京都大学 / 0048 / 新制・課程博士 / 博士(理学) / 甲第20550号 / 理博第4308号 / 新制||理||1618(附属図書館) / 京都大学大学院理学研究科化学専攻 / (主査)教授 竹腰 清乃理, 教授 吉村 一良, 教授 松本 吉泰 / 学位規則第4条第1項該当 / Doctor of Science / Kyoto University / DGAM

Die komplexe Analysen großer Datensätze stellt in der Informationsvisualisierung eine zunehmende Herausforderung dar. Mit Hilfe von Magic Lenses wird die teilweise unübersichtliche Visualisierung dieser Datensätze lokal manipuliert und vereinfacht. Dabei spielen besonders der Umfang an Filterfunktionen und wie sie verändert werden können eine Rolle. Die Vorteile eines Multitouchdisplays im Vergleich zu herkömmlicher Maus- oder Keyboardinteraktion kommen dabei zum Einsatz. Es treten jedoch stetig Probleme bei der Adaption bisheriger Menüdesigns auf. Da Magic Lenses über Menüs parametrisiert werden sollen, stellt sich die Frage welche Menü- und Interaktionsarten besser dazu geeignet sind. In dieser Arbeit wird ein Multitouch-basiertes Kontextmenü für Magic Lenses evaluiert. Es befindet sich direkt am Linsenrand und ist kompakt jedoch neuartig. Es wird die Konkurrenzfähigkeit zu einem speziell für die Studie entworfenen und implementierten klassischen, globalen Menü getestet. Dieses ist für Nutzer vertrauter, aber distanziert sich von der Linse. Die Ergebnisse werden anschließend unter quantitativen und qualitativen Punkten zusammengefasst und ausgewertet. Es zeigt sich, dass klassische Menüs mit Touchinteraktion performanter waren. Das Multitouch-basierte Kontextmenü war allerdings bei den Probanden beliebter und wurde für die Arbeit mit Linsen bevorzugt. / The complex analysis of huge data sets is an increasing challenge in information visualization. With the help of emph{Magic Lenses} the somtimes confusing visualization of those data sets is being locally manipulated and simplified. Especially the amount of filter functions and how they can be altered matter. The advantages of multitouch displays in comparison to conventional mouse and keyboard interaction are used. However, there occur continual problems with the adaption of existing menu designs. Since emph{Magic Lenses} have to be parameterized with those menus the question arises which kind of menu and interaction are more fitting. In this work we evaluate a multitouch based context menu for emph{Magic Lenses}. It is located directly at the lens and compact but new to users. We test its competitiveness to a classical global menu specifically designed and implemented for this study. Users are more familiar with it but it is distanced from the lens. Finally, the results are summarized and analyzed under quantitative and qualitative points. It turns out that classical menus with touch interaction performed best. The multitouch-based context menu though was more popular with probands and was preferred for the work with lenses.

The question of magic in the later middle ages has a rather long tradition in the Bohemian historical milieu in the argument over the manuscripts of Kues. However, it is only one of the very aspects of the subject, and others were until now more or less neglected. Therefore I would like to bring a new fresh perspective and clearly define the field of research into its dynamic complexity. My argument is composed from three integrally interconnected parts. Firstly, I should bring forward the question: What is magic? The exact definition of this word is still not agreed upon despite the grand effort of scholars not only from the last decades. By examination of the word "magic" I have to have as a condition a very good referential background for it. With the second question, I concentrate on diachronic of the historical context and its dynamics of the transfer and contra-transfer of learned magic in Bohemia. At last, I am taking into account the close investigation of the written sources and the overall dynamics of the bigger European picture of the period. The main argument proposed by this thesis, is that the used sources are predating the Kues manuscript and that in the 14th century the unprecedented growth of the artistic faculty of the Prague university, as one of the first, brought into play the...

Cette thèse fait suite à un travail de terrain mené de 2007 à 2010 dans un village d'agriculteurs-pêcheurs du sud-est de l'île de Zanzibar intégré à l'arc swahili. L'histoire du peuplement du village est placée dans la création et la dynamique de la société swahili depuis ses origines dans une perspective afro-centrée, afin d'analyser les raisons et les modes de la conversion des habitants à l'islam. Les populations ont construit dans le temps leur croyance religieuse de manière sélective, ce qui a maintenu le système de représentation et de pensée traditionnel. La recomposition contemporaine dans la communauté est explorée par le biais de l'organisation du village, de sa vie sociale et des traditions bantoues aux côtés de l'islam qui rythme le quotidien. La société, non figée, possède son libre arbitre en préservant une pluralité culturelle (place et rôle des ancêtres, cultes de possession etc.) et en ayant accepté une reconstitution avec des emprunts islamiques qui l'ont enrichie en termes de cohésion sociale et de valeurs morales notamment. Les pratiques magiques et sorcellaires largement détaillées, qui se trouvent au cœur de la démonstration, font apparaître que l'imaginaire collectif est assis sur un socle magique qui continue à expliquer les phénomènes de la maladie, de l'infortune etc. au delà des convictions religieuses musulmanes sincères des habitants. La magie et la sorcellerie, banales dans le quotidien, sont constituées d'une juxtaposition ou d'un assemblage de rituels opéré par une magie opportuniste qui utilise l'islam (manipulations diverses du Coran) pour renforcer les pratiques bantoues quand cela est nécessaire et légitimer des actes peu compatibles avec les principes de la religion. La dynamique de la sorcellerie africaine et islamique se trouve renforcée par de nouvelles données sociologiques (convoitise et jalousie exacerbées, montée des individualismes et perte d'influence des anciens). La thèse suggère, dans une orientation relativiste, que les représentations quotidiennes ancrées dans la matrice africaine bantoue demeurent le mode d'accès à la vérité du monde. Les compromis complexes et multiformes opérés avec l'islam à travers un système de «fertilisation croisée», permettent de maintenir un équilibre social et spirituel et d'affirmer une compatibilité des schémas entre eux dans une communauté qui a refusé de choisir entre deux systèmes de sens. / This thesis follows my field work carried out from 2007 to 2010 in a village located in the south eastern part of Zanzibar Island, part of the Swahili area and peopled by farmers and fishermen. The way the village became populated is related to the creation and the dynamics of the Swahili society in an afro-centred perspective so as to analyse the reasons for and the modes of the population's conversion to Islam. Over the years the peoples have secured their faith in Islam in a selective way, which has kept the traditional system of representation and thinking alive. The contemporary reconstitution within the community is scrutinized through the organisation of the village, its social life and Bantu traditions as well as the Islamic religion pulsing the population's daily life. This society, in constant evolution, keeps its own free will by safeguarding a cultural multiplicity (place and role of the ancestors, cults of possession…) and by accepting Islamic elements to be part and parcel of their community, which has made it both richer and stronger in terms of social cohesion and moral values. The fully-detailed magic and witchcraft practices at the core of the demonstration reveal that the collective imagination is deeply rooted in a magic base which keeps accounting for the phenomena of diseases, ill-fortune and so on, despite the sincere Muslim religious beliefs of the inhabitants. Magic and witchcraft, commonplace in their everyday life, are made up of a juxtaposition or an assembly of rituals initiated by some opportunistic magic which resorts to Islam (diverse manipulations of the Koran) in order to strengthen Bantu practices when necessary and to legitimize acts far from being compliant with religious tenets. The dynamics of African and Islamic witchcraft is being enhanced by new sociological data (a heightened sense of covetousness and jealousy, a steady rise in individualism and the ancestors gradually losing their clout). The present thesis, suggests in a relativist perspective that the daily representations remain firmly anchored in the African Bantu matrix as an access to the truth of the world and that the complex and multifaceted compromises with Islam through some « cross-fertilization » system contribute to maintaining a social and spiritual equilibrium and to advocating some compatibility between the different thinking patterns in a community which has refused to choose between the two of them.

Aujourd'hui, alors que le nombre de marqueurs génétiques disponibles augmente rapidement, de nouvelles populations doivent être créées pour exploiter au mieux cette quantité d'informations dans le but de mieux comprendre l'architecture génétique de caractères complexes. Les populations de type MAGIC ont été créées pour rassembler les avantages des populations bi-parentales et des panels d'associations, la bonne puissance de détection et une localisation précise. L'objectif de cette thèse était d'étudier l'intérêt de la population MAGIC INRA pour l'analyse de l'architecture génétique de la précocité de floraison. Cette population a été créée à partir de 60 parents brassés durant 12 générations de panmixie grâce à l'introduction d'un gène de stérilité mâle (ms1b). Cette étude a été réalisée sur 56 parents toujours disponibles en banque de graines et 380 lignées dérivées de la population après les 12 générations de recombinaison. Cette population a été génotypée avec la puce 9K iSelect, représentant environ 5 000 SNPs localisés sur tout le génome, additionnée de 14 marqueurs localisés dans des gènes candidats. Ce jeu de données moléculaires a été complété par des données fines de phénotypage de la précocité de floraison. Suite aux 12 générations de panmixie, le DL de cette population a été très réduit, à longue comme à moyenne distance (<10cM). Ce faible DL nous a amené à développer un algorithme basé uniquement sur le DL qui ordonne les marqueurs de manière à avoir un DL décroissant monotone avec la distance. L'algorithme ordonne globalement de la même manière que la carte génétique les marqueurs à longue distance mais à courte distance le DL est moins lié à la distance génétique. La différence réside sur l'équilibre entre les effets de la recombinaison et de la dérive génétique sur le DL. L'intérêt de la population MAGIC INRA pour détecter des QTLs a ensuite été étudié avec deux approches : une approche évolutionniste et une approche de génétique d'association. La première approche détecte les loci soumis à sélection par comparaison des fréquences alléliques de la population initiale (G0) et de la population évoluée (G12) grâce à une nouvelle méthode. La population initiale est composée des parents pondérés par une contribution estimée avec une nouvelle méthode bayésienne. 26 régions génomiques soumises à sélection ont été détectées. Une analyse de génétique d'association avec les marqueurs détectés sous sélection a montré que respectivement cinq et trois zones étaient associées à la précocité avec un semis d'automne et au caractère printemps/hiver. Une analyse phénotypique a effectivement mis en évidence la précocification de la date de floraison et une augmentation de la proportion de plantes de type printemps. Une analyse de génétique d'association a ensuite été réalisée sur les lignées SSD sur 12 caractères x environnements i.e. la date d'épiaison et le temps de remplissage du grain mesurés dans six environnements. Les tests d'association ont aussi été réalisés avec des variables synthétisant l'information présente dans plusieurs traits phénotypiques soit avec une ACP, soit avec un modèle écophysiologique. Au total, toutes ces analyses ont détecté six QTLs dont trois correspondants à des gènes majeurs. Parmi ces six QTLs, deux sont spécifiques des caractères mesurés avec un semis d'automne et deux avec ceux mesurés avec un semis de printemps. / Nowadays, with the dramatically increase of available molecular markers, there is a deep need for new populations allowing to exploit all of this information to better understand the genetic architecture of complex traits. MAGIC populations as they are built to bring together bi-parental populations and association panel advantages, provide such powerful detection and fine mapping capacities. The aim of these PhD was to study the MAGIC INRA population usefulness for the study of genetic architecture of earliness. This population is derived from 12 cycles of random crosses between 60 founders, turning wheat from selfing to outcrossing thanks to the use of a nuclear male sterility gene (ms1b, Probus donor). This population is composed of 56 parents still available and 380 SSD lines. Parents and SSD lines were genotyped using the 9K iSelect SNPs array, providing around 5 000 SNPs on the whole genome, as well as 14 addition markers located in candidate genes. They were also finely phenotyped for earliness traits. With the 12 panmictic generations, the population LD decreased strongly, especially at long and medium distance (<10cM). This allowed us to develop an algorithm mapping markers on the sole pairwise LD information, ordering markers in a way to have the LD decreasing along the distance. When considering long distances, overall the results were consistent with the order found on genetic maps while at short distance LD was poorly linked to genetic distance. These differences between long and short distances were linked to the balance between recombination and drift effects on LD. The usefulness of the MAGIC INRA population for QTL detection was analyzed with two approaches: an evolutionary approach and an association genetics approach. The first one detects loci under selection by identifying high shift in allelic frequency with a new method. The initial population was composed of founders weighted by a contribution estimated with a new Bayesian method. 26 genomic areas under selection were detected. An association genetics analysis with the markers detected as under selection showed respectively five and three genomic regions associated with earliness and growth habit. Actually the G12 population was found phenotypically earlier than the G0 and with more spring individuals. A broader association genetics analysis was performed on G12 population, studying 12 traits x environments i.e. heading date and grain filling time, both observed in six environmental conditions. Two additional integrated traits from either PCA or ecophysiological model were also analyzed. In all, these different analyses detected six QTLs, three of them corresponding to candidate genes. Among these six QTLs, two were specific to autumn sowing and two specific to spring sowing.

A radioterapia externa pós-operatória em mulheres diagnosticadas com câncer de mama em estágio inicial é tido como um procedimento padrão, no entanto durante o planejamento para irradiação do volume alvo as possíveis incertezas dosimétricas introduzidas dado o movimento respiratório intrínseco da paciente são desconsideradas. Este estudo avalia não apenas a influência da respiração na distribuição tridimensional da dose, mas como essa distribuição se modifica dado a técnica radioterápica empregada para o tratamento. Três técnicas de planejamento foram analisadas: a radioterapia conformacional tridimensional (3D-RT) com filtros, a radioterapia com intensidade modulada (IMRT) usando planejamento direto e o IMRT inverso. A fim de simular o movimento de contração e expansão da caixa torácica, utilizou-se uma plataforma com amplitudes de oscilação pré-determinadas, sendo a frequência de oscilação provida por uma fonte de tensão variável. Para simular a mama usou-se objetos simuladores semiesféricos preenchidos com gel dosimétrico (MAGIC-f). Os planejamentos para cada técnica foram realizados sobre a mesma tomografia computadorizada (CT) do objeto simulador preenchido com água no modo estático. Foram produzidos três lotes de dosímetro gel para o projeto, cada lote foi irradiado com uma técnica radioterápica diferente, sendo que cada lote inclui cinco objetos simuladores e um conjunto de nove tubos de calibração preenchidos com gel MAGIC-f. O primeiro dos objetos simuladores é utilizado como referência, o segundo é irradiado no modo estático, os demais são irradiados em diferentes amplitudes, respectivamente: 0,34 cm, 0,88 cm e 1,22 cm. A informação volumétrica de dose foi obtida utilizando imagens por ressonância magnética nuclear (IRMN), para cada lote foram adquiridos IRMN com sequência multi spin echo e os mapas de relaxometria, que são associados à dose, foram extraídos em um software desenvolvido e aprimorado pelo nosso grupo de pesquisa. A comparação quantitativa dos mapas de relaxometria dos objetos simuladores em movimento em relação ao modo estático foi realizado pelo índice gamma tridimensional (3% / 3mm / 15% Threshold). Para o 3D-RT a porcentagem de pontos aprovados do objeto estático em relação ao oscilante na amplitude de 0,34 cm foi de 96,44%, para amplitude de 0,88 cm foi de 93,23% e para amplitude de 1,22 cm foi de 91,65%. Para o IMRT direto a porcentagem de pontos aprovados do objeto estático em relação ao oscilante na amplitude de 0,34 cm foi de 98,42%, para amplitude de 0,88 cm foi de 95,66% e para amplitude de 1,22 cm foi de 94,31%. Para o IMRT inverso a porcentagem de pontos aprovados do objeto estático em relação ao oscilante na amplitude de 0,34 cm foi de 94,49%, para amplitude de 0,88 cm foi de 93,51% e para amplitude de 1,22 cm foi de 86,62%. A partir dos resultados, infere-se que a movimentação respiratória de baixa amplitude, para tratamentos de câncer de mama, não é um fator preocupante para a rotina clínica, porém o aumento da amplitude da oscilação aumenta a inomogeneidade de dose e pode afetar os parâmetros dosimétricos da cobertura do volume alvo em relação ao planejamento do tratamento. Observou-se em conjunto que a distribuição de dose se modifica claramente com a técnica em uso e no caso do IMRT inverso para amplitude de oscilação de 1,22 cm a aprovação no índice gamma foi menor que 90% / External postoperative radiotherapy in women diagnosed with early stage breast cancer is considered as a standard procedure, however during planning for target volume irradiation as possible dosimetric uncertainties reabsorption of the patient\'s intrinsic respiratory movement are disregarded. This study evaluates not only the influence of respiration on the three-dimensional distribution of the dose but how this distribution is modified due to the radiotherapy technique used for treatment. Three planning techniques were analyzed: three-dimensional conformational radiotherapy (3D-RT) with filters, intensity-modulated radiotherapy (IMRT) using direct planning and inverse IMRT. In order to simulate the movement of contraction and expansion of the chest wall, a platform with predetermined oscillation amplitudes was used, the oscillation frequency was provided by a variable voltage source. To simulate the breast, semi-spherical simulator objects filled with dosimetric gel (MAGIC-f) were used. The plannnings for each technique were performed on the computerized tomography (CT) of the simulator object filled with water in static mode. Three batches of gel dosimeters were prepared for the project, each batch was irradiated with a different radiothermic technique and comprised five simulator objects and a set of nine calibration tubes filled with MAGIC-f gel. The first simulator objects is used as reference, the second is irradiated in the static mode, the others are irradiated using different amplitudes, respectively: 0,34 cm, 0,88 cm and 1,22 cm. Volumetric dose information was obtained using Nuclear Magnetic Resonance Imaging, each batch was scanned with a multi spin echo sequence and the dose-related relaxometry maps were extracted in a software developed and improved by our Group of research. The quantitative comparison of the relaxometry maps of the moving simulator objects with respect to the static mode was performed by the three-dimensional gamma index (3% / 3mm / 15% threshold). For the 3D-RT, the percentage of approved points of the static object with respect to the oscillator in the amplitude of 0.34 cm was 96.44%, for amplitude of 0.88 cm was 93.23% and for amplitude of 1.22 cm was 91.65%. For the direct IMRT the percentage of approved points of the static object in relation to the oscillator in the amplitude of 0.34 cm was 98.42%, for amplitude of 0.88 cm was 95.66% and for amplitude of 1.22 cm was 94.31%. For the inverse IMRT, the percentage of approved points of the static object in relation to the oscillator in the amplitude of 0.34 cm was 94.49%, for amplitude of 0.88 cm was 93.51% and for amplitude of 1.22 cm was 86.62%. From the results, it is inferred that a low-amplitude respiratory movement, for breast cancer treatments, is not a worrying factor for clinical routine, however, increasing the amplitude of the oscillation increases the inomogeneity of the dose and this affects the dosimetry parameters of the target volume coverage. It was observed that the dose distribution changes with the technique in use and in the case of the inverse IMRT for amplitude of oscillation of 1.22 cm, less than 90% of points were approved in the gamma index evaluation

A radiocirugia estereotáxica é uma técnica que fornece altas doses de radiação utilizando campos pequenos para conformação da dose no volume alvo do tratamento. Devido à complexidade desta técnica torna-se necessária a verificação da distribuição de dose no volume de tratamento. Neste trabalho, as distribuições tridimensionais (3D) de doses de casos clínicos de neoplasias cranianas foram estudadas utilizando-se um objeto simulador de cabeça. A reconstrução das distribuições de doses nos volumes alvo e nas regiões adjacentes a estes foram avaliadas com o código de simulação PENELOPE, o dosímetro MAGIC-f gel e com o sistema de planejamento iPlan. Filmes radiocrômicos também foram empregados para a determinação das distribuições de dose em planos do tratamento. As respostas obtidas com as ferramentas dosimétricas utilizadas foram analisadas através de distribuições de índices gama, comparando-se os mapas centrais das distribuições de dose obtidas com as quatro ferramentas dosimétricas utilizadas. Usando-se critérios de tolerância de 3% e 3mm, a análise realizada na região da prescrição de dose (isodoses de 95%) mostrou-se equivalente para todas as ferramentas dosimétricas utilizadas; resultado diferente foi observado para isodoses menores, com uma equivalência máxima de 76,5%. As distribuições volumétricas, obtidas através do PENELOPE, MAGIC-f gel e o iPlan, foram comparadas, ainda, através dos histogramas dose-volume, para cada caso estudado, mostrando que 95% da dose absorvida relativa encontra-se dentro do volume alvo para todos os planos estudados. A probabilidade de controle tumoral, TCP, foi avaliada para os casos de radiocirurgia estudados, a partir das distribuições volumétricas de dose, resultando em uma probabilidade de controle tumoral máxima de 72%, para todos os casos, conforme o modelo matemático de TCP utilizado. Das comparações realizadas pode-se inferir que o dosímetro MAGIC-f gel e o código de simulação PENELOPE-Monte Carlo podem ser utilizados para determinar as distribuições de dose em 3D para a técnica de radiocirurgia estereotáxica. Essas ferramentas dosimétricas podem, dessa forma, auxiliar no comissionamento de unidades de terapia e em verificações 3D de doses do tratamento dos pacientes, permitindo avaliações dentro e ao redor do volume alvo e podendo se tornar ferramentais de rotina nos serviços de radioterapia. / Stereotactic radiosurgery is a technique which delivers high radiation doses using small fields to conform the absorbed dose into the target volume. Due to the complexity of this technique it is necessary to verify the dose distribution in the treatment volume. Thus, in this study the three-dimensional (3D) dose distributions of selected clinical cases of cranial tumors were obtained using a head phantom. The the dose distributions of target volumes and adjacent regions were evaluated with PENELOPE Monte Carlo simulation code, MAGIC-f dosimeter and iPlan® treatment planning system. Radiochromic films were also used to determine the dose distribution on selected plans of the treatment. The obtained results for the proposed dosimetric tools were analyzed by the gamma index distributions, comparing the maps of the central dose distributions obtained with the four dosimetric tools. Using the dose criteria of 3% in 3 mm, the gamma index test showed equivalence in the region of dose prescription (95% isodose) and a different result was observed for lower isodoses, with maximum accordance of 76.5%. The volumetric dose distributions obtained with PENELOPE, MAGIC-f and iPlan were also compared using the dose-volume histograms for each studied case, showing that 95% of the absorbed dose yield within the target volume. The tumor control probability, TCP, was evaluated for the studied radiosurgery cases, from the dose distributions-volumetric, resulting in a maximum probability of tumor control of 72% for all cases, for the used mathematical model of TCP. From the results it can be inferred that the MAGIC-f gel dosimeter and the PENELOPE Monte Carlo simulation code can be used to determine 3D dose distributions for stereotactic radiosurgery. These dosimetric tools can assist the commissioning of treatment units and 3D dose verifications of patients treatments, allowing assessments in and around the target volume and may become routine in radiotherapy services.

Drei Botenteilchen koennen benutzt werden, um Informationen ueber Quellen der Kosmischer Strahlung zu erhalten: Photonen, geladene Teilchen und Neutrinos. In dieser Arbeit wird anhand von Beobachtungsdaten und theoretischen Modellen der Zusammenhang zwischen extrem hochenergetischer Gammastrahlung und Neutrinos untersucht. Um die Wahrscheinlichkeit fuer die Entdeckung einer Neutrino-Punktquelle zu erhoehen, wurden neue Ansaetze entwickelt. Zum einen wurde fuer 7 Objekte eine Suche nach Zeit- und Richtungskorrelationen zwischen Neutrinoereignissen, registriert vom AMANDA-II Teleskop am Suedpol, und den von IACT-Teleskopen im Zeitraum 2004-2006 beobachteten Gammastrahlungsausbruechen durchgefuehrt. Zum anderen wurde das selbe AMANDA-II Datensatz analysiert, unter Verwendung eines neuen Algorithmus zur Suche nach Strukturen in der zeitlichen Verteilung von Neutrino-Ereignissen aus einer vordefinierten Richtungen. Keine der Analysen fuehrte zur Entdeckung einer Neutrino-Punktquelle. Die zeitlich lueckenhafte Aufzeichnung von TeV Gammastrahlungs Daten, stellt eine der schwerwiegendste Einschraenkung bei Korrelationsstudien dar. Dieses Problem wurde in der vorliegenden Arbeit durch die Analyse historischer IACT Daten und neuer Ergebnisse des MAGIC AGN Beobachtungsprogramms beruecksichtigt. Anhand dieser Daten konnte eine statistische Analyse der verschiedenen Emissionszustaende zweier extragalaktischer Gammastrahlungsquellen durchgefuehrt werden. Aufgrund einer zu geringen Statistik der Messungen konnten jedoch keine endgueltigen Schluesse ueber die Wahrscheinlichkeit, diese Quellen in einem Emmisionszustand oberhalb eines gewissen Schwellenwertes anzufinden, gezogen werden. Fuer die zwei Quellen, Mrk501 und 1ES1959+650, werden hier die Ergebnisse des MAGIC AGN Beobachtungsprogramms von 2007 bis 2008 vorgestellt. Beide Quellen wurden in einem aehnlich niedrigen Zustand vorgefunden und wiesen maessige Variabilitaet und keine auffaelligen Ausbrueche auf. / Three messengers can be used to extract information about the sources of cosmic rays: photons, charged particles and neutrinos. In this work the connection between the TeV gamma-rays and neutrinos is investigated in the context of recent observations and theoretical models. In order to increase the probability of detecting a neutrino point source two new approaches were developed. First, a correlation study of possible time and directional coincidences of neutrino events, detected by the AMANDA-II telescope at the South Pole, and gamma-ray flares, observed by the Imaging Atmospheric Cherenkov Telescopes in the years 2004-2006, was performed for 7 objects. Secondly, the same AMANDA-II data set was analyzed using a new algorithm which looks for structures in the time distribution of the neutrino events from pre-defined directions. None of the analysis resulted in a detection of a neutrino point source. The sparse time and flux state coverage of the TeV gamma-ray data is one of the most serious issues connected with any correlation study involving photons from the high energy range. This problem was addressed in this work by an analysis of historical gamma-ray data and of the recently obtained results from the MAGIC AGN monitoring program. Based on this data a statistical analysis of different emission states of two extragalactic TeV gamma-ray sources, was performed. Due to still low flux statistics, no final conclusions concerning the probability of finding those sources in a flux state above a certain threshold can be made. The results of the MAGIC AGN monitoring program from the observational season 2007/2008 are presented here, for two sources: Mrk501 and 1ES1959+650. Both sources were found in a similarly low state and show moderate variability with no prominent flares. Since a part of the 2008 monitoring data of Mrk501 was collected during a multiwavelength campaign a modeling of its broad-band Spectral Energy Distribution is also discussed.

Die hier vorgestellte Analyse nutzt die MAGIC Teleskope, zwei abbildende Cherenkov-Teleskope, zum Vermessen des Elektronenflusses. Der Energiebereich dieser Teleskope überschneidet sich großflächig sowohl mit dem der Satellitenmissionen Fermi-LAT und AMS-02 als auch mit den hochenergetischen Messungen der Cherenkov-Teleskope VERITAS und H.E.S.S.. Diese Arbeit hat das Elektronenspektrum im Bereich von 135 GeV bis 4 TeV mittels der MAGIC Teleskope vermesssen. Das Spektrum lässt sich in diesem Bereich mit einem einfachen Potenzgesetz mit dem Index -3.14+-0.05(stat)+-0.5(syst) beschrieben werden. Die für diese Messung entwickelte Analyse weicht grundlegend von der Standardanalyse in MAGIC ab. Die Differenzierung von Signal und Untergrund kann nicht anhand der Richtung der eintreffenden Teilchen vorgenommen werden. Stattdessen basiert die Differenzierung auf einem Algorithmus für maschinelles Lernen, welcher eine Unterscheidung zwischen elektromagnetischen und hadronischen Luftschauern ermöglicht. Der Untergrund muss für diese Analyse anhand von Monte Carlo Simulationen geschätzt werden. Dafür wurden Protonen simuliert. Zudem liegt ein Schwerpunkt der Arbeit auf der Abschätzung systematischer Fehler und Unsicherheiten der neuen Analyse. Erwartungsgemäß sind die Unsicherheiten dieser indirekten Messmethode deutlich größer als bei direkten Messungen der Satellitenexperimente. Aufgrund der großen Unsicherheiten kann ein Bruch bei 800 GeV jedoch auch nicht ausgeschlossen werden. Die hier präsentierte Messung stimmt innerhalb der Fehler mit den Ergebnissen von AMS-02 und Fermi-LAT sowie innerhalb von zwei Standardabweichungen mit den Messungen von H.E.S.S. und VERITAS überein. Eine Interpretation des Elektronenflusses gestaltet sich aufgrund des großen Fehlers als schwierig. Im Endeffekt kann keine der potentiellen neuen Quellen kosmischer Elektronen ausgeschlossen werden. / The measurement presented in this thesis seeks to provide an increased overlap of the Fermi-LAT and AMS-02 measurement, as well as the very-high-energy H.E.S.S. and VERITAS measurement. The MAGIC telescopes, a stereoscopic system of imaging air-shower Cherenkov telescopes, are a good candidate for such a measurement. They overlap largely with the Fermi-LAT energy range, down to 130 GeV, and extend into the energy range of the H.E.S.S. system, extending the measurement up to 4 TeV. The measurement performed in this thesis uses a non-standard method developed especially for this analysis. It is based on a machine-learning-algorithm which differentiates between hadronic and electro-magnetic air showers. The background needs to be simulated from Monte Carlo protons, which were produced in large quantities for this thesis. As this is an indirect detection method, the systematic uncertainties are much larger than those of the satellite missions. A detailed study of the systematic uncertainties was performed in the scope of this thesis, which prove to be much larger than the statistical uncertainties. The measured spectrum presented here extends from 135 GeV up to 4 TeV. It shows no clear break in the spectrum and is in line with an extension of the single power-law observed by Fermi-LAT and AMS-02. A broken power-law interpretation was disfavored when compared to the single power-law. The final spectrum has a powerlaw index of -3.14+-0.05(stat)+-0.5(syst). Due to the large uncertainties no definitive conclusion can be given at this point. Also, the cutoff seen by H.E.S.S. can not be ruled out. The result presented in this thesis is compatible with the Fermi-LAT and AMS-02 results, however there is minor tension with the H.E.S.S. and VERITAS results around 4 TeV. The limiting factor of the method is the large systematic uncertainty, making it impossible to distinguish between different electron sources for the results presented in this thesis.

Die Kerne aktiver Galaxien (AGNs) und einige galaktische Objekte wie z.B. Supernovaüberreste gelten als vielversprechende Kandidaten für die Quellen der hochenergetischen kosmischen Strahlung. Der Nachweis der Emission von hochenergetischen Neutrinos von diesen Objekten wäre ein starker Hinweis für die Beschleunigung von Protonen oder schwereren Kernen. Bisher wurde jedoch keine Punktquelle hochenergetischer Neutrinos identifiziert. Durch die Beobachtung aktiver galaktischer Kerne mit gamma-Strahlung im TeV-Bereich ist bekannt, dass die Emission von AGNs zeitlich extrem variabel ist. Modelle sagen vorher, dass auch die Neutrinoemission diese Variabilität aufweist. Um im Falle der Detektion zeitabhängiger Neutrinoemission von AGNs möglichst viel über den Emissionsmechanismus zu lernen, ist es entscheidend, Daten verschiedener Energiebereiche und Botenteilchen (Neutrinos und Photonen) zur Verfügung zu haben. Durch das beschränkte Gesichtsfeld und den geringen Duty-Cycle der TeV-gamma Instrumente, können diese jedoch nicht alle potentiell interessanten Quellen lückenlos überwachen. Diese Arbeit beschreibt die Entwicklung und die ersten Resultate eines Systems, dass Daten des Neutrinoteleskops IceCube direkt am Südpol analysiert, um Alarme an die TeV-Teleskope MAGIC und VERITAS zu senden, falls eine erhöhte Neutrinoemission eines überwachten Objekts detektiert wird. Der Katalog überwachter Objekte, der im ersten Jahr dieses Programms aktiv war, umfasste 109 Objekte in der nördlichen Himmelshemisphäre (delta>0). Das System befindet sich seit März 2012 kontinuierlich Betrieb und hat von Mai 2012 bis Mai 2013 fünf Alarme generiert. Ein Alarm am 9.November 2012 resultierte in einer Folgebeobachtung durch die VERITAS-Teleskope. Es wurde kein signifikanter gamma-Fluss im TeV-Bereich detektiert. Weiterhin werden Verbesserungen der IceCube Online-Analysemethode beschrieben, die die Sensitivität des vorgestellten Programms in naher Zukunft weiter verbessern werden. / Active Galactiv Nuclei (AGN) and galactic objects like e.g. supernova remnants are promising candidates for the sources of the high-energy cosmic rays. The detection of high-energy neutrinos from these objects would be a strong hint for the acceleration of protons or heavier nuclei. No source of high-energy astrophysical neutrinos has been identified up to now. From the observation of AGN with TeV gamma-rays it is known that their emission is highly variable. Models predict that also the neutrino emission should show that variability. If time-dependent neutrino emission would be detected it would be desirable to have simultaneous data for different messengers (neutrinos and photons) and energy ranges, to learn as much as possible about the emission mechanism. However, due to the small field of view and the low duty cycle of the TeV gamma instruments, not all interesting sources can be continuously monitored. This work describes the development and the first results of a system, that analyses data of the IceCube neutrino telescope online at the South Pole, in order to send alerts to the TeV telescopes MAGIC and VERITAS in case a statistically interesting cluster of neutrinos is detected from an monitored source. This program is termed the Neutrino Triggered Target of Opportunity program (NToO). The catalog of sources monitored during the first year of operation contained 109 objects in the northern sky (delta>0). The system has been continuously operated since March 2012 and has sent five alerts between May 2012 and May 2013. One alarm issued on 9 November 2012 resulted in a follow-up observation by the VERITAS telescopes. No significant TeV-gamma flux has been detected. Improvements to the IceCube online analysis are described that will further improve the sensitivity of the NToO in the near future.