Bridge networks are expensive and complex infrastructures and are essential components of today's transportation systems. Despite the advancement in computer aided modeling and increasing the computational power which is increasing the accessibility for developing the fragility curves of bridges, the complexity of the problem and uncertainties involved in fragility analysis of the bridge structures in addition to difficulties in validating the results obtained from the analysis requires precaution in utilization of the results as a decision making tool. The main focus of this research is to address, study and treatment of uncertainties incorporated in various steps of performance based assessments (PBA) of the bridge structures. In this research the uncertainties is divided into three main categories. First, the uncertainties that come from ground motions time and frequency content alteration because of scarcity of the recorded ground motions in the database. Second, uncertainties associated in the modeling and simulation procedure of PBA, and third uncertainties originated from simplistic approach and methods utilized in the conventional procedure of PBA of the structures. Legitimacy of the scaling of ground motions is studied using the response of several simple nonlinear systems to amplitude scaled ground motions suites. Bias in the response obtained compared to unscaled records for both as recorded and synthetic ground motions. Results from this section of the research show the amount of the bias is considerable and can significantly affect the outcome of PBA. The origin of the bias is investigated and consequently a new metric is proposed to predict the bias induced by ground motion scaling without nonlinear analysis. Results demonstrate that utilizing the predictor as a scaling parameter can significantly reduce the bias for various nonlinear structures. Therefore utilizing the new metric as the intensity measuring parameter of the ground motions is recommended in PBA. To address the uncertainties associated in the modeling and simulation, MSSS concrete girder bridge class were selected due to the frequency of the construction in USCS region and lack of seismic detailing. A large scale parameters screening study is performed using Placket-Burman experimental design that considers a more complete group of parameters to decrease the computational expense of probabilistic study of the structure's seismic response. Fragility analysis for MSSS bridge is performed and the effect of removing the lesser important parameters the probabilistic demand model was investigated. This study reveals parameters reduction based on screening study techniques can be utilized to increase efficiency in fragility analysis procedure without compromising the accuracy of the outcome. The results from this study also provides more direct information on parameter reduction for PBA as well as provide insight into where future investments into higher fidelity finite element and constitutive models should be targeted. Conventional simplistic PBA approach does not account for the fundamental correlation between demand and capacity models. A more comprehensive PBA approach is presented and fragility analysis is performed with implementation of a new formulation in the component fragility analysis for MSSS bridge class and the outcome is compared with the one from conventional procedure. The results shows the correlation between demand and capacity affects the outcome of PBA and the fragility functions variation is not negligible. Therefore using the presented approach is necessary when accuracy is needed.

Purpose of Review: The incidence of diabetes is increasing worldwide. Diabetes mellitus is characterized by hyperglycemia, which in the long-term damages the function of many organs including the eyes, the vasculature, the nervous system, and the kidneys, thereby imposing an important cause of morbidity for affected individuals. More recently, increased bone fragility was also noted in patients with diabetes. While patients with type 1 diabetes mellitus (T1DM) have low bone mass and a 6-fold risk for hip fractures, patients with type 2 diabetes mellitus (T2DM) have an increased bone mass, yet still display a 2-fold elevated risk for hip fractures. Although the underlying mechanisms are just beginning to be unraveled, it is clear that diagnostic tools are lacking to identify patients at risk for fracture, especially in the case of T2DM, in which classical tools to diagnose osteoporosis such as dual X-ray absorptiometry have limitations. Thus, new biomarkers are urgently needed to help identify patients with diabetes who are at risk to fracture. - Recent Findings: Previously, microRNAs have received great attention not only for being involved in the pathogenesis of various chronic diseases, including osteoporosis, but also for their value as biomarkers. - Summary: Here, we summarize the current knowledge on microRNAs and their role in diabetic bone disease and highlight recent studies on miRNAs as biomarkers to predict bone fragility in T1DM and T2DM. Finally, we discuss future directions and challenges for their use as prognostic markers.

Immediate occupancy and functionality of critical facilities including hospitals, emergency operations centers, communications centers, and police and fire stations is of utmost importance immediately after a damaging earthquake, as they must continue to provide fundamental health, emergency, and security services in the aftermath of an extreme event. Although recent earthquakes have proven the acceptable performance of the structural system in such buildings, when designed according to recent seismic design codes, in many cases damage to the nonstructural components and systems was the main cause of disruption in their functionality. Seismic isolation is proven to be an effective technique to protect building structures from damaging earthquakes. It has been the method of choice for critical facilities, including hospitals in Japan and the United States in recent years. Seismic isolation appears to be an ideal solution for protecting the nonstructural components as well. While this claim was made three decades ago, the supporting research for freestanding (unanchored) equipment and contents (EC) is fairly new. With the focus on freestanding EC, this study investigates the seismic performance of sliding and wheel/caster-supported EC in fixed-base and base-isolated buildings. The study adopts a comparative approach to provide a better understanding of the advantages and disadvantages of using each structural system. The seismic response of sliding EC is investigated analytically in the first part of the thesis, while the response of EC supported on wheels/casters is examined through shake table experiments on two pieces of hospital equipment. The study finds base isolation to be generally effective in reducing seismic demands on freestanding EC, but it also exposes certain situations where isolation in fact increases demands on EC. Increasing the frictional resistance for sliding EC or locking the wheel/casters in the case of wheel/caster-supported EC is highly recommended for EC in base-isolated buildings to prevent excessive displacement demands. Furthermore, the study suggests several design probability functions that can be used by practicing engineers to estimate the peak seismic demands on sliding and wheel/caster-supported EC in fixed-base and base-isolated buildings. / Dissertation / Doctor of Philosophy (PhD)

The traditional construction practice used in masonry buildings throughout the world is limited to walls with rectangular cross sections that, when reinforced with steel bars, typically accommodate only single-leg horizontal ties and a single layer of vertical reinforcement. This arrangement provides no confinement at the wall toes, and it may lead to instability in critical wall zones and significant structural damage during seismic events. Conversely, the development of a new building system, constructed with reinforced masonry (RM) walls with boundary elements, allows closed ties to be used as confinement reinforcement, thus minimizing such instability and its negative consequences. Relative to traditional walls, walls with boundary elements have enhanced performance because they enable the compression reinforcement to remain effective up to much larger displacement demands, resulting in a damage tolerant system and eventually, more resilient buildings under extreme events. Research on the system-level (complete building) performance of RM walls with boundary elements is, at the time of publication of this dissertation, nonexistent in open literature. What little research has been published on this innovative building system has focused only on investigating the component-level performance of RM walls with boundary elements under lateral loads. To address this knowledge gap, the dissertation presents a comprehensive research program that covered: component-level performance simulation; system-level (complete building) experimental testing; seismic risk assessment tools; and simplified analytical models to facilitate adoption of the developed new building system. In addition, and in order to effectively mobilize the knowledge generated through the research program to stakeholders, the work has been directly related to building codes in Canada and the USA (NBCC and ASCE-7) as well as other standards including FEMA P695 (FEMA 2009) (Chapter 2), TMS 402 and CSA S304 (Chapter 3), FEMA P58 (FEMA 2012) (Chapter 4), and ASCE-41 (Chapter 5). Chapter 1 of the dissertation highlights its objectives, focus, scope and general organization. The simulation in Chapter 2 is focused on evaluating the component-level overstrength, period-based ductility, and seismic collapse margin ratios under the maximum considered earthquakes. Whereas previous studies have shown that traditional RM walls might not meet the collapse risk criteria established by FEMA P695, the analysis presented in this chapter clearly shows that RM shear walls with boundary elements not only meet the collapse risk criteria, but also exceed it with a significant margin. Following the component-level simulation presented in Chapter 2, Chapter 3 focused on presenting the results of a complete two-story asymmetrical RM shear wall building with boundary elements, experimentally tested under simulated seismic loading. This effort was aimed at demonstrating the discrepancies between the way engineers design buildings (as individual components) and the way these buildings actually behave as an integrated system, comprised of these components. In addition, to evaluate the enhanced resilience of the new building system, the tested building was designed to have the same lateral resistance as previously tested building with traditional RM shear walls, thus facilitating direct comparison. The experimental results yielded two valuable findings: 1) it clearly demonstrated the overall performance enhancements of the new building system in addition to its reduced reinforcement cost; and 2) it highlighted the drawbacks of the building acting as a system compared to a simple summation of its individual components. In this respect, although the slab diaphragm-wall coupling enhanced the building lateral capacity, this enhancement also meant that other unpredictable and undesirable failure modes could become the weaker links, and therefore dominate the performance of the building system. Presentation of these findings has attracted much attention of codes and standards committees (CSA S304 and TMS 402/ACI 530/ASCE 5) in Canada and the USA, as it resulted in a paradigm shift on how the next-generation of building codes (NBCC and ASCE-7) should be developed to address system-levels performance aspects. Chapter 4 introduced an innovative system-level risk assessment methodology by integrating the simulation and experimental test results of Chapters 2 and 3. In this respect, the experimentally validated simulations were used to generate new system-level fragility curves that provide a realistic assessment of the overall building risk under different levels of seismic hazard. Although, within the scope of this dissertation, the methodology has been applied only on buildings constructed with RM walls with boundary elements, the developed new methodology is expected to be adopted by stakeholders of other new and existing building systems and to be further implemented in standards based on the current FEMA P58 risk quantification approaches. Finally, and in order to translate the dissertation findings into tools that can be readily used by stakeholders to design more resilient buildings in the face of extreme events, simplified backbone and hysteretic models were developed in Chapter 5 to simulate the nonlinear response of RM shear wall buildings with different configurations. These models can be adapted to perform the nonlinear static and dynamic procedures that are specified in the ASCE-41 standards for both existing and new building systems. The research in this chapter is expected to have a major positive impact, not only in terms of providing more realistic model parameters for exiting building systems, but also through the introduction of analytical models for new more resilient building systems to be directly implemented in future editions of the ASCE-41. This dissertation presents a cohesive body of work that is expected to influence a real change in terms of how we think about, design, and construct buildings as complex systems comprised of individual components. The dissertation’s overarching hypothesis is that previous disasters have not only exposed the vulnerability of traditional building systems, but have also demonstrated the failure of the current component-by-component design approaches to produce resilient building systems and safer communities under extreme events. / Dissertation / Doctor of Philosophy (PhD)

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Concentrically braced frames with replaceable brace modules (RBMs) have the potential of improving the constructability of braced frames, mitigating the structural damage during earthquakes, and minimizing the time of post-earthquake repairs. To fill the gaps between the component-level performance of RBMs and system-level behaviour of SCBFs with RBMs, this thesis focused on the overall system-level seismic performance of SCBFs with RBMs in three steps. Firstly, the effects of beam-column connection fixity on the behaviour of three SCBFs were investigated to determine what level of fixity, if any, is required to ensure adequate collapse capacity of an SCBF. Secondly, the effects of column design parameters on braced frame seismic performance were investigated, where two different brace-to-frame connections were considered: 1) conventional gusset plate connection and 2) the newly proposed connection detail with RBMs. Detailed numerical modelling was undertaken to develop improved provisions for designing columns in SCBFs. Finally, a large-scale experimental program was conducted to evaluate the seismic performance of braced frames with initial and replaced RBMs where realistic boundary conditions were provided. Three different beam-column connections that can be used in SCBFs with RBMs were designed and tested. Based on the current work, the recently proposed concept of replaceable brace modules, accompanied by the recommended methods for designing columns and detailing beam-column connections, appears to be a promising approach. The fabrication and installation are simpler, the seismic performance is similar to that of SCBFs with currently accepted connection detailing, and the approach can increase the post-earthquake reparability of steel concentrically braced frames. / Dissertation / Doctor of Philosophy (PhD)

The performance of nonstructural components in critical infrastructure, such as nuclear power plants (NPPs), has been primarily based on experience and historical data. This topic has been attracting increased interest from researchers following the Fukushima Daiichi nuclear disaster in 2011. This disaster demonstrated the importance of using batteries in NPPs as an auxiliary power system, where such systems can provide the necessary power to mitigate the risk of serious accidents. However, little research has been conducted on such nonstructural components to evaluate their performance following the post- Fukushima safety requirements, recommended by several nuclear regulators worldwide [e.g., Nuclear Regulatory Commission (NRC), and Nuclear Safety Commission (NSC)]. To address this research gap, this dissertation investigates the lateral performance of an auxiliary battery power system (ABPS) similar to those currently existing/operational in NPPs in Canada. The ABPS was experimentally tested under displacement-controlled quasi-static cyclic fully-reversed loading that simulates lateral seismic demands. Due to the presence of sliding batteries, the ABPS was then tested dynamically under increased ground motion levels on a shake table. The experimental results demonstrated that the design guidelines and fragility curves currently assigned to battery rack systems in the FEMA P58 prestandards do not encompass all possible failure mechanisms. A 3D numerical model was also developed using OpenSees software. The model was validated using the experimental results. The model results showed that the lateral performance of ABPS with different configurations (i.e. different lengths, tiers, and seismic categories) is influenced by the capacity of the L-shaped connection between the side rails and the end rail. However, the model was not able to predict all the damage states from the dynamic experimental tests, since the rocking/sliding/impact behavior of the batteries is a highly complex nonlinear problem by nature and beyond the scope of this study. The model presented is limited to the assessment of the lateral performance of different ABPS statically. This dissertation demonstrated the difference between the observed behavior of laboratory-controlled lateral performance tests of ABPSs operational/existing in NPPs and the behavior of ABPSs found in the literature that relied on limited historical and experience data. Finally, this dissertation laid the foundations for the need to further investigate the behavior of other safety-related components in NPPs and assess their compliance with new post-Fukushima design requirements. / Thesis / Doctor of Philosophy (PhD)

Abstract : Fragility curves are a very useful tool for seismic risk assessment of bridges. A fragility curve describes the probability of a structure being damaged beyond a specific damage state for different levels of ground shaking. Since more than half of all bridges in the province of Quebec (Canada) are in service for more than 30 years and that these bridges were designed at that time without seismic provisions, generating fragility curves for these structures is more than necessary. These curves can be used to estimate damage and economic loss due to an earthquake and prioritize repairs or seismic rehabilitations of bridges. Previous studies have shown that seismic damage experienced by bridges is not only a function of the epicentral distance and the severity of an earthquake but also of the structural characteristics of the bridge and the soil type on which it is built. Current methods for generating fragility curves for bridges do not account for soil conditions. In this work, analytical fragility curves are generated for multi-span continuous concrete girder bridges, which account for 21% of all bridges in Quebec, for the different soil profile types specified in the Canadian highway bridge design code (CAN/CSA-S6-06). These curves take into account the different types of abutment and foundation specific to these bridges. The fragility curves are obtained from time-history nonlinear analyses using 120 synthetic accelerograms generated for eastern Canadian regions, and from a Monte Carlo simulation to combine the fragility curves of the different structural components of a bridge||Résumé : Les courbes de fragilité sont un outil très utile pour l’évaluation du risque sismique des ponts. Une courbe de fragilité représente la probabilité qu'une structure soit endommagée au-delà d'un état d'endommagement donné pour différents niveaux de tremblement de terre. Étant donné que plus de la moitié des ponts dans la province de Québec (Canada) ont plus de 30 années de service et que ces ponts n'ont pas été conçus à l'époque à l'aide de normes sismiques, la génération de courbes de fragilité pour ces structures est plus que nécessaire. Ces courbes peuvent servir à estimer les dommages et les pertes économiques causés par un tremblement de terre et à prioriser les réparations ou les réhabilitations sismiques des ponts. Des études antérieures ont montré que l'endommagement subi par les ponts suite à un tremblement de terre n'est pas seulement fonction de la distance de l'épicentre et de la sévérité du tremblement de terre, mais aussi des caractéristiques structurales du pont et du type de sol sur lequel il est construit. Les méthodes actuelles pour générer les courbes de fragilité des ponts ne tiennent pas compte des conditions du sol. Dans ce travail de recherche, des courbes de fragilité analytiques sont générées pour les ponts à portées multiples à poutres continues en béton armé, soit pour 21% des ponts au Québec, pour les différents types de sol spécifiés dans le Code canadien sur le calcul des ponts routiers (CAN/CSA-S6-06). Ces courbes prennent en compte les différents types de culée et de fondation spécifiques à ces ponts. Les courbes de fragilité sont obtenues à partir d'analyses temporelles non linéaires réalisées à l'aide de 120 accélérogrammes synthétiques généres pour l’est du Canada, et d'une simulation de Monte Carlo pour combiner les courbes de fragilité des différentes composantes du pont.

2007-2008的金融大海嘯中，影子銀行及系統重要性金融機構(systemically important financial institutions, SIFIs)扮演重要角色。金融機構證券化移轉資產的個別風險，以資產池最低報酬作為擔保品，發行高品質債權證券。隨投資人財富愈多，對安全資產需求愈大，金融機構擴大槓桿及風險資產投資。SIFIs數量少但規模大，相對於其他小型金融機構有較好的投資效率，其投資、證券化及其他業務與經濟體系具有複雜而規模大的關係，具有太大、太複雜以致不能倒的性質。SIFIs透過證券化移轉個別風險，在景氣蕭條及經濟個體普遍忽略尾端風險下，金融體系具有脆弱性。在已經存在SIFIs的金融體系下，金融脆弱性隨SIFIs及其他小型金融機構投資效率差距愈大愈加增強。 / The shadow banking system and systemically important financial institutions (SIFIs) play important roles in recent financial crisis. Financial institutions (FIs) securitize risky assets and use the lowest payoffs of the securitized assets as collateral to issue riskless debts. As the demand for riskless assets increases, FIs initiate more risky assets and increase leverage. SIFIs are large and advantageous to invest in risky assets compared to small FIs. The complex connection between SIFIs and economy make them too big or complex to fail. SIFIs transfer idiosyncratic risk and undertake systemic risk via securitization. Financial system is fragile to recession when entities neglect tail risks. In the financial system in which SIFIs exist,the financial fragility is severer when the gap of the investment ability between SIFIs and other small FIs becomes larger.