Evaluation of crash count data as a function of roadway characteristics allows Departments of Transportation to predict expected average crash risks in order to assist in identifying segments that could benefit from various treatments. Currently, the evaluation is performed using negative binomial regression, as a function of average annual daily traffic (AADT) and other variables. For this thesis, a crash study was carried out for the interstate, primary and secondary routes, in the Salem District of Virginia. The data used in the study included the following information obtained from Virginia Department of Transportation (VDOT) records: 2010 to 2012 crash data, 2010 to 2012 AADT, and horizontal radius of curvature (CV). Additionally, tire-pavement friction or skid resistance was measured using a continuous friction measurement, fixed-slip device called a Grip Tester. In keeping with the current practice, negative binomial regression was used to relate the crash data to the AADT, skid resistance and CV. To determine which of the variables to include in the final models, the Akaike Information Criterion (AIC) and Log-Likelihood Ratio Tests were performed. By mathematically combining the information acquired from the negative binomial regression models and the information contained in the crash counts, the parameters of each network's true average crash risks were empirically estimated using the Empirical Bayes (EB) approach. The new estimated average crash risks were then used to rank segments according to their empirically estimated crash risk and to prioritize segments according to their expected crash reduction if a friction treatment were applied. / Master of Science

Wearable and mobile devices are an important part of our daily life. Most of those devices are powered by batteries. The limited life span of batteries constitutes a limitation, especially in a multiple-day expedition, where electrical power can not access conveniently. At the same time, there is a huge amount of energy stored in the human body. While walking, there is a large amount of power dissipated in the human body as negative muscle work and the energy loss by impact. By sourcing locally and using locally, human body energy harvesting is a promising solution. This dissertation focuses on harvesting energy from the human body to power wearable and mobile devices while poses a minimum burden on the human body. Three topics related to the human body energy harvesting are explored, i.e, energy harvesting backpack, negative muscle work harvester, and energy harvesting tile/paver. The energy harvesting backpack was invented in 2006. Extensive work was done to improve the performance of backpack energy harvester. The backpack is modeled as a spring-mass-damper system. Mechanical Motion Rectifier was added to the spring-mass-damper system to increase the frequency bandwidth. A spring is added to the spring-mass-damper system, between the harvester and the backpack mass, and a inerter-based 2DOF (degree-of-freedom) backpack is created. The inerter-based 2DOF backpack improves the power output, frequency bandwidth, and power stroke ratio performance. MMR was added to the inerter-based 2DOF backpack to reduce the peak stroke. Compared with the conventional spring-mass-damper backpack, the MMR and inerter-based 2DOF backpack can harvest more power with large bandwidth at a small sacrifice of stroke. The electric damping was also tuned to increase the power output and bandwidth for the energy harvesting backpack. The negative work harvester mounts on the human ankle and harvests energy in the terminal stance phase in human walking, when the calf muscle is doing negative muscle work. This harvester is an analogy to regenerative brake in vehicles. The energy harvesting paver/tile harvests energy when the heel contacts with ground and energy are dissipated by impact. / Doctor of Philosophy / Wearable and mobile devices are an important part of our daily life. Most of those devices are powered by batteries. The limited life span of batteries constitutes a limitation, especially in a multiple-day expedition, where electrical power can not access conveniently. At the same time, there is a huge amount of energy stored in the human body. While walking, there is a large amount of power dissipated in the human body as negative muscle work and the energy loss by impact. By sourcing locally and using locally, human body energy harvesting is a promising solution. This dissertation focuses on harvesting energy from the human body to power wearable and mobile devices while poses a minimum burden on the human body. Three topics related to the human body energy harvesting are explored, i.e, energy harvesting backpack, negative muscle work harvester, and energy harvesting tile/paver. The energy harvesting backpack was invented in 2006. Extensive work was done to improve the performance of backpack energy harvester. The backpack is modeled as a spring-mass-damper system. Extensive work have been done to make the energy harvesting backpack broad frequency bandwidth. The negative work harvester mounts on the human ankle and harvests energy in the terminal stance phase in human walking. This harvester is an analogy to regenerative brake in vehicles. The energy harvesting paver/tile harvests energy when the heel contacts with ground and energy are dissipated by impact.

Given the ubiquity of media use, especially among young children, the current study examines the impact of problematic media use (PMU) on children's (N = 418, M age = 53.62 months, SD = 3.38 months, M and SD are taken from the full sample of 418 children) physiological functioning. With previous studies reporting relations between media use, temperament, and physiological regulation, it was hypothesized that children with greater levels of PMU would have lower levels of baseline respiratory sinus arrhythmia (RSA; a measure of physiological regulatory capacity). It is further hypothesized that, higher levels of negative affect, and lower levels of effortful control (two distinct domains of temperament) would be linked to both PMU and RSA and that temperament might mediate the associations between PMU and physiological regulation (RSA) (i.e., higher negative affect, lower effortful control linked to higher PMU and lower RSA). Data were drawn from Wave 5 of Project M.E.D.I.A, a longitudinal study of the effects of media on children's development. Findings revealed that PMU was significantly linked to lower baseline RSA for girls, but not for boys. Both boys' and girls' PMU was linked to higher levels of negative affect. Girls' PMU was linked to lower effortful control. The hypothesis that temperament would meditate links between PMU and RSA was not supported. The sex difference in the relation between PMU and baseline RSA are discussed, including potential differences in content of media girls are using as well as potential developmental differences for girls' reactivity compared to boys. Overall, PMU may lead to diminished physiological regulation, especially for girls, and appears to be linked to higher levels of negative affect in children. It is important for parents to be aware of the potential impact media use may have on their children's development.

Yes / Background: miRNAs (microRNAs) play a key role in triple-negative breast cancer (TNBC) progression, and its heterogeneity at the expression, pathological and clinical levels. Stratification of breast cancer subtypes on the basis of genomics and transcriptomics profiling, along with the known biomarkers’ receptor status, has revealed the existence of subgroups known to have diverse clinical outcomes. Recently, several studies have analysed expression profiles of matched mRNA and miRNA to investigate the underlying heterogeneity of TNBC and the potential role of miRNA as a biomarker within cancers. However, the miRNA-mRNA regulatory network within TNBC has yet to be understood. Results and Findings: We performed model-based integrated analysis of miRNA and mRNA expression profiles on breast cancer, primarily focusing on triple-negative, to identify subtype-specific signatures involved in oncogenic pathways and their potential role in patient survival outcome. Using univariate and multivariate Cox analysis, we identified 25 unique miRNAs associated with the prognosis of overall survival (OS) and distant metastases-free survival (DMFS) with “risky” and “protective” outcomes. The association of these prognostic miRNAs with subtype-specific mRNA genes was established to investigate their potential regulatory role in the canonical pathways using anti-correlation analysis. The analysis showed that miRNAs contribute to the positive regulation of known breast cancer driver genes as well as the activation of respective oncogenic pathway during disease formation. Further analysis on the “risk associated” miRNAs group revealed significant regulation of critical pathways such as cell growth, voltage-gated ion channel function, ion transport and cell-to-cell signalling. Conclusion: The study findings provide new insights into the potential role of miRNAs in TNBC disease progression through the activation of key oncogenic pathways. The results showed previously unreported subtype-specific prognostic miRNAs associated with clinical outcome that may be used for further clinical evaluation. / EPSRC (EP/R043787/1).

<p dir="ltr">Timing and time perception is essential to humans, whose lives and biology are organized around clocks. From the simple give-and-take of conversation to understanding cause and effect, individuals rely on accurate time perception to successfully complete tasks and organize their lives. However, accurate time perception is vulnerable to all manner of influence, from both internal and external sources, including affect. A robust body of literature suggests that negative affect is positively associated with time dilation, or subjective lengthening of time, whereas positive affect is positively associated with time constriction, or subjective shortening of time. Collectively, these are known as time distortion, which has been preliminarily linked to increased impairment in anxiety, depression, and BPD. However, this literature features two key limitations. First, researchers have mostly examined time perception as an objective measure, through the use of measures such as the temporal bisection tasks, which limits our understanding of the subjective experience of time distortion and how it may contribute to psychopathology. Second, across studies, time perception is most often studied as an outcome, rather than examining the role of time perception in predicting affective change, i.e., contextualizing the role of time distortion in clinically-relevant research questions. The current project aimed to address these gaps in the literature through two studies which examined (1) the roles of brief affect and time perception manipulations on affective change and subjective time perception in an online study (Study 1) and (2) the effect of a longer time perception manipulation on affective change during an in-person experimental protocol (Study 2).</p><p dir="ltr">Across studies, participants included a community-based sample of U.S. adults over age 18 and two separate undergraduate samples recruited from introductory psychology courses at Purdue University. In Study 1, the final sample size exceeded 750 and was comprised of community-based and undergraduate participants. Online participants reported on dispositional levels of clinical measures [e.g., rumination, borderline personality disorder (BPD) features] and then completed an experimental protocol with brief mood and time perception manipulations while repeatedly reporting on their negative affect. Results suggested that the time perception manipulation was not effective, but that across the protocol, negative affect rose and positive affect decreased. Further, participants reported overall that time seemed to be passing by slower than usual during the protocol. These findings informed the design of Study 2, which lengthened the time perception manipulation and eliminated the mood induction component in order to address the more basic question of whether time perception manipulation influences mood, particularly during neutral cognitive tasks.</p><p dir="ltr">One hundred and twenty-seven undergraduate participants completed Study 2. As in Study 1, participants filled out self-report surveys about dispositional symptoms of psychopathology (e.g., rumination, emotion dysregulation, and symptoms associated with BPD, depression, and anxiety) before completing an experimental protocol which included a manipulated clock (accelerated or control clock), three runs of a modified Erkisen flanker task, and repeated measures of negative and positive affect. Primary results suggested that the time perception manipulation was successful but that the influence of time distortion was more nuanced than hypothesized. Specifically, individuals with elevated clinical symptoms exhibited lower rating of negative and positive affect levels in the accelerated clock condition, compared to individuals endorsing low symptoms, who reported higher positive affect and higher negative affect in the accelerated clock condition.</p><p dir="ltr">Altogether, the results across studies highlight the complexity of time perception in influencing affect and help provide foundational information regarding the empirical convergence between cognitive and clinical phenomena.</p>

Extracting meaningful information from large collections of text data is problematic because of the sheer size of the database. However, automated analytic methods capable of processing such data have emerged. These methods, collectively called text mining first began to appear in 1988. A number of additional text mining methods quickly developed in independent research silos with each based on unique mathematical algorithms. How good each of these methods are at analyzing text is unclear. Method development typically evolves from some research silo centric requirement with the success of the method measured by a custom requirement-based metric. Results of the new method are then compared to another method that was similarly developed. The proposed research introduces an experimentally designed testing method to text mining that eliminates research silo bias and simultaneously evaluates methods from all of the major context-region text mining method families. The proposed research method follows a random block factorial design with two treatments consisting of three and five levels (RBF-35) with repeated measures. Contribution of the research is threefold. First, the users perceived a difference in the effectiveness of the various methods. Second, while still not clear, there are characteristics with in the text collection that affect the algorithms ability to extract meaningful results. Third, this research develops an experimental design process for testing the algorithms that is adaptable into other areas of software development and algorithm testing. This design eliminates the bias based practices historically employed by algorithm developers.

Syftet med studien var att undersöka förekomsten av arbetsplatsmobbning mot HR-anställda, samt om det fanns några könsrelaterade skillnader gällande tendensen att fallaoffer för arbetsplatsmobbning. Sammanlagt kontaktades 300 organisationer genom ettsystematiskt urval och 58 enkätsvar samlades in. En svensk översättning av verktygetNAQ-R (Rosander &amp; Blomberg, 2018) användes för att identifiera respondenter utsatta förarbetsplatsmobbning. Av de 58 svar som samlades in hade två (3%) respondenter blivitutsatta för arbetsplatsmobbning. Detta var en lägre siffra än vad som tidigare forskningrapporterat inom den svenska arbetsmarknaden. Analys genom användning av MannWhitney U-test visade att det inte fanns några signifikanta könsrelaterade skillnader. Vårslutsats är därför att det inom HR-yrket är ovanligare att falla offer för arbetsplatsmobbningän i det svenska arbetslivet i stort, och att det inte finns några könsrelaterade skillnadergällande tendensen att falla offer för arbetsplatsmobbning inom HR-yrket.

This study explored whether women who have breast augmentation are more vulnerable to negative stereotypes about their intelligence and abilities than women who do not elect to have breast augmentation. Furthermore, whether the motivation for seeking such surgery contributes to stereotypes was also explored. Participants in this study read experimentally manipulated biographies of a fictitious female author, followed by her short story. The only manipulation was one line in the author's biography which varied the reason for the plastic surgery across 4 conditions (for herself, for her significant other, for medical reconstructive reasons, or no surgery). The participants were asked to read and evaluate the author and her work. The results of this study suggest that women who elect to have plastic surgery for herself or her husband are perceived as being less deep. The results also suggest that women who have previously elected to have plastic surgery judged the authors' fictional work more critically when she had plastic surgery for herself or for her husband.

The concept behind "Drop, then Fade" draws inspiration from the convergence of "negative space" found in traditional Chinese art forms, such as painting, calligraphy, and seal cutting, and the evocative paintings of contemporary Chinese-Canadian artist Matthew Wong. In traditional Chinese painting, the concept of "negative space" is integral, symbolizing the harmony between humanity and nature, accentuating the subject, and conveying a sense of boundless space to evoke profound artistic depth. During a recent visit to the Museum of Fine Arts, I was deeply moved by Wong's works, which Raffi Khatchadourian eloquently describes as portraying "solitary figures, set adrift" amidst nature's overwhelming presence—whether depicted riding in a car at dusk or navigating through swathes of paint that seem to stretch endlessly. A discernible dialogue emerges between Wong's paintings and the concept of "negative space." "Drop, then Fade" delves into the musical interpretation of negative space, exploring how it intricately interacts with other elements—sometimes leaving them adrift, solitary, or overflowing, akin to ink drops diffusing into water and gradually dissipating. Within this musical framework, I integrate a poem I composed following my encounter with Wong's exhibition, adding another layer of artistic expression to the dialogue between visual and auditory media. / 2026-05-22T00:00:00Z

Malaria is one of the leading causes of mortality and morbidity globally. Land use/land cover (LULC) change have been found to affect the transmission and distribution of malaria in other regions, but no study has attempted to examine such relationships in Nepal. Therefore, this study was conducted in Nepal to assess LULC change between 2000 and 2010, to study the spatial and temporal trend of malaria incidence rate (MIR) between 1999 and 2015, and to understand the relationship between LULC and malaria. The land cover types used for this study are forest, water bodies, agriculture, grassland, shrubland, barren areas, built-up areas and paddy areas. Change detection techniques were used to study LULC change. The temporal trend of MIR in 58 districts, and the relationship between MIR and LULC were evaluated using Poisson and negative binomial regression. Forest, water bodies, snow cover, and built-up area increased in Nepal by 28.5%, 2.96%, 55.12% and 21.19% respectively while the rest of the LULC variables decreased. MIR decreased significantly in 21 districts; however, four districts namely Pyuthan, Kaski, Rupandehi and Siraha had a significantly increasing trend of MIR. During 2001, 2002, and 2003, MIR was positively related to water bodies and paddy areas. Similarly, MIR of 2010 was negatively related to grassland. However, there was no relationship between LULC and MIR in 2000, 2011, 2012 and 2013. It may be because MIR is decreasing significantly in the country and thus the influence of LULC change is also decreasing. / MS / Malaria is one of the major public health concern worldwide. Among many other factors, Land use/land cover (LULC) change have impact in the transmission and distribution of malaria which have been studied in other regions, however, no study has attempted to examine such relationships in Nepal. Therefore, this study was conducted in Nepal to understand the relationship between LULC and malaria. The land cover types used for this study are forest, water bodies, agriculture, grassland, shrubland, barren areas, built-up areas and paddy areas. The relationship between malaria incidence rate (MIR) and LULC were evaluated using Poisson and negative binomial regression. Water bodies and paddy cultivation had positive relationship with MIR during 2001, 2002, and 2003. Similarly, MIR of 2010 was negatively related to grassland. However, there was no relationship between LULC and MIR in 2000, 2011, 2012 and 2013. It may be because MIR is decreasing significantly in the country and thus the influence of LULC change is also decreasing.