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A millimeter-wave (W-Band) down-converter for Phased Focal Plane Arrays (PFPAs) has been designed and fabricated using the IBM Silicon-Germanium (SiGe) BiCMOS 8HP process technology. The radio frequency (RF) input range of the down-converter chip is from 70 95GHz. The intermediate frequency (IF) range is from 5 30GHz. The local oscillator (LO) frequency is fixed at 65GHz. The down-converter chip has been designed to achieve a conversion gain greater than 20dB, a noise figure (NF) below 10dB and input return loss greater than 10dB. The chip also has novel LO circuitry facilitating LO feed-through among down-converters chips in parallel. This wide bandwidth down-converter will be part of millimeter-wave PFPA receiver designed and fabricated in collaboration with the University of Massachusetts-Amherst Department of Astronomy. This PFPA receiver will be installed on Green Bank Telescope (GMT) / Large millimeter wave telescope (LMT) in Q2 of 2014. This project is collaboration between the University of Massachusetts-Amherst (UMass), Brigham Young University (BYU) and National Radio Astronomy Observatory (NRAO). To the best of the author’s knowledge, this is first wide bandwidth down-converter at W-band to achieve this high gain and low noise figure among Si/SiGe based systems.

京都大学 / 新制・論文博士 / 博士(医学) / 乙第13560号 / 論医博第2289号 / 新制||医||1067(附属図書館) / 京都大学大学院医学研究科医学専攻 / (主査)教授 森信 暁雄, 教授 村井 俊哉, 教授 林 康紀 / 学位規則第4条第2項該当 / Doctor of Medical Science / Kyoto University / DFAM

Den relationella pedagogiken är svårformulerad. Därtill är den svår att undersöka empiriskt. Martin Bubers dialogfilosofi ger dock ett väl genomtänkt stöd för teoribildningen och diskussionen om den relationella pedagogik som jag applicerar på den nutida svenska skolan. Jag diskuterar i denna uppsats de möten mellan lärare och elev som är en förutsättning för relationspedagogiken. Det möte som är mest intressant för denna pedagogik är det autentiska mötet. Martin Buber kallar detta för ett Jag - Du-möte. Det finns många hinder för att uppnå ett sådant möte i skolmiljön. Det vanligaste mötet inom skolvärlden är emellertid Jag - Det-mötet. Detta är ett möte som kategoriserar och ger struktur. Statusskillnaden mellan lärare och eleven, betygsjakten, den tvångsmässiga socialisationen i skolmiljön är bara några av de hinder som ligger i vägen för det genuina mötet. Det är därför svårt att hitta utrymme och möjlighet för ett autentiskt möte mellan lärare och elev. Enligt relationspedagogiken är det emellertid i detta möte som det uppkommer en brännpunkt som ger eleven kraft för lärande och utveckling. Om denna brännpunkt är grunden för pedagogen så vore det kanske önskvärt om vår nutida svenska skola gav utrymme för autentiska möten.

Vitronectin (VTN) is a blood protein produced mainly by the liver. We show that VTN leaks from the bloodstream into the injury site and neighboring subventricular zone (SVZ) following ischemic stroke (middle cerebral artery occlusion, MCAO) in adult mice. MCAO is known to increase neurogenesis after stroke. VTN inhibits this response in females, but not in males, as shown by ~70% more stroke-induced SVZ neurogenesis in female VTN−/− mice at 14 d. In female VTN−/− mice, stroke-induced expression of interleukin-6 (IL-6) at 24 h was reduced in the SVZ. The closely related leukemia inhibitory factor (LIF) or pro-neurogenic ciliary neurotrophic factor (CNTF) were not affected. The female-specific effect of VTN on IL-6 expression was not due to sex hormones, as shown by ovariectomy and castration. IL-6 injection next to the SVZ reversed the MCAO-induced increase in neurogenesis seen in VTN−/− mice. Our in vitro and vivo data suggest that plasma VTN activates focal adhesion kinase (FAK) in the SVZ following MCAO, which reduces IL-6 expression in astrocytes but increases it in other cells such as microglia/macrophages. Inducible conditional astrocytic FAK deletion increased MCAO-induced IL-6 expression in females at 24 h and blocked MCAO-induced neurogenesis at 14 d, confirming a key detrimental role of IL-6. Collectively, these data suggest that leakage of VTN into the SVZ reduces the neurogenic response to stroke in female mice by promoting IL-6 expression. Reducing VTN or VTN signaling may be an approach to promote neurogenesis for neuroprotection and cell replacement after stroke in females.

<div><b>Rationale:</b> Focal cortical dysplasia (FCD) is a neurodevelopmental disorder that is associated with abnormal cortical development and is one of the most common drug-resistant epilepsies. The mechanistic target of rapamycin (mTOR) pathway is a highly complex pathway </div><div>associated with cell proliferation, synaptic plasticity, neuroinflammation, and cortical development. Hyperactivation of this pathway has also been implicated in hyperexcitability, seizures, and accumulation of beta-amyloid (Aβ) plaques and neurofibrillary tangles (NFT) through hyperphosphorylation of tau. Interestingly, Aβ and hyperphosphorylated tau have been reported in both rodent models and human patients of temporal lobe epilepsy (TLE) and FCD however, the mechanisms through which this occurs are still yet to be defined. Therefore, to identify the possible link between Aβ and tau pathology in FCD, we determined the spatial distribution and protein levels of Aβ and phosphorylated tau (p-tau) along with mTOR signaling </div><div>molecules. We hypothesized that there would be presence of Aβ and tau pathology as well as an increase in Aβ and p-tau protein levels that would be correlated with hyperactivation of the mTOR and GSK3 signaling pathways in tissue biopsies from human FCD patients compared to brain tissues from non-epileptic (NE) individuals.</div><div><br></div><div><b>Methods:</b> Cortical brain samples surgically resected from patients with FCD were used and compared to NE samples surgically resected from glioblastoma patients with no history of seizures or epilepsy. Immunostaining was used to determine the distribution of phosphorylation of S6 (p-S6), a marker for mTOR activation, and NeuN, a marker for neurons, along with Aβ and p-tau. Additionally, western blotting (WB) was used to determine the levels of mTOR signaling through p-S6 and GSK3 (p-GSK) along with Aβ and p-tau.</div><div><br></div><div><b>Results:</b> We found cortical dyslamination, mTOR activation, p-tau, and Aβ accumulation in cortices of patients with FCD with drug-resistant epilepsy. However, we did not find a </div><div>significant difference in the protein levels of p-S6 (p = 0.422), p-GSK3 (p = 0.947), p-tau (p = 0.649), and Aβ (p = 0.852) in cortical tissue homogenates derived from FCD patients when compared to those of NE samples. Additionally, we did not find sex differences in the protein </div><div>levels of p-S6 (p = 0.401), p-GSK3 (p = 0.331), p-tau (p = 0.935), and Aβ (p = 0.526). There was no significant correlation between age and p-S6 (p = 0.920), age and p-GSK3 (p = 0.089), age and p-tau (p = 0.956), and age and Aβ (p = 0.889). Moreover, there was no significant correlation between mTOR activation (p-S6), Aβ (p = 0.586) and p-tau (p = 0.059) nor GSK3 activation (p-GSK3), Aβ (p = 0.326), and p-tau (p = 0.715). Lastly, there was no significant correlation within the mTOR and GSK3 pathway activation within the same patients (p = 0.602).</div><div><br></div><div><b>Conclusion:</b> These data suggest that mTOR hyperactivation occurs alongside the presence of Aβ and tau pathology. However, several unknown factors such as medical and medication history may be altering the expression or suppression of these proteins. Additionally, there may be alternative pathways that crosstalk with mTOR signaling therefore influencing Aβ and tau pathology in FCD patients with drug-resistant epilepsy. Further investigation will need to be conducted to understand the detailed mechanisms through which Aβ and tau pathology occur in </div><div>FCD.</div>

Radio frequency interference (RFI) is a growing problem for radio astronomers. One potential solution utilizes spatial filtering by placing an array of electrically small antennas at the focal plane of a parabolic reflector. This thesis documents the design and characterization of a prototype array feed and RF receiver that were used to demonstrate the spatial filtering principle. The array consists of a 7-element hexagonal arrangement of thickened dipole antennas tuned to a center frequency of 1600 MHz. The receiver is a two-stage, low-noise frequency mixer that is tunable over the entire L-band. This thesis also documents a new receiver design that is part of an upgrade to the outdoor antenna test range for the National Radio Astronomy Observatory in Green Bank, West Virginia. The array feed was demonstrated on a three-meter parabolic reflector by recovering a weak signal of interest that was obscured by a strong, broadband interferer. Similar results were also obtained when the interferer moved with an angular velocity of 0.1 degree per second, but only when the power in the interferer dominated the signal. The aperture efficiency was measured at 64%, but adaptive beamformers can slightly perturb this value through distortions in the beam pattern. This phenomenon, called pattern rumble, effectively reduced the sensitivity of the radio telescope, and was measured by comparing the SNRs of adaptive beamformers to the SNR of a fixed-weight beamformer. It was found that pattern rumble can reduce the useful integration time by roughly one order of magnitude. It was also found that mechanical instability of the primary reflector introduces a great deal of pattern rumble, even when the interferer is fixed in direction.

Presented herein is the design and construction process in the expansion of BYU's seven-element experimental platform to a nineteen-element platform for phased array feed experiments. The nineteen-element system was deployed at the National Radio Astronomy Observatory (NRAO) in Green Bank West Virginia for use on the Green Bank 20-Meter Telescope. Numerical simulations were performed to determine how sensitivity was affected by electronic beam steering and offset of the phased array feed (PAF) relative to the focal plane of the reflector. These simulated results were then compared to experimental data.

Focal stacking is a technique that allows us to create images with a large depth of field, where everything in the scene is sharp and clear. However, creating such images is not easy, as it requires taking multiple pictures at different focus settings and then blending them together. In this paper, we present a novel approach to blending a focal stack using a special type of autoencoder, which is a neural network that can learn to compress and reconstruct data. Our autoencoder consists of several parts, each of which processes one input image and passes its information to the final part, which fuses them into one output image. Unlike other methods, our approach is capable of inpainting and denoising resulting in sharp, clean all-in-focus images. Our approach does not require any prior training or a large dataset, which makes it fast and effective. We evaluate our method on various kinds of images and compare it with other widely used methods. We demonstrate that our method can produce superior focal stacked images with higher accuracy and quality. This paper reveals a new and promising way of using a neural network to aid in microphotography, microscopy, and visual computing, by enhancing the quality of focal stacked images.