Diss. (sammanfattning) Stockholm : Karolinska institutet, 2005. / Härtill 5 uppsatser.

Diss. (sammanfattning) Linköping : Linköpings universitet, 2008. / Härtill 5 uppsatser.

Thesis (Ph.D. in Physiology & Biophysics) -- University of Colorado Denver, 2007. / Typescript. Includes bibliographical references (leaves 125-138). Free to UCD affiliates. Online version available via ProQuest Digital Dissertations;

Thesis (Ph.D.)--University of Delaware, 2009. / Principal faculty advisor: Xiang-Gen Xia, Dept. of Electrical & Computer Engineering. Includes bibliographical references.

Thesis (M.Sc.)--University of Alberta, 2009. / A thesis submitted to the Faculty of Graduate Studies and Research in partial fulfillment of the requirements for the degree of Master of Science, Oncology. Title from pdf file main screen (viewed on October 24, 2009). Includes bibliographical references.

Η αντιμετώπιση του καρκίνου του προστάτη (αλλά και των υπόλοιπων νεοπλασματικών νοσημάτων) δεν περιλαμβάνει απλώς την ανεύρεση νέων χημειοθεραπευτικών φαρμάκων. Αφορά και την κατοχύρωση ορισμένων δεικτών που μπορούν να μας δώσουν περισσότερες πληροφορίες για την ύπαρξη της νόσου, αλλά και του σταδίου εξέλιξης που βρίσκεται έτσι ώστε να παίρνονται οι πλέον σωστές αποφάσεις για την διαχείριση του ασθενούς. Η βιβλιογραφική αναφορά που ακολουθεί θα ασχοληθεί εκτενώς με αυτά τα ζητήματα (δηλ. τους δείκτες νόσου/σταδίου νόσου του καρκίνου του προστάτη) και ιδιαίτερα με μια υποομάδα αυτών: των μοριακών δεικτών της σταδιοποίησης της λεμφαδενικής νόσου στον καρκίνο του προστάτη. Αφορά μια πολλά υποσχόμενη μερίδα μοριακών δεικτών στην αντιμετώπιση της συγκεκριμένης νόσου που ενδέχεται να επηρεάσει και την προσέγγιση άλλων συμπαγών όγκων. / Use of new molecular markers for staging of lymph node disease in the prostate cancer.

Le sujet de thèse a pour objectif de revisiter le paradigme d'acquisition d'images dans les circuits intégrés pour le rendre robuste et scalable en technologies nanométriques (telles que le 28nm FDSOI). Ceci, afin de répondre aux contraintes d’imagerie imposée par des applications de type internet des objets. Dans ce cas, un système sur puce (SoC) hétérogène conçut en technologie avancée permettrait de répondre aux contraintes de consommation d’énergie. L’utilisation des imageurs standard actuels n’est alors pas compatible avec cette exigence à cause de leur consommation excessive et leur non compatibilité avec les technologies FDSOI 28nm. De plus, les ressources importantes de calcul numérique disponibles dans ces types de SoC couplées avec de nouveaux modes de captures d'images permettraient d’atteindre des niveaux de consommation d’énergie extrêmement bas tout en offrant la possibilité d’implémenter des algorithmes de traitement d’image complexes. Après une étude bibliographique sur les différentes méthodes d’acquisition d’image ainsi qu’une étude bibliographique sur les imageurs en technologies dites avancées pour l’imagerie et pour des applications basse consommation, il a été montré qu’il était nécessaire de numériser au plus tôt l’information lumineuse reçue par le capteur. C’est pourquoi le sujet a été orienté vers une architecture de type événementielle. L’architecture d’un capteur d’image événementiel avec traitement intelligent associé a été développée, en prenant en considération les contraintes liées à la technologie. Afin de définir ces contraintes, un circuit de test de pixel en FDSOI 28nm a été réalisé permettant d’évaluer la réponse électro-optique. Les pixels ont chacun des types et des tailles de photodiodes différentes afin de valider le type et la taille les plus efficaces. Deux architectures événementielles ont été étudiées durant cette thèse afin de répondre aux contraintes d’une implémentation en technologies FDSOI 28nm : une architecture de type « Time-to-first-Spike » (TTFS) avec un système d’inhibition et une architecture dite « multi-bus » utilisant les possibilités d’interconnections denses offertes par la technologie. Ces deux architectures visent à réduire le flot de données sortant ainsi que la consommation d’énergie. Les traitements associés à l’acquisition ont été validés par des simulations MATLAB émulant l’acquisition événementielle et les prétraitements. Ce système de vision extrait donc une carte binaire correspondant aux contrastes locaux en utilisant un principe d’inhibition par bloc. Cette architecture de traitement est basée sur le pixel TTFS (et son principe d’inhibition) en adaptant son implémentation. La carte binaire est extraite de manière synchrone ce qui permet d’éviter l’ajout de matériel lié à une implémentation purement événementielle. Cette carte binaire peut servir dans des applications telles que de la détection de mouvement, ou de la classification telles que la méthode des histogrammes des gradients (HoG) le permet. La carte binaire extraite se rapproche des motifs binaires locaux (LBP) qui sont des outils fréquemment utilisés dans la détection et la reconnaissance de visage. Une partie de la thèse a également été consacrée à l’exploitation des possibilités qu’offre la technologie FDSOI 28nm. Notamment des architectures pixels utilisant une photodiode sous le transistor ont été étudiées. Il a également été développé dix matrices de 3 par 3 pixels en intégration 3D séquentielle utilisant la technologie CoolCube™ du LETI. / The goal of this thesis is to study new image acquisition paradigm in integrated vision circuits to enhance their robustness and scalability using nanometric technologies (such as the 28nm FDSOI) in order to satisfy the imaging constraints imposed by applications such as Internet of Things. In this case, a heterogeneous system-on-chip (SoC) designed in advanced technology would meet the energy consumption constraints. Using standard imagers is not compatible with this requirement because of their excessive power consumption and their architectures non-compatible with 28nm FDSOI technologies. In addition, in these SoC, significant available digital computational resources coupled with new image acquisition modes would allow ultra-low power consumption while providing the ability to implement complex image processing.After a bibliographic study on the state of the art on image acquisition methods and a study on imagers designed with advanced technologies and on low-power applications, it has been shown that it is necessary to quickly digitize light information received by the sensor (i.e. in the pixel). This is why the subject has been oriented towards an event-based vision sensor architecture.The architecture of an event-based image sensor with its associated smart processing has been developed, taking into account technology constraints. In order to define these constraints, a 28nm FDSOI pixel test circuit has been carried out to evaluate the electro-optical response. Each pixel has a different type and size of photodiodes in order to validate the most effective type and size.Two event-based architectures were studied during this thesis in order to fit with the constraints of an implementation in 28nm FDSOI technologies: a "Time-to-first-Spike" (TTFS) architecture with an inhibition system and an architecture called "multi-bus "using the dense interconnections possibilities offered by the technology. These two architectures aim to reduce the data throughput as well as energy consumption.The processing associated to the acquisition have been validated by MATLAB simulations emulating the event acquisition and pre-processing. This vision system therefore extracts a binary map corresponding to the local contrasts using block inhibition mechanism. This processing architecture is based on TTFS pixel (and its inhibition mechanism) with a dedicated pixel schematic. The binary map is extracted in a synchronous manner, thus avoiding hardware addition inherent to an AER (Adress Event Representation) implementation. This binary map can be used for applications such as motion detection, or classification such as histogram of gradient method (HoG). This extracted binary map approaches local binary patterns (LBP), which are frequently used tools in face detection and recognition.A part of this thesis has been dedicated also to the exploration of FDSOI 28nm capabilities in terms of pixel implementation. Notably, by studying pixels using a photodiode under the FDSOI transistor. It has also been developed ten 3 by 3 pixels matrices using 3D integration with LETI technology CoolCube™.

Orientadora: Rosemeri de Oliveira Vasconcelos / Banca: Valéria Marçal Felix de Lima / Banca: Antonio Carlos Alessi / Resumo: A Leishmaniose Visceral (LV) é uma zoonose de interesse em saúde pública e o cão é o principal reservatório doméstico de Leishmania chagasi. Este protozoário modula a resposta imune do hospedeiro. A citocina MIF favorece a permanência do macrófago no sítio da injúria e protege-o da apoptose. O objetivo deste estudo foi avaliar a presença de MIF nos linfonodos de cães com LV, comparando estes achados com a densidade de macrófagos parasitados nos linfonodos e com o estadiamento clínico dos cães. Neste estudo utilizou-se 33 cães oriundos de Araçatuba, município endêmico para a LV. Os cães foram distribuídos nos grupos assintomático (A), oligossintomático (O) e sintomático (S). As alterações morfológicas dos linfonodos poplíteo, subescapular, ilíaco e mesentérico foram avaliadas quanto ao perfil celular, determinado por escores. A carga parasitária e a imunodetecção de MIF foi feita pela técnica de imuno-histoquímica. Nos cães dos grupos com sinais clínicos (O e S), as reações inflamatória granulomatosa e plasmocitária foram predominantes. No grupo S, a atrofia linfóide predominou e associou-se ao maior número de granulomas e a maior carga parasitária. A densidade de parasitos nos linfonodos periféricos diferiu significativamente do grupo S para os demais grupos (P<0,05). A densidade de macrófagos imunomarcados com MIF foi maior no grupo S e apresentou uma correlação significativa com a carga parasitária no linfonodo poplíteo (P<0,05). Conclui-se que macrófagos são uma das células mais envolvidas na resposta ao parasito. O protozoário utiliza MIF para manter o macrófago no sítio de infecção, favorecendo a sua sobrevivência no hospedeiro / Abstract: Visceral leishmaniasis (VL) is a zoonotic disease critical for the public health and the dog is the main Leishmania chagasi„s domestic reservoir. This protozoan modulates the immune response of the host. The MIF cytokine facilitates the permanence of the macrophage in the site of injury and protects it from apoptosis. The aim of this study was to evaluate the MIF presence in the lymph nodes of dogs with VL, comparing these findings with the parasite density in the lymph nodes and with the clinical outcome of the dogs. Third three dogs from Araçatuba, an endemic city for VL, were used in this study. Dogs were distributed in the asymptomatic (A), oligosymptomatic (O) and symptomatic (S) groups. The cellular profile of the morphologic changes of the popliteal, subscapular, iliac and mesenteric lymph nodes were evaluated and scored. Immunohistochemistry did the parasite load and the MIF immunodetection technique. Granulomatous and plasmocitary inflammatory reaction predominated in the groups with clinical signs (O and S). In the S group, lymphoid atrophy predominated and was associated with high number of granulomas and high parasite load. Comparing the groups, the density of the parasites in the peripheral lymph nodes was significantly different for the S group (P<0.05). The density of the immunolabeling MIF macrophages was higher in the S group and had a significant positive correlation with the parasite load in the popliteal lymph node (P<0.05). In conclusion, the macrophages are the most involved cells, and the protozoan uses the MIF to keep the macrophage in the infection site, helping its survival in the host / Mestre

In this paper we thoroughly cover the issue of blank nodes, which have been defined in RDF as "existential variables". We first introduce the theoretical precedent for existential blank nodes from first order logic and incomplete Information in database theory. We then cover the different (and sometimes incompatible) treatment of blank nodes across the W3C stack of RDF-related standards. We present an empirical survey of the blank nodes present in a large sample of RDF data published on the Web (the BTC-2012 dataset), where we find that 25.7% of unique RDF terms are blank nodes, that 44.9% of documents and 66.2% of domains featured use of at least one blank node, and that aside from one Linked Data domain whose RDF data contains many "blank node cycles", the vast majority of blank nodes form tree structures that are efficient to compute simple entailment over. With respect to the RDF-merge of the full data, we show that 6.1% of blank-nodes are redundant under simple entailment. The vast majority of non-lean cases are isomorphisms resulting from multiple blank nodes with no discriminating information being given within an RDF document or documents being duplicated in multiple Web locations. Although simple entailment is NP-complete and leanness-checking is coNP-complete, in computing this latter result, we demonstrate that in practice, real-world RDF graphs are sufficiently "rich" in ground information for problematic cases to be avoided by non-naive algorithms.

Increasing number of devices demand for low latency and high-speed data transmission require that the computation resources to be closer to users. The emerging Mobile Edge Computing (MEC) technology aims to bring the advantages of cloud computing which are computation, storage and networking capabilities in close proximity of user. MEC servers are also integrated with cloud servers which give them flexibility of reaching vast computational power whenever needed. In this thesis, leveraging the idea of Mobile Edge Computing, we propose algorithms for cost-efficient and energy-efficient the placement of Mobile Edge nodes. We focus on uplink energy-efficiency which is essential for certain applications including augmented reality and connected vehicles, as well as extending battery life of user equipment that is favorable for all applications. The experimental results show that our proposed schemes significantly reduce the uplink energy of devices and minimizes the number of edge nodes required in the network.