Thesis (Ph. D.)--University of California, San Diego, 1998. / Vita. Includes bibliographical references (leaves 152-154).

Thesis (D.Tech.: Clinical Technology)-Durban Institute of Technology, 2005 xxiv, 235 leaves ; ill. ; 30 cm / Fumonisin B1 (FB1) and ochratoxin A (OTA) represent examples of mycotoxins of greatest public health and agro-economic significance. They ex¬ert adverse effects on humans, animals and crops that result in illnesses and economic losses. Fumonisin B1 are cancer-promoting metabo¬lites of Fusarium proliferatum and F verticillioides, (formerly moniliforme), and are implicated in oesophageal cancer. Ochratoxins are metabolites of both Aspergillus and Penicillium species. These compounds are known for their nephrotoxic effects in all animal species and may promote tumours in humans. In man OTA exhibits unusual toxicokinetics, with a half-life in blood of 840 h (35 days) after oral ingestion. Although much is known regarding the toxicology of these toxins, little is known of the effects of these toxins on the immune system. The aim of this study was to determine and compare the immunomodulating effects of FB1 and OTA in human carcinoma. Initial experiments involved isolating lymphocytes and neutrophils from healthy volunteers. The isolated cells were exposed to either FB1 or OTA on a dose and time dependent level and LD50 of the toxins was determined. Thereafter, challenge tests were performed, whereby lymphocytes and neutrophils isolated from volunteers, oesophageal cancer patients and breast cancer patients were exposed to the LD50 dose of either FB1 or OTA for the appropriate time. The effect of the toxins was demonstrated by viability studies, light microscopy and electron microscopy. Cytokine receptors (CK, TNF and CSF) were evaluated by immuno-cytochemical methods and the levels of circulating cytokines (IL –1, IL-6, IL-8, IL-10 and TNF-) were determined using ELISA kits.

Over the past 60 years, India has undergone immense political, economic, and social changes, which have led to its emergence as a global economic power and regional military power. During this period, the population has surged, growing from 233 million to 1.2 billion people, making India the second most populous nation in the world. In the course of this change, there have been key indicators of medical progress, such as rising life expectancy and a falling infant mortality rate. Another striking indicator, specifically in the area of medical technology, is the fact that India in 2006 was a net exporter of HIV medications to dozens of countries around the globe, earning a reputation as the pharmacist of the developing world. Although many books and papers have been written about the emergence of the country's economy and military, little has been written on how it has been able to achieve its leadership in medical technology. This thesis, 'A History of Medical Technology in Postcolonial India: 1947-1991', is the first major study examining the development of medical technology in India in the period directly following colonial rule. The period covered in this research is crucial because it highlights the evolution and impact of medical technology in postcolonial India, leading up to, but excluding, the free-market reforms enacted by the Indian government in 1991. This thesis will also illustrate the impact diffusion had on the evolution of medical technology. Most importantly, this thesis introduces a new concept appropriate to understanding India's trajectory in this period: the medical technology complex. It will be shown that this complex consists of different groups working toward an aligned objective. It is not the point of this thesis to characterize the medical technology complex in a positive light or a negative one. Its primary concern is to demonstrate through historical evidence that this construct grew throughout the twentieth century and still exists today.

123 f. / Submitted by Ana Valéria de Jesus Moura (anavaleria_131@hotmail.com) on 2013-05-24T19:28:39Z No. of bitstreams: 1 DISSERTAÇÃO - MESTRADO UFBA - RENATA OLIVEIRA DA ROCHA - 201.pdf: 937205 bytes, checksum: fffc66f309529ceb7daf1d7ed0d666de (MD5) / Approved for entry into archive by Ana Valéria de Jesus Moura(anavaleria_131@hotmail.com) on 2013-05-24T19:30:19Z (GMT) No. of bitstreams: 1 DISSERTAÇÃO - MESTRADO UFBA - RENATA OLIVEIRA DA ROCHA - 201.pdf: 937205 bytes, checksum: fffc66f309529ceb7daf1d7ed0d666de (MD5) / Made available in DSpace on 2013-05-24T19:30:19Z (GMT). No. of bitstreams: 1 DISSERTAÇÃO - MESTRADO UFBA - RENATA OLIVEIRA DA ROCHA - 201.pdf: 937205 bytes, checksum: fffc66f309529ceb7daf1d7ed0d666de (MD5) Previous issue date: 2013 / O estudo tem como objetivo fundamental avaliar o compartilhamento democrático do acesso da população aos bens e serviços de saúde resultantes do progresso científico. O direito à saúde na pós-modernidade apresenta dilemas que o Direito, diante da crise paradgmática atual, não consegue responder sem se adequar à nova realidade, aos novos atores e, evidentemente, sem utilizar novas ferramentas. O progresso científico na área médica ao mesmo tempo que pede reflexões a respeito dos limites que devem ser impostos aos experimentos científicos com seres humanos, tendo em vista, especialmente, os perigos ainda desconhecidos dessa prática, evidencia a necessidade de que sejam criados meios para que esse progresso exista tão somente para o bem da humanidade. Contudo, o que se nos depara na realidade é a exclusão dos menos favorecidos, dos “vulnerados”, com relação ao acesso aos benefícios decorrentes das tecnologias médicas avançadas em face, notadamente, dos elevados custos que as acompanham. Diante desses casos, a Bioética constitui a ferramenta legítima e pertinente, em condições de oferecer o arcabouço teórico de critérios de alocação de recursos para a solução do problema, em consonância com a justiça social. O Estado, nesse mister, tem o dever de efetivar políticas públicas, com ampla participação popular, que contemple, no serviço público de saúde, tecnologias médicas avançadas quando indispensáveis para a manutenção da vida e dignidade humana. A judicialização do direito em saúde é um dos reflexos de políticas públicas não efetivadas da forma devida e constitui prática legítima, fazendo a justiça do caso concreto quando diante da negativa de atendimento a ser prestado pelo Estado a situações em que o tratamento é indispensável para a manutenção da vida e dignidade do paciente. / Salvador

Thesis (MTech (Mechanical Engineering))--Cape Peninsula University of Technology, 2013. / This thesis outlines a proposed mechanical design, prototyping and testing of a five fingered artificial hand made of 15 articulated joints actuated by Shape Memory Alloys (SMAs) mimicking muscular functions. SMAs Artificial muscles were incorporated in the forearm and artificial tendons made of nylon wires passing through a hollow palm transmit the pulling force to bend the fingers. Torsion springs set in each joint of the fingers create enough restoring force to straighten the finger when the actuators are disengaged. Nickel-Titanium (NiTi) wires were intrinsically embedded within the hand structure allowing significant movements mimicking human hand-like gestures. A control box made of switches connected to the artificial hand helps to control each gesture. A modular approach was taken in the design to facilitate the manufacture and assembly processes. Nickel-Titanium wires were used as actuators to perform the artificial muscle functions by changing their crystallographic structures due to Joule's heating. Rapid prototyping techniques were employed to manufacture the hand in ABS plastic.

Thesis (MTech (Information Technology))--Cape Peninsula University of Technology, 2016. / Zimbabwe has a fairly developed health-care delivery system that is served by public and private hospitals at district, provincial and national level. The public health-care system is the largest provider of health-care services and caters for the majority of the population but this is done in a resource-restricted context, typical of a developing context. In this context, this research sought to establish the potential of mHealth Technologies in Zimbabwe’s maternal health sector using Parirenyatwa and Harare hospitals as case studies. The reviewed body of knowledge, which was largely a comparative assessment of mHealth technology adoption in developing countries, indicated that the full adoption of the prevailing eHealth strategy in Zimbabwe remains hamstrung by the slow pace of policy implementation. This is a qualitative study and data was collected with unstructured interviews. Purposive and snowball sampling were used to recruit the participants. The gathered data was analyzed through content and thematic analysis. Four broad themes emerged from the primary data collected during the interviews and these include: trends in information dissemination in Zimbabwe’s Public Health System; information needs for expectant women and midwives; the prevalence of ICT use in Zimbabwe’s Public Health System, and mobile technology use in the maternal health sector in Zimbabwe. The research was able to establish that while there is a high proliferation of smartphone use among most expectant women, this has not translated into their use for health information-related purposes.

Orientador: Antonieta Keiko Kakuda Shimo / Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas / Made available in DSpace on 2018-08-05T09:24:00Z (GMT). No. of bitstreams: 1 Ozaki_LuciaMariaTonzarRistori_M.pdf: 1979155 bytes, checksum: 1fc804f15fc5551ca95f43f174e4d1c7 (MD5) Previous issue date: 2005 / Resumo: Trata-se de um estudo descritivo/exploratório com abordagem qualitativa cujo objetivo é descrever o significado da vacina contra a rubéola para mulheres que se descobriram grávidas após receberem a vacina dupla viral, por ocasião da campanha contra rubéola2001, na DIR XX de São João da Boa Vista (DIR XX). Pretende-se, também, analisar a percepção das mulheres relativa às orientações recebidas por ocasião da campanha e durante o acompanhamento pré-natal e como foram apoiadas para enfrentar o processo. O estudo foi realizado nos municípios pertencentes à DIR XX e os sujeitos da pesquisa foram 18 mulheres grávidas e mulheres que engravidaram até 30 dias após aplicação da vacina contra rubéola, consideradas suscetíveis para a rubéola, residentes em 10 municípios da região. Foi utilizado como quadro teórico a teoria das representações sociais, tecnologia em saúde e os aspectos clínicos, epidemiológicos e preventivos da rubéola e da síndrome da rubéola congênita. A coleta de dados foi realizada através de entrevistas semi-estruturas, gravadas. A ordenação dos dados foi realizada através da técnica do Discurso do Sujeito Coletivo proposta por Lefèvre e Lefèvre, emergindo dois temas: I. A mulher. A campanha de vacinação contra a rubéola. O acompanhamento prénatal. II. O significado da vacina contra a rubéola (representada socialmente como ameaça a integridade física da mulher, à de seu filho e ao seu relacionamento conjugal). Os resultados revelaram que o processo de orientação da mulher nas várias fases da atenção foi normatizado, fragmentado, muitas vezes, inadequado e sem qualificação, de modo a não favorecer o "empowerment" e não ajudar a mulher a atravessar com tranqüilidade a situação vivenciada. Observou-se profissionais de saúde despreparados tecnicamente para proverem o cuidado às mulheres, falta de integração entre os serviços, gerando descontinuidade e a não oportunidade da atenção, bem como a não incorporação de toda tecnologia de saúde disponível, no cuidado com a mulher. Constatou-se a importância das redes de apoio social e profissional auxiliando no enfrentamento da situação. As mulheres, através do discurso, desvelaram a situação vivenciada por elas e a diversidade de significados da vacina contra a rubéola quando aplicada durante a gravidez. Constitui-se um grande desafio para gestores e profissionais de saúde a produção do cuidado, ao se disponibilizar procedimentos em saúde. O estudo está inserido na linha de pesquisa - processo de cuidar em saúde e enfermagem, área temática - saúde da mulher / Abstract: This is a descriptive and exploratory research with a qualitative approach, whose objectives are to describe what did the vaccine against rubella mean to women who have found themselves pregnant after having received the measles-rubella vaccine, during the 2001 's campaign against rubella, in the DIR XX from São João da Boa Vista (DIR XX); and to analyze how those women interpreted the orientation given during the campaign and during the antenatal examination, and how were they supported when facing the situation. The research occurred in the municipal districts under the control of DIR XX and the individual were women who were considered to be susceptible to rubella and became pregnant within 30 days after being vaccinated against it. It took part of the study, 18 women who lived in 10 different towns in the region. As the theoretical framework of the study, it was used the theory of social representation, technology in Health, and the clínic, epidemical and preventive aspects of rubella and congenital rubella syndrome. Data was gathered through recording semi-structured interviews, following a guideline script. The data was organized using the technique of the Collective Subject Speech proposed by Lefévre e Lefèvre, which unveiled two topics: I.The woman. The vaccination campaign against rubella. The antenatal care. II. The signification of the rubella vaccine (socially seem as a threat to the woman's physical integrity, as well as to their sons and to their conjugal relationship). The results suggest that the orientation process during the various phases of attention during the occasion has been unsatisfactorily standardized, fragmented, and, in several cases, improper and not qualified, and thus it does not allow the empowerment, and does not help women to experience the situation tranquilly. It can be observed health professionals technically unprepared to fulfill women with proper care; a lack of integration between services, which generates discontinuity and incapability of being properly attended, as well as the incapability to incorporate all technologies available to their care. It has been confirmed the importance of the social and professional networks to help women under this situation. Through their speech, women have unveiled their situation and the various meanings of by being vaccinated during pregnancy. It is a great challenge to supervisors and health professionals to produce care and to make available health procedures. The study is related to research lines - procedures to take care in health and nursing, thematic field - woman's health / Mestrado / Enfermagem e Trabalho / Mestre em Enfermagem

Una de las características que define al mundo en este momento es la movilidad e inmediatez. La aparición disruptiva del Covid-19 no sólo nos forzó a cambiar hábitos de conducta para evitar la propagación del virus; sino también aceleró la transformación digital. Hoy como parte de esta transformación la tecnología se ha convertido en vital e imprescindible para el día a día, desde la forma en como nos comunicamos, como trabajamos, como nos mantenemos informados, y obviamente como cuidamos de nuestra salud y la de los nuestros. El Perú no fue ajeno a esta revolución digital, muchas empresas tuvieron que migrar sus servicios al online para subsistir, y bajo aplicativos y/o páginas web transformaron al usuario tradicional en digital. En una economía compartida o colaborativa donde el acceder a servicios o búsquedas se realiza gracias a las tecnologías móviles conectadas a Internet. Frente a este nuevo escenario, es que nace esta propuesta de modelo de negocio que apunta a satisfacer dos demandas entorno a la salud, en la población limeña: Atención médica personalizada y Mejora económica. “AppSalud” es una plataforma que proporciona a sus clientes un servicio de intermediación a través de un software de aplicación móvil, que permite al usuario recibir atención médica personalizada en su domicilio o donde lo requiera, bajo procedimientos administrados por profesionales de la salud en enfermería y/o técnicos con experiencia médica; conectando la demanda de atención medica personalizada con la de profesionales de la salud que requieren un ingreso adicional para mejorar su economía. Innovando de esta manera, la prestación de servicios de salud en el Perú con calidad, tiempo, precio y tecnología para un usuario digitalizado. / One of the defining characteristics of the world at this time is mobility and immediacy. The disruptive appearance of Covid-19 not only forced us to change behavior habits to avoid the spread of the virus; it also accelerated the digital transformation. Today, as part of this transformation, technology has become vital and essential for the day to day, from the way we communicate, how we work, how we stay informed, and obviously how we take care of our health and ours. Peru wasn´t stranger to this digital revolution, many companies had to migrate their services to online to survive, and under applications or web pages, they transformed the traditional user into digital. In a shared or collaborative economy where access to services or searches is done thanks to mobile technologies connected to the Internet. Faced with this new stage, this business model proposal was born, that aims to satisfy two demands related to health, in the Lima population: Personalized medical attention and Economic improvement. "AppSalud" is a platform that provides its clients with an intermediation service through mobile application software, which allows the user to receive personalized medical attention at home or wherever required, under procedures administered by health professionals, nurses and / or technicians with medical experience; connecting the demand for personalized medical attention with that of health professionals who require an additional income to improve their economy. Innovating in this way, the provision of health services in Peru with quality, time, price and technology for a digitized user. / Trabajo de investigación

Aus der Einleitung: "Im Tissue Engineering und in der Medizintechnik gewinnt das Rapid Prototyping (RP), das zu den additiven Fertigungsverfahren zählt, zunehmend an Bedeutung (Zhang, et al. 2015) (Li, et al. 2014). Für die Verarbeitung von thermoplastischen Biopolymeren ist das Fused Deposition Modeling (FDM, schematische Darstellung in Abbildung 1) von zentralem Stellenwert. ..."

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