Imagética motora é um processo mental que produz modulações na amplitude dos sinas de eletroencefalogramas em progresso. Os padrões presentes nestas modulações podem ser usados para classificar este processo mental, mas a identificação destes padrões não é uma tarefa trivial, porque eles estão presentes em bandas de frequências que são específicas para cada pessoa. Neste trabalho, apresenta-se um novo método para selecionar as bandas de frequência específicas para cada pessoa baseado na arquitetura do método Filter Bank Common Spatial Pattern. Para selecionar as bandas de frequência mais relevantes para cada pessoa, o método proposto aplica uma busca exaustiva para encontrar o melhor subconjunto de bandas de frequência contendo os padrões mais discriminativos dentro de um espaço de busca restrito a um tamanho fixo para este subconjunto. Esse tamanho é determinado usando validação cruzada e o método Sequential Forward Floating Selection. O método proposto foi avaliado usando a base de dados pública 2b da BCI Competition IV, mostrando melhores resultados do que todos os métodos também avaliados nessa base de dados. / Motor imagery is a mental process that when performed, produces modulations in the amplitude of ongoing electroencephalogram signals. These modulations happen following a series of patterns that can be used to classify this mental process, but the detection of those patterns is not a trivial task, because they occur in frequency bands that are specific for each person. In this work, we present a method to select these subject-specific frequency bands based on the arquitecture of the Filter Bank Common Spatial Pattern approach. To select the most relevant frequency bands for each person, our method uses an exhaustive search to find the best subset of frequency bands containing the most discriminative patterns, but with one restriction, the search space is restricted to find a subset with a fixed number of frequency bands. The number is determined using cross-validation and the Sequential Forward Floating Selection method. We demonstrate that, using the data set 2b of the BCI Competition IV, our method is more accurate than current methods evaluated on the same data set.

Developmental Coordination Disorder (DCD) is characterised by impairments to motor control and learning, the cause of which remains unclear. Recently, researchers have used cognitive neuroscientific approaches to explore the basis of poor coordination in children, with one hypothesis suggesting that an internal modelling deficit (IMD) is one of the underlying causes of DCD. The aim of this thesis was to further test the IMD hypothesis using a motor imagery paradigm - the mental rotation of hands. Versions of this task were used in all studies to assess motor imagery ability, with an additional whole-body task used in Studies 2 and 3. Further, an alphanumeric rotation task was used in Studies 1 and 2 to assess visual imagery ability. Studies 1 and 2 provided varying levels of support for the IMD hypothesis. In Study 1, only a subgroup of DCD children performed differently from other children in the study on the hand tasks, but tighter task constraints in Study 2 led to overall group differences between DCD and controls in terms of accuracy. The DCD group were also significantly less accurate than controls in the whole-body task, but there were no group differences in either Study 1 or 2 on the visual imagery task. Interestingly, in Study 2, there was an indication that children with severe levels of motor impairment were less accurate than children with less severe motor impairment, suggesting that motor impairment level could play a role in the severity of motor imagery deficits. Study 3 was designed to explore the impact of motor impairment severity on motor imagery ability further. The results confirmed that children with severe DCD had greater motor imagery impairment than children with mild DCD - children with severe DCD performed less accurately than both controls and those with mild DCD in the hand task with instructions and the controls in the whole-body task. Further, those children with mild DCD were able to respond somewhat to motor imagery instructions, whereas those with severe DCD were not. This study provided support to the IMD hypothesis, though the deficit was shown to be dependent on a number of factors. Chapter 5 presents a reasoned account of these various findings and their implications are discussed. It is concluded that motor imagery deficits are evident in many children with DCD, but more so in children with severe motor impairment. A general imagery deficit was ruled out based on the findings of Studies 1 and 2 which showed that visual imagery processes appear intact in children with DCD. Taken together with previous imagery and IMD studies, and related research on feedforward control in DCD, it is concluded that the deficits in motor imagery observed in this thesis are consistent with the hypothesis that an IMD is one likely causal factor in the disorder, particularly in more severe DCD. The observation of differing response patterns between children with mild and severe forms of DCD has important implications for developing a theory of DCD and for remediation.

The human brain is unquestionably the most complex organ of the body as it controls and processes its movement and senses. A healthy brain is able to generate responses to the signals it receives, and transmit messages to the body. Some neural disorders can impair the communication between the brain and the body preventing the transmission of these messages. Brain Computer Interfaces (BCIs) are devices that hold immense potential to assist patients with such disorders by analyzing brain signals, translating and classifying various brain responses, and relaying them to external devices and potentially back to the body. Classifying motor imagery brain signals where the signals are obtained based on imagined movement of the limbs is a major, yet very challenging, step in developing Brain Computer Interfaces (BCIs). Of primary importance is to use less data and computationally efficient algorithms to support real-time BCI. To this end, in this thesis we explore and develop algorithms that exploit the sparse characteristics of EEGs to classify these signals. Different feature vectors are extracted from EEG trials recorded by electrodes placed on the scalp. In this thesis, features from a small spatial region are approximated by a sparse linear combination of few atoms from a multi-class dictionary constructed from the features of the EEG training signals for each class. This is used to classify the signals based on the pattern of their sparse representation using a minimum-residual decision rule. We first attempt to use all the available electrodes to verify the effectiveness of the proposed methods. To support real time BCI, the electrodes are reduced to those near the sensorimotor cortex which are believed to be crucial for motor preparation and imagination. In a second approach, we try to incorporate the effect of spatial correlation across the neighboring electrodes near the sensorimotor cortex. To this end, instead of considering one feature vector at a time, we use a collection of feature vectors simultaneously to find the joint sparse representation of these vectors. Although we were not able to see much improvement with respect to the first approach, we envision that such improvements could be achieved using more refined models that can be subject of future works. The performance of the proposed approaches is evaluated using different features, including wavelet coefficients, energy of the signals in different frequency sub-bands, and also entropy of the signals. The results obtained from real data demonstrate that the combination of energy and entropy features enable efficient classification of motor imagery EEG trials related to hand and foot movements. This underscores the relevance of the energies and their distribution in different frequency sub-bands for classifying movement-specific EEG patterns in agreement with the existence of different levels within the alpha band. The proposed approach is also shown to outperform the state-of-the-art algorithm that uses feature vectors obtained from energies of multiple spatial projections.

Brain-computer interfaces are an emerging technology that could provide channels for communication and control to severely disabled people suffering from locked-in syndrome. It has been found that motor imagery can be detected and classified from EEG signals. The motivation of the present work was to compare several algorithms for motor imagery classification in EEG signals as well as to test several novel algorithms. The algorithms tested included the popular method of common spatial patterns (CSP) spatial filtering followed by linear discriminant analysis (LDA) classification of log-variance features (CSP+LDA). A second set of algorithms used classification based on concepts from Riemannian geometry. The basic idea of these methods is that sample spatial covariance matrices (SCMs) of EEG epochs belong to the Riemannian manifold of symmetric positive-definite (SPD) matrices and that the tangent space at any SPD matrix on the manifold is a finite-dimensional Euclidean space. Riemannian classification methods tested included minimum distance to Riemannian mean (MDRM), tangent space LDA (TSLDA), and Fisher geodesic filtering followed by MDRM classification (FGDA). The novel algorithms aimed to combine the CSP method with the Riemannian geometry methods. CSP spatial filtering was performed prior to sample SCM calculation and subsequent classification using Riemannian methods. The novel algorithms were found to improve classification accuracy as well as reduce the computational costs of Riemannian classification methods for binary, synchronous classification on BCI competition IV dataset 2a. / Master of Science

It is still controversial whether mental practice – the internal rehearsal of movements to improve later performance – relies on processes engaged during physical motor performance and, if so, which processes these are. This series of experiments investigates this question. It utilizes a framework of ideomotor action planning theories, and tests whether mental practice may specifically draw upon planning- rather than execution-related motor processes, specifically those processes that “bind” intended action features to action plans. Experiments 1 to 4 utilize a classical stimulus response compatibility paradigm. Participants mentally practiced complex rhythms with either feet or hands while using the same or different body parts to respond to unrelated sounds. In contrast to previous work on stimulus response compatibility, we indeed found that responses were impaired – rather than facilitated – for those body parts that were concurrently used in mental practice. This result was found when participants mentally trained to memorize the rhythms (Experiment 1), to merely improve their performance (Experiment 3), when mental practice and execution directly followed one another and when separated by a different task (Experiment 4). These data link mental practice not to execution but planning related motor processes that are involved in binding intended action features to intended action plans. Experiment 5 and 6 then extend these results to imitation learning. Participants were instructed to learn the rhythms by observing somebody else, while again making unrelated responses with their hand and feet. While previous work on stimulus response compatibility focussed on testing automatic imitation processes, here imitation was therefore goal directed. We found, as in the previous experiments, that responses with the same body parts as used in the observed rhythms were impaired, suggesting that goal-directed imitation might rely on the same planning-related motor processes as the mental practice of action (Experiment 5). Importantly, these effects were only found as long as participants observed the actions with VI the purpose of imitating them later (i.e. formed action plans), but not when they merely tried to memorize the rhythms for later recognition (Experiment 6). The previous experiments suggest that mental practice and observation learning draw upon body-part specific planning processes. Ideomotor theories suggest, however, that action plans can be relatively abstract, and represented in terms of higher-level goals (i.e. the sequence of left and right button presses independent of the body part used). Experiment 7 and 8 therefore tested whether rhythms learned through mental practice or observation learning could be transferred to other body parts. As expected, we found a relatively high amount of potential transfer when rhythms were mentally practiced with one body part, and then had to be transferred to another body part (Experiment 7). However, this only held when participants learned the rhythms based on an abstract rhythm description, as in Experiments 1 to 4. If participants learned the same rhythms during action observation, any benefits were only obtained when the rhythms later had to be executed with the same (rather than a different) body part. Together, the present data suggest that mental practice does not rely on execution related-motor processes, and points to an involvement of planning related motor processes instead. We argue that such a planning-based account of mental practice is more compatible with the available evidence from body neuroscientific and behavioral studies, and allows one to resolve several debates. Moreover, it allows one to conceptualize goal-directed imitation in a similar manner as mental practice.

Quel rôle joue la gravité dans les représentations internes de l'action ? Au-delà des contraintes d'équilibre, le vecteur gravitaire influence-t-il l'action de façon globale, jusqu'à la perception des mouvements de nos semblables ? Ces questions ont été celles qui ont guidé mes travaux de thèse. L'originalité de notre approche a été de placer l'exécution et la perception de l'action dans un « continuum fonctionnel » s'articulant autour des représentations internes de l'action. Pour ce faire, l'outil de choix qui est commun aux trois expériences de cette thèse est la microgravité (0G). Les expériences de cette thèse ont montré que les représentations internes de l'action se nourrissaient des informations graviceptives pour se construire et s'adapter constamment. Cependant, dans certaines conditions telle que la 0G à court terme, apparaît un ordre de priorité. En effet, le SNC est capable de mettre en place des solutions immédiates et efficaces pour l'exécution, comme en témoigne la repondération sensorielle rapide qui s'opère en 0G dans une tâche d'orientation posturale. Cependant, un temps de latence est observé dans la recalibration des modèles internes sur la base des afférences sensorielles fortement perturbées. C'est ce que nous avons montré grâce à un protocole d'imagerie motrice, mettant en évidence une perte de l'isochronie entre les mouvements exécutés et imaginés en 0G. Enfin, nous avons mis en évidence, chez des sujets sans expérience aucune de microgravité, que la perception du mouvement humain est efficace même lorsque ce dernier est exécuté en apesanteur, bien que des réseaux cérébraux différents soient mis en jeux. / What is the role of gravity in the internal representations of action? Beyond the constraints of balance, does the gravity vector influence the action globally, up to the perception of our peers' movement? These issues have guided my thesis work. The originality of our approach was to place the execution and the perception of action in a "functional continuum" built around the internal representations of the action. To do this, the tool of choice, that is common to all three experiments presented here, is microgravity (0G). The experiments of this thesis showed that the internal representations of action are fed with graviceptive information to build and adapt constantly. However, under certain conditions such as short-term 0G, an order of priority appears. Indeed, the CNS is able to implement immediate and effective solutions, as we demonstrate it with the fast sensorial reweighting observed during a postural orientation task. However, a lag is observed in the recalibration of internal models based on sensory inputs severely disrupted. This is what we have shown through a protocol of motor imagery, showing a loss of isochrony between executed and imagined movements under 0G. Finally, we have demonstrated in subjects without any experience of microgravity, that the perception of human movement is effective even when it is performed in weightlessness, although different cerebral networks are involved.

Les travaux portant sur l’imagerie motrice (IM) ont montré l’identité des processus de production réelle et de représentation mentale du mouvement. Diverses voies expérimentales incluant la chronométrie mentale, les indices physiologiques (dont ceux issus de la neuroimagerie) ont été utilisées pour montrer que la représentation mentale de l’action repose sur les mêmes mécanismes que la préparation motrice et agirait sur la plasticité cérébrale. Le rôle de l’IM dans l’amélioration et l’apprentissage du mouvement, la récupération motrice après une lésion des effecteurs musculo-articulaires a été démontré chez le sujet sain. L’entraînement mental pourrait donc être intégré dans les protocoles thérapeutiques suite à une lésion centrale ou périphérique. Si plusieurs expériences ont montré son efficacité lorsqu’il est pratiqué après un accident vasculaire cérébral, aucune étude n’a porté sur son rôle dans la réadaptation fonctionnelle du patient médullo-lésé. L’hypothèse est que l’entraînement par IM associé à la rééducation classique peut facilement être intégrer dans les protocoles de réadaptation de ces patients et favoriserait la récupération et l’amélioration de la préhension chez les patients tétraplégiques / The mental representation of movement may help motor functions recovery after central or peripheral stroke. There is now ample evidence that motor performance and learning ma benefit from mental rehearsal in healthy subjects. However, whether the ability to perform motor imagery is preserved after spinal cord injury, the effectiveness of mental rehearsal on prehension rehabilitation has to be questioned. The review of relevant literature about motor imagery and rehabilitation show that integrating mental practice into the rehabilitation process may be a reliable tool. Traditional stroke rehabilitation therapies are usually based upon actual movement aimed at improving motor functions. However, this may be limited by muscle spasticity, muscle weakness, or persistent deficit in movement coordination. As motor imagery and actual movement share the same neural substrate, mental rehearsal may serve motor rehabilitation by involving cerebral plasticity and thus facilitating recovery. More specifically, it will be useful to elaborate guideline of mental practice in rehabilitation. Additional clinical issues, including brain mapping studies, need to be performed

Denna studie undersökte motorisk planering hos vuxna (20-27 år) och barn i nio till tio års ålder samt dess associationer med Motor Imagery (MI), den interna representationen av en handling. Detta genom att undersöka skillnader hos barn och vuxnas förmåga att planera motoriska handlingar i form av MI och end-state comfort effekter (ESC). ESC, ett begrepp kopplat till MI, innebär en prioritering av greppbekvämlighet i slutskedet av en handling istället för i början. För att undersöka MI togs responstider, tiden det tog att avge ett svar efter stimuli presenterats, ut från den mentala rotationsuppgiften Hand Laterality Judgement Task (HLJ). För att undersöka motorisk planering fick deltagarna utföra målinriktade förflyttningar av en pinne (semicirkulära pinntestet, SPT), ett test vilket inkluderar MI och ESC. I SPT manipuleras planeringsbehovet experimentellt då greppformationskraven varieras mellan försöken. Tiden från försökets början till initiering av handledsrörelse togs ut som ett mått på planering. Vidare undersöktes motorisk planering hos vuxna och barn samt dess associationer med exekutiva funktioner (inhibering, skiftning, planering och arbetsminne). I studien deltog 15 personer, varav sju stycken barn. En experimentell design tillämpades där tester av exekutiva funktioner, SPT, HLJ och en visuell mental rotationsuppgift utfördes. Resultaten fann att barn i nio till tio års ålder skiljde sig från vuxna gällande att barnen hade längre latenstid på SPT, responstid på HLJ samt lägre responsprecision på bägge test. Ytterligare en skillnad var att de vuxna uppvisade en association mellan MI och exekutiva funktionerna, vilket inte återfanns hos barnen. / This study examined motor planning in adults (20-27 years) and children nine to ten years old and its associations with motor imagery (MI), the internal representation of an action. This by examining differences in children and adults' ability to plan motor actions in the form of MI and End-state comfort effects (ESC). ESC, a concept linked to MI, involves a prioritization of grip comfort in the end of an action instead of the beginning. To examine MI, response times, the time it took to respond after stimuli were presented, were taken out from the mental rotation task Hand Laterality Judgement Task (HLJ). To examine motor planning participants performed a peg movement task (Semi-Circular Peg task, SPT) that included aspects of MI and ESC. In the SPT, the need for planning is experimentally manipulated as grip formation demands varies across trials. The time from trial onset to wrist movement initation was extracted as a measure of planning. Furthermore motor planning was examined in adults and children and its associations with executive functions (inhibition, shifting, planning and working memory). In the study 15 people participated, of which seven were children. An experimental design was applied in which tests of executive functions, SPT, HLJ and a visual mental rotation task were performed. The results found that children aged nine to ten differed from adults in that the children had longer latency time on SPT, response time on HLJ and a lower response precision on both tests. Another difference was that the adults showed an association between MI and executive functions which was not found for in the children.

L’objectif de ce travail de thèse était d’évaluer les bénéfices thérapeutiques d’un entraînement par imagerie motrice chez les patients ayant subi une prothèse totale de genou unilatérale. Combiner l’imagerie motrice avec la physiothérapie classique a permis de diminuer la douleur et d’augmenter la force du quadriceps durant la phase aiguë, au 1er mois postopératoire. Durant la phase chronique, au 6ème mois postopératoire, l’imagerie motrice permettrait de corriger l’asymétrie de la marche, d’une part en augmentant la force du quadriceps ipsilatéral et, par conséquent, en accentuant la charge sur le genou opéré, et d’autre part en augmentant la flexion maximale du genou durant la phase oscillante. L’imagerie motrice pourrait également aider les personnes âgées après la prothèse totale du genou à monter les escaliers plus rapidement, en toute sécurité. Cela peut atténuer le risque de chute dans les escaliers et, par conséquent, diminuer la fréquence des blessures graves. En conclusion, intégrer l’imagerie motrice dans les programmes de rééducation après prothèse totale du genou primaire unilatérale est pertinent et prometteur / The primary aim of the present work was to determine the therapeutic benefits of a specific motor imagery training. Combining motor imagery with classical physical therapy was found to be effective in reducing pain and increasing quadriceps strength after total knee arthroplasty during the acute phase at the first month postoperatively. During the chronic phase, at the 6th month postoperatively, motor imagery might contribute to correct the asymmetry of gait by increasing the strength of the ipsilateral quadriceps and, consequently accentuating the weight loading on the operated knee, as well as by improving knee proprioception through an increase in the maximum knee flexion during the swing phase. MI might also help elderly people after total knee arthroplasty to climb stairs more quickly, easily, and safely. This could attenuate the risk of falls on stairs, and consequently decrease the frequency of major injuries. In summary, the integration of motor imagery in clinical rehabilitation programs after primary unilateral total knee arthroplasty is relevant and promising

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