「未設董事會公司」乃日本於二○○五年修法時參考美國法制引進之「閉鎖性股份有限公司」（close corporation），並廢除原有之有限公司制度。修正後之公司法，賦予股份有限公司更彈性的機關設計，尤其在未公開募集資金之股份有限公司，不再強制設置董事會；若資本額未逾五億日圓或負債合計額未逾二百億日圓，亦不強制設置監察人，提供原僅得成立有限公司之中小企業更多企業型態選擇模式。 日本於二○○五年六月二十九日修正之公司法中，參考美國LLC（Limited Liability Company）制度創設合同公司為新的公司類型，並與無限公司、兩合公司合稱為「持份公司」。合同公司指出資者全部係有限責任股東，原則上以其出資價額為限，對公司之債務負間接、有限責任。合同公司乃獨立之法人，並以對內擁有高度之章程自治、構成員對外負有限責任為其特徵。該制度之旨趣在於促進著重股東個性之產業並同時活用人合之特質。 「未設置董事會公司」、「合同公司」之制度設計，均在創設更彈性之企業組織供中小企業選用。反觀我國現今預設為中小企業選用企業型態，僅有有限公司。然因股份有限公司籌資便利、企業形象及信用較佳等優點，使中小企業選用股份有限公司者亦不在少數。我國是否有必要如日本法廢除有限公司制度，引進閉鎖性股份有限公司制度；抑或應引進閉鎖性有限公司制度之同時，保留有限公司制度，並就現存之問題，修法加以解決，值得深加探究。 另外，未設置董事會公司及合同公司法雖參考美國法而來，但仍配合其國情而有相當之修正，為與美國法之用語加以區別，故本文直接以「未設置董事會公司」及「合同公司」為題，特此說明。

Atualmente, a Leucemia Linfocítica Crônica (LLC) pode ser dividida em dois grupos: um com mutações somáticas no gene da região variável da cadeia pesada da imunoglobulina (MIgVH) e outro sem mutações (NMIgVH). Alguns estudos mostraram que a expressão de CD38 na superfície das células B de LLC pode estar correlacionada com o estado mutacional do gene VHIg, entretanto, esses controversos. Estudos recentes mostraram que a expressão da proteína tirosina quinase Zap-70 está melhor associada com o estado mutacional do gene IgVH. O objetivo deste estudo foi avaliar a expressão de Zap-70 e CD38, por citometria de fluxo, nas células CD19+ de pacientes com LLC e correlacioná-los com o estádio clínico (EC), sobrevida livre de tratamento (SLT) e sobrevida global (SG). A expressão de Zap-70 e CD38 foi avaliada, em 144 de pacientes com LLC classificados nos estádios clínicos A, B e C de acordo com os critérios de Binet: 59 (41%) do EC-A, 38 (26%) do EC-B e 47 (33%) do EC-C. Foi observada menor positividade para Zap-70 e CD38 nos pacientes do EC-A do que nos EC-B e C. Quando avaliada a SLT nos pacientes do EC-A, os casos Zap-70+ assim como os CD38+ apresentaram menor SLT. A média de SG dos pacientes Zap-70+ e CD38+ foi menor quando comparado com os Zap-70- e CD38- entretanto quando correlacionada com o EC não foi observada diferença estatisticamente significante entre a expressão desses marcadores e o EC-A, B ou C. Pela analise combinada de CD38 e Zap-70, dividimos os pacientes em dois grupos (Zap-70-/CD38- e Zap-70+ ou CD38+). Observamos que a expressão positiva desses dois marcadores estava associada ao EC, uma vez que a grande maioria dos pacientes dos estádios B (74%) e C (66%) expressam Zap-70 ou CD38. Entretanto, os pacientes do EC-A, Zap-70+ ou CD38+, apresentaram SG menor quando comparado com os Zap-70-/CD38-. Essa diferença não foi observada nos pacientes do EC-B e do EC-C. Também foi observada menor SLT nos pacientes no EC-A, Zap-70+ ou CD38+. Esses resultados sugerem que análise combinada de Zap-70 e CD38 podem ser empregadas na avaliação dos pacientes do EC-A para se acompanhar a evolução clinica desse grupo de pacientes. Porém, estudos adicionais devem ser realizados para se validar a utilização clínica desses marcadores. / Actually, chronic lymphocytic leukemia (CLL) can be divided in two subsets: one with somatically mutated immunoglobulin heavy-chain variable-region genes (MIgVH) and other with unmutated sequences. (UMIgVH). Some studies have shown that CD38 expression in CLL cells are correlated with IgVH mutational status. However, the value of CD38 as surrogate IgVH mutational status is controversial. Recent studies, have found that Zap-70 protein tyrosine kinase expression is strongly associated with the mutational status IgVH. The aim of this study was to evaluate the Zap-70 and CD38 expression, for flow cytometry, in CD19+ LLC cells and correlate with the Binet’s staging system, treatment-free survival (TFS) and a overall survival (OS). Zap-70 and CD38 was evaluated, in 144 CLL patients that was classified in A, B and C Binet’s staging system: 59 (41%) in stage A, 38 (26%) in B and 47 (33%) in C. We observed low Zap-70 and CD38 expression in stage A patients than in stage B and C cases. When we analyzed the TFS in stage A patients Zap-70+ and CD38+ patients showed shorter TFS than Zap-70- and CD38-. Then we observed that the OS of Zap-70+ and CD38+ patients was, also, shorter than Zap-70- and CD38- cases. However, statistical differences was not found when Zap-70 and CD38 expression was correlated with stage A, B or C Binet’s staging system. To understand the associated Zap-70 and CD38 expression, we divided the CLL patients in two subgroups (Zap-70-/CD38 - and Zap-70+ or CD38+). We observed that CD38+ or Zap-70+ was associated Binet’s staging system, once most of stage B (74%) and C (66%) patients are Zap-70+ or CD38+. However, stage A patients, Zap-70+ or CD38+, showed shorter OS than Zap-70-/CD38-. These differences were not observed in stage B and C patients. Shorter TFS was also observed in the Zap-70+ or CD38+ stage A patients. These results suggest that combined analysis of Zap-70 and CD38 can be used to evaluate stage A patients to observe the clinical evolution of the disease. Nevertheless, other studies must be carried to confirm the clinical use of these markers.

<p>There are several standards for wireless communication. People that are involved in computers and networking recognize names like Bluetooth, HiperLAN and IEEE 802.11. The last one was standardized in 1997 [2,6]and has begun to reach acceptance as a solid ground for wireless networking. A fundamental part of an IEEE 802.11 node is the Medium Access Controller, or MAC. It establishes and controls communication with other nodes, using a physical layer unit. </p><p>The work has been carried out as final project at Linkopings Universitet, it has been about the improvement of the functions of MAC layer. I have developed some of the required functions that PUM uses to interact with the MAC layer. Because of that, I have implemented the Reception functions of MAC layer, having the possibility of using short control frames RTS/CTS to minimize collision.</p>

There are several standards for wireless communication. People that are involved in computers and networking recognize names like Bluetooth, HiperLAN and IEEE 802.11. The last one was standardized in 1997 [2,6]and has begun to reach acceptance as a solid ground for wireless networking. A fundamental part of an IEEE 802.11 node is the Medium Access Controller, or MAC. It establishes and controls communication with other nodes, using a physical layer unit. The work has been carried out as final project at Linkopings Universitet, it has been about the improvement of the functions of MAC layer. I have developed some of the required functions that PUM uses to interact with the MAC layer. Because of that, I have implemented the Reception functions of MAC layer, having the possibility of using short control frames RTS/CTS to minimize collision.

Chronic Lymphocytic Leukemia is the primary lymphoid neoplasm in adults and and it is especially manifested in the elderly. Because it is a heterogeneous disease it awakens great interest regarding its prognosis. Rai and Binet developed staging systems to predict the evolution of the disease and currently, the analysis of expression of CD38 and Zap-70 has been investigated as a prognostic factor for indicating presence or absence of the mutation in the gene IgVH, so, the objective of this study was to analyze the clinical and laboratory profiles of patients with Chronic Lymphocytic Leukemia taking as reference the clinical staging of Rai and Binet and quantification of CD38 and Zap-70 expression as prognosis factors. We searched the medical records of 64 patients treated at University Hospital of Santa Maria and the variables considered were swollen lymph nodes, presence or absence of hepatomegaly and / or splenomegaly, hematological evaluation of peripheral blood and immunophenotype. The data obtained were correlated with the staging of Rai (1975) and Binet (1981), the expression of CD38 and Zap-70 and clinical stage. The results showed no association between ataging Rai and Binet and the expression of CD38, Zap-70 and Binet clinical staging. / A Leucemia Linfocítica Crônica é a principal neoplasia linfóide em adultos e se manifeta principalmente em indivíduos idosos. Por ser uma doença heterogênea, desperta grande interesse quanto ao seu prognóstico. Rai e Binet desenvolveram sistemas de estadiamento capazes de prever a evolução da doença e atualmente, a análise da expressão de CD38 e Zap- 70 tem sido investigada como fator prognóstico por indicar presença ou ausência da mutação no gene IgVH, assim, o objetivo deste estudo foi analisar o perfil clínico-laboratorial dos pacientes com Leucema Linfocítica Crônica, tomando como referência os estadiamentos clínicos de Rai e Binet e a quantificação da expressão de CD38 e Zap-70 como fatores prognóstico. Foram pesquisados 64 prontuários médicos de pacientes atendidos no Hospital Universitário de Santa Maria e as variáveis consideradas foram aumento de linfonodos, presença ou ausência de hepatomegalia e/ou esplenomegalia, avaliação hematológica de sangue periférico e imunofenótipo. Os dados obtidos foram correlacionados com o estadiamento de Rai (1975) e Binet (1981), a expressão de CD38 e Zap-70 com o estádio clínico de Binet. Os resultados demonstraram que não há associação entre o estadiamento de Raí e Binet e a expressão de CD38, Zap-70 com o estadiamento clínico de Binet.

Atualmente, a Leucemia Linfocítica Crônica (LLC) pode ser dividida em dois grupos: um com mutações somáticas no gene da região variável da cadeia pesada da imunoglobulina (MIgVH) e outro sem mutações (NMIgVH). Alguns estudos mostraram que a expressão de CD38 na superfície das células B de LLC pode estar correlacionada com o estado mutacional do gene VHIg, entretanto, esses controversos. Estudos recentes mostraram que a expressão da proteína tirosina quinase Zap-70 está melhor associada com o estado mutacional do gene IgVH. O objetivo deste estudo foi avaliar a expressão de Zap-70 e CD38, por citometria de fluxo, nas células CD19+ de pacientes com LLC e correlacioná-los com o estádio clínico (EC), sobrevida livre de tratamento (SLT) e sobrevida global (SG). A expressão de Zap-70 e CD38 foi avaliada, em 144 de pacientes com LLC classificados nos estádios clínicos A, B e C de acordo com os critérios de Binet: 59 (41%) do EC-A, 38 (26%) do EC-B e 47 (33%) do EC-C. Foi observada menor positividade para Zap-70 e CD38 nos pacientes do EC-A do que nos EC-B e C. Quando avaliada a SLT nos pacientes do EC-A, os casos Zap-70+ assim como os CD38+ apresentaram menor SLT. A média de SG dos pacientes Zap-70+ e CD38+ foi menor quando comparado com os Zap-70- e CD38- entretanto quando correlacionada com o EC não foi observada diferença estatisticamente significante entre a expressão desses marcadores e o EC-A, B ou C. Pela analise combinada de CD38 e Zap-70, dividimos os pacientes em dois grupos (Zap-70-/CD38- e Zap-70+ ou CD38+). Observamos que a expressão positiva desses dois marcadores estava associada ao EC, uma vez que a grande maioria dos pacientes dos estádios B (74%) e C (66%) expressam Zap-70 ou CD38. Entretanto, os pacientes do EC-A, Zap-70+ ou CD38+, apresentaram SG menor quando comparado com os Zap-70-/CD38-. Essa diferença não foi observada nos pacientes do EC-B e do EC-C. Também foi observada menor SLT nos pacientes no EC-A, Zap-70+ ou CD38+. Esses resultados sugerem que análise combinada de Zap-70 e CD38 podem ser empregadas na avaliação dos pacientes do EC-A para se acompanhar a evolução clinica desse grupo de pacientes. Porém, estudos adicionais devem ser realizados para se validar a utilização clínica desses marcadores. / Actually, chronic lymphocytic leukemia (CLL) can be divided in two subsets: one with somatically mutated immunoglobulin heavy-chain variable-region genes (MIgVH) and other with unmutated sequences. (UMIgVH). Some studies have shown that CD38 expression in CLL cells are correlated with IgVH mutational status. However, the value of CD38 as surrogate IgVH mutational status is controversial. Recent studies, have found that Zap-70 protein tyrosine kinase expression is strongly associated with the mutational status IgVH. The aim of this study was to evaluate the Zap-70 and CD38 expression, for flow cytometry, in CD19+ LLC cells and correlate with the Binet’s staging system, treatment-free survival (TFS) and a overall survival (OS). Zap-70 and CD38 was evaluated, in 144 CLL patients that was classified in A, B and C Binet’s staging system: 59 (41%) in stage A, 38 (26%) in B and 47 (33%) in C. We observed low Zap-70 and CD38 expression in stage A patients than in stage B and C cases. When we analyzed the TFS in stage A patients Zap-70+ and CD38+ patients showed shorter TFS than Zap-70- and CD38-. Then we observed that the OS of Zap-70+ and CD38+ patients was, also, shorter than Zap-70- and CD38- cases. However, statistical differences was not found when Zap-70 and CD38 expression was correlated with stage A, B or C Binet’s staging system. To understand the associated Zap-70 and CD38 expression, we divided the CLL patients in two subgroups (Zap-70-/CD38 - and Zap-70+ or CD38+). We observed that CD38+ or Zap-70+ was associated Binet’s staging system, once most of stage B (74%) and C (66%) patients are Zap-70+ or CD38+. However, stage A patients, Zap-70+ or CD38+, showed shorter OS than Zap-70-/CD38-. These differences were not observed in stage B and C patients. Shorter TFS was also observed in the Zap-70+ or CD38+ stage A patients. These results suggest that combined analysis of Zap-70 and CD38 can be used to evaluate stage A patients to observe the clinical evolution of the disease. Nevertheless, other studies must be carried to confirm the clinical use of these markers.

With off-chip memory access taking 100's of processor cycles, getting data to the processor in a timely fashion remains one of the key performance bottlenecks in current systems. With increasing core counts, this problem aggravates and the memory access latency becomes even more critical in multi-core systems. Thus the Last Level Cache (LLC) is of particular importance as any miss experienced at the LLC translates into a costly off-chip memory access. A combination of on-chip caches and prefacers is used to hide the off-chip memory access latency. While a hierarchy of caches focus on exploiting locality by retaining useful data, prefacers complement them by initating data accesses early for blocks that are likely to be accessed in future. In the first half of this thesis, we focus on improving the performance of LLC in single-core processors by focusing on prefetchers. In the case of multi-cores, the LLC is shared across many cores and therefore by many programs running on them. Thus, in the second half of this thesis, we focus on novel and efficient management mechanisms for shared LLC to improve the performance of programs running on the various cores. Prefetchers observe a training stream of primary misses in the cache and rely on the regularity present in them to predict and avoid future misses. We quantify the regularity present in the training stream using the information theoretic measure of entropy and study the impact on regularity by extending the training stream to include secondary misses and accesses. We also consider triggering prefetches on secondary misses. We _nd that the extended histories are more regular in general and it is beneficial to trigger prefetches on secondary misses also. However, the best design choice varies on a per-benchmark and prefetcher basis, necessitating a dynamic approach to identify the best prefetcher configuration. We propose an inexpensive bloom filter based dynamic mechanism to identify the best performing prefetch design point at run time. The adaptive scheme improves the performance in terms of Instructions Per Cycle (IPC) by 4.6% on average over a baseline prefetcher. This performance improvement is achieved along with a reduction in memory traffic requirements. It is well known that aggressive prefetching can harm performance due to increased contention for memory bandwidth and cache pollution. Prefetchers treat all loads as equal and try to eliminate as many misses as possible while certain (static) load instructions are known to be more performance critical. As our second contribution, we propose Focused Prefetching, a generic mechanism to introduce performance awareness in prefetching. We identify that a small number of static loads, referred to as Loads Incurring Majority of Commit Stalls (LIMCOS), account for a majority of the commit stalls in processors. We propose simple history-based classifier to identify LIMCOS with high accuracy. We use the classifier to focus the prefetching efforts on LIMCOS. This is achieved in a generic prefetcher-agnostic fashion by filtering the history used by the prefetchers. Focused Prefetching improves performance in terms of IPC by 9.8% for a set of memory intensive SPEC2000 workloads. This performance gain is achieved along with a reduction in memory traffic and an improvement in prefetch accuracy. In the second part of the thesis, we focus on improving the performance of shared caches in multi-core systems. Last level caches are affected by a lack of temporal locality in the access stream as the locality gets filtered out by caches above it. In the case of multi-cores, the interleaving of accesses from the various cores further adds to the problem. To overcome this, we propose a PC-Centric Next-Use Aware Cache Organization (NUcache) for shared caches in multi-cores, with an ability to retain a subset of cache blocks longer. This is achieved by a logical partitioning of the associative ways of a cache set into Main Ways and Deli Ways. While all the blocks have access to the Main Ways, blocks that are likely to be accessed in the near future (with shorter Next-Use distance) are candidates to be retained longer in the Deli Ways to eliminate future misses. We make use of the fact that a small number of PCs, referred to as delinquent PCs, bring in a majority of the cache blocks and learn the Next-Use characteristic of blocks brought in by them. We propose an intelligent cost-benefit based PC-selection mechanism to identify the best set of delinquent PCs that should have access to the Deli Ways to maximize the cache hits. Performance evaluation reveals that NUcache improves the performance (in terms of Average Normalized Turnaround Time, ANTT) of multi-programmed workloads by 6.2%, 13.9%, 15.8% and 19.6% in dual, quad, eight and sixteen core machines respectively. NUcache also performs better than some of the state-of-the-art cache partitioning mechanisms. The last part of the thesis deals with effective shared cache management in multi-core systems to achieve various performance objectives. Explicitly controlling the shared cache occupancy of competing applications is a flexible and practical way to achieve a variety of high level performance goals. Existing solutions control cache occupancy at a coarser granularity, do not scale well to large core counts and, in some cases, lack the flexibility to support a variety of performance goals. To overcome this, we propose Probabilistic Shared Cache Management (PriSM), a framework to manage the cache occupancy of different cores at cache block granularity by controlling their eviction probabilities. The proposed framework requires only simple hardware changes to implement, can scale to larger core count and is flexible enough to support a variety of performance goals like hit-maximization, fairness and QoS. PriSM with Hit-Maximization improves the performance (of multi-programmed workloads) in terms of ANTT by 16.5%, 18.7% and 12.7% over baseline LRU in eight, sixteen and thirty two core machines respectively.

Nous avons identifié une nouvelle forme de phospho-S27-S33-Ku70 constitutivement surexprimée dans des cellules issues de la leucémie lymphocytaire chronique résistante à la chimiothérapie basée sur des agents alkylants de l’ADN et/ou analogues nucléotidiques. La protéine Ku70 est une protéine essentielle du maintien de la stabilité génomique par son rôle dans la réparation non-homologue (système NHEJ) des cassures double brin de l’ADN (CDB) et par sa fonction télomérique. Le laboratoire d’accueil a déjà démontré, in vitro et in vivo, dans les cellules LLC résistantes une altération de la réparation par le système NHEJ et un dysfonctionnement télomérique. Le travail de thèse a porté sur la caractérisation fonctionnelle de cette nouvelle forme phospho-S27-S33-Ku70. Pour ceci, nous avons utilisé des vecteurs d’expression permettant simultanément d’inhiber l’expression du Ku70 endogène (shRNA) et d’exprimer de façon épisomale différentes formes de Ku70 exogène. Ainsi, nous avons démontré : i) une stricte colocalisation de pS27-pS33-Ku70 avec les foyers γ-H2AX; ii) des cassures double brin (DSB) induisent la phosphorylation de S27-S33-Ku70 sous forme hétérodimère avec Ku80. Cette phosphorylation a lieu quelques minutes après le stress génotoxique et implique l'activité et l'interaction physique avec pS2056-DNA-PKcs, reliant ainsi pS27-pS33-Ku70 au système NHEJ ; iii) les cellules exprimant la forme sauvage exogène S27-S33-Ku70 ou la forme phosphomimétique E27-E33-Ku70 présentent une cinétique de réparation de l’ADN plus rapide que celle des cellules exprimant la forme mutée A27-A33-Ku70. Cependant, iv) la forme sauvage de Ku70 contribue à un niveau plus élevé d'aberrations structurales chromosomiques après la première division cellulaire suite à un stress génotoxique indiquant une infidélité lors de la réparation des dommages de l’ADN. En outre, les cellules exprimant A27-A33-Ku70 possèdent un index cellulaire plus élevé qui est corrélé avec une activation de la voie β-caténine. En adéquation avec sa surexpression dans la forme résistante de la LLC, l’ensemble de ces résultats suggère un rôle oncogénique de la forme phosphorylée de Ku70. Nous avons ensuite testé l’effet des nanodiamants hydrogénés (ND-H) dans des lignées exprimant différentes formes de Ku70. Grâce à leurs propriétés physico-chimiques les ND-H sont capables de potentialiser sous irradiation la production intracellulaire des espèces réactives de l’oxygène (ROS) et ainsi augmenter le taux des cassures (simple et double brin de l’ADN) et solliciter d’avantage le système de réparation de l’ADN. Nous observons que indépendamment de la forme exprimée de Ku70, ce double traitement induisait la sénescence cellulaire ; une découverte d’un intérêt à la fois fondamental (compréhension des voies apoptotiques vs senescence) et d’utilité pharmacologique potentielle. / We have identified a new form of phospho-S27-S33-Ku70 constitutively overexpressed in a subset of chronic lymphocytic leukemia (CLL) B cells resistant to apoptosis induced by DNA double strand breaks (DSB). Ku70 is one of the essential proteins involved in the maintenance of genomic stability through its role in DNA double strand break repair (non-homologous end-joining, NHEJ) and in telomeric protection.Laboratory previously established that resistant CLL cells disclose an upregulated NHEJ DNA repair and an impaired structure of telomeres. The goal of this thesis was to characterize the biological function(s) of this new form of Ku70. For this purpose we have constructed specific EBV-based vectors (siRNA / cDNA) enabling a simultaneous inhibition of endogenous Ku70 and an expression of different forms (mutated, wild, phosphomimetic at ser27-33) of Ku70 resistant to siRNA. Thus, we showed: i) a strict colocalisation of phospho-Ku70 with γ-H2AX foci; ii) that DSB induces the phosphorylation of Ku70 within minutes after genotoxic stress in heterodimer complex Ku70/Ku80. This phosphorylation necessitates both the physical interaction and the activity of pS2056-DNA-PKcs and/or ATM, linking phospho-Ku70 to NHEJ-mediated DNA DSB repair; iii) cells expressing mutated A27-A33-Ku70 exhibit a delayed G2/M cell cycle arrest, slower kinetic of DNA repair, lower level of genotoxic stress-induced chromosomal aberrations, and a higher cellular impedance correlated with translocation of transcriptional factor β-catenin from cytoplasmic membrane to the nucleus. Together, these data unveil an involvement of phospho-Ku70 in fast and inaccurate DNA repair; new paradigm for NHEJ regulation and to the control of resistance and maintenance of malignant cells.In parallel, we have initiated experimental approaches to explore other potential roles of phospho-Ku70. Especially, we were interested to determine whether it could play a role in an initiation of cell senescence induced by combined cells’ treatment by hydrogenated nanodiamonds (H-NDs) particles and ionizing irradiation. H-NDs exhibit positive surface charge in aqueous solutions allowing, when irradiated by photons, electrons’ emission and the release of reactive oxygen species (ROS) causing DNA damage. Effectively, we have established an intracellular increase of ROS that drive cell cycle arrest in G1/S in addition to the G2 arrest activated by irradiation alone. Finally, cells underwent the senescence process characterized byγ-galactosidaze activity, persistent large γ-H2AX foci and senescence-associated heterochromatinisation. Noteworthy, the senescence induced in this way occurred independently of Ku70 (ser27-ser33) status and irrespectively of cell resistance to genotoxic agents administrated alone; a finding of potential use in clinical trials.

With the increasing demand for fast, cheaper, and efficient power converters come the need for a single-stage power factor correction (PFC) converter. Various single-stage PFC converter proposed in the literature has the drawback of high DC bus voltage at the input side and together with the shift to wide bandgap switches like GaN drives the converter cost higher. However, an interleaved topology with high-frequency isolation was proposed in this research work due to the drastic reduction in the DC bus voltage and extremely low input current ripple thereby making the need for an EMI filter circuit optional.   Meanwhile, this research work focuses on adapting the proposed topology for a high voltage low current application (EV charger - 400V, 7KW) and low voltage high current application (telecom power supply - 58V,  58A) owing to cost benefits. However, all single-stage PFC are faced with the drawback of second-order (100Hz) output harmonic ripple. Therefore, the design and simulation presented a huge peak to peak ripple of about 50V/3A and 26V/26A for the EV charger and telecom power supply case, respectively. This created the need for the design of a ripple cancellation circuit as the research required a peak to peak ripple of 8V and 200mV for the EV - charger and telecom power supply, respectively.   A novel output passive ripple cancellation technique was developed for the EV charger case due to the ease it offers in terms of control, circuit complexity and extremely low THDi when compared with the active cancellation approach. The ripple circuit reduced the 50V ripple to 431mV with the use of a total of 2.2mF capacitance at the output stage.   Despite designing the passive technique, an active ripple cancellation circuit was designed using a buck converter circuit for the telecom power supply. The active approach was chosen because the passive has a slow response and incurs more loss at a high current level. Adding the active ripple cancellation circuit led to a quasi-single stage LLC PFC converter topology. A novel duty-ratio feedforward control was added to synchronize the PFC control of the input side with the buck topology ripple cancellation circuit. The addition of the ripple circuit with the feedforward control offered a peak to peak ripple of 6.7mV and a reduced resonant inductor current by half.   After analysis, an extremely low THDi of 0.47%, PF of 99.99% and a peak efficiency of 97.1% was obtained for the EV charger case. The telecom power supply offered a THDi of 2.3%, PF of 99.96% with a peak efficiency of 95%.

Диссертация посвящена исследованию особенностей организации и функционирования современного корпоративного музея на примере проекта корпоративного музея ООО «Уральские локомотивы». В работе уточняется понятие, сущность, функции музея; определяется его место в системе корпоративной культуры; прослеживается историческая трансформация музейного дела в России; дается типология музейных институций в современной России, раскрывается опыт их работы и современные вызовы, а также анализируется международный опыт организации и функционирования интерактивных музеев. В третьей главе диссертации представлена разработанная концептуальная и содержательная составляющие проекта корпоративного музея ООО «Уральские локомотивы». / The dissertation is devoted to the study of the features of the organization and functioning of a modern corporate museum on the example of the Ural Locomotives LLC corporate museum project. The paper clarifies the concept, essence, and functions of the museum; determines its place in the system of corporate culture; traces the historical transformation of museum business in Russia; gives the typology of museum institutions in modern Russia, reveals the experience of their work and modern challenges, and analyzes the international experience of the organization and functioning of interactive museums. The third chapter of the dissertation presents the developed conceptual and substantive components of the project of the Ural Locomotives LLC corporate museum.