Made available in DSpace on 2014-07-29T14:57:47Z (GMT). No. of bitstreams: 1 Dissertacao Valdomeria N de M Morgado 2010.pdf: 793904 bytes, checksum: 6ebfc3ed36711bf080787eaa46eea743 (MD5) Previous issue date: 2010-11-22 / An Information System (IS) has three main aspects: a database that contains data which is processed to generate business information; an application functions which transforms data in information; and business rules which control and restrict data manipulated by the functions. An IS evolves continuously to follow the corporation changes, and the database should be change to attend the new requirements. This dissertation presents a model driven approach to generate and evolve IS databases. A software component, called Especialista em Banco de Dados (EBD), was developed. There are two mapping sets for database generation: from Modelo de Meta Objeto (MMO) (used to representing IS) to Relational Model (RM), and from this to DBMS PostgreSQL SQL dialect. The component EBD is a part of a framework for modeling, building and maintaining enterprise information systems software. This component provides services to other framework components. To validate the proposed approach, Software Engineers had developed IS using the component EBD. The Dissertation main contributions are an approach to support IS database life cycle, a software architecture to generate and evolve IS database schema, an IS data representation model (MMO), a mapping specification to generate schema and stored procedures and the definition of automated operation sets to evolve IS database schema. / Um Sistema de Informação (SI) Corporativo tem três aspectos principais: o banco de dados, que contém dados que são processados para gerar informações do negócio; as funções de aplicação, que transformam dados em informações; e as regras de negócio, que controlam e restringem a manipulação dos dados pelas funções. Um SI precisa evoluir continuamente para acompanhar as mudanças na corporação e, consequentemente, o banco de dados deve ser modificado para atender aos novos requisitos de negócio. Esta dissertação apresenta uma abordagem dirigida por modelos para a automatização do processo de transformação na geração e evolução de bancos de dados de Sistema de Informação. Para isso foi criado um componente de software denominado Especialista em Banco de Dados (EBD). Dois conjuntos de mapeamentos são apresentados para a geração de esquemas, um do modelo conceitual chamado Modelo de Meta Objeto (MMO), utilizado para representação de SI, para o Modelo Relacional; e deste para o dialeto SQL do SGBD PostgreSQL. O componente EBD faz parte de um framework que gera, evolui e gerencia Sistemas de Informação. Este componente fornece também serviços para outros componentes deste framework. Uma experimentação foi feita com engenheiros de software com experiência em desenvolvimento de Sistema de Informação para validar a abordagem proposta. As principais contribuições desta dissertação são: abordagem que apoia ciclo de vida de BD de SI, arquitetura de software que permite a geração e evolução de esquema de SI, especificação de um modelo de representação de dados de SI (MMO), especificação de mapeamentos para geração de esquema e procedimentos de manipulação e definição de um conjunto de operações que automatizam o processo de evolução de esquema de BD de SI.

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A travers le cas des fournisseurs de Marques de Distributeurs (MDD) en agro-alimentaire, cette thèse vise à montrer que la satisfaction du fournisseur peut être expliquée par la proximité entre ce dernier et son distributeur. En adoptant une posture épistémologique positiviste et une démarche hypothético-déductive, nous avons réalisé une revue de littérature qui a permis d’élaborer un modèle conceptuel. Celui-ci postule que la proximité, déclinée en quatre dimensions-proximité relationnelle, proximité identitaire, proximité de processus et proximité géographique, est un antécédent de la confiance et in fine de la satisfaction de cette relation B to B. Afin de tester les hypothèses formulées, nous avons ensuite mené une étude empirique auprès de 93 fournisseurs de MDD de la Grande Distribution Alimentaire. Une première phase de collecte des données s’est déroulée au salon MDDEXPO en avril 2014 et a permis de recueillir 51 questionnaires. La deuxième phase de collecte a été réalisée via le réseau social numérique professionnel VIADEO et a permis de recueillir 42 réponses. Puis, nous avons soumis notre modèle au test avec la méthode PLS sous le logiciel SMARTPLS3. Les résultats de cette recherche montrent que deux dimensions de la proximité permettent d’accroitre directement la satisfaction du fournisseur de MDD de la relation, sans « passer par la confiance du fournisseur de MDD envers son distributeur ». / Through the case of private label supplier in food sector, this thesis aims to show that the satisfaction of private label supplier can be explained by the proximity with his distributor. By adopting a positivist epistemological position and hypothetical-deductive approach, we conducted a literature review that allowed us to develop an integrative model made up of four dimensions: relational proximity, identity proximity, process proximity and geographical proximity. Then realized an empirical study alongside 93 suppliers of private label. A first data collection stage took place in MDDEXPO on April 2014 and has enabled to collect 51 questionnaires. The second phase of collection was done via VIADEO and which came up with 42 responses. Further, we submitted our model to test using PLS method under SMARTPLS3 software. The results of this research show that two dimensions of proximity have direct relationship with increasing private label supplier satisfaction. They are, in the order of importance of structural relations, level of cooperation (relational proximity) and adaptations (process proximity). They also indicate that three dimensions of proximity are used to increase the satisfaction of private label supplier. They are , in order of importance of structural relationships, identity proximity (shared values), social bonds (sub-scale relational proximity) and geographic proximity. Moreover, they show that two sub-dimensions of proximity do not significantly influence the confidence nor the satisfaction of private label supplier to its retailer. It is a question of information exchange (relational proximity) and idiosyncratic assets (process proximity).

We discuss the design and analysis of a code generator for C++, implemented in the Umple model-oriented programming technology. Umple adds UML constructs and patterns to various base programming languages such as Java and PhP. Umple code generators create code for those constructs, which can include UML associations and state machines, as well as patterns such as immutable and singleton. Base language methods are passed through unchanged along with the generated code. Creating a C++ code generator for Umple posed many challenges, all of which are discussed in this thesis: We had to focus on the appropriate C++ idioms and stylistic conventions to follow. We followed a test-driven development process to ensure that the resulting code was correct. To evaluate the work, we compared our C++ generator with those in other tools such as ArgoUML and IBM Rational Software Architect. We conclude that our C++ generator is superior in many ways to these widely used tools because it is more complete and generates better quality code.

Internet se ha convertido por méritos propios en el medio de comunicación por excelencia. La velocidad con la que se puede intercambiar información unida a la eliminación de las barreras geográ?cas y tecnológicas han convertido a Internet en la plataforma preferida para divulgar el conocimiento y hacer negocios. Para llevar a cabo el desarrollo de aplicaciones software en estos entornos, han aparecido numerosas aproximaciones que aplican lo que se conoce como Ingeniería Web. Estas aproximaciones de?nen processos de desarrollo y extensiones conceptuales basadas en modelos, orientadas a la construcción de aplicaciones web. Por otro lado están los principios del Desarrollo Dirigido por Modelos donde se proporcionan marcos conceptuales y entornos que permiten construir processos de desarrollo con generación de código a partir de modelos. Bajo esta perspectiva se enmarca esta tesis, en la que se de?ne OOWS, un entorno de producción de software para la web que aplica los principios que se proponen en la Ingeniería Web y en el Desarrollo Dirigido por Modelos. Este entorno de?ne un proceso de desarrollo en base a unos modelos conceptuales extendidos con características web y una estrategia para obtener automáticamente la aplicación web a partir de estos modelos OOWS. Para dar suporte a esta aproximación se ha construido una herramienta que permite editar y gestionar estos modelos conceptuales web, y que implementa las transformaciones que permiten obtener un prototipo de la aplicación web a partir de estos modelos. / Fons Cors, JJ. (2008). OOWS: un mètode dirigit per models per al desanvolupament d'aplicacions web [Tesis doctoral no publicada]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/1989 / Palancia

Graphene is a two-dimensional carbon based material with unique properties, such as electrical and thermal conductivity. When a textile is coated with graphene, it becomes conductive, while remaining low weight, soft, breathable, flexible, and stretchable. The purpose of this thesis is to investigate what products are suitable to be made with graphene textiles, by using the method Material Driven Design (MDD). Reflections are also made to determine how this method is affected by being applied to a two-dimensional material. To help with this, three kinds of graphene textiles from the company Grafren AB are investigated; conductive textiles, heatable textiles, and textile sensors. The product goal is to develop a portfolio containing 5-8 conceptual products based on these graphene textiles. The process includes conducting an investigation of the technical properties of the material, a user study, and a benchmarking study. This is done to understand the limitations and opportunities of the material, how it is perceived, and what similar materials there are on the market. After that, the material's characteristics are reflected upon to establish a vision for how it should be used in future applications. Then, to follow that vision, a user study is conducted to investigate how people perceive different materials and products, in order to create design guidelines to ensure that the material and product are perceived as intended. Next, concepts are developed according to the previously determined guidelines. To achieve this, idea generating workshops are conducted, where 14 concepts are selected for further development. The portfolio is then created, meant to inspire further usage of the material. It contains the following seven concepts. A heatable textile meant for cooking on camping trips. A fabric containing sensors that can notify when it is damaged. A keyboard made of fabric, for an easy and comfortable use and transportation. A stroller with sensors and heaters, for a more comfortable and safe user experience. A conductive jacket that can electrocute mosquitoes that come in contact with it. Pressure sensors in a carpet that can keep track of the people inside and provide assistance in emergencies. Gloves with sensors in them that can translate sign language live to text or speech. Since MDD heavily focuses on the sensorial qualities and physical characteristics of the material, the method needs to be adapted to become useful when working with such a versatile two-dimensional material. Fortunately, most adaptations can be made fairly easily. The timing of each step should also be considered, to ensure that the vision and guidelines can be made specific enough to be useful.

Background and objectives: Whilst Active and Receptive Music Therapy techniques have been widely researched and are employed within a range of contexts and with diverse client populations, this study reports on their specific qualitative musical and verbal affordances in major depressive disorder and schizophrenia-spectrum psychotic disorders. The study also describes and compares the respective and joint contributions of the music therapy techniques in giving rise to the affordances as well as reporting on the similarities and differences within and between diagnostic groups. This is the first study of its kind within the South African context. Methods: A qualitative research approach using a case study design, sampled purposefully twenty patients of the above mentioned diagnostic groups for participation in this study comprising a course of eight twice weekly music therapy sessions. The primary data sources were transcribed video recordings of therapy sessions and an individual in-depth semi-structured interview after the course of therapy. Clinical session notes served as a corroborative data source. In-depth content and thematic analysis explored and compared qualitative affordances during music therapy comprising active and Receptive Music Therapy techniques. The qualitative affordances under investigation were i) musical qualities, and ii) verbal expressions. Emerging from these affordances were the respective and combined affordances of the music therapy techniques as well as the similarities and differences between the diagnostic groups. Findings: Thirteen themes emerged from the analysis of clients' verbatim verbal responses to both active music making and Receptive Music Therapy techniques. These themes are: i) not to feel; ii) to do or not to do; iii) grappling with the desired future; iv) hurt and fear of undesirable outcomes; v) sadness, brokenness and futility; vi) anger, trust and vulnerability; vii) desire for connection with and affection of others; viii) barricaded from being present, now; ix) tensing and un-tensing; x) personal relating to one’s musical expression; xi) reflections on the music and music making in therapy; xii) resilience and courage and xiii) invigoration and liberation. The Active Music Therapy techniques comprising clinical improvisation, structured musical exercises, drumming, vocal work, songwriting and movement, gave rise to ten themes expressing the musical affordances. The themes that emerged were i) reciprocal responding; ii) the explicit use of symbols through music; iii) regularity; iv) disturbance and difficulty; v) turning points; vi) energy bursting or lacking; vii) bodily synchrony; viii) intensified emotional expression; ix) exploring new territory and Active Music Therapy techniques comprising clinical improvisation, structured musical exercises, drumming, vocal work, songwriting and movement, gave rise to ten themes expressing the musical affordances. The themes that emerged were i) reciprocal responding; ii) the explicit use of symbols through music; iii) regularity; iv) disturbance and difficulty; v) turning points; vi) energy bursting or lacking; vii) bodily synchrony; viii) intensified emotional expression; ix) exploring new territory and x) resolution and arrival. The emerging themes express the extent of musical and verbal expression of all clients representing both diagnostic groups. Most saliently among clients with depression the affordances were the themes on accessing creativity, accessing and articulating internal feelings, experiencing resilient parts of self, reflecting on and integrating symbolic material, motivation to act and extending musical and verbal expression during social interaction. Among clients suffering from schizophrenia spectrum disorder, the most striking affordances were experiences of regularity and flow within disorganization, orientation to ‘here and now’ experiences through active music making and working with symbolic material expressed on a continuum of concrete to abstract. Clients from both diagnostic groups experienced a reduction in unwanted symptoms as expressed through increased energy levels, experiences of pleasure in music making and spontaneous musical and verbal self-expression. Conclusion: This study revealed qualitative affordances of specific music therapy techniques expressed through verbal content and musical qualities. These showed responses within a therapeutic relationship that express inter- and intra-personal connection, give voice to what is not always verbally accessible and facilitate multi-sensory, creative experiences, increased motivation, emotional expression, and the reclamation of energy, spontaneity and resilience. / Thesis (PhD)--University of Pretoria, 2017. / Psychiatry / PhD / Unrestricted

Unternehmen agieren heute in einer hochdynamischen Umwelt, wodurch die Anforderungen an Business Intelligence-Systeme (BI-Systeme) sich stetig verändern. Durch zügiges Reagieren darauf können sich Unternehmen Wettbewerbsvorteile verschaffen. Die dazu notwendige Wandlungsfähigkeit von BI-Systemen setzt voraus, dass bereits die BI-Architektur auf Flexibilität ausgelegt ist. Die Anwendung des Paradigmas der modellgetriebenen Softwareentwicklung auf die Domäne des Data Warehouse Engineerings (DWE) kommt diesem Bedarf nach. Zudem muss neben der Agilität von BI-Systemen auch der Faktor der Korrektheitsprüfung nach vorgenommenen Änderungen betrachtet werden. Es soll untersucht werden, inwieweit sich die im modellgetriebenen DWE anfallenden Metadaten zur Unterstützung und Automatisierung von Softwaretests zur Korrektheitsprüfung nutzen lassen. Die so erzielte Verringerung des Überprüfungsaufwandes führt zu einer verbesserten Wandlungsfähigkeit von BI-Architekturen und kommt somit dem Bedarf von effizienten agilen BI-Lösungen nach.

Genome-wide association studies (GWASs) have reported numerous associations between risk variants and major psychiatric disorders (MPDs) including schizophrenia (SCZ), bipolar disorder (BPD), major depressive disorder (MDD) and others. We reviewed all of the published GWASs, and extracted the genome-wide significant (p<10) and replicated associations between risk SNPs and MPDs. We found the associations of 6 variants located in 6 genes, including L type voltage-gated calcium channel (LTCCs) subunit alpha1 C gene (), that were genome-wide significant ( ) and replicated at single-point level across at least two GWASs. Among them, the associations between MPDs and rs1006737 within are most robust. Thus, as a next step, the expression of the replicated risk genes in human hippocampus was analyzed. We found had significant mRNA expression in human hippocampus in two independent cohorts. Finally, we tried to elucidate the roles of venlafaxine and ω-3 PUFAs in the mRNA expression regulation of the replicated risk genes in hippocampus. We used cDNA chip-based microarray profiling to explore the transcriptome-wide mRNA expression regulation by ω-3 PUFAs (0.72/kg/d) and venlafaxine (0.25/kg/d) treatment in chronic mild stress (CMS) rats. ω-3 PUFAs and venlafaxine treatment elicited significant up-regulation. We concluded that might confer the genetic vulnerability to the shared depressive symptoms across MPDs and CACNA1C might be the therapeutic target for depressive endophenotype as well.

Made available in DSpace on 2016-06-02T19:06:01Z (GMT). No. of bitstreams: 1 4801.pdf: 4117819 bytes, checksum: b4df67024157ee1a2c79256315a97e7d (MD5) Previous issue date: 2012-11-13 / Universidade Federal de Sao Carlos / Software development techniques continually evolve in order to improve development and maintenance processes in addition to lower costs and higher quality. The goal of MDD is to reduce the semantic distance between a problem and its solution specification. Therefore MDD focuses on high-level abstraction modeling and successive model transformations, until finally, generate code. Studies assert that model-driven development can be significantly more efficient than traditional source code-driven software development and still reduce the possibility of occurrence of several problems during the software life-cycle. Likewise, Web engineering can also be benefited by MDD adoption, especially when supported by approaches that facilitate MDD use. Web development is usually agile with frequent releases, these approaches must be flexible to adapt to this context. However, generally, the approaches proposed by the academic community have complex processes which involve many different model definitions, programming languages, plug-ins and IDEs. These features contradict the practices adopted by Web developers. This paper presents the MWDA (Model-Driven Web Applications) approach that provides a simple process to support model-driven web development. This approach does not depend on tools, technologies or plug-ins and encourage combination with other forms of reuse and development processes. Furthermore, the Ruby- MDWA was developed with Ruby language and Ruby on Rails framework support, in order to create Web applications with MDWA assistance. This tool provides a set of textual models and defines M2M and M2C transformation tools, maintaining the requirements traceability since its specification to its construction and further maintenance. In order to show the use of the approach and tool, it was performed a real study case with a software company, from São Carlos SP, where a project management system was developed. In parallel, two experiments were conducted with undergraduate students in Computer Science and Computer Engineering and a Masters in Computer Science, to evaluate the gains and limitations of the Ruby-MDWA tool. / As técnicas de desenvolvimento de software evoluem continuamente com a finalidade de melhorar processos de construção e manutenção de software, além de obter ganhos em tempo, custo e qualidade. O objetivo do MDD é reduzir a distância semântica entre um problema e a especificação de sua solução. Para isso, MDD tem enfoque na modelagem de alto nível de abstração e em sucessivos refinamentos dos modelos construídos em artefatos mais detalhados, até enfim, gerar código. Há afirmações de que o desenvolvimento orientado a modelos pode ser significativamente mais eficiente que o desenvolvimento tradicional guiado por código fonte, além de reduzir a possibilidade de ocorrência de uma série de problemas durante o ciclo de vida do software. Da mesma forma, a engenharia de aplicações Web também pode ser beneficiada pela adoção de MDD, em especial com o apoio de abordagens que facilitem sua utilização. Como o desenvolvimento de aplicações Web comumente é ágil e com publicações freqüentes, essas abordagens devem ser flexíveis para que se adaptem a esse contexto. Entretanto, em geral, as abordagens propostas pela comunidade acadêmica apresentam processos complexos que envolvem diversos modelos, linguagens de programação, plug-ins e ambientes de programação. Essas características contrariam as práticas aprovadas pelos desenvolvedores Web. Esta dissertação apresenta a abordagem MDWA (Model-Driven Web Applications) que fornece um processo simples para desenvolvimento de software Web com apoio de MDD. A abordagem não depende de ferramentas, tecnologias ou plug-ins e estimula a combinação com outras formas de reuso e processos de desenvolvimento. Além disso, foi construída uma ferramenta, denominada Ruby-MDWA, baseada na linguagem Ruby e no framework Ruby on Rails destinada à criação de aplicações Web com auxílio da abordagem MDWA. Essa ferramenta fornece um conjunto de quatro modelos textuais e define transformadores M2M e M2C, que mantém a rastreabilidade de um requisito desde sua especificação até sua construção e posterior manutenção. Para mostrar o uso da abordagem e da ferramenta, foi realizado um estudo de caso real em conjunto com uma empresa de software de São Carlos SP, onde um sistema de gerenciamento de projetos foi desenvolvido. De forma paralela, foram conduzidos dois experimentos com alunos de graduação em Bacharelado em Ciência da Computação e Engenharia de Computação e mestrado em computação da UFSCar, visando avaliar os ganhos e as limitações da ferramenta Ruby-MDWA.