiques, ce qui amène à penser que l’oxygène singulet agit principalement par cytotoxicité. Cependant, il a été récemment établi que l’oxygène singulet fonctionne aussi comme une molécule signal impliquée dans la signalisation rétrograde chloroplaste-noyau conduisant soit à la mort cellulaire programmée, soit à l’acclimatation. En raison des propriétés particulières de l’oxygène singulet, il est peu probable que cette ERO voyage en dehors du chloroplaste pour induire des changements d’expression de gènes nucléaires. Une possibilité est que l’oxygène singulet agisse via des médiateurs. Nous avons identifié un produit d’oxydation du β-carotène, le dihydroactinidiolide (dhA), comme intermédiaire dans la voie de signalisation de l’oxygène singulet, qui agit d’une manière similaire à un autre produit d’oxydation du β-carotène, le β-cyclocitral, précédemment identifié comme intermédiaire dans la voie de signalisation de l’oxygène singulet. Nous avons aussi mis en évidence le rôle dans la voie de signalisation régulée par le β-cyclocitral de la protéine MBS1 (METHYLENE BLUE SENSITIVITY 1), et montré que la mort cellulaire programmée induite par l’oxygène singulet chez l’Arabidopsis est controllée par une serine-threonine kinase, OXI1 (OXIDATIVE SIGNAL INDUCIBLE 1). / During biotic and abiotic stress conditions, the production of several reactive oxygen species (ROS) at different specialized compartments of the cell is inevitable. Singlet oxygen (1O2) was identified to be the predominant ROS produced in the chloroplast during high light stress. This molecule is highly reactive, with a short life time of about 3 µs in biological tissues. Such properties make believe that the predominant effect of 1O2 in plants is cytotoxicity. However, 1O2 has been identified to function as a chloroplast-to-nucleus retrograde signaling molecule, leading to acclimation or programmed cell death (PCD). Cognizant of the properties of 1O2, it is most unlikely to travel directly from the chloroplast to the nucleus to signal changes in nuclear gene expression. One possibility is that 1O2 carries out this signaling function with the help of mediators. We identify a β-carotene oxidation product, dihydroactinidiolide (dhA) as a 1O2 signaling intermediate, which function similarly to the β-carotene oxidation product β-cyclocitral, previously identified to be a mediator of 1O2 plastid-nuclear retrograde signaling in Arabidopsis. We reveal a dependence of the β-cyclocitral-mediated signaling pathway on the MBS1 (METHYLENE BLUE SENSITIVITY 1) protein, and show that Programmed cell death induced by 1O2 is mediated by the serine-threonine kinase, OXI1(OXIDATIVE SIGNAL INDUCIBLE 1).

La conductivité hydraulique racinaire (Lpr) traduit la facilité du passage de l'eau au travers des racines. Ce paramètre, majoritairement contrôlé par l'activité de canaux hydriques membranaires (aquaporines), est modulable par diverses contraintes environnementales. Ce travail a permis de caractériser, sur un même organisme (Arabidopsis), les effets d'un ensemble de contraintes abiotiques et biotiques, représentatives de situations environnementales, sur la Lpr. Alors que la flagelline n'affecte pas la Lpr, les contraintes osmotiques (NaCl, mannitol), oxydantes (H2O2, NO) et nutritionnelles (carence en phosphate, en nitrate, culture des plantes en nuit prolongée) inhibent la Lpr. Par contre, la réalimentation en phosphate ainsi que l'addition de saccharose à des plantes cultivées en nuit prolongée stimulent la Lpr. Une approche phosphoprotéomique quantitative, basée sur l'analyse par MS de protéines microsomales racinaires purifiées à partir de plantes cultivées dans trois de ces contextes (NaCl, NO, phosphate) a permis de quantifier les variations d'abondance de l'ensemble des aquaporines racinaires ainsi que de leur état de MPT. D'un point de vue qualitatif, 22 aquaporines ont été identifiées dans la racine ainsi que plusieurs types de MPTs, incluant des nouveaux sites de phosphorylation (7), de méthylation (13 à 15), de formylation (4) et de déamidation (25 à 26). D'un point de vue quantitatif, cette étude a permis de conclure que les observations réalisées au niveau de la Lpr sont la résultante de mécanismes multifactoriels incluant l'état de phosphorylation des trois sites de l'extrémité C terminale de PIP2;1/2;2/2;3, l'état de phosphorylation de l'extrémité N terminale de PIP1;1/1;2, ainsi que les aquaporines TIPs. Ce travail permet donc de proposer de nouveaux mécanismes moléculaires impliqués dans la régulation de la Lpr en réponse à des contraintes de l'environnement / The water uptake capacity of plant roots (root hydraulic conductivity, Lpr) is mainly determined by water channels (aquaporins) and is modulated by environmental constraints. The present work characterised, in a unique organism (Arabidopsis), effects on Lpr of abiotic and biotic constraints representative of environmental situations. Whereas flagelline does not affect Lpr, osmotic (NaCl or mannitol), oxidative (H2O2 or NO) and nutritional (phosphate or nitrate starvation, prolonged night) stimuli inhibit Lpr. However, phosphate and sucrose resupply stimulate Lpr. A phosphoproteomics approach based on MS analysis of microsomal proteins extracted from roots of plants cultivated in different environmental constraints (NaCl, NO,phosphate starvation and resupply) allowed to quantify variations of abundance of roots aquaporins and of their PTMs. As a qualitative point of view, 22 aquaporins were identified in roots as well as several post-translational modifications including new sites of phosphorylation (7), methylation (13 to 15), formylation (4) and deamidation (25 to 26). From a quantitative point of view, the present work drove to the conclusion that the modulations of Lpr result from multifactorial mechanisms including the phosphorylation status of the C terminal part of PIP2;1/2;2/2;3 and of the N-terminal part of PIP1;1/1;2 and TIP aquaporins. This study proposes new molecular mechanisms implicated in Lpr regulation in response to various environmental situations.

Dans la nature, les plantes sont constamment exposées à des modifications de leur environnement générant un stress oxydant auquel elles doivent s’adapter du fait de leur immobilité. Les végétaux ont donc développé un grand nombre de mécanismes antioxydants permettant de protéger leurs fonctions vitales. L’étude d’une enzyme de type peroxyrédoxine (PRX) localisée dans le chloroplaste montre que son activité antioxydante est importante pour la croissance et la tolérance des végétaux aux contraintes environnementales. De plus, cette PRX pourrait interagir avec d’autres protéines impliquées notamment dans des mécanismes antioxydants et dans le métabolisme du carbone. Parmi elles, une protéine de type fibrilline participant à la protection des structures photosynthétiques, pourrait avec la PRX protéger la photosynthèse, fonction propre aux végétaux et essentielle pour la vie sur terre. / In nature, plants are constantly exposed to environmental changes leading to oxidative stress, to which they must adapt due to their immobility. Plants have developed many antioxidant systems allowing them to maintain their vital functions. The study of a peroxiredoxin, enzyme (PRX) localized in chloroplasts, shows that its direct antioxidant activity is essential for growth and tolerance of plants to environmental constraints. In addition, this PRX could interact with other proteins especially involved in antioxidant mechanisms and carbon metabolism. Among them, fibrillin proteins, which participate in the protection of the photosynthetic structures, could preserve with the PRX the plant photosynthesis, which is essential for the life on earth.

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES / Coastal environments are complex due to their natural dynamics, fragilities and multiple socioeconomic interests. They are peculiar environments and of differentiated character, that must be considered in their singularity, and they need special attention for a correct planning and management. The new rationality of occupation of the coastal environments associates the demand of a leisure society with a demand for zones of work and housing. Given this, there is a need for studies that present proposals for environmental planning aiming at a balance between the use and maintenance of natural resources. The purpose of this study was to analyze in an integrated way the environmental and socioeconomic dynamics of the fluvio lagoon plain associated with the Betume River and its surroundings from the perspective of land use and land use planning. In order to do so, the systemic approach was adopted as a way of researching the landscape, which made it possible to understand the reality and thus propose a zoning resulting from the application of the pressure-state-impact-response methodology. Bibliographical review, documentary research, field work, cartographic document elaboration, were the methodological procedures adopted and subsidized the integrated analysis of the environmental and social dimensions that culminated in a zoning proposal. The plain formed by fluvio lagoons deposits associated with the Betume River has a geological-geomorphologic evolution developed from events of transgressions and marine regressions of the Quaternary and is inserted between dunes strands in marine and paleo cliffs terraces of the Barreiras Group. Its structure points to a level of marked environmental fragility. In contrast, the uses attributed to this environment have shown growth, namely: activities and interests aimed at tourism; Primary economic activities of fishing, shrimp farming, pasture, agriculture and plant extractive activities. The level of occupation is unevenly distributed, as is the intensity of modification and degradation. Zoning, from environmental and socioeconomic diagnostics, proposes guidelines for land use and occupation in order to sustain environmental quality. / Os ambientes costeiros são complexos devido sua dinâmica natural, fragilidades e os múltiplos interesses socioeconômicos. São ambientes peculiares e de caráter diferenciado, que devem ser considerados em sua singularidade, e necessitam de atenção especial para um correto planejamento e gestão. A nova racionalidade de ocupação dos ambientes costeiros associa a demanda de uma sociedade de lazer a uma demanda por zonas de trabalho e habitação. Diante disso, há a necessidade de estudos que apresentem propostas de ordenamento ambiental visando um equilíbrio entre o uso e a manutenção dos recursos naturais. A proposta desse estudo foi analisar de forma integrada a dinâmica ambiental e socioeconômica da planície fluviolagunar associada ao rio Betume e adjacências na perspectiva do ordenamento do uso e ocupação do solo. Para tanto foi adotada a abordagem sistêmica como caminho de investigação da paisagem, que possibilitou entender a realidade e assim propor um zoneamento resultante da aplicação da metodologia pressão-estado-impacto-resposta. Revisão bibliográfica, pesquisa documental, trabalhos de campo, elaboração de documentos cartográficos, foram os procedimentos metodológicos adotados e subsidiaram a análise integrada das dimensões ambiental e social que culminaram em uma proposta de zoneamento. A planície formada por depósitos fluviolagunares associada ao Rio Betume tem uma evolução geológico-geomorfológica desenvolvida a partir de eventos de transgressões e regressões marinhas do Quaternário e encontra-se inserida entre cordões de dunas em terraços marinhos e paleofalésias do Grupo Barreiras. Sua estrutura aponta um nível de fragilidade ambiental acentuado. Em contrapartida os usos atribuídos a esse ambiente tem apresentado crescimento, a saber: atividades e interesses voltados para o turismo; atividades econômicas primárias de pesca, carcinicultura, pastagens, agricultura e atividades de extrativismo vegetal. O nível de ocupação está distribuído de forma irregular, assim como a intensidade de modificação e degradação. O zoneamento, oriundo dos diagnósticos ambiental e socioeconômico, propõe orientações de uso e ocupação do solo visando a sustentação da qualidade ambiental. / São Cristóvão, SE