Os objetivos deste trabalho foram: comparar a força muscular (FM) e as habilidades motoras de pacientes com Distrofia Muscular de Duchenne (DMD) em corticoterapia com a evolução natural da doença (Scott, 1982) e identificar a idade ideal de início da corticoterapia. Noventa pacientes com DMD em seguimento ambulatorial no Hospital das Clínicas da Faculdade de Medicina da USP, submetidos à corticoterapia (deflazacort ou prednisolona) por um período variável de um a sete anos, foram avaliados quanto à FM através da escala MRC e quanto às habilidades motoras através da escala Hammersmith motor ability score. Foram incluídos no estudo todos os pacientes com idade entre cinco e 12 anos, que compreendiam comandos verbais e que não haviam sido submetidos a cirurgias ortopédicas corretivas ou interrompido em algum momento a corticoterapia. A relação entre FM e habilidades motoras, a comparação dos dados com aqueles do estudo de Scott et al. e a análise da influência do tempo de tratamento, da idade de início e da idade na avaliação, sobre os valores obtidos nos testes foram submetidas a tratamento estatístico. Concluiu-se que: a progressão da perda da FM e das habilidades motoras em relação à idade foi mais lenta do que a da evolução natural em todas as faixas etárias avaliadas; quanto maior a idade maior a diferença entre os dois estudos; a perda da FM foi mais intensa do que a perda da funcionalidade; a metodologia utilizada não permitiu estabelecer com clareza a influência da idade de início do tratamento sobre os parâmetros avaliados, porém demonstrou a influência positiva do tempo de tratamento sobre a FM e habilidades motoras. / The aims of this study were: to compare muscle strength (MS) and motor abilities of Duchenne Muscular Dystrophy (DMD) patients in use of steroids, with the natural evolution of the disease (Scott, 1982) and to identify the ideal age for starting on steroid therapy. Ninety patients with DMD followed as outpatients at the Clinics Hospital of the University of São Paulo School of Medicine and submitted to steroid therapy (deflazacort or prednisolone) for a period of one to seven years were assessed for MS using the MRC scale, and for motor abilities with the motor ability score from the Hammersmith scale. All patients aged between five and 12 years who understood verbal commands and who had not been submitted to corrective orthopedic surgery and had no interruption in steroid therapy, were included in the study. Statistical analysis was carried out to assess the relationship between MS and motor abilities and to compare our data against results of Scott\'s study. The influence of length of treatment, age at disease onset and first assessment, on values obtained in the tests was investigated. We concluded that: the progression in loss of MS and of motor abilities with age was slower than the natural evolution across all age groups studied; the higher the age the greater the difference between the two studies; loss of MS was more intense than loss of functionality; the methodology used was unable to clearly ascertain the influence of age at treatment on the parameters assessed, but a positive influence of length of treatment on both MS and motor abilities was identified.

A Amiotrofia Espinhal Progressiva (AEP) é uma doença autossômica recessiva que afeta os motoneurônios do corno anterior da medula espinhal, acarretando hipotonia e fraqueza muscular. A partir do conhecimento do mecanismo molecular da AEP, abriu-se um campo para testes clínicos com agentes farmacológicos que possam aumentar o nível da proteína SMN2. Diversas drogas com esta ação estão sendo testadas na tentativa de encontrar um possível tratamento para esta trágica doença. O ácido valpróico (AV), droga muito utilizada para o tratamento da epilepsia mostrou ter a propriedade de ativar o promotor do gene da proteína SMN2, aumentando a sua produção. Tendo em vista que não há uniformização do sistema de avaliação clínica dos resultados do tratamento em diferentes países, foi elaborado um protocolo selecionando métodos de avaliação fáceis, rápidos e já validados a fim de verificar se o AV é eficaz para manter ou melhorar a força muscular dos pacientes com AEP. Os métodos selecionados foram: escala Medical Research Council (MRC) para força muscular; Hammersmith motor ability score para habilidade motora; goniometria das principais articulações; cronometragem de tempo despendido para deambular, quando possível; índice de Barthel para atividades da vida diária e, por fim, um questionário para verificar as modalidades de fisioterapia e hidroterapia em uso. Vinte e dois pacientes com AEP tipo II e III, com idades variando de 2 a 18 anos, medicados com AV, foram avaliados a cada três meses durante um ano, totalizando cinco visitas, das quais a primeira ocorreu nos dias anteriores ao início do tratamento. Os resultados dos testes demonstraram que, durante o seguimento de um ano, os pacientes obtiveram melhora na habilidade motora, porém não na força muscular, o que é um resultado extremamente positivo. Crianças com idade menor ou igual a 6 anos mostraram melhores ganhos quanto à habilidade motora. / Spinal Muscular Atrophy (SMA) is an autosomal recessive disorder that affects the spinal motoneurons, resulting in hypotonia and muscle weakness. The knowledge of the molecular mechanism of SMA has originated new researches including clinical trials with pharmacological agents that increase SMN2 protein level. Many drugs with this action are being tested with the aim of finding a possible treatment for this severe disease. The valproic acid (VA), a well-known drug used to treat epilepsy has the property of activating the SMN2 gene promoter and then to increase SMN2 protein level. Since there isnt an uniform system for the clinical evaluation of the treatment results, we selected a set of easy, fast and already validated methods to evaluate if the VA is effective to stabilize or improve the motor function in patients with SMA. The selected methods were: Medical Research Council scale (MRC) to muscular strength; Hammersmith motor ability score to motor ability; goniometry of the main joints; time to walk when possible; Barthel índex for daily activities, and a questionnaire to verify the types of physiotherapy and hydrotherapy in use. Twenty two patients with SMA II and III, aged between 2 and 19 years, and treated with VA were evaluated every three months during the period of one year; the first evaluation occurred immediately before the onset of the treatment. The results of the tests demonstrated that along the period of 12 months the patients didnt gain muscle strength but improved their motor ability, that can be considered a positive result. Children aged six years or younger had a higher gain in motor ability along the period of the study.

A Amiotrofia Espinhal Progressiva (AEP) é uma doença autossômica recessiva que afeta os motoneurônios do corno anterior da medula espinhal, acarretando hipotonia e fraqueza muscular. A partir do conhecimento do mecanismo molecular da AEP, abriu-se um campo para testes clínicos com agentes farmacológicos que possam aumentar o nível da proteína SMN2. Diversas drogas com esta ação estão sendo testadas na tentativa de encontrar um possível tratamento para esta trágica doença. O ácido valpróico (AV), droga muito utilizada para o tratamento da epilepsia mostrou ter a propriedade de ativar o promotor do gene da proteína SMN2, aumentando a sua produção. Tendo em vista que não há uniformização do sistema de avaliação clínica dos resultados do tratamento em diferentes países, foi elaborado um protocolo selecionando métodos de avaliação fáceis, rápidos e já validados a fim de verificar se o AV é eficaz para manter ou melhorar a força muscular dos pacientes com AEP. Os métodos selecionados foram: escala Medical Research Council (MRC) para força muscular; Hammersmith motor ability score para habilidade motora; goniometria das principais articulações; cronometragem de tempo despendido para deambular, quando possível; índice de Barthel para atividades da vida diária e, por fim, um questionário para verificar as modalidades de fisioterapia e hidroterapia em uso. Vinte e dois pacientes com AEP tipo II e III, com idades variando de 2 a 18 anos, medicados com AV, foram avaliados a cada três meses durante um ano, totalizando cinco visitas, das quais a primeira ocorreu nos dias anteriores ao início do tratamento. Os resultados dos testes demonstraram que, durante o seguimento de um ano, os pacientes obtiveram melhora na habilidade motora, porém não na força muscular, o que é um resultado extremamente positivo. Crianças com idade menor ou igual a 6 anos mostraram melhores ganhos quanto à habilidade motora. / Spinal Muscular Atrophy (SMA) is an autosomal recessive disorder that affects the spinal motoneurons, resulting in hypotonia and muscle weakness. The knowledge of the molecular mechanism of SMA has originated new researches including clinical trials with pharmacological agents that increase SMN2 protein level. Many drugs with this action are being tested with the aim of finding a possible treatment for this severe disease. The valproic acid (VA), a well-known drug used to treat epilepsy has the property of activating the SMN2 gene promoter and then to increase SMN2 protein level. Since there isnt an uniform system for the clinical evaluation of the treatment results, we selected a set of easy, fast and already validated methods to evaluate if the VA is effective to stabilize or improve the motor function in patients with SMA. The selected methods were: Medical Research Council scale (MRC) to muscular strength; Hammersmith motor ability score to motor ability; goniometry of the main joints; time to walk when possible; Barthel índex for daily activities, and a questionnaire to verify the types of physiotherapy and hydrotherapy in use. Twenty two patients with SMA II and III, aged between 2 and 19 years, and treated with VA were evaluated every three months during the period of one year; the first evaluation occurred immediately before the onset of the treatment. The results of the tests demonstrated that along the period of 12 months the patients didnt gain muscle strength but improved their motor ability, that can be considered a positive result. Children aged six years or younger had a higher gain in motor ability along the period of the study.

Este trabalho de mestrado teve como objetivo realizar a validação formal para quatro métodos de medição do Laboratório de Ativação Neutrônica (LAN) do IPEN - CNEN/SP por Análise por Ativação com Nêutrons Instrumental (INAA). Os mensurandos foram a concentração total de As em tecido de mexilhão (método-BIO-1), a concentração total de Co, Cr, Fe, Rb, Sc, Se e Zn em tecido de mexilhão (método-BIO-2), a concentração total de As e Sb em sedimento marinho (método-GEO-1) e a concentração total Co, Cr, Fe, Sc e Zn em sedimento marinho (método-GEO-2). Em um primeiro momento, foi realizado um estudo univariado para investigar a influência causada ao resultado final em diferentes configurações no preparo dos padrões sintéticos e no tempo de medição da atividade do mensurando no padrão sintético. Outras variáveis, como o tempo de medição da atividade do mensurando na amostra, distância entre amostra e detector e tempo de decaimento para medição da amostra foram estudadas em um processo multivariado, por meio da realização de um Planejamento Fatorial 23 completo (DOE). Os parâmetros de desempenho estudados para a validação dos métodos de medição em INAA foram: seletividade, exatidão (precisão e veracidade), linearidade, faixa de trabalho, seletividade, limite de detecção, limite de quantificação, robustez e incerteza de medição. Os métodos foram validados de acordo com as recomendações do Guia de validação do INMETRO DOQ-CGCRE-008. A estimativa das fontes de incertezas foi realizada de acordo com as recomendações do Guia para a expressão da incerteza de medição (ISO GUM) com o uso do método simulado. / The objective of this study was the validation of four measurement methods by Instrumental Neutron Activation Analysis (INAA) at the Neutron Activation Laboratory (LAN) of IPEN - CNEN/SP. The measurands were: mass fraction of As in biological matrix sample (método-BIO-1), mass fraction of Co, Cr, Fe, Rb, Sc, Se and Zn in biological matrix sample (método-BIO-2), mass fraction of As and Sb in geological matrix sample (método-GEO-1) and mass fraction of Co, Cr, Fe, Sc and Zn in geological matrix sample (método-GEO-2). First, a univariate method optimization was performed to investigate the influence of the the preparation of synthetic standard (monoelemental standard and/or multielemental standard) and standard measurement times. In a second step, a multivariate method optimization was carried to verify the influence of sample measurement time, sample decay time and sample distance to detector by means of a 23 full factorial design (DOE). Investigated method performance characteristics were: selectivity, accuracy (trueness and precision), linearity, work range, selectivity, limit of detection, limit of quantification, robustness and measurement uncertainty. The methods were validated according to recommendations of INMETRO DOQ-CGCRE-008 Validation Guide. The estimate of uncertainty sources was carried out according to recommendations of Guide to the expression of uncertainty in measurement (ISO GUM) using the simulated method.

Este trabalho de mestrado teve como objetivo realizar a validação formal para quatro métodos de medição do Laboratório de Ativação Neutrônica (LAN) do IPEN - CNEN/SP por Análise por Ativação com Nêutrons Instrumental (INAA). Os mensurandos foram a concentração total de As em tecido de mexilhão (método-BIO-1), a concentração total de Co, Cr, Fe, Rb, Sc, Se e Zn em tecido de mexilhão (método-BIO-2), a concentração total de As e Sb em sedimento marinho (método-GEO-1) e a concentração total Co, Cr, Fe, Sc e Zn em sedimento marinho (método-GEO-2). Em um primeiro momento, foi realizado um estudo univariado para investigar a influência causada ao resultado final em diferentes configurações no preparo dos padrões sintéticos e no tempo de medição da atividade do mensurando no padrão sintético. Outras variáveis, como o tempo de medição da atividade do mensurando na amostra, distância entre amostra e detector e tempo de decaimento para medição da amostra foram estudadas em um processo multivariado, por meio da realização de um Planejamento Fatorial 23 completo (DOE). Os parâmetros de desempenho estudados para a validação dos métodos de medição em INAA foram: seletividade, exatidão (precisão e veracidade), linearidade, faixa de trabalho, seletividade, limite de detecção, limite de quantificação, robustez e incerteza de medição. Os métodos foram validados de acordo com as recomendações do Guia de validação do INMETRO DOQ-CGCRE-008. A estimativa das fontes de incertezas foi realizada de acordo com as recomendações do Guia para a expressão da incerteza de medição (ISO GUM) com o uso do método simulado. / The objective of this study was the validation of four measurement methods by Instrumental Neutron Activation Analysis (INAA) at the Neutron Activation Laboratory (LAN) of IPEN - CNEN/SP. The measurands were: mass fraction of As in biological matrix sample (método-BIO-1), mass fraction of Co, Cr, Fe, Rb, Sc, Se and Zn in biological matrix sample (método-BIO-2), mass fraction of As and Sb in geological matrix sample (método-GEO-1) and mass fraction of Co, Cr, Fe, Sc and Zn in geological matrix sample (método-GEO-2). First, a univariate method optimization was performed to investigate the influence of the the preparation of synthetic standard (monoelemental standard and/or multielemental standard) and standard measurement times. In a second step, a multivariate method optimization was carried to verify the influence of sample measurement time, sample decay time and sample distance to detector by means of a 23 full factorial design (DOE). Investigated method performance characteristics were: selectivity, accuracy (trueness and precision), linearity, work range, selectivity, limit of detection, limit of quantification, robustness and measurement uncertainty. The methods were validated according to recommendations of INMETRO DOQ-CGCRE-008 Validation Guide. The estimate of uncertainty sources was carried out according to recommendations of Guide to the expression of uncertainty in measurement (ISO GUM) using the simulated method.

Fatigue is a distressing, complex, and multidimensional sensation, that is common in individuals with chronic obstructive pulmonary disease (COPD), and impacts negatively on their functioning and quality of life. Limited research has been conducted to examine how various factors may influence the different dimensions of subjective fatigue experienced in these individuals. Four dimensions of subjective fatigue including: emotional, behavioural, cognitive, and physical, were examined in a convenience sample of 42 participants with COPD who attended an outpatient pulmonary rehabilitation program. The primary purpose of this feasibility study was to determine the proportion of individuals experiencing the four dimensions of fatigue, and to examine the relationships between these dimensions of fatigue and various influencing factors (dyspnea, depression, anxiety, sleep quality, activity limitation, heart rate, and oxygen saturation). The secondary purpose was to compare the four dimensions of fatigue by sex, supplemental oxygen use, smoking status, and severity of dyspnea, and to examine the relationships between the four dimensions of fatigue and age, the number of co-morbidities, and the amount of pulmonary rehabilitation received. Self-report questionnaires were used to measure fatigue (Multidimensional Fatigue Inventory MFI), anxiety and depression (Hospital Anxiety and Depression Scale HADS), and sleep quality (Pittsburgh Sleep Quality Index PSQI). Pulmonary rehabilitation health records were accessed to collect data on the remaining variables. The majority of the participants (61.9% - 81.0%) experienced moderate levels of subjective fatigue in all four dimensions. Moderate to severe levels of physical fatigue were experienced in 95.3% of the participants. The only significant relationship was between anxiety and emotional fatigue; all other relationships were statistically insignificant. There were no significant differences between sex, supplemental oxygen use, smoking status, and severity of dyspnea on the four dimensions of subjective fatigue. Many of the participants had probable presence of clinical anxiety (42.9%), where the prevalence of anxiety was nearly twice as high as depression (21.4%). Findings from this study can be used by healthcare professionals to gain a better understanding of fatigue in individuals with COPD who attend pulmonary rehabilitation, and help in developing effective interventions for reducing the distressing effects of fatigue.

Fatigue is a distressing, complex, and multidimensional sensation, that is common in individuals with chronic obstructive pulmonary disease (COPD), and impacts negatively on their functioning and quality of life. Limited research has been conducted to examine how various factors may influence the different dimensions of subjective fatigue experienced in these individuals. Four dimensions of subjective fatigue including: emotional, behavioural, cognitive, and physical, were examined in a convenience sample of 42 participants with COPD who attended an outpatient pulmonary rehabilitation program. The primary purpose of this feasibility study was to determine the proportion of individuals experiencing the four dimensions of fatigue, and to examine the relationships between these dimensions of fatigue and various influencing factors (dyspnea, depression, anxiety, sleep quality, activity limitation, heart rate, and oxygen saturation). The secondary purpose was to compare the four dimensions of fatigue by sex, supplemental oxygen use, smoking status, and severity of dyspnea, and to examine the relationships between the four dimensions of fatigue and age, the number of co-morbidities, and the amount of pulmonary rehabilitation received. Self-report questionnaires were used to measure fatigue (Multidimensional Fatigue Inventory MFI), anxiety and depression (Hospital Anxiety and Depression Scale HADS), and sleep quality (Pittsburgh Sleep Quality Index PSQI). Pulmonary rehabilitation health records were accessed to collect data on the remaining variables. The majority of the participants (61.9% - 81.0%) experienced moderate levels of subjective fatigue in all four dimensions. Moderate to severe levels of physical fatigue were experienced in 95.3% of the participants. The only significant relationship was between anxiety and emotional fatigue; all other relationships were statistically insignificant. There were no significant differences between sex, supplemental oxygen use, smoking status, and severity of dyspnea on the four dimensions of subjective fatigue. Many of the participants had probable presence of clinical anxiety (42.9%), where the prevalence of anxiety was nearly twice as high as depression (21.4%). Findings from this study can be used by healthcare professionals to gain a better understanding of fatigue in individuals with COPD who attend pulmonary rehabilitation, and help in developing effective interventions for reducing the distressing effects of fatigue.

One of the challenges of distributed cooperative orthogonal frequency division multiplexing systems is that the multiple carrier frequency offsets (CFOs) simultaneously present at the receiver. According to our knowledge up to now, even the CFOs are known at the receiver, the way to perfectly eliminate the effect of CFOs is still an open problem. This thesis proposes a scheme to mitigate the effect due to multiple CFOs by using the concept of intercarrier interference self-cancellation in transitional OFDM systems, a scheme where the data are simultaneously modulated on symmetric subcarriers between two transmit antennas. Before processing FFT, two values related to CFOs are used to adjust the time-domain signal resulting in better signal-to-interference ratio in even and odd subcarriers respectively. After that, the data are combined by applying maximum ratio combining and then decoded. Simulation results are given to demonstrate the effectiveness of the proposed scheme as compared to previous scheme.

Bibliographische Beschreibung Krupnik, Viktoria Koordination zwischen Atmung und rhythmischen Unterarm-Trackingbewegungen bei unterschiedlichen mentalen Bedingungen der Trackingaufgabe Universität Leipzig, Dissertation 55 Seiten, 49 Lit., 9 Abb., 2 Tab., 1 Artikel Referat: Präzisionsbewegungen kommt eine steigende Rolle im täglichen Leben zu, z.B. bei der Bedienung von Smartphones und Computern. Sie unterliegen, wie alle motorischen Aktionen, der Koordination. Koordination bezeichnet die gegenseitige Beeinflussung des zeitlichen Ablaufs gleichzeitig ablaufender motorischer Prozesse, welche die Verschmelzung zu einem gemeinsamen Rhythmus oder die Einstellung stabiler Frequenz- bzw. Phasenbeziehungen zur Folge hat. Von besonderem Interesse ist die Koordination intendierter Bewegungen mit der stetig ablaufenden Atmung, die die Funktionsziele beider Prozesse beeinträchtigen kann. Wir untersuchten Atmungs-Bewegungs-Koordination (MRC) bei visuell geführten Folgebewegungen des Unterarms unter zwei hauptsächlichen Fragestellungen: a) Beeinträchtigt MRC die Genauigkeit der Folgebewegung? b) Wie beeinflussen erhöhte Genauigkeitsanforderung, Üben und aufgabenbezogene Belastung die Stärke der MRC? Ausgangshypothese war, dass die Folgegenauigkeit durch MRC verschlechtert wird. Außerdem vermuteten wir, dass die Stärke der MRC durch erhöhte Aufmerksamkeit und wiederholtes Üben verstärkt, durch höhere aufgabenspezifische Belastung (höhere Komplexität der Bewegung) dagegen verringert wird. 35 Probanden führten 8 Versuche unter verschiedenen Bedingungen durch: positive (gleichsinnige) Signal- Response-Beziehung (SRR), negative (gegensinnige) SRR als aufgabenbezogene Belastung, strenge (Leistungsanforderung) und weniger strenge (lockere) Instruktion. Die Versuche mit positiver und negativer SRR wurden zur Untersuchung von Übungseffekten je dreimal vorgenommen. Während die Stärke der MRC unter allen Bedingungen gleich blieb, variierte das Phasenkopplungsmuster. Unter positiver SRR und weniger strenger Instruktion wurde eine bestimmte Phasenbeziehung zur Atemperiode bevorzugt. Bei negativer SRR und strenger Instruktion zeigte sich ein engeres Kopplungsmuster mit zwei bevorzugten Phasenbeziehungen zur Atemperiode. MRC verbesserte die Folgegenauigkeit unter allen Versuchsbedingungen mit Ausnahme derjenigen mit lockerer Instruktion. Zur Verbesserung der Folgegenauigkeit trug vor allem ein geringerer Amplitudenfehler bei. Die Ergebnisse zeigen, dass erhöhte Konzentration die Phasenkopplung zwischen Folgebewegungen und Atmung verstärkt und die MRC-bedingte Verbesserung der Folgegenauigkeit weiter steigert.:I. INHALTSVERZEICHNIS Seite I. Inhaltsverzeichnis …………………………………………………………………. 3 II. Abkürzungsverzeichnis …………………………………………………………… 5 1. Einleitung ……………………………………………………………………………. 6 1.1. Einführung in die Thematik: Koordination in der Motorik ………………………… 6 1.1.1. Kennzeichen stabiler Koordination ………………………………………………… 8 1.1.2. Koordination der Atmung mit nichtrhythmischen Bewegungen ………………… 9 1.1.3. Wechselseitigkeit der MRC …………………………………………………………. 9 1.1.4. Worin könnte die biologische Funktion der Atmungs-Bewegungs-Koordination bestehen? ……………………………………………………………………………. 10 1.1.5. Einflüsse auf die Stärke bzw. Stabilität der Atmungs-Bewegungs-Koordination.. 11 1.2. Methodische Betrachtungen: Visuell geführte Folgebewegungen (Tracking-Tests) ……………………………………………………………………… 13 2. Zielstellungen der Arbeit …………………………………………………………. 15 3. Publikation …………………………………………………………………………. 16 4. Zusätzliches Material ………………………………………………………………. 31 4.1. Zusätzliche Probandendaten ………………………………………………………. 31 4.1.1. Charakterisierung der Probanden …………………………………………………. 31 4.1.2. Befindlichkeitsbezogene Auskünfte der Probanden ……………………………… 33 4.1.3. Zusammenfassende Bewertung der zusätzlichen Probandendaten ……………. 34 4.2. Versuchsplanung …………………………………………….……………………….. 34 4.3. Ergänzungen zum Versuchsaufbau ………………………………………………… 35 4.4. Beurteilung der Koordinationsstärke ………………………………………………. 37 4.4.1. Bestimmung des MRC-Grades ……………………………………………………. 37 4.4.2. Analyse der Verteilung der relativen Phase ………………………………………. 39 4.5. Zusätzliche graphische Darstellungen von Ergebnissen ………………………… 39 4.5.1. Verteilung der relativen Phasen ……………………………………………………. 39 4.5.2. Vergleich der Amplitudenabweichungen in koordinierten und nicht- koordinierten Abschnitten …………………………………………………………… 42 5. Zusammenfassung ………………………………………………………………… 44 6. Literaturverzeichnis ......................................................................................... 48 Anhang III. Publikationsverzeichnis …………………………………………………………… 52 IV. Erklärung über die eigenständige Abfassung der Arbeit …………………… 53 V. Beitrag der Autoren zur Publikation ……………………………………………. 54 VI. Danksagung …………………………………………………………………………. 55

Yes / We report an evaluation of the cytotoxicity of a series of electron-deficient (16-electron) half-sandwich precious metal complexes of ruthenium, osmium and iridium ([Os/Ru(η6-pcymene)( 1,2-dicarba-closo-dodecarborane-1,2-dithiolato)] (1/2), [Ir(η5-pentamethylcyclopentadiene)(1,2-dicarba-closo-dodecarborane- 1,2-dithiolato)] (3), [Os/Ru(η6-p-cymene)(benzene-1, 2-dithiolato)] (4/5) and [Ir(η5-pentamethylcyclopentadiene) (benzene-1,2-dithiolato)] (6)) towards RAW 264.7 murine macrophages and MRC-5 fibroblast cells. Complexes 3 and 6 were found to be non-cytotoxic. The anti-inflammatory activity of 1–6 was evaluated in both cell lines after nitric oxide (NO) production and inflammation response induced by bacterial endotoxin lipopolysaccharide (LPS) as the stimulus. All metal complexes were shown to exhibit dose-dependent inhibitory effects on LPS-induced NO production on both cell lines. Remarkably, the two iridium complexes 3 and 6 trigger a full anti-inflammatory response against LPS-induced NO production, which opens up new avenues for the development of non-cytotoxic anti-inflammatory drug candidates with distinct structures and solution chemistry from that of organic drugs, and as such with potential novel mechanisms of action. / We thank the Royal Society (University Research Fellowship No. UF150295 to NPEB), and the University of Bradford for financial support.