Knotenfärbungen mit Abstandsbedingungen sind graphentheoretische Konzepte, motiviert durch das praktische Problem der Frequenzzuweisung in Mobilfunknetzen. In der Arbeit werden verschiedene Varianten solcher Färbungen vorgestellt. Für (Listen-)Färbungen mit einer beliebigen Anzahl r von Abstandsbedingungen werden allgemeine Eigenschaften und Schranken für die benötigte Anzahl von Farben bewiesen. Anschließend wird der Spezialfall r=2 behandelt. Färbungen mit zwei Abstandsbedingungen - die sogenannten L(d,s)-Labellings - werden für eine Reihe von Graphenklassen untersucht, u.a. für reguläre Parkettierungen, Weg- und Kreispotenzen und Graphen mit Durchmesser 2. Die Listenversion dieser Färbungen - die sogenannten L(d,s)-List Labellings - werden für Wege, Sterne, Kreise und Kakteen betrachtet. Ferner werden Untersuchungen zum Zusammenhang von L(2,1)-Labellings und L(2,1)-List Labellings bei speziellen Bäumen durchgeführt.

This thesis focuses on the role of a teacher in the educational process of gifted children. The main objective of the thesis is to examine teachers' attitudes toward gifted children and the ways in which these attitudes impact the development of potential and educational motivation in gifted children. The theoretical part of the thesis discusses the issues of gifted children. Next, the thesis focuses on the teacher's profession and describes factors through which teachers can influence the education of gifted, particularly teachers' attitudes toward gifted and communication and interaction styles between teachers and gifted children. The empirical part of the thesis involves a qualitative study based on semi-structured interviews with teachers of gifted children, as well as with gifted children themselves, focused on the perceived influence of teachers on the education and motivation of gifted children. The findings of the qualitative analysis bring insights into the teachers' influence on the educational process of gifted students, as perceived from both the perspectives of teachers and gifted children.

El objetivo general de esta investigación es analizar la importancia de la iconoplástica y del diseño de información para generar una mejor percepción al diseño del etiquetado frontal en los productos industrializados. Por este motivo, la hipótesis planteada para esta investigación es la propuesta de intervención del estudio iconoplástico y el diseño de información en el sistema de etiquetado frontal generan una mejor percepción en los jóvenes adultos. Esta investigación es cualitativa porque se realizaron encuestas a 50 consumidores para conocer sus molestias visuales sobre el etiquetado frontal. Además, se entrevistó a abogados e ingenieros agroindustriales para saber si el etiquetado frontal de advertencias puede ser modificado. Por último, se entrevistó a diseñadores para corroborar los errores técnicos que presenta este sistema de etiquetado en cuanto a diseño gráfico. Para esta investigación la solución consiste en la modificación del etiquetado frontal de productos industrializados. Para ello, se utiliza una retícula para ordenar la información de manera profesional, se cambió la forma de octágono porque da más espacio a la composición. Como resultados se obtuvo que los consumidores consideran una buena propuesta ya que los símbolos se organizan de mejor manera dentro de un espacio reducido. Las conclusiones de este proyecto es que el estudio iconoplástico y el diseño de la información ayudan a resolver la gráfica del etiquetado frontal puesto que la información se organiza mejor. Además, este proyecto fue testeado por un público piloto y se concluyó que generaría impacto en cualquier grupo porque la está mejor organizada. / The main objective for this research is to analyze the importance of iconoplastic and design information to create a better perception on front-of-pack labelling of industrialized products. For this reason, the hypothesis is that the intervention approach of the iconoplastic study and design information on front-of-pack labelling creates a better perception in young adults. This research is qualitative because surveys were made to 50 consumers that confirms their visual disturbance about the front-of-pack labelling design. Also, lawyers and Agro-industrial engineers were interviewed to prove that this labelling could be modified in the future. Finally, designers were also interviewed to corroborate some graphic design technical issues. The research’s solution consists on modifying the front-of-pack labelling of industrialized products. For this, a grid was used for organizing all the information to create uniformity between the symbols, the form was changed from octagon to hexagon, the typography was changed to Franklin Gothic Condensed because it leaves more blank space for the composition. As a result, it was obtained that consumers consider this is a good solution because the symbols are organized in a better way. The conclusions that were found at the end of this project are that the iconoplastic study and the design information help to resolve graphic problems that preset the front-of-pack labelling because the information is organized on grids. Also, this project was only tested on a small group of people, but they consider this solution could generate impact in any public because the information is better organized. / Trabajo de investigación

Les chaperonines sont des machines moléculaires impliquées dans la protection des protéines contre le mauvais repliement et l’agrégation. Ces macromolécules de tailleimportante (environ 1 MDa) sont présentes dans tous les domaines du vivant et sontorganisées en deux anneaux concentriques et empilés l’un sur l’autre, possèdent chacun une cavité en leur centre. Les chaperonines sont particulièrement intéressantes car peu caractérisées par rapport aux autres chaperones, notamment dû à leur grande taille et à leur complexité intrinsèque. Leur mécanisme d’action reste donc assez flou.Ce travail de thèse est centré sur l’étude de PhCPN, la chaperonine de Pyrococcushorikoshii, et son interaction avec différentes protéines substrats, grâce à une combinaison d’outils biochimiques et biophysiques tels que la RMN. En effet, la spectroscopie RMN est un outil particulièrement adapté à l’étude des interactions moléculaires transitoires à l’échelle atomique. L’utilisation dans ce cadre du marquage isotopique spécifique des groupements méthyles permet d’étudier des ensembles protéiques de taille importante tels que PhCPN, tandis que la RMN plus classique reste limitée à des poidsmoléculaires inférieurs à 30 kDa. Afin d’étudier le repliement des protéines à l’intérieur des cavités de PhCPN, deux protéines substrats de taille hétérogène et d’activité différentes ont été sélectionnées.En particulier, l’un de ces deux substrats (laMalate Synthase G ou MSG), formedes agrégats amorphes lorsqu’elle elle chauffée tandis que la seconde (l’Amyline) est capable de s’auto associer de manière plus organisée, créant des fibres amyloïdes de haut poids moléculaire. J’ai observé lors de cette étude que PhCPN est capable d’empêcher l’agrégation de ces deux substrats.En effet, la Chaperonine PhCPN est capable de se lier de manière irreversible à laproteine MSG, dépliée par une augmentation de la temperature, dans un ratio stoechiométrique 1/1. Le complexMSG/PhCPN a été isolé et characterisé. En particulier, la surface d’interaction entre PhCPN et cette large protéine substrat a été déterminée grâce à la RMN et la mciroscopie électronique.De plus, l’inhibition de la formation de fibres amyloïdes issues de l’Amyline parla Chaperonine a été étudiée par RMN et fluorescence de la ThT. Il a été notammentmontré que la Chaperonine retarde l’apparition des fibres amyloïdes, quelque soit l’état oligomerique de PhCPN. Le rôle de la Chaperonine sur les méchanismes de nucléation et d’élongation des fibres amyloïdes de l’Amylin a également été étudié. / Chaperonins are molecular machineries involved in the prevention of protein misfolding. These large macromolecules (approximately 1 MDa) are present in all domains of life and globally organized in two stacked rings on top of one another, hosting a cavity in their respective centers. By hydrolyzing ATP within their cavities, these rings can switch between twomajor structural states, an open and a closed conformation, to trap and refold misfolded proteins. Among the different types of molecular chaperones, chaperonins are of particular interest because their mechanism of action is not yet totally understood.This thesis focused on the study of PhCPN, the Chaperonin fromPyrococcus horikoshii,and its interaction with substrate proteins by various biochemical and biophysical techniques including NMR. In fact, NMR spectroscopy is a powerful tool to probe transient interactions in solution, at atomic resolution. Especially, specific isotope labeling of methyl groups is a technique of choice to study huge protein assemblies such as PhCPN chaperonin because they overcome the liquid-state NMR size limitation. To study the protein folding within the cavities of PhCPN, two different model substrate of various sizes and biological functions were selected. Particularly, one of these substrates (Malate Synthase G /MSG) forms amorphous aggregates when submitted to heat while the other (Amylin) is able to self-associate into amyloid fibrils. During this thesis, I have demonstrated that the Chaperonin PhCPN can prevent the aggregation of the chosen substrates.In fact, the PhCPN Chaperonin is able to irreversibly bind thermally unfoldedMSGin a 1/1 ratio. TheMSG/PhCPN complex was isolated and characterized. Especially, theinteraction surface between PhCPN and this large substrate protein was investigated using a combination of NMR and EM.In addition, the inhibition of the Amylin fibrillation by the Chaperonin was investigated using NMR and ThT fluorescence assays. It was shown that the Chaperonin delays the fibrils formation, no matter its oligomeric state. The role of the Chaperonin on the Amylin nucleation and fibril elongation mechanisms was investigated.

No description available.

<p>Labelling Theory stipulates that once an individual exhibits deviant behaviour, such as acting outside of the norm, the public and even close relatives will react to this behaviour by labelling it. Some of these labels result in social and psychological consequences for the individual, and Labelling theorists argue that, at the very extreme, they culminate in a self-fulfilling prophecy wherein the labelled individual fulfills the expectations others have placed upon him/her. Labelling Theory has been questioned for its lack of consistent supporting empirical evidence and still faces much scrutiny by leaving many unanswered questions, particularly within educational contexts. Several societal changes have created a profoundly different climate for labelling in the domains of mental health and education and beg the re-evaluation of labelling theory’s original arguments.</p> <p>This dissertation empirically tests the main tenets of Labelling Theory within an educational setting by exploring the experiences of children identified as having symptoms of Developmental Coordination Disorder in aNorthern Ontariocity. This study finds that children who are yet undiagnosed with DCD are often stigmatized not only by their peers, but also by educators, public, and even close relatives. However, those children who were formally labelled were granted more opportunities and were often more accommodated within the educational context. It also finds that formally labelled children often had varying degrees of self-confidence; conversely, those who were not labelled or awaiting diagnosis were often more critical of their abilities and were frequently socially isolated. Finally, this study found that parents played an active role in acquiring formal labels and services for their children throughout the diagnostic process and afterwards. These findings have implications for educational and health care related policies and future research for Labelling Theory.</p> / Doctor of Philosophy (PhD)

Yes / In the last 10 years the University of Bradford Library Acquisitions Department has shrunk from 13 members of staff to 5. This has led to us embracing new technology to help streamline workflows within the department. As well as utilising EDI functionality, changing processing workflows and using shelf-ready books, we have devised innovative ways of dealing with everyday tasks. Topics included cover: PDA deduplication; spine labelling on a large scale; the weeding of discarded books; using saved global updates on incoming MARC records and using load profiles innovatively.

Yes / One of the main obstacles to therapeutic success in colorectal cancer (CRC) is the development of acquired resistance to treatment with drugs such as 5-fluorouracil (5-FU). Whilst some resistance mechanisms are well known, it is clear from the stasis in therapy success rate that much is still unknown. Here, a proteomics approach is taken towards identification of candidate proteins using 5-FU-resistant sublines of human CRC cell lines generated in house. Using a multiplexed stable isotope labelling with amino acids in cell culture (SILAC) strategy, 5-FU-resistant and equivalently passaged sensitive cell lines were compared to parent cell lines by growing in Heavy medium with 2D liquid chromatography and Orbitrap Fusion™ Tribrid™ Mass Spectrometry analysis. Among 3003 commonly quantified proteins, six (CD44, APP, NAGLU, CORO7, AGR2, PLSCR1) were found up-regulated, and six (VPS45, RBMS2, RIOK1, RAP1GDS1, POLR3D, CD55) down-regulated. A total of 11 of the 12 proteins have a known association with drug resistance mechanisms or role in CRC oncogenesis. Validation through immunodetection techniques confirmed high expression of CD44 and CD63, two known drug resistance mediators with elevated proteomics expression results. The information revealed by the sensitivity of this method warrants it as an important tool for elaborating the complexity of acquired drug resistance in CRC. / Sadr ul-Shaheed and the University of Bradford Proteomics Facility were supported by Yorkshire Cancer Research, UK (Cancer Medicine Discovery II, grant B381PA).

The field of computer vision has long pursued the challenge of understanding the three-dimensional world. This endeavour is further fuelled by the increasing demand for technologies that rely on accurate perception of the 3D environment such as autonomous driving and augmented reality. However, the labelled data scarcity in the 3D domain continues to be a hindrance to extensive research and development. Semi-Supervised Learning is a valuable tool to overcome data scarcity yet most of the state-of-art methods are primarily developed and tested for two-dimensional vision problems. To address this challenge, there is a need to explore innovative approaches that can bridge the gap between 2D and 3D domains. In this work, we propose a technique that both leverages the existing abundance of two-dimensional data and makes the state-of-art semi-supervised learning methods directly applicable to 3D tasks. Multi-View Meta Pseudo Labelling (MV-MPL) combines one of the best-performing architectures in 3D shape recognition, Multi-View Convolutional Neural Networks, together with the state-of-art semi-supervised method, Meta Pseudo Labelling. To evaluate the performance of MV-MPL, comprehensive experiments are conducted on widely used shape recognition benchmarks ModelNet40, ShapeNetCore-v1, and ShapeNetCore-v2, as well as, Objaverse-LVIS. The results demonstrate that MV-MPL achieves competitive accuracy compared to fully supervised models, even when only \(10%\) of the labels are available. Furthermore, the study reveals that the object descriptors extracted from the MV-MPL model exhibit strong performance on shape retrieval tasks, indicating the effectiveness of the approach beyond classification objectives. Further analysis includes the evaluation of MV-MPL under more restrained scenarios, the enhancements to the view aggregation and pseudo-labelling processes; and the exploration of the potential of employing multi-views as augmentations for semi-supervised learning. / Forskningsområdet för datorseende har länge strävat efter utmaningen att förstå den tredimensionella världen. Denna strävan drivs ytterligare av den ökande efterfrågan på teknologier som är beroende av en korrekt uppfattning av den tredimensionella miljön, såsom autonom körning och förstärkt verklighet. Dock fortsätter bristen på märkt data inom det tredimensionella området att vara ett hinder för omfattande forskning och utveckling. Halv-vägledd lärning (semi-supervised learning) framträder som ett värdefullt verktyg för att övervinna bristen på data, ändå är de flesta av de mest avancerade semisupervised-metoderna primärt utvecklade och testade för tvådimensionella problem inom datorseende. För att möta denna utmaning krävs det att utforska innovativa tillvägagångssätt som kan överbrygga klyftan mellan 2D- och 3D-domänerna. I detta arbete föreslår vi en teknik som både utnyttjar den befintliga överflöd av tvådimensionella data och gör det möjligt att direkt tillämpa de mest avancerade semisupervised-lärandemetoderna på 3D-uppgifter. Multi-View Meta Pseudo Labelling (MV-MPL) kombinerar en av de bästa arkitekturerna för 3D-formigenkänning, Multi-View Convolutional Neural Networks, tillsammans med den mest avancerade semisupervised-metoden, Meta Pseudo Labelling. För att utvärdera prestandan hos MV-MPL genomförs omfattande experiment på väl använda uvärderingar för formigenkänning., ModelNet40, ShapeNetCore-v1 och ShapeNetCore-v2. Resultaten visar att MV-MPL uppnår konkurrenskraftig noggrannhet jämfört med helt vägledda modeller, även när endast \(10%\) av etiketterna är tillgängliga. Dessutom visar studien att objektbeskrivningarna som extraherats från MV-MPL-modellen uppvisar en stark prestanda i formåterhämtningsuppgifter, vilket indikerar effektiviteten hos tillvägagångssättet bortom klassificeringsmål. Vidare analys inkluderar utvärderingen av MV-MPL under mer begränsade scenarier, förbättringar av vyaggregerings- och pseudomärkningsprocesserna samt utforskning av potentialen att använda bilder från flera vinklar som en metod att få mer data för halv-vägledd lärande.

The relationship between international regimes regulating intellectual property, traditional knowledge and biodiversity has received much attention in recent times. Of the many complex and controversial issues in contemporary international legal discourse on this matter, the protection of traditional knowledge (TK) stands out as a significant challenge. Choices abound in the search for modalities to regulate rights to use and control TK systems and their underlying biodiversity. In recent times, the protection of geographical indications (GIs) has emerged as an option for protecting TK. Despite the considerable enthusiasm over it, there is appreciable research dearth on how far and in what context GIs can be used as a protection model. Indeed, not only is the concept of GIs itself widely misunderstood. As well, analyses as to their applicability for protecting TK often reflect underlying cultural differences in the nature, scope and the jurisprudence regarding GIs across jurisdictions. This thesis examines the relationship between GIs and TK, focusing on the responsiveness of GIs to the needs and desires of indigenous peoples and local communities (ILCs). The thesis posits that the search for a model to protect TK should involve identifying different modalities, including those based on intellectual property, to fit to the nature and uses of TK in particular contexts. The analysis conceptualizes GIs as a form of IP that are structurally and functionally suitable to protect aspects of TK in traditional knowledge-based agricultural products (TKBAPs). Substantively, the thesis draws attention to the conceptual underpinnings of GIs as encompassing cultural and economic objectives in the protection of TK. As such, it is argued that stronger protection of GIs should be achieved by integrating the negotiations and discussion concerning GIs and TK at the international level. Further, the case is made for the determination of immediate challenges and long-term opportunities in choosing a legal means for protecting GIs at the national level. In this connection, the thesis suggests that the potential of GIs to meet national and local imperatives to protect TK be assessed, inter alia, based on their instrumentality for economic, biodiversity, cultural and food security objectives in protecting TKBAPs.