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A popular way to reduce weight in industrial products without compromising the strength or stiffness is to replace components made of metal by plastics that have been reinforced by glass fibers. When fibers are introduced in a plastic, the resulting composite usually becomes anisotropic, which makes it much more complex to work with in simulation software. This thesis looks at modeling of such a composite using the multi-scale material modeling tool Digimat. An injection molding simulation of a brush cutter casing made of a short fiber reinforced plastic has been performed in order to obtain information about the glass fiber orientations, and thus the anisotropy, in each material point. That information has then been transferred over from the injection mesh to the structural mesh via a mapping routine. An elasto-viscoplastic material model with failure has been employed and calibrated against experimental data to find the corresponding material parameters. Lastly, a finite element analysis simulating a drop test has been performed. The results from the analysis have been compared with a physical drop test in order to evaluate the accuracy of the methodology used. The outcome has been discussed, conclusions have been drawn and suggestions for further studies have been presented.

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If X is a simply connected CW complex, then it has a unique (up to isomorphism) minimal Sullivan model. There is an important rational homotopy invariant, called the rational Lusternik–Schnirelmann of X, denoted cat0(X), which has an algebraic formulation in terms of the minimal Sullivan model of X. We study another such numerical invariant called the rational retraction index of X, denoted r0(X), which is defined in terms of the minimal Sullivan model of X and satisfies 0 ≤ r0(X) ≤ cat0(X). It was introduced by Cuvilliez et al. as a tool to estimate the rational Lusternik–Schnirelmann category of the total space of a fibration. In this thesis we compute the rational retraction index on a range of rationally elliptic spaces, including for example spheres, complex projective space, the biquotient Sp(1) \ Sp(3) / Sp(1) × Sp(1), the homogeneous space Sp(3)/U(3) and products of these. In particular, we focus on formal spaces and formulate a conjecture to answer a question posed in the original article of Cuvilliez et al., “If X is formal, what invariant of the algebra H∗(X;Q) is r0(X)?”

Candidate: Nikola Kollárová Title of diploma thesis: Detection of Sap2 in the secretome of Candida albicans cell wall and secretory mutants Charles University, Faculty of Pharmacy in Hradec Králové, Department of Biological and Medicinal Sciences Complutense University of Madrid, Faculty of Pharmacy, Department of Microbiology II Study program: Pharmacy Backgound: The aim of this diploma thesis was to search for C. albicans proteins involved in the secretion of the secreted aspartyl proteinase 2 enzyme (Sap2) evaluating the ability to degrade BSA (bovine serum albumin) as a source of nitrogen in several cell wall and secretory mutants of C. albicans. The work was carried out at the Department of Microbiology II, Faculty of Pharmacy, Complutense University of Madrid. Methods: The supernatant samples of several Candida albicans mutants were tested by SDS-PAGE electrophoresis and stained. Bands corresponding to BSA were observed and compared to controls. The other method was counted with 96-well plate. Results: The correlation between optical density and degradation of BSA was observed. Some mutants with disability to degrade BSA were found in a pilot screening of the ability to degrade BSA using 96-well plate method. That fact was confirmed by SDS-PAGE electrophoresis. C. albicans mutants showing...

As part of the development process for new stamping dies, in the automotive sheet metal forming (SMF) industry, the majority of all forming operations are simulated with the Finite Element Method (FEM) before the dies are manufactured. Today, these simulations are conducted with rigid tools under the assumption that there are no tool deformations. However, research shows that tool deformations have an influence on the finished product. In real production these deformations are compensated by manual rework during the try-out. Additional reason for simulating with rigid dies is that there are non-existing simulation methods elaborated for elastic stamping dies. Also, simulation of elastic tools requires high computational power.     Since simulations today are performed with rigid stamping dies the purpose of this work is to investigate the conditions of how to conduct SMF-simulations with elastic stamping dies. The object that will be studied is a stamping die for a Volvo XC90 inner door used in a single-action press. This work is part of the development to minimize the manual rework, with the goal to compensate for tool deformations in a virtual environment.    Results for rigid stamping dies in LS-Dyna was compared to currently used AutoForm as a pre-study. A simple model was then created to find a suitable method while using elastic stamping dies. The developed method was used for an industrial size stamping die.     Since there are little amount of research performed on simulations using elastic stamping dies, elasticity and complexity were gradually introduced into the FE-model. As a first step, only the punch was included as an elastic solid. Secondly, the die was added. Finally, the entire die was simulated as elastic together with the hydraulic cushion of the press. When the FE-model worked as expected a suitable method for minimizing the simulation time with acceptable results was studied.     Comparisons of measured- and simulation results show a high correlation. To improve the results from the FE-model factors such as press deformations, advanced friction models, etc. should be included.    Conclusions from this work shows that it is possible to perform SMF-simulations with elastic stamping dies. As the computational time normally is high this work also presents a method first step to reduce the computational time with acceptable results. Comparisons between simulations with rigid and elastic stamping dies proves that there are significant differences in the outcome of the two methods. / Reduced Lead Time through Advanced Die Structure Analysis - Vinnova

When operating hydraulic mining excavators the loading equipment is exposed to harsh conditions which lead to extensive wear of the equipment, especially the bucket and bucket teeth. Simulations are used to better understand the wear development and to evaluate new methods to operate excavators more efficiently. At the Aitik mine, operated by the high-tech metal company Boliden Mines, hydraulic excavators are used when loading the mined ore. One of the hydraulic excavators used at Aitik is the Komatsu PC7000. In this master thesis, a simulation model for the hydraulic excavator Komatsu PC7000 was developed with the simulation software LS-DYNA. This model consists of multi rigid body dynamics to describe the motion of the excavator and a granular material model to describe the rocks loaded into the bucket of the excavator. Simulations with two different types of granular material models have been utilized to study the wear development of the bucket. One of the models (bonded DE model) uses bonded discrete elements to describe the large rocks and single discrete elements are used to describe smaller rocks. This model is compared to the current FE-DE model which is being used today at Boliden. This model uses finite elements (FE) to model the larger rocks and discrete element spheres (DES) for smaller rocks. By using the bonded DE method a 71\% reduction in simulation time could be achieved. This can be partly explained by the reduction of the number of elements included in the rock pile.  Archard's wear law was used to numerically describe the wear development of the bucket. When simulating the wear a total of 30 bucket fillings were performed with the excavator. This was done with both the bonded DE method and the FE-DE method. In this wear study, the inside of the bucket was of interest. The resulting simulated wear map was compared to experimental measurements from which the plate thickness of the bucket had been measured two times to obtain the wear depth of some points inside the bucket. The experimental measurements and two 3D scanned point clouds were used to determine the wear depth inside the bucket. Results from the simulation showed that the wear is concentrated to the center of the bucket while less wear is concentrated to the sides of the bucket. With the bonded DE method the wear appeared to be more evenly distributed inside the bucket while the wear from the FE-DE method appeared in spots inside the bucket. The experimental results also showed that the wear was more extensive in the center of the bucket and also in the back of the bucket. Both simulation methods also showed that the wear was concentrated to the back of the bucket. From the simulations, it was also seen that the behavior of the material flow differed between the two methods. In the bonded DE method the material flow had more sliding behavior while the material flow in the FE-DE method had more rolling behavior. This could also be the reason why the bonded DE method captures the wear more evenly. The rolling behavior seen in the FE-DE method leads to more impact wear which is not captured by Archard's wear law. Overall, the bonded DE method leads to a big reduction in simulation time which is favorable when it comes to simulation. The larger rocks will have simpler shapes without sharp corners. However, the method allows for a more complex shape than just an ordinary sphere which is the simplest and most common shape to describe granular material. The bonded DE method also allows for easier configuration of contact definition since fewer contact interfaces must be added to the model. Furthermore, the post-processing of wear in LS-DYNA was facilitated since the wear does not have to be divided into two wear collectors for FE elements and DE elements.

The auditory brainstem response is an evoked potential that can be clinically used to estimate hearing sensitivity and to identify auditory nervous system pathology. Recently, there has been an increase in the implementation of the CE-Chirp stimulus in AABR equipment for neonatal hearing screening. The purpose of this study is to evaluate the diagnostic accuracy of the LS CE-Chirp-evoked ABR compared to the traditionally used click-evoked ABR for the identification of different degrees and configurations of sensorineural (SNHL) hearing loss. An exploratory within-subject comparative research design was used. 49 ears with mild to moderate sensorineural hearing loss were assessed. Participants were assessed in a single session. Audiometric pure tone thresholds were obtained at 125-8000 Hz and ABR thresholds were measured using the click and LS CE-Chirp stimuli respectively. Click- and LS CE-Chirp-evoked thresholds were compared with each other and with behavioural pure tone average (PTA), high frequency average (HFA) and low frequency average (LFA). Diagnostic accuracy of the two ABR stimuli was also compared by using ROC curves. Differences between click- and LS CE Chirp-evoked ABR, and behavioural thresholds were not statistically significant (p>0.05). The strongest significant correlation for ABR using clicks to behavioural thresholds was found at 2000 and 4000 Hz, whereas, the strongest correlation for LS CE-Chirp ABRs to behavioural thresholds was found at 1000, 2000 and 4000 Hz (r>0.7, p<0.001). A very strong, positive correlation was found between both click (r=0.805) and LS CE-Chirp (r=0.825) and the behavioural PTA (p<0.001). The mean differences for LS CE-Chirp were smaller than those of the click for PTA and low frequency range. ROC curves indicated better AUC values for the LS CE-Chirp at LFA and HFA compared to the click, also showing a narrower confidence interval and less variance than the click. The predictive accuracy of the LS CE-Chirp-evoked ABR was slightly better than that of the click with reference to PTA, HFA and LFA thresholds; furthermore, it is less variable and more accurate than the click-evoked ABR with reference to HFA. Thus, the LS CE-Chirp is an accurate stimulus for estimation of hearing sensitivity using ABR when compared to the gold standard click stimulus for the purpose of identification of different configurations of SNHL. / Dissertation (MA Audiology) University of Pretoria, 2019. / Speech-Language Pathology and Audiology / MA (Audiology) / Unrestricted

Indiana University-Purdue University Indianapolis (IUPUI) / The design optimization of laminated composite structures is of relevance in automobile, naval, aerospace, construction and energy industry. While several optimization methods have been applied in the design of laminated composites, the majority of those methods are only applicable to linear or simplified nonlinear models that are unable to capture multi-body contact. Furthermore, approaches that consider composite failure still remain scarce. This work presents an optimization approach based on design and analysis of computer experiments (DACE) in which smart sampling and continuous metamodel enhancement drive the design process towards a global optimum. Kriging metamodel is used in the optimization algorithm. This metamodel enables the definition of an expected improvement function that is maximized at each iteration in order to locate new designs to update the metamodel and find optimal designs. This work uses explicit finite element analysis to study the crash behavior of composite parts that is available in the commercial code LS-DYNA. The optimization algorithm is implemented in MATLAB. Single and multi-objective optimization problems are solved in this work. The design variables considered in the optimization include the orientation of the plies as well as the size of zones that control the collapse of the composite parts. For the ease of manufacturing, the fiber orientation is defined as a discrete variable. Objective functions such as penetration, maximum displacement and maximum acceleration are defined in the optimization problems. Constraints are included in the optimization problem to guarantee the feasibility of the solutions provided by the optimization algorithm. The results of this study show that despite the brittle behavior of composite parts, they can be optimized to resist and absorb impact. In the case of single objective problems, the algorithm is able to find the global solution. When working with multi-objective problems, an enhanced Pareto is provided by the algorithm.

京都大学 / 0048 / 新制・課程博士 / 博士(工学) / 甲第19285号 / 工博第4082号 / 新制||工||1629(附属図書館) / 32287 / 京都大学大学院工学研究科社会基盤工学専攻 / (主査)教授 寶 馨, 教授 角 哲也, 准教授 佐山 敬洋 / 学位規則第4条第1項該当 / Doctor of Philosophy (Engineering) / Kyoto University / DFAM