La recherche sur les questions touchant aux leaders de groupes sectaires et à la violence sectaire a mené à l’étude du rôle joué par l’autorité charismatique, tel que défini par Weber (1922) et repris par Dawson (2010). À ce sujet, d’éminents spécialistes des études sur les sectes sont d’avis qu’un vide important dans la recherche sur l’autorité charismatique dans le contexte de groupes sectaires et de nouveaux mouvements religieux reste à combler (ajouter les références ‘d’éminents spécialistes’). Ce mémoire vise à contribuer à l’étude cet aspect négligé, le rôle de l’autorité charismatique dans le recours è la violence dans les groupes sectaires, par une étude de cas historique d’un groupe de la Réformation protestante du XVIe siècle, le Royaume anabaptiste de Münster (AKA), sous l’influence d’un leader charismatique, Jan van Leiden. Cette recherche s’intéresse plus spécifiquement aux divers moyens utilisés par Jan van Leiden, pour asseoir son autorité charismatique et à ceux qui ont exercé une influence sur le recours à des actes de violence. L’étude de cas est basé sur le matériel provenant de deux comptes-rendus des faits relatés par des participants aux événements qui se sont déroulés à pendant le règne de Leiden à la tête du AKA. L’analyse du matériel recueilli a été réalisé à la lumière de trois concepts théoriques actuels concernant le comportement cultuel et le recours à la violence.. L’application de ces concepts théoriques a mené à l’identification de quatre principales stratégies utilisées par Jan van Leiden pour établir son autorité charismatique auprès de ses disciples, soit : 1) la menace du millénarisme, 2) l’exploitation d’une relation bilatérale parasitique avec ses disciples, 3) l’utilisation de l’extase religieuse et de la prophétie, 4) l’utilisation du désir de voir survenir des changements sociaux et religieux. En plus de ces quatre stratégies, trois autres dimensions ont été retenues comme signes que le recours à la violence dans le Royaume anabaptiste de Münster résultait de l’établissement de l’autorité charismatique de son leader, soit : 1) la violence liée au millénarisme, 2) la notion d’identité et de violence partagée, 3) des facteurs systémiques, physiques et culturels menant à la violence. / Research surrounding questions regarding cultic behaviors, leadership and issues of sectarian violence has lead to the study of charismatic leadership. Prominent cultic scholars have identified that there remains a rather large void in research when analyzing charismatic leadership within the context of sectarian groups and new religious movements. This thesis will attempt to bridge that gap through a historical case study analysis of a 16th century protestant reformation group, the Anabaptist Kingdom of Münster (AKM), under the influence of a charismatic leader, Jan van Leiden. More specifically, this research will focus on the various means utilized by the group’s leader, to establish charismatic leadership and how this affected the group’s recourse to acts of violence. The case material was obtained through two primary source accounts from participants in the events that unfolded in Münster during Leiden’s reign. The analysis of this material was made using three current theoretical concepts on cultic behavior and violence, that is Casoni (2000), Robbins (2002) and Dawson (2010). It appears that four major strategies were utilized by Jan van Leiden to establish his charismatic leadership over his followers: (1) the threat of millenarianism, (2) the exploitation of a bilateral parasitic relationship with his followers, (3) the use of religious ecstasy and prophecy, and (4) the use of their desire for social and religious change. By contrasting the results of the analyses undertaken in chapters three and four, three factors that have played a crucial role in Leiden’s charismatic leadership, as it relates to the recourse to violence in the AKM, will be identified. These are: (1) millennial violence, (2) shared identity, and (3) macro-level dimensions.

Objetivo: A trombose da veia porta é uma causa importante de hiper-tensão porta em crianças e adolescentes, porém, em uma proporção importante dos casos, não apresenta fator etiológico definido. O objetivo desse estudo é determinar a freqüência de deficiência das proteínas inibidoras da coagulação – proteínas C, S e antitrombina − e das mutações fator V Leiden, G20210A no gene da protrombina e C677T da metileno-tetraidrofolato redutase em crianças e adolescentes com trom-bose da veia porta, definir o padrão hereditário de uma eventual deficiência das pro-teínas inibidoras da coagulação nesses pacientes e avaliar a freqüência da deficiên-cia dessas proteínas em crianças e adolescentes com cirrose. Casuística e Métodos: Foi realizado um estudo prospectivo com 14 crianças e adolescentes com trombose da veia porta, seus pais (n = 25) e dois gru-pos controles pareados por idade, constituídos por um grupo controle sem hepato-patia (n = 28) e um com cirrose (n = 24). A trombose da veia porta foi diagnosticada por ultra-sonografia abdominal com Doppler e/ou fase venosa do angiograma celíaco seletivo. A dosagem da atividade das proteínas C, S e antitrombina foi determinada em todos os indivíduos e a pesquisa das mutações fator V Leiden, G20210A da pro-trombina e C677T da metileno-tetraidrofolato redutase, nas crianças e adolescentes com trombose da veia porta, nos pais, quando identificada a mutação na criança, e nos controles sem hepatopatia. Resultados: Foram avaliados 14 pacientes caucasóides, com uma média e desvio padrão de idade de 8 anos e 8 meses ± 4 anos e 5 meses e do diagnóstico de 3 anos e 8 meses ± 3 anos e seis meses. Metade dos pacientes pertenciam ao gênero masculino. O motivo da investigação da trombose da veia porta foi hemorra-gia digestiva alta em 9/14 (64,3%) e achado de esplenomegalia ao exame físico em 5/14 (35,7%). Anomalias congênitas extra-hepáticas foram identificadas em 3/14 (21,4%) e fatores de risco adquiridos em 5/14 (35,7%) dos pacientes. Nenhum pa-ciente tinha história familiar de consangüinidade ou trombose venosa. A deficiência das proteínas C, S e antitrombina foi constatada em 6/14 (42,9%) (p < 0,05 vs con-troles sem hepatopatia), 3/14 (21,4%) (p > 0,05) e 1/14 (7,1%) (p > 0,05) pacientes com trombose da veia porta, respectivamente. A deficiência dessas proteínas não foi identificada em nenhum dos pais ou controles sem hepatopatia. A mutação G20210A no gene da protrombina foi identificada em um paciente com trombose da veia porta e em um controle sem hepatopatia (p = 0,999), mas em nenhum desses foi identificado a mutação fator V Leiden. A mutação C677T da metileno-tetraidrofo-lato redutase foi observada na forma homozigota, em 3/14 (21,4%) dos pacientes com trombose da veia porta e em 5/28 (17,9%) controles sem hepatopatia (p = 0,356). A freqüência da deficiência das proteínas C, S e antitrombina nos pacientes com cir-rose foi de 14/24 (58,3%), 7/24 (29,2%) e 11/24 (45,8%), respectivamente (p < 0,05 vs controles sem hepatopatia), sendo mais freqüente nos pacientes do subgrupo Child-Pugh B ou C, que foi de 11/12 (91,7%), 5/12 (41,7%) e 9/12 (75%), respectivamente (p < 0,05 vs controles sem hepatopatia). Conclusões: A deficiência de proteína C foi freqüente nas crianças e adolescentes com trombose da veia porta e não parece ser de origem genética. A deficiência de proteína S, antitrombina e as presenças das mutações G20210A da protrombina e C677T da metileno-tetraidrofolato redutase foram observadas mas não apresentaram diferença estatística significativa em relação ao grupo controle sem hepatopatia. O fator V Leiden não foi identificado. Os resultados deste estudo sugerem que a deficiência da proteína C pode ocorre como conseqüência da hiper-tensão porta. Os distúrbios pró-trombóticos hereditários não parecem apresentar um papel importante em relação à trombose nas crianças e adolescentes estudadas. / Objective: Portal vein thrombosis is a major cause of portal hypertension in children and adolescents; yet, its etiology is not clearly defined in a considerable number of cases. The present study aims at determining the prevalence of blood coagulation disorders – protein C, protein S and antithrombin – and factor V Leiden, G20210A prothrombin, and C677T methylenetetrahydrofolate reductase mutations in children and adolescents with portal vein thrombosis, as well as assessing the hereditary character of these disorders in these patients, and also evaluating the prevalence of blood coagulation disorders in children and adolescents with cirrhosis. Study design: A prospective study was carried out, including children and adolescents with portal vein thrombosis (n = 14), their parents (n = 25), two age-matched control groups, one without liver disease (n = 28), and another with cirrhosis (n = 24). Portal vein thrombosis was diagnosed through abdominal Doppler ultrasonography and/or venous phase of selective coeliac angiograms. The activity of protein C, protein S and antithrombin was evaluated for all individuals; the presence of factor V Leiden, G20210A prothrombin, and C677T methylenetetrahydrofolate reductase gene mutations was investigated in children and adolescents with portal vein thrombosis, in parents when their respective children presented any of these mutations, and in the control group without liver disease. Results: 14 Caucasian patients were assessed. The mean and standard deviation for age were 8 years and 8 months ± 4 years and 5 months while the mean and standard deviation for diagnosis were 3 years and 8 months ± 3 years and six months. Half of the patients were males. Initial clinical manifestations upon diagnosis were digestive hemorrhage in 9/14 (64.3%) and splenomegaly on physical examination in 5/14 individuals (35.7%). Patients presented extrahepatic anomalies in 3/14 (21.4%) and acquired risk factors in 5/14 (35.7%) of the cases. None of the patients had a family history of consanguinity or venous thrombosis. The frequency of protein C, protein S and antithrombin deficiency was observed in 6/14 (42.9%) (p < 0.05 vs. controls without liver disease), 3/14 (21.4%) (p > 0.05) and 1/14 (7.1%) (p > 0.05) of patients, respectively. None of the portal vein thombosis patients or controls presented protein C, S or antithrombin deficiency. One portal vein patient and one control (p = 0.999) presented G20210A prothrombin mutation. None of these patients presented the factor V Leiden. The homozygous form of C677T methylenetetrahydrofolate reductase mutation was observed in 3/14 patients with portal vein thrombosis (21.4%) and in 5/28 controls (17.9%) (p = 0.356). The frequency of coagulation inhibitor deficiency was high in cirrhotic patients (14/24 (58.3%) PC, 7/24 (29.2%) PS and 11/24 (45.8%) AT; p < 0.05 vs. controls), especially in Child-Pugh B and C patients (11/12 (91.7%) PC, 5/12 (41.7%) PS and 9/12 (75%) AT; p < 0.05 vs. controls). Conclusions: Protein C deficiency was frequent in children and adolescents with portal vein thrombosis and does not seem to be an inherited condition. Protein S and antithrombin deficiency, and G20210A prothrombin and C677T methylenetetrahydrofolate reductase mutations were observed but did not present statistically significant differences when compared to the controls without liver disease. Factor V Leiden was not observed. The results suggest the protein C deficiency may originates from portal hypertension. The hereditary prothrombotic disorders do not seem to play a vital role in thrombosis in children and adolescents with portal vein thrombosis.

Objetivo: A trombose da veia porta é uma causa importante de hiper-tensão porta em crianças e adolescentes, porém, em uma proporção importante dos casos, não apresenta fator etiológico definido. O objetivo desse estudo é determinar a freqüência de deficiência das proteínas inibidoras da coagulação – proteínas C, S e antitrombina − e das mutações fator V Leiden, G20210A no gene da protrombina e C677T da metileno-tetraidrofolato redutase em crianças e adolescentes com trom-bose da veia porta, definir o padrão hereditário de uma eventual deficiência das pro-teínas inibidoras da coagulação nesses pacientes e avaliar a freqüência da deficiên-cia dessas proteínas em crianças e adolescentes com cirrose. Casuística e Métodos: Foi realizado um estudo prospectivo com 14 crianças e adolescentes com trombose da veia porta, seus pais (n = 25) e dois gru-pos controles pareados por idade, constituídos por um grupo controle sem hepato-patia (n = 28) e um com cirrose (n = 24). A trombose da veia porta foi diagnosticada por ultra-sonografia abdominal com Doppler e/ou fase venosa do angiograma celíaco seletivo. A dosagem da atividade das proteínas C, S e antitrombina foi determinada em todos os indivíduos e a pesquisa das mutações fator V Leiden, G20210A da pro-trombina e C677T da metileno-tetraidrofolato redutase, nas crianças e adolescentes com trombose da veia porta, nos pais, quando identificada a mutação na criança, e nos controles sem hepatopatia. Resultados: Foram avaliados 14 pacientes caucasóides, com uma média e desvio padrão de idade de 8 anos e 8 meses ± 4 anos e 5 meses e do diagnóstico de 3 anos e 8 meses ± 3 anos e seis meses. Metade dos pacientes pertenciam ao gênero masculino. O motivo da investigação da trombose da veia porta foi hemorra-gia digestiva alta em 9/14 (64,3%) e achado de esplenomegalia ao exame físico em 5/14 (35,7%). Anomalias congênitas extra-hepáticas foram identificadas em 3/14 (21,4%) e fatores de risco adquiridos em 5/14 (35,7%) dos pacientes. Nenhum pa-ciente tinha história familiar de consangüinidade ou trombose venosa. A deficiência das proteínas C, S e antitrombina foi constatada em 6/14 (42,9%) (p < 0,05 vs con-troles sem hepatopatia), 3/14 (21,4%) (p > 0,05) e 1/14 (7,1%) (p > 0,05) pacientes com trombose da veia porta, respectivamente. A deficiência dessas proteínas não foi identificada em nenhum dos pais ou controles sem hepatopatia. A mutação G20210A no gene da protrombina foi identificada em um paciente com trombose da veia porta e em um controle sem hepatopatia (p = 0,999), mas em nenhum desses foi identificado a mutação fator V Leiden. A mutação C677T da metileno-tetraidrofo-lato redutase foi observada na forma homozigota, em 3/14 (21,4%) dos pacientes com trombose da veia porta e em 5/28 (17,9%) controles sem hepatopatia (p = 0,356). A freqüência da deficiência das proteínas C, S e antitrombina nos pacientes com cir-rose foi de 14/24 (58,3%), 7/24 (29,2%) e 11/24 (45,8%), respectivamente (p < 0,05 vs controles sem hepatopatia), sendo mais freqüente nos pacientes do subgrupo Child-Pugh B ou C, que foi de 11/12 (91,7%), 5/12 (41,7%) e 9/12 (75%), respectivamente (p < 0,05 vs controles sem hepatopatia). Conclusões: A deficiência de proteína C foi freqüente nas crianças e adolescentes com trombose da veia porta e não parece ser de origem genética. A deficiência de proteína S, antitrombina e as presenças das mutações G20210A da protrombina e C677T da metileno-tetraidrofolato redutase foram observadas mas não apresentaram diferença estatística significativa em relação ao grupo controle sem hepatopatia. O fator V Leiden não foi identificado. Os resultados deste estudo sugerem que a deficiência da proteína C pode ocorre como conseqüência da hiper-tensão porta. Os distúrbios pró-trombóticos hereditários não parecem apresentar um papel importante em relação à trombose nas crianças e adolescentes estudadas. / Objective: Portal vein thrombosis is a major cause of portal hypertension in children and adolescents; yet, its etiology is not clearly defined in a considerable number of cases. The present study aims at determining the prevalence of blood coagulation disorders – protein C, protein S and antithrombin – and factor V Leiden, G20210A prothrombin, and C677T methylenetetrahydrofolate reductase mutations in children and adolescents with portal vein thrombosis, as well as assessing the hereditary character of these disorders in these patients, and also evaluating the prevalence of blood coagulation disorders in children and adolescents with cirrhosis. Study design: A prospective study was carried out, including children and adolescents with portal vein thrombosis (n = 14), their parents (n = 25), two age-matched control groups, one without liver disease (n = 28), and another with cirrhosis (n = 24). Portal vein thrombosis was diagnosed through abdominal Doppler ultrasonography and/or venous phase of selective coeliac angiograms. The activity of protein C, protein S and antithrombin was evaluated for all individuals; the presence of factor V Leiden, G20210A prothrombin, and C677T methylenetetrahydrofolate reductase gene mutations was investigated in children and adolescents with portal vein thrombosis, in parents when their respective children presented any of these mutations, and in the control group without liver disease. Results: 14 Caucasian patients were assessed. The mean and standard deviation for age were 8 years and 8 months ± 4 years and 5 months while the mean and standard deviation for diagnosis were 3 years and 8 months ± 3 years and six months. Half of the patients were males. Initial clinical manifestations upon diagnosis were digestive hemorrhage in 9/14 (64.3%) and splenomegaly on physical examination in 5/14 individuals (35.7%). Patients presented extrahepatic anomalies in 3/14 (21.4%) and acquired risk factors in 5/14 (35.7%) of the cases. None of the patients had a family history of consanguinity or venous thrombosis. The frequency of protein C, protein S and antithrombin deficiency was observed in 6/14 (42.9%) (p < 0.05 vs. controls without liver disease), 3/14 (21.4%) (p > 0.05) and 1/14 (7.1%) (p > 0.05) of patients, respectively. None of the portal vein thombosis patients or controls presented protein C, S or antithrombin deficiency. One portal vein patient and one control (p = 0.999) presented G20210A prothrombin mutation. None of these patients presented the factor V Leiden. The homozygous form of C677T methylenetetrahydrofolate reductase mutation was observed in 3/14 patients with portal vein thrombosis (21.4%) and in 5/28 controls (17.9%) (p = 0.356). The frequency of coagulation inhibitor deficiency was high in cirrhotic patients (14/24 (58.3%) PC, 7/24 (29.2%) PS and 11/24 (45.8%) AT; p < 0.05 vs. controls), especially in Child-Pugh B and C patients (11/12 (91.7%) PC, 5/12 (41.7%) PS and 9/12 (75%) AT; p < 0.05 vs. controls). Conclusions: Protein C deficiency was frequent in children and adolescents with portal vein thrombosis and does not seem to be an inherited condition. Protein S and antithrombin deficiency, and G20210A prothrombin and C677T methylenetetrahydrofolate reductase mutations were observed but did not present statistically significant differences when compared to the controls without liver disease. Factor V Leiden was not observed. The results suggest the protein C deficiency may originates from portal hypertension. The hereditary prothrombotic disorders do not seem to play a vital role in thrombosis in children and adolescents with portal vein thrombosis.

Le but de la présente étude « Le Rôle des Troupes de Démons Hostiles aux Vivants dans l’Égypte Ancienne » est déterminé les critères qui définissent le rôle des catégories des démons qui manifestent en troupes pour influencer les gens dans la vie terrestre. Le premier chapitre de la thèse intitulée « Le début du rôle des troupes de démons dans la vie terrestre et les aspects qui Identifient son nature » identifie trois points principaux: « Les Sources qui témoignent le rôle des troupes de démons avec les gens sur la terre », « Le rôle des troupes de démons: Quand et pourquoi? », et « Remarques préliminaires sur les troupes de démons ». Chapitre deux porte le titre « Identification des troupes de démons ». Les troupes étudiées dans ce chapitre sont disposés en fonction de leur importance, cet aspect est déterminé lors de l'analyse des rôles attribués à chacun de ces troupes en ce qui concerne la date de l'apparition et de la diversité des rôles. Ces troupes sont: #Atyw « Les Exécuteurs », Wpwtyw « Les Messagers », ^mAyw « Les Errants », @nTtyw « Les Bouchers », awAyw « Les Voleurs », %wAw « Les Passants », et @rytyw « Ceux qui répandent la terreur ». Les détails concernant les connotations du nom, les rôles principaux et les tâches sont discutées en sous-titres sous les rubriques qui discutent chaque troupe des démons. Chapitre trois intitulé « Désignations: Ontologie de l'identité et du caractère » traite des différents titres et épithètes qui sont apparus dans le corpus comme désignation pour les troupes de démons identifiés dans le chapitre deux. Le plus important de ces désignations sont: NTrw « Divine », NDstyw « Divinités mineures », Mdwt « Les paroles (des dieux) », Prryw m Irt Ra « qui sortent de l'Œil de Rê », &pyw-a-%xmt « Avant-gardes de Sekhmet », Imyw-xt-%xmt « Arrière-gardes de Sekhmet », ^msw « Les cortèges », Wpwtyw « Les Messagers », nTrw mDAwt « Dieux de Livres », Apdw « Les Oiseaux », TAw « Les Vents », %bAw « Les Etoiles », Imyw-spspw « Ceux qui sont avec les couteaux », %tyw « Ceux qui tirent des flèches », ^srw « Les Flèches », _Sr « Le rouge », +Ayw « Les adversaires », +ww « Les maux ». Ces désignations sont classées selon les catégories thématiques qui les identifient. Chapitre quatre est intitulé « Propagation et Provocation des troupes de démons sur Terre: Dieux maîtres des Démons et les zones de menace ». Il traite des principaux aspects qui contrôlent la manifestation de démons sur terre. L'élément le plus important est les divinités qui contrôlent les démons. Chapitre cinq traite la « Nature de la tâche de troupes des démons sur Terre ». Les rubriques de ce chapitre étudient les aspects qui permettent d'identifier le rôle des démons dans la vie terrestre et comment la tâche démoniaque peut être défini en ce qui concerne les éléments de la dualité et de l'inimitié, etc. Chapitre six présente « Le Plan et le cours de la tâche ». Le but de ce chapitre est d'identifier les actions que les démons suivent afin d'affecter les gens. Les chapitres sept et huit traitent « Les Effets des troupes des démons dans la vie terrestre ». Ils discutent respectivement « la mort » et « la maladie ». Enfin le chapitre neuf définit « Le rôle de la magie dans la protection des Mortels contre les troupes des démons sur Terre ». Dans ce chapitre les aspects liés au temps et la cible sont entraîné. Concernant le contenu du corpus, les sources de l'étude sont disposées en quatre parties, dont chacune traite avec un groupe de textes de la même catégorie. Le sujet de cette étude est présenté dans neuf chapitres et une annexe y compris le corpus. La présentation des catégories est ordonnée selon leurs importances. La première partie est intitulée « Les Incantations magiques prophylactiques ». Cette partie est d'abord introduite comme l'apogée de la pensée égyptienne concernant la capacité des démons d'influer les différents aspects de la vie des gens sur la terre. Les textes de la première partie sont classés en deux sections... / The present study The Role of Malevolent Demon Troops with the Livings in Ancient Egypt aims to determine the criteria that defines the role of the category of demons who manifest in troops to affect people in the earthly life. The subject of this study is discussed in nine chapters and an annex including the corpora.It is better to start by displaying the contents of the corpora. The first chapter of the thesis entitled Arising of the Role of Demon Troops in Terrestrial Life and Aspects Identifying its Nature identifies three main points: Sources Recording the Role of Demon Troops with Mortals on Earth, The Role of Demon Troops: When and Why? And Preliminary Notes about Demon Troops.Chapter two bears the title Identification of Demon Troops. The troops studied in this chapter are arranged according to their importance, that aspect is determined upon the analysis of the roles attributed to each of these troops regarding the time of appearance and the diversity of roles. These troops are: #Atyw “The Executioners, Wpwtyw “The Messengers”, ^mAyw “The Wanderers”, @nTtyw “The Butchers”, awAyw “The Robbers”, %wAw “The Passers-by”, and @rytyw “Those Who Spread Terror”. Details about the connotations of the name, the main roles and tasks are discussed under each troop of demons.Chapter three entitled Designations: The Ontology of Identity and Character discusses the different titles and epithets that appeared in the corpora as designation for the troops of demons identified in chapter two. The most important of these designations are: NTrw “Divine”, NDstyw “minor Divinities”, Mdwt “Words (of Gods)”, Prryw m Irt Re “Who Go Out from the Eye of Re”, &pyw-a-%xmt “Vaunguards of Sekhmet”, Imyw-xt %xmt “Rearguards of Sekhmet”, ^msw “The Retinues”, Wpwtyw “Messengers”, NTrw mDAwt “Gods of Books”, Apdw “Birds”, TAw “Winds”, %bAw “Stars”, Imyw-spspw “Those with the knives”, %tyw “Those who shoot arrows”, ^srw “Arrows”, bin “The Bad”, _Sr “The red”, +Ayw “The Adversaries”, +ww “The Evil”. These designations are presented classified according to thematic categories identifying them.Chapter four bears the title Propagation and Provocation of Demon Troops on Earth: Superordinate Deities and Threat Zones. It deals with the main aspects that control the manifestation of demons on earth. The most important element is the deities who control demons. Chapter five deals with Nature of Task of the Demon Troops on Earth. The rubrics of this chapter study the aspects that identify the role of demons in the earthly life and how the demonic task can be defined regarding the elements of duality and enmity and so on.Chapter six presents Plan and Course of the Task. The aim of this chapter is identifying the actions that demons follow in order to affect people.Chapters seven and eight deal with the Impact of Demon Troops in Terrestrial Life. They respectively discusses the Death and the Disease.Finally chapter nine comes to define The Role of Magic in the Protection of Mortals against Demon Troops on Earth. The aspects connected to time, location and the targeted are also entailed.Concerning the corpora, the sources of the study are arranged in four parts, each of which deals with a group of texts from the same category. The order of presenting the categories is according to their importance. In the first part the Magical Prophylactic Incantations are firstly introduced as the apogee of the Egyptian thought concerning the capacity of demons to affect the different aspects of the life of people on earth.

German text / Die vorliegende Arbeit setzt sich mit der zentralen Leidensthematik des Ersten Petrusbriefes auseinander. Einer vorläufigen Betrachtung der Entwicklung und des Gebrauchs des zentralen Leidens- Begriffs folgt die ausführliche Untersuchung und Darstellung der Urheber des Leidens und der Ursachen und Gründe für rechtes und falsches Leiden. Es folgt unter Berücksichtigung einiger kulturanthropologischer Einsichten und moderner psychologischer Analysen bezüglich der Wirkung von verbaler Gewalt eine Betrachtung der Arten und Formen des Leidens sowie der Begründungen und Ziele des Leiden. Der zweite Hauptteil untersucht Verhaltensanweisungen, Trost und Anleitung zur Leidensbewältigung, die der Verfasser seinen Empfängern zukommen lässt. Dabei wird zum einen ein Vergleich zwischen den Aussagen des Ersten Petrusbriefs und der antiken Konsolationsliteratur vorgenommen, zum anderen zwischen den vorgeschlagenen Bewältigungsstrategien des Briefes und den Strategien der modernen Sozialpsychologie zum hilfreichen Umgang mit Diskriminierung und Verfolgung. Abschließend werden die zentralen Beobachtungen zusammengefasst. / This dissertation addresses the central theme of suffering in the First Epistle of Peter. After a detailed survey of research, it begins with an examination of the development and use of the terminology for suffering. This is followed by a thorough examination of the origin of suffering and the causes and reasons for right and false suffering. Careful attention to Greek lexicography and grammar is combined with rhetorical criticism. Analysis of both the forms of suffering and the reasons and purposes of suffering is combined with insights from cultural anthropology and modern studies of the effects of verbal violence. The second main part examines the behavioural instructions, comfort and ways of coping with suffering. Furthermore, 1 Peter is compared with the comfort given in various ancient consolation literatures. In addition, the strategies for coping with discrimination and suffering in 1 Peter are compared to insights from modern social psychology. A concluding chapter summarises the results and reflects on their present-day significance. / New Testament / M. Th. (New Testament)

German text / Die vorliegende Arbeit setzt sich mit der zentralen Leidensthematik des Ersten Petrusbriefes auseinander. Einer vorläufigen Betrachtung der Entwicklung und des Gebrauchs des zentralen Leidens- Begriffs folgt die ausführliche Untersuchung und Darstellung der Urheber des Leidens und der Ursachen und Gründe für rechtes und falsches Leiden. Es folgt unter Berücksichtigung einiger kulturanthropologischer Einsichten und moderner psychologischer Analysen bezüglich der Wirkung von verbaler Gewalt eine Betrachtung der Arten und Formen des Leidens sowie der Begründungen und Ziele des Leiden. Der zweite Hauptteil untersucht Verhaltensanweisungen, Trost und Anleitung zur Leidensbewältigung, die der Verfasser seinen Empfängern zukommen lässt. Dabei wird zum einen ein Vergleich zwischen den Aussagen des Ersten Petrusbriefs und der antiken Konsolationsliteratur vorgenommen, zum anderen zwischen den vorgeschlagenen Bewältigungsstrategien des Briefes und den Strategien der modernen Sozialpsychologie zum hilfreichen Umgang mit Diskriminierung und Verfolgung. Abschließend werden die zentralen Beobachtungen zusammengefasst. / This dissertation addresses the central theme of suffering in the First Epistle of Peter. After a detailed survey of research, it begins with an examination of the development and use of the terminology for suffering. This is followed by a thorough examination of the origin of suffering and the causes and reasons for right and false suffering. Careful attention to Greek lexicography and grammar is combined with rhetorical criticism. Analysis of both the forms of suffering and the reasons and purposes of suffering is combined with insights from cultural anthropology and modern studies of the effects of verbal violence. The second main part examines the behavioural instructions, comfort and ways of coping with suffering. Furthermore, 1 Peter is compared with the comfort given in various ancient consolation literatures. In addition, the strategies for coping with discrimination and suffering in 1 Peter are compared to insights from modern social psychology. A concluding chapter summarises the results and reflects on their present-day significance. / New Testament / M. Th. (New Testament)

Die Familienlinien Schlegel waren seit Mitte des 18. Jahrhunderts nachweisbar in die Stadt Altenburg involviert, hatten teilweise durchaus die Geschicke und die Geschichte der Stadt mitgetragen und beeinflusst. In der Zeit um 1800 existierten zwei bedeutende Schlegel-Linien in Altenburg, die des Instrumentenfabrikanten Elias Schlegel (1750 Prößdorf - 1805 Baalsdorf) und die der Rotgießer-Familie Schlegel, die mit Melchior Schlegel (1746 Ungarn - 1805 Altenburg) in der Stadt ansässig wurde. Dessen Sohn David Schlegel (* 17. Okt. 1769, † 4. Dez. 1850) führte die Linie als Gelbgießermeister in Altenburg weiter. Sein ältester Sohn war Hermann Schlegel (1804 Altenburg - 1884 Leiden). Hermann Schlegel, befreundet mit dem Ornithologen Brehm, wurde zu einem bedeutenden europäischen Gelehrten, der noch nicht 18-jährig seine Geburtsstadt Altenburg verließ, um über die Stationen Dresden und Wien in Leiden/Holland am Reichsmuseum Präparator und Konservator zu werden und sich zu einem der verdientesten Ornithologen und Zoologen seiner Zeit hochzuarbeiten. Sein Schaffen wurde begünstigt durch die Forschungsreisenden und ihre Neuentdeckungen der Tier- und Pflanzenwelt in den Kolonien der Niederlande. Er wurde als Naturwissenschaftler schließlich Professor und Direktor des „Königlichen Niederländischen Reichsmuseums für Naturgeschichte“ in Leiden. Unter seiner Leitung und Neuordnung entwickelte sich das Reichsmuseum zu einer der größten und bedeutendsten Einrichtungen Europas, zu einem Institut von Weltruf. Er hatte enge Kontakte zu berühmten Zeitgenossen, die seinen wissenschaftlichen Rat und seine Bekanntschaft suchten. Schlegel wurde bereits zu Lebzeiten als einer der letzten universellen Naturwissenschaftler hochgeschätzt und hatte sich, in seinem fast 60-jährigen Wirken an einer der größten Museen Europas, höchste Anerkennung und Ruhm in der Fachwelt erworben. Seine Söhne wurden ebenfalls zu Berühmtheiten. Sein ältester Sohn Gustav (auch: Gustaaf, 1840-1903) war ein berühmter Sinologe und hatte eine Professur an der Universität Leiden inne, der jüngste Sohn Leander (1844-1913) studierte in Leipzig Musik und war ein niederländischer Pianist, Direktor einer Musikschule und Komponist in Haarlem / Nordholland.

Frans Vredenrijk Engelenburg (1863-1938) played a major role in the development and expansion of Afrikaans and the Afrikaans academic culture - especially in the northern part of South Africa. As a Dutch intellectual, lawyer and journalist in the nineteenth century South African Republic (Transvaal), he in particular played an important role as advisor and opinion maker from the 1890s onward. One of his biggest achievements was the key role that he played in the establishment of De Zuid Afrikaanse Akademie voor Taal, Letteren en Kunst in 1909. This study is the first part of a more comprehensive biographical project on the life of Engelenburg and the role he fulfilled in the history of the Akademie and South Africa until the thirties of the twentieth century. Since the 1600s the Engelenburg family has played a prominent role in the community where they lived. Aside from the high positions they had held for centuries before, they had in the fourth and again in the sixth generation married into noble families. This contributed to their important position in the community. Due to circumstances Engelenburg was not raised in the Engelenburg milieu. A family break in 1836 was the cause that Engelenburg's father, as a baby, was spirited away from this family milieu. Engelenburg received an extraordinarily good schooling. The solid intellectual foundation already laid then, to a large extent determined the course of his life. He was at the Stedelijk Gymnasium Arnhem when he met Marie Koopmans-De Wet (1834-1906), an aunt by marriage who lived in Cape Town, when on a visit to Europe. She was his soul mate and acted as a mentor and advisor to Engelenburg. The friendship strengthened with the years. He already at school had the desire to visit South Africa one day. His parents' divorce when he was still a student at the University of Leyden, steered his life in a very different direction than what he had foreseen for himself. The divorce was to a large extent the reason that, although he had studied law, he discarded the notion of a career in law after only a year. His decision to follow a career in journalism affected the rest of his life. The Transvaal War (1880-1881) meant that the Dutch developed an admiration for the Transvaalers for the determination and courage they displayed in their attempts to defeat the British army. President Paul Kruger's call shortly after the war that the Transvaal needed young Dutchmen further encouraged Engelenburg to come to South Africa. Previously Engelenburg had for a year worked for Fred Hogendorp at the Dagblad van Suidholland en s’Gravenhage in The Hague. Circumstances abruptly changed when Hogendorp suddenly became insane. During the same time, the owner of De Volksstem newspaper in Pretoria had committed suicide and Engelenburg seized the work opportunity. Within a matter of three months, he arrived in the Transvaal. Within a month after his arrival he was appointed chief editor of De Volksstem. He had studied the Transvaal situation thoroughly and by means of the newspaper and through tireless efforts, he contributed to improving the farming community’s cultural literacy. The education situation in the Transvaal enjoyed his constant attention. After the Anglo-Boer War (ABW) (1899-1902), he continued to work towards improving the education system in the Transvaal. He early on became involved in the Transvaal University College (later University of Pretoria). Before the ABW he did everything possible to promote the Dutch language to the Boer people. However, after the war he realised that Afrikaans had a rightful place, and he, in addition to Dutch, became a champion for the Afrikaans language. The battle between the proponents of Dutch and Afrikaans respectively, increased after the ABW. To achieve unity of action between the two groups, De Zuid Afrikaanse Akademie voor Taal, Letteren and Kunst was founded in 1909. Behind the scenes Engelenburg was one of the major driving forces to assist with the founding of the organisation. As a board member and later as chairman, he gave impetus to the Akademie. In 2009 the organisation celebrated its centenary. This is an important milestone, especially seen in the light of the current political climate in South Africa. The Akademie can now be regarded as a monument to Engelenburg as the fruit of his labour and perseverance during the first three decades of the Akademie’s existence. / Thesis (M.A. (History))--North-West University, Vaal Triangle Campus, 2010.

Frans Vredenrijk Engelenburg (1863-1938) played a major role in the development and expansion of Afrikaans and the Afrikaans academic culture - especially in the northern part of South Africa. As a Dutch intellectual, lawyer and journalist in the nineteenth century South African Republic (Transvaal), he in particular played an important role as advisor and opinion maker from the 1890s onward. One of his biggest achievements was the key role that he played in the establishment of De Zuid Afrikaanse Akademie voor Taal, Letteren en Kunst in 1909. This study is the first part of a more comprehensive biographical project on the life of Engelenburg and the role he fulfilled in the history of the Akademie and South Africa until the thirties of the twentieth century. Since the 1600s the Engelenburg family has played a prominent role in the community where they lived. Aside from the high positions they had held for centuries before, they had in the fourth and again in the sixth generation married into noble families. This contributed to their important position in the community. Due to circumstances Engelenburg was not raised in the Engelenburg milieu. A family break in 1836 was the cause that Engelenburg's father, as a baby, was spirited away from this family milieu. Engelenburg received an extraordinarily good schooling. The solid intellectual foundation already laid then, to a large extent determined the course of his life. He was at the Stedelijk Gymnasium Arnhem when he met Marie Koopmans-De Wet (1834-1906), an aunt by marriage who lived in Cape Town, when on a visit to Europe. She was his soul mate and acted as a mentor and advisor to Engelenburg. The friendship strengthened with the years. He already at school had the desire to visit South Africa one day. His parents' divorce when he was still a student at the University of Leyden, steered his life in a very different direction than what he had foreseen for himself. The divorce was to a large extent the reason that, although he had studied law, he discarded the notion of a career in law after only a year. His decision to follow a career in journalism affected the rest of his life. The Transvaal War (1880-1881) meant that the Dutch developed an admiration for the Transvaalers for the determination and courage they displayed in their attempts to defeat the British army. President Paul Kruger's call shortly after the war that the Transvaal needed young Dutchmen further encouraged Engelenburg to come to South Africa. Previously Engelenburg had for a year worked for Fred Hogendorp at the Dagblad van Suidholland en s’Gravenhage in The Hague. Circumstances abruptly changed when Hogendorp suddenly became insane. During the same time, the owner of De Volksstem newspaper in Pretoria had committed suicide and Engelenburg seized the work opportunity. Within a matter of three months, he arrived in the Transvaal. Within a month after his arrival he was appointed chief editor of De Volksstem. He had studied the Transvaal situation thoroughly and by means of the newspaper and through tireless efforts, he contributed to improving the farming community’s cultural literacy. The education situation in the Transvaal enjoyed his constant attention. After the Anglo-Boer War (ABW) (1899-1902), he continued to work towards improving the education system in the Transvaal. He early on became involved in the Transvaal University College (later University of Pretoria). Before the ABW he did everything possible to promote the Dutch language to the Boer people. However, after the war he realised that Afrikaans had a rightful place, and he, in addition to Dutch, became a champion for the Afrikaans language. The battle between the proponents of Dutch and Afrikaans respectively, increased after the ABW. To achieve unity of action between the two groups, De Zuid Afrikaanse Akademie voor Taal, Letteren and Kunst was founded in 1909. Behind the scenes Engelenburg was one of the major driving forces to assist with the founding of the organisation. As a board member and later as chairman, he gave impetus to the Akademie. In 2009 the organisation celebrated its centenary. This is an important milestone, especially seen in the light of the current political climate in South Africa. The Akademie can now be regarded as a monument to Engelenburg as the fruit of his labour and perseverance during the first three decades of the Akademie’s existence. / Thesis (M.A. (History))--North-West University, Vaal Triangle Campus, 2010.

<p dir="ltr">The genetic perturbations caused by spaceflight on biological systems tend to have a system-wide effect which is often difficult to deconvolute into individual signals with specific points of origin. Single cell multi-omic data can provide a profile of the perturbational effects but does not necessarily indicate the initial point of interference within a network. The objective of this project is to take advantage of large scale and genome-wide perturbational or Perturb-Seq datasets by using them to pre-train a generalist machine learning model that is capable of predicting the effects of unseen perturbations in new data. Perturb-Seq datasets are large libraries of single cell RNA sequencing data collected from CRISPR knock out screens in cell culture. The advent of generative machine learning algorithms, particularly transformers, make it an ideal time to re-assess large scale data libraries in order to grasp cell and even organism-wide genomic expression motifs. By tailoring an algorithm to learn the downstream effects of the genetic perturbations, we present a pre-trained generalist model capable of predicting the effects of multiple perturbations in combination, locating points of origin for perturbation in new datasets, predicting the effects of known perturbations in new datasets, and annotation of large-scale network motifs. We demonstrate the utility of this model by identifying key perturbational signatures in RNA sequencing data from spaceflown biological samples from the NASA Open Science Data Repository.</p>