The aim of this study was to assess the extent on how effective was the prevention of mother-to-child transmission of Human Immunodeficiency Virus (HIV) infection at Oshakati District Health Centre. Explanatory survey was used to conduct the research. A total of 160 nurses experienced in prevention of mother-to-child transmission and women who attended antenatal care and post natal care services participated in the study. Respondents expressed unsatisfactory with the promoting involvement of male partners, high quality voluntary counselling and testing services, couple counselling and testing, integration of Highly Active Antiretroviral Therapy services, administration of short course of Zidovudine to pregnant mothers and the provision of antiretroviral drugs to infants. Therefore, promoting involvement of male partners, couple counselling and testing, administration of short course of Zidovudine to pregnant mothers and educating women about exclusive breastfeeding prior to delivery are some of recommendations for effective prevention of mother-to-child transmission of HIV infections. / Health Studies / M.A. (Public Health)

Indiana University-Purdue University Indianapolis (IUPUI) / The transcriptional repressor BCL6 has been shown to be essential for the differentiation of germinal center (GC) B cells and follicular T helper (TFH) cells. The interaction of TFH and GC B cells is necessary for the development of high affinity antibodies specific for an invading pathogen. Germline BCL6-deficient mouse models limit our ability to study BCL6 function in T cells due to the strong inflammatory responses seen in these mice. To overcome this, our lab has developed a new BCL6 conditional knockout (cKO) mouse using the cre/lox system, wherein the zinc finger region of the BCL6 gene is flanked by loxP sites. Mating to a CD4-Cre mouse allowed us to study the effects of BCL6 loss specifically in T cells, without the confounding effects seen in germline knockout models. Using this cKO model, we have reaffirmed the necessity of BCL6 for TFH differentiation, including its role in sustained CXCR5 surface expression, a signature marker for TFH cells. This model also allowed us to recognize the role of BCL6 in promoting the expression of PD-1, another key surface marker for TFH cells. Without BCL6, CD4+ T cells cannot express PD-1 at the high levels seen on TFH cells. Our discovery of DNMT3b as a target for BCL6 suggests BCL6-deficient T cells have increased DNA methyltransferase activity at the PD-1 promoter. This data establishes a novel pathway for explaining how BCL6, a transcriptional repressor, can activate genes. Experiments with the BCL6 cKO model have also established a role for BCL6 in naïve CD4+ T cell activation. Furthermore, we did not observe increased differentiation of other helper T cell subsets, in contrast to what has been reported elsewhere with germline BCL6-deficient models. Unexpectedly, we found decreased T helper type 2 (Th2) cells, whereas mouse models with a germline mutation of BCL6 have increased Th2 cells. These results indicate that BCL6 activity in non-T cells is critical for controlling T cell differentiation. Finally, using an HIV-1 gp120 immunization model, we have, for the first time, shown BCL6-dependent GCs to be limiting for antibody development and affinity maturation in a prime-boost vaccine scheme.

The aim of this study was to firstly examine via a literature study, the response of the South African Department of Education (DoE) to HIV/AIDS. This required contextualizing this response in national as well as global terms. South African policies that impact on HIV/AIDS and the role of stakeholders in Education were focussed on. The various models of health behaviours were also examined. The efficacy of the Department of Education's response was then evaluated by conducting an empirical study at selected schools. Areas focussed on were: educators' and learners' knowledge of HIV/AIDS-related issues, their attitudes to HIV/AIDS and persons with HIV/AIDS, as well as their health behaviours. Research findings indicated that HIV/AIDS-related policies in Education were in place since 1999. The DoE, however, had not communicated these policies effectively to educators and learners, who were therefore unaware of the Universal Precautions related to safer behaviour practices in respect of HIV/AIDS. The DoE had not been effective in its response to HIV/AIDS in changing educator' and learners' risk behaviours. / Educational Studies / M.Ed. (Guidance and Counselling)

Women throughout the world are suffering the brunt of HIV/AIDS. They carry the unenviable tag of being the suffering group who are at risk. Women's vulnerability to HIV/AIDS is a subject that has not received adequate attention to date. This empirical study examines the socio-cultural factors and practices that impede upon behavioural change of Zimbabwean women in an era of HIV/AIDS. Firstly, a sample of 1002 women respondents is purposefully drawn from the six major Zimbabwean ethnic groups to participate in this research study. A survey questionnaire is administered to respondents in the age group 18 to 59 years to quantify the levels and magnitude of the HIV/AIDS problem among women. Secondly, fifty in-depth interviews with key informants are conducted to assess the nature of the problem confronting and impeding upon women's quest to attain good reproductive health. Thirdly, six focus group discussions for each of the respective six ethnic groups are conducted with forty-eight mature women to understand broadly the concepts of the study. This study employs a combination of mainly qualitative and some quantitative methods of data collection and analysis, which is called triangulation. Underlying the methodology of this study is an overarching functionalist theoretical perspective, also referring to gender development theory which serves as the basis for data analyses. The main findings of this study include the view that power dynamics, gender roles and cultural practices have impacted negatively on women's quest to attain safe sexual behaviour. The problem of HIV/AIDS remains a complicated and awesome one among Zimbabwe's ethnic groups. For Zimbabwean women the HIV/AIDS problem begins with a total lack of control over sexual lives and behaviour of their husbands especially outside marriage. The women have noted that the majority stay faithful to their husbands and partners according to cultural prescriptions and roles, while their husbands do not comply. Women noted that cultural prescriptions in their various ethnic settings condone male infidelity but expect women to stay faithful to their partners. As a result it is found that women sometimes contract HIV/AIDS straight on their matrimonial beds. / SOCIOLOGY / Thesis (D. Phil. (Sociology))

The global spread of HIV and Aids has greatly exceeded the most pessimistic projections. Infection rates are not declining and human tragedy is escalating. South Africa is a nation in mourning. If one is not infected, one is affected. Notwithstanding the catastrophic effects that are already being experienced, the full consequences of the pandemic seem yet to be felt. Developmental psychology and ecological systems theory were used in this study to examine the research problem. It has become necessary to determine the level of knowledge that adolescents have of HIV and Aids and whether Life Skills programmes stimulate any change in behaviour. This initially took the form of a quantitative study in which questionnaires were administered. A combination of quantitative and qualitative research (focus group interviews) was applied for verification. The goals of the research were achieved, providing valuable findings, confirming that there has been no behaviour change and adolescent knowledge remains inadequate. South African adolescents have insufficient knowledge of responsible sexual behaviour. Recommendations with regard to the content and course of the programme as well as further research are formulated as a result of the conclusions. / Educational Studies / M.Ed. (Socio-Education)

Text in Afrikaans / Summaries in Afrikaans and English / VIGS is 'n gesondheidsprobleem wat 'n impak uitoefen op alle gebiede in die samelewing. Voorkoming is die enigste vorm van bekamping. As gevolg hiervan, word VIGS-voorkoming binne die funksies van primere gesondheidsorg geplaas. Die persoon wat die funksies van primere gesondheidsorg uitoefen, is die gemeenskapsgesondheidswerker. Binne hierdie raamwerk is die terme primere gesondheidsorg, gemeenskapsgesondheidswerker en VIGS bespreek en die onderlinge interaksie is aangetoon. Die opleiding wat die gemeenskapsgesondheidswerker op VIGS-gebied ondergaan, is meegemaak. Die prioriteite wat op nasionale, provinsiale en plaaslike vlak bestaan is deur middel van onderhoude nagevors. Die effektiwiteit van die VIGS-voorkomingsboodskap soos oorgedra deur die gemeenskapsgesondheidswerker is tydens 'n inligtingsessie van hoerskoolleerlinge bepaal. Gevolgtrekkings en aanbevelings is in elk van bogenoemde gevalle gemaak. VIGS-voorkomingsinisiatiewe is nog in die kinderskoene in Suid-Afrika, maar het 'n belangrike rol te speel. / AIDS is a health problem that impacts on all societal spheres. Prevention is the only form of combat. Therefore, AIDS prevention falls within the functions of primary health care. The person performing these functions is the community health worker. Within this framework the terms primary health care, community health worker and AIDS were discussed and their interrelatedness illustrated. A session during which community health workers received training in aspects of AIDS was attended. Priorities existing at national, provincial and local levels were researched through interviews. The effectiveness of the community health worker in spreading the AIDS prevention message was determined during an information session for secondary school pupils. Conclusions and recommendations were made in each of these cases. AIDS prevention initiatives are still in its infancy in South Africa, but has an important role to play. / Health Studies / M.A. (Ontwikkelingsadministrasie)

The aim of this study was to firstly examine via a literature study, the response of the South African Department of Education (DoE) to HIV/AIDS. This required contextualizing this response in national as well as global terms. South African policies that impact on HIV/AIDS and the role of stakeholders in Education were focussed on. The various models of health behaviours were also examined. The efficacy of the Department of Education's response was then evaluated by conducting an empirical study at selected schools. Areas focussed on were: educators' and learners' knowledge of HIV/AIDS-related issues, their attitudes to HIV/AIDS and persons with HIV/AIDS, as well as their health behaviours. Research findings indicated that HIV/AIDS-related policies in Education were in place since 1999. The DoE, however, had not communicated these policies effectively to educators and learners, who were therefore unaware of the Universal Precautions related to safer behaviour practices in respect of HIV/AIDS. The DoE had not been effective in its response to HIV/AIDS in changing educator' and learners' risk behaviours. / Educational Studies / M.Ed. (Guidance and Counselling)

Women throughout the world are suffering the brunt of HIV/AIDS. They carry the unenviable tag of being the suffering group who are at risk. Women's vulnerability to HIV/AIDS is a subject that has not received adequate attention to date. This empirical study examines the socio-cultural factors and practices that impede upon behavioural change of Zimbabwean women in an era of HIV/AIDS. Firstly, a sample of 1002 women respondents is purposefully drawn from the six major Zimbabwean ethnic groups to participate in this research study. A survey questionnaire is administered to respondents in the age group 18 to 59 years to quantify the levels and magnitude of the HIV/AIDS problem among women. Secondly, fifty in-depth interviews with key informants are conducted to assess the nature of the problem confronting and impeding upon women's quest to attain good reproductive health. Thirdly, six focus group discussions for each of the respective six ethnic groups are conducted with forty-eight mature women to understand broadly the concepts of the study. This study employs a combination of mainly qualitative and some quantitative methods of data collection and analysis, which is called triangulation. Underlying the methodology of this study is an overarching functionalist theoretical perspective, also referring to gender development theory which serves as the basis for data analyses. The main findings of this study include the view that power dynamics, gender roles and cultural practices have impacted negatively on women's quest to attain safe sexual behaviour. The problem of HIV/AIDS remains a complicated and awesome one among Zimbabwe's ethnic groups. For Zimbabwean women the HIV/AIDS problem begins with a total lack of control over sexual lives and behaviour of their husbands especially outside marriage. The women have noted that the majority stay faithful to their husbands and partners according to cultural prescriptions and roles, while their husbands do not comply. Women noted that cultural prescriptions in their various ethnic settings condone male infidelity but expect women to stay faithful to their partners. As a result it is found that women sometimes contract HIV/AIDS straight on their matrimonial beds. / SOCIOLOGY / Thesis (D. Phil. (Sociology))

The global spread of HIV and Aids has greatly exceeded the most pessimistic projections. Infection rates are not declining and human tragedy is escalating. South Africa is a nation in mourning. If one is not infected, one is affected. Notwithstanding the catastrophic effects that are already being experienced, the full consequences of the pandemic seem yet to be felt. Developmental psychology and ecological systems theory were used in this study to examine the research problem. It has become necessary to determine the level of knowledge that adolescents have of HIV and Aids and whether Life Skills programmes stimulate any change in behaviour. This initially took the form of a quantitative study in which questionnaires were administered. A combination of quantitative and qualitative research (focus group interviews) was applied for verification. The goals of the research were achieved, providing valuable findings, confirming that there has been no behaviour change and adolescent knowledge remains inadequate. South African adolescents have insufficient knowledge of responsible sexual behaviour. Recommendations with regard to the content and course of the programme as well as further research are formulated as a result of the conclusions. / Educational Studies / M.Ed. (Socio-Education)

Text in Afrikaans / Summaries in Afrikaans and English / VIGS is 'n gesondheidsprobleem wat 'n impak uitoefen op alle gebiede in die samelewing. Voorkoming is die enigste vorm van bekamping. As gevolg hiervan, word VIGS-voorkoming binne die funksies van primere gesondheidsorg geplaas. Die persoon wat die funksies van primere gesondheidsorg uitoefen, is die gemeenskapsgesondheidswerker. Binne hierdie raamwerk is die terme primere gesondheidsorg, gemeenskapsgesondheidswerker en VIGS bespreek en die onderlinge interaksie is aangetoon. Die opleiding wat die gemeenskapsgesondheidswerker op VIGS-gebied ondergaan, is meegemaak. Die prioriteite wat op nasionale, provinsiale en plaaslike vlak bestaan is deur middel van onderhoude nagevors. Die effektiwiteit van die VIGS-voorkomingsboodskap soos oorgedra deur die gemeenskapsgesondheidswerker is tydens 'n inligtingsessie van hoerskoolleerlinge bepaal. Gevolgtrekkings en aanbevelings is in elk van bogenoemde gevalle gemaak. VIGS-voorkomingsinisiatiewe is nog in die kinderskoene in Suid-Afrika, maar het 'n belangrike rol te speel. / AIDS is a health problem that impacts on all societal spheres. Prevention is the only form of combat. Therefore, AIDS prevention falls within the functions of primary health care. The person performing these functions is the community health worker. Within this framework the terms primary health care, community health worker and AIDS were discussed and their interrelatedness illustrated. A session during which community health workers received training in aspects of AIDS was attended. Priorities existing at national, provincial and local levels were researched through interviews. The effectiveness of the community health worker in spreading the AIDS prevention message was determined during an information session for secondary school pupils. Conclusions and recommendations were made in each of these cases. AIDS prevention initiatives are still in its infancy in South Africa, but has an important role to play. / Health Studies / M.A. (Ontwikkelingsadministrasie)