Thesis (Ph. D.)--University of Chicago, 2002. / Includes bibliographical references (leaves 255-266). Also available on the Internet.

ABSTRACT The purpose of this thesis was to explore the origins, formulation, course and outcome of the Intergovernmental Committee for Political Refugees meeting (better known as the Evian Conference) of July 1938. Special emphasis was placed on contemporary and later historical assessments of this assembly which represented the first international cooperative attempt to solve an acute refugee crisis. A general review followed by a more detailed evaluation was made of existing official and un-official accounts of the meeting utilizing both public records, private diaries, books, newspapers, journals and other periodicals for the period of January 1, 1938 through December 31, 1939. This data was supplemented by later recollections of conference participants as well as post-Holocaust historical scholarship. Various appraisals have been made of the motivations behind the summit and its ultimate success or failure. Franklin Roosevelt has particularly come under criticism by scholars who believed that his Administration had "abandoned" the Jews to their fate. The President's supporters, on the other hand, declared that FDR did everything possible given the existing political, economic and social conditions of the late 1930's. It is my conclusion that although Roosevelt may have been sympathetic to the plight of Central European Jewish refugees their resettlement and ultimate destiny merited a lower priority given his focus upon rebuilding the national economy and defense. The President clearly recognized the looming threat of Nazi Germany and Imperial Japan but was unwilling to expend political capital on an issue that faced domestic and political opposition. I further maintain that the conference was set up to fail while providing propaganda value for the participating democracies. The hypocritical rhetoric and actions of the delegates and the ineffectiveness of the conference's sole creation, the Intergovernmental Committee for Political Refugees, was clearly recognized by Nazi Germany and ultimately influenced its anti-Jewish policies. Thus, it is not a coincidence that the pogrom of November 1938, Kristallnacht, occurred only four months later. The avoidance of dealing with the Jewish refugee problem was further highlighted in the futile Wagner-Rogers Bill of 1939, the Hennings bill of 1940 and especially the Bermuda Conference of 1943, a time in which the details of mass murder of Jews and other groups was already well known within official circles. Further work needs to be done on the diverse responses of the Jewish community both within the United States and abroad to the peril facing their co-religionists.

This dissertation is organized into four chapters: an introduction followed by three chapters, each based on one of three separate papers. In Chapter 2 we consider gradient descent equations for energy functionals of the type [mathematical equation] where A is a second-order uniformly elliptic operator with smooth coefficients. We consider the gradient descent equation for S, where the gradient is an element of the Sobolev space H[superscipt beta], [beta is an element of](0, 1), with a metric that depends on A and a positive number [gamma] > sup |V₂₂|. The main result of Chapter 2 is a weak comparison principle for such a gradient flow. We extend our methods to the case where A is a fractional power of an elliptic operator, and we provide an application to the Aubry-Mather theory for partial differential equations and pseudo-differential equations by finding plane-like minimizers of the energy functional. In Chapter 3 we investigate the differentiability of the minimal average energy associated to the functionals [mathematical equation] using numerical and perturbation methods. We use the Sobolev gradient descent method as a numerical tool to compute solutions of the Euler-Lagrange equations with some periodicity conditions; this is the cell problem in homogenization. We use these solutions to determine the minimal average energy as a function of the slope. We also obtain a representation of the solutions to the Euler-Lagrange equations as a Lindstedt series in the perturbation parameter [epsilon], and use this to confirm our numerical results. Additionally, we prove convergence of the Lindstedt series. In Chapter 4 we present a method for determining the stability of a class of stochastically forced ordinary differential equations, where the forcing term can be obtained by passing white noise through a filter of arbitrarily high degree. We use the Fokker-Planck equation to write a partial differential equation for the second moments, which we turn into an eigenvalue problem for a second-order differential operator. We develop ladder operators to determine analytic expressions for the eigenvalues and eigenfunctions of this differential operator, and thus determine the stability. / text

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Mémoire numérisé par la Division de la gestion de documents et des archives de l'Université de Montréal

Inanda Dam situated near Durban in the Mngeni River, in the province of KwaZulu-Natal was completed in the late 1980s. As a typical large dam of the modern era, one major impact of the dam was the displacement and resettlement of over 1300 rural households living under communal ("tribal") tenure. Households were relocated to different places some kilometres away from their original places. These new relocation areas, where different tenure and other arrangements prevailed, then became their permanent residential location. This study was initiated to investigate two key issues. It sought to understand how the relocation altered the quality of life of removed families. It also sought to explore adaptation strategies adopted by the settlers and constraints to effective adaptation. Primary data were collected by means of in-depth interviews and direct observation of certain indicators of quality of life in the study area, over a period of five months. Fourteen households participated in the study. Simple quantitative methods were used to supplement the overall qualitative research design. Because of the small sample that was used, the study is perhaps not widely generalizable. However the study does provide insights into the long-term impacts of this inadequately mitigated displacement. It is also a case study of the nature of long-term environmental injustice and disruption associated with the construction of large dams. This is an injustice made worse by the political system of apartheid prevailing when the dam was planned and built. The general findings are that the dam did impact negatively on the quality of life of the displaced families. Thirteen years after compulsory relocation, the quality of life of several families has deteriorated instead of slowly improving. While the process of adaptation for some families has been easy, other families are still battling to reconstruct their livelihoods and quality of life. Where benefits of access to services such as potable piped water and electricity are enjoyed, these benefits are overshadowed by inability to pay and lack of access to other goods such as proper housing and adequate land. Loss of access to common property resources has meant a shift towards more money-based livelihood generation strategies. Constraints to adaptation are both internal and external. Low levels of socioeconomic status, poor access to environmental resources and the unfavourable political conditions in the relocation areas are some of the major constraints to effective adaptation. While the individual and group coping strategies employed have assisted families in the adaptation process, it is argued that the inadequacy of state support mechanisms significantly retarded the ability of households to adapt to life in the relocation areas. / Thesis (M.A.)-University of Natal, Durban, 2002.

Sildenafil, a selective phosphodiesterase type 5 (PDE5) inhibitor, is registered for the treatment of male erectile dysfunction (Viagra®) and pulmonary hypertension (Revatio®) in the United States. PDE5 is found in the endothelium of blood vessels in the penile corpus cavernosum, pulmonary vessels and also brain and other peripheral tissue. Sildenafil crosses the blood brain barrier, leading to side-effects such as headache and dizziness, as well as behavioural manifestations including depression, anxiety and aggression (Milman & Arnold, 2002). According to the Food and Drug Administration (2001), 12378 adverse events were reported after the use of sildenafil and 274 of these reports implicated sildenafil in neurologic, emotional, or psychological disturbances between January 1998 and 21 February 2001. In addition, in vivo studies in rats indicate that sildenafil has anxiogenic and stressogenic actions (Harvey et al., 2005; Volke et al., 2003). This is a clear indication that sildenafil influences neurological processes in the brain and may influence various signalling systems, which play major roles in the neural circuitry of the above-mentioned disturbances. Recent in vitro studies in our laboratory suggest that sildenafil may potentiate cholinergic muscarinic receptor signalling (Eager, 2004). These results suggest potential depressogenic actions, since an increase in acetylcholine is associated with depression-like symptoms (El- Yousef et al., 1973). It was therefore postulated that sildenafil may in fact possess antidepressant activity that is masked by a cholinergic-driven depressogenic activity. In a study conducted by Muller and Benkert in 2000, patients reported a decrease in depression-like symptoms when treated with sildenafil for erectile dysfunction. This implied that sildenafil not only had a direct effect on erectile function in about 50-80% of men with erectile dysfunction (Langtry and Markham, 1999; Padma-Nathan, 1999) but might also improve anhedonia and depression. The substantial correlation between the International Index of Erectile Function and Epidemiologic Studies-Depression Scale scores supported this assumption (Muller & Benkert, 2000). In addition, Raffaele et al. (2002) reported an indirect improvement in depressive-like symptoms in patients treated for erectile dysfunction with idiopathic Parkinson's disease. Aims: The current study investigated the behavioural and neuroreceptor properties of sildenafil in a rat model of depression. We also investigated a hypothesis that sildenafil displays antidepressant-like properties, but which are masked by its potentiation of the cholinergic system. Methods: The experimental layout was divided into three pilot studies. Pilot Study 1 validated the FST under our laboratory conditions, Sprague-Dawley rats received saline intraperitoneally (i.p.) for 7 days, whereafter half of the rats were pre-exposed to a 15 minute swim trial, while the remaining rats were not pre-exposed. All rats were then evaluated 24 hours later in the 5 minute scored swim trial. In Pilot Study 2 Sprague-Dawley rats were treated for 3, 7 or 11 days with vehicle (control) or 20 mg/kg fluoxetine to establish the time-dependency of the onset of antidepressant-like effects in a rat model of depression. We measured immobility in the rat forced swim test (FST), as well as changes in P-adrenergic receptor (P-AR) concentration in rat frontal cortex. In pilot study 3, rats were treated for 7 days with vehicle (control), 20 mg/kg fluoxetine, 10 mg/kg sildenafil, 1 mg/kg atropine or various combinations of these drugs. Again we employed the FST and measured cortical p-AR concentration. Results: In the FST pre-exposure to a 15 minute swim trial 24 hours before the scored swim trial significantly increased immobility. Fluoxetine inhibited this development of increased immobility in FST and decreased P-AR concentration after 7 and 11 days of treatment with fluoxetine, but not after 3 days. Seven days of treatment with atropine and sildenafil alone did not exert any changes in immobility in the FST or changes in p-AR concentration. However, a combination of atropine and sildenafil exerted a significant antidepressant-like behavioural effect, comparable with fluoxetine. Moreover, the combination of atropine and fluoxetine as well as the a triple combination of fluoxetine, sildenafil and atropine was superior to fluoxetine alone. Conclusion: Muscarinic cholinergic mechanisms mask the antidepressant-like properties of sildenafil in a rat model of depression. The antidepressant properties of the combination of sildenafil and atropine are comparable to that of fluoxetine in an animal model of depression. The combination of fluoxetine with atropine, and atropine and sildenafil enhances the antidepressant-like properties of fluoxetine. / Thesis (M.Sc. (Pharmacology))--North-West University, Potchefstroom Campus, 2007.

The social displacement enforced by the South African Group Areas Act between 1954 and 1955 was understandably experienced as a destructive process with physical and emotional consequences arising from various types of losses, separation and feelings of helplessness. Although the forced removals affected all the people in the community - also in later years and generations, it seems as if older people are affected the more as they still remember the losses they experienced when they were removed from their homes and their communities, when their heritage and their culture were displaced. The sense of belonging being experienced by older people, who were subjected to these forceful removals, is therefore unclear. In this study the sense of belonging is defined as the effective participation, involvement, contribution and emersion of people when relating to their social, physical, spiritual, emotional and cultural places. In this study older (aged 60 and above) Setswana speaking residents of Ikageng, a community just outside Potchefstroom in the North West Province, South Africa, who were also forcibly relocated from Kloppersville to Ikageng, 10 kilometers away from Kloppersville, were asked to identify places that are important to them in Ikageng and to describe the meanings they attach to these places. In the research, no one identified any places of importance in Ikageng, instead throughout the research they kept on referring to their lives in Kloppersville, their former place of residence, the place where they were forcibly removed from – giving purpose and direction to this study and leading to the question: What are the experiences related to the sense of belonging of Setswana speaking older women who were forcibly relocated during Apartheid in South Africa? The older persons’ experiences of their sense of belonging in the place where they were forcibly relocated to must be understood in relation to the past. A qualitative research approach was used and a narrative research design followed. Two sets of data were gathered and are reported on in this article that focuses on the narrations of 11 older Tswana people from the Day Care Centre for the Aged in Ikageng. Narrative data collection and analysis, as well as a variety of qualitative research methods and media, were used to collect data. These include: focus group discussions, the Mmogo– MethodTM, videos, audio, photographs and observational notes. The thematic analysis of textual data, narrative–oriented inquiry as well as visual data, established trustworthiness of this research through crystallization. By drawing on the deeper symbolic meaning derived through the use of the MmogomethodTM, the study has revealed that the sense of belonging is a relational phenomenon that cannot be understood in absence of the different relational environments. In an African culture the relationship with the current environment resonates with the effects that historical processes, structural abuses, discrimination, racism and devaluation had on individuals whose lives have been uprooted. This study has shown that the older women have a micro–organic relational sense of belonging to the place of relocation and not to the whole context and other relational environments and that they revealed more sense of belonging towards the place where they were relocated from. / Thesis (M.A. (Research Psychology))--North-West University, Potchefstroom Campus, 2012.

Sildenafil, a selective phosphodiesterase type 5 (PDE5) inhibitor, is registered for the treatment of male erectile dysfunction (Viagra®) and pulmonary hypertension (Revatio®) in the United States. PDE5 is found in the endothelium of blood vessels in the penile corpus cavernosum, pulmonary vessels and also brain and other peripheral tissue. Sildenafil crosses the blood brain barrier, leading to side-effects such as headache and dizziness, as well as behavioural manifestations including depression, anxiety and aggression (Milman & Arnold, 2002). According to the Food and Drug Administration (2001), 12378 adverse events were reported after the use of sildenafil and 274 of these reports implicated sildenafil in neurologic, emotional, or psychological disturbances between January 1998 and 21 February 2001. In addition, in vivo studies in rats indicate that sildenafil has anxiogenic and stressogenic actions (Harvey et al., 2005; Volke et al., 2003). This is a clear indication that sildenafil influences neurological processes in the brain and may influence various signalling systems, which play major roles in the neural circuitry of the above-mentioned disturbances. Recent in vitro studies in our laboratory suggest that sildenafil may potentiate cholinergic muscarinic receptor signalling (Eager, 2004). These results suggest potential depressogenic actions, since an increase in acetylcholine is associated with depression-like symptoms (El- Yousef et al., 1973). It was therefore postulated that sildenafil may in fact possess antidepressant activity that is masked by a cholinergic-driven depressogenic activity. In a study conducted by Muller and Benkert in 2000, patients reported a decrease in depression-like symptoms when treated with sildenafil for erectile dysfunction. This implied that sildenafil not only had a direct effect on erectile function in about 50-80% of men with erectile dysfunction (Langtry and Markham, 1999; Padma-Nathan, 1999) but might also improve anhedonia and depression. The substantial correlation between the International Index of Erectile Function and Epidemiologic Studies-Depression Scale scores supported this assumption (Muller & Benkert, 2000). In addition, Raffaele et al. (2002) reported an indirect improvement in depressive-like symptoms in patients treated for erectile dysfunction with idiopathic Parkinson's disease. Aims: The current study investigated the behavioural and neuroreceptor properties of sildenafil in a rat model of depression. We also investigated a hypothesis that sildenafil displays antidepressant-like properties, but which are masked by its potentiation of the cholinergic system. Methods: The experimental layout was divided into three pilot studies. Pilot Study 1 validated the FST under our laboratory conditions, Sprague-Dawley rats received saline intraperitoneally (i.p.) for 7 days, whereafter half of the rats were pre-exposed to a 15 minute swim trial, while the remaining rats were not pre-exposed. All rats were then evaluated 24 hours later in the 5 minute scored swim trial. In Pilot Study 2 Sprague-Dawley rats were treated for 3, 7 or 11 days with vehicle (control) or 20 mg/kg fluoxetine to establish the time-dependency of the onset of antidepressant-like effects in a rat model of depression. We measured immobility in the rat forced swim test (FST), as well as changes in P-adrenergic receptor (P-AR) concentration in rat frontal cortex. In pilot study 3, rats were treated for 7 days with vehicle (control), 20 mg/kg fluoxetine, 10 mg/kg sildenafil, 1 mg/kg atropine or various combinations of these drugs. Again we employed the FST and measured cortical p-AR concentration. Results: In the FST pre-exposure to a 15 minute swim trial 24 hours before the scored swim trial significantly increased immobility. Fluoxetine inhibited this development of increased immobility in FST and decreased P-AR concentration after 7 and 11 days of treatment with fluoxetine, but not after 3 days. Seven days of treatment with atropine and sildenafil alone did not exert any changes in immobility in the FST or changes in p-AR concentration. However, a combination of atropine and sildenafil exerted a significant antidepressant-like behavioural effect, comparable with fluoxetine. Moreover, the combination of atropine and fluoxetine as well as the a triple combination of fluoxetine, sildenafil and atropine was superior to fluoxetine alone. Conclusion: Muscarinic cholinergic mechanisms mask the antidepressant-like properties of sildenafil in a rat model of depression. The antidepressant properties of the combination of sildenafil and atropine are comparable to that of fluoxetine in an animal model of depression. The combination of fluoxetine with atropine, and atropine and sildenafil enhances the antidepressant-like properties of fluoxetine. / Thesis (M.Sc. (Pharmacology))--North-West University, Potchefstroom Campus, 2007.

The social displacement enforced by the South African Group Areas Act between 1954 and 1955 was understandably experienced as a destructive process with physical and emotional consequences arising from various types of losses, separation and feelings of helplessness. Although the forced removals affected all the people in the community - also in later years and generations, it seems as if older people are affected the more as they still remember the losses they experienced when they were removed from their homes and their communities, when their heritage and their culture were displaced. The sense of belonging being experienced by older people, who were subjected to these forceful removals, is therefore unclear. In this study the sense of belonging is defined as the effective participation, involvement, contribution and emersion of people when relating to their social, physical, spiritual, emotional and cultural places. In this study older (aged 60 and above) Setswana speaking residents of Ikageng, a community just outside Potchefstroom in the North West Province, South Africa, who were also forcibly relocated from Kloppersville to Ikageng, 10 kilometers away from Kloppersville, were asked to identify places that are important to them in Ikageng and to describe the meanings they attach to these places. In the research, no one identified any places of importance in Ikageng, instead throughout the research they kept on referring to their lives in Kloppersville, their former place of residence, the place where they were forcibly removed from – giving purpose and direction to this study and leading to the question: What are the experiences related to the sense of belonging of Setswana speaking older women who were forcibly relocated during Apartheid in South Africa? The older persons’ experiences of their sense of belonging in the place where they were forcibly relocated to must be understood in relation to the past. A qualitative research approach was used and a narrative research design followed. Two sets of data were gathered and are reported on in this article that focuses on the narrations of 11 older Tswana people from the Day Care Centre for the Aged in Ikageng. Narrative data collection and analysis, as well as a variety of qualitative research methods and media, were used to collect data. These include: focus group discussions, the Mmogo– MethodTM, videos, audio, photographs and observational notes. The thematic analysis of textual data, narrative–oriented inquiry as well as visual data, established trustworthiness of this research through crystallization. By drawing on the deeper symbolic meaning derived through the use of the MmogomethodTM, the study has revealed that the sense of belonging is a relational phenomenon that cannot be understood in absence of the different relational environments. In an African culture the relationship with the current environment resonates with the effects that historical processes, structural abuses, discrimination, racism and devaluation had on individuals whose lives have been uprooted. This study has shown that the older women have a micro–organic relational sense of belonging to the place of relocation and not to the whole context and other relational environments and that they revealed more sense of belonging towards the place where they were relocated from. / Thesis (M.A. (Research Psychology))--North-West University, Potchefstroom Campus, 2012.